LOCUS       NM_080671               2915 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily E regulatory
            subunit 4 (KCNE4), mRNA.
ACCESSION   NM_080671
VERSION     NM_080671.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2915)
  AUTHORS   Sun,J., Ding,Y., Zhou,Q., Kalds,P., Han,J., Zhang,K., Wei,Y.,
            Wu,W., Wang,X. and Zheng,W.
  TITLE     KCNE4 is a crucial host factor for Orf virus infection by mediating
            viral entry
  JOURNAL   Virol J 21 (1), 181 (2024)
   PUBMED   39118175
  REMARK    GeneRIF: KCNE4 is a crucial host factor for Orf virus infection by
            mediating viral entry.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2915)
  AUTHORS   Olivencia,M.A., Villegas-Esguevillas,M., Sancho,M., Barreira,B.,
            Paternoster,E., Adao,R., Larriba,M.J., Cogolludo,A. and
            Perez-Vizcaino,F.
  TITLE     Vitamin D Receptor Deficiency Upregulates Pulmonary Artery Kv7
            Channel Activity
  JOURNAL   Int J Mol Sci 24 (15), 12350 (2023)
   PUBMED   37569725
  REMARK    GeneRIF: Vitamin D Receptor Deficiency Upregulates Pulmonary Artery
            Kv7 Channel Activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2915)
  AUTHORS   Tian,K., Tao,Z., Chen,Y., Du,J., Chen,M., Wang,D. and Li,Z.
  TITLE     KCNE4 expression is correlated with the pathological
            characteristics of colorectal cancer patients and associated with
            the radioresistance of cancer cells
  JOURNAL   Pathol Res Pract 241, 154234 (2023)
   PUBMED   36459833
  REMARK    GeneRIF: KCNE4 expression is correlated with the pathological
            characteristics of colorectal cancer patients and associated with
            the radioresistance of cancer cells.
REFERENCE   4  (bases 1 to 2915)
  AUTHORS   Mano,R., Tanaka,T., Hashiguchi,S., Takahashi,H., Sakata,N.,
            Kondo,S. and Kodama,S.
  TITLE     Induction of potassium channel regulator KCNE4 in a submandibular
            lymph node metastasis model
  JOURNAL   Sci Rep 12 (1), 13208 (2022)
   PUBMED   35915077
  REMARK    GeneRIF: Induction of potassium channel regulator KCNE4 in a
            submandibular lymph node metastasis model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2915)
  AUTHORS   Vallejo-Gracia,A., Sastre,D., Colomer-Molera,M., Sole,L.,
            Navarro-Perez,M., Capera,J., Roig,S.R., Pedros-Gamez,O.,
            Estadella,I., Szilagyi,O., Panyi,G., Hajdu,P. and Felipe,A.
  TITLE     KCNE4-dependent functional consequences of Kv1.3-related leukocyte
            physiology
  JOURNAL   Sci Rep 11 (1), 14632 (2021)
   PUBMED   34272451
  REMARK    GeneRIF: KCNE4-dependent functional consequences of Kv1.3-related
            leukocyte physiology.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2915)
  AUTHORS   Grunnet,M., Olesen,S.P., Klaerke,D.A. and Jespersen,T.
  TITLE     hKCNE4 inhibits the hKCNQ1 potassium current without affecting the
            activation kinetics
  JOURNAL   Biochem Biophys Res Commun 328 (4), 1146-1153 (2005)
   PUBMED   15707997
  REMARK    GeneRIF: Based upon previous studies and the present results, it is
            concluded that both hKCNE4 and mKCNE4 have a drastic inhibitory
            impact on both hKCNQ1 and mKCNQ1 currents.
REFERENCE   7  (bases 1 to 2915)
  AUTHORS   Grunnet,M., Rasmussen,H.B., Hay-Schmidt,A., Rosenstierne,M.,
            Klaerke,D.A., Olesen,S.P. and Jespersen,T.
  TITLE     KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium
            channels
  JOURNAL   Biophys J 85 (3), 1525-1537 (2003)
   PUBMED   12944270
  REMARK    GeneRIF: KCNE4 beta-subunit has a drastic inhibitory effect on
            currents generated by Kv1.1 and Kv1.3 potassium channels
REFERENCE   8  (bases 1 to 2915)
  AUTHORS   Teng,S., Ma,L., Zhen,Y., Lin,C., Bahring,R., Vardanyan,V., Pongs,O.
            and Hui,R.
  TITLE     Novel gene hKCNE4 slows the activation of the KCNQ1 channel
  JOURNAL   Biochem Biophys Res Commun 303 (3), 808-813 (2003)
   PUBMED   12670483
  REMARK    GeneRIF: expressed strongly in heart, skeletal muscle, and kidney,
            less in placenta, lung, and liver, and weakly in brain and blood
            cells. Electrophysiological study showed that KCNE4 modulates the
            activation of the KCNQ1 channel.
REFERENCE   9  (bases 1 to 2915)
  AUTHORS   Grunnet,M., Jespersen,T., Rasmussen,H.B., Ljungstrom,T.,
            Jorgensen,N.K., Olesen,S.P. and Klaerke,D.A.
  TITLE     KCNE4 is an inhibitory subunit to the KCNQ1 channel
  JOURNAL   J Physiol 542 (Pt 1), 119-130 (2002)
   PUBMED   12096056
REFERENCE   10 (bases 1 to 2915)
  AUTHORS   Abbott,G.W., Sesti,F., Splawski,I., Buck,M.E., Lehmann,M.H.,
            Timothy,K.W., Keating,M.T. and Goldstein,S.A.
  TITLE     MiRP1 forms IKr potassium channels with HERG and is associated with
            cardiac arrhythmia
  JOURNAL   Cell 97 (2), 175-187 (1999)
   PUBMED   10219239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC017014.4.
            
            On Jul 27, 2020 this sequence version replaced NM_080671.3.
            
            Summary: Voltage-gated potassium (Kv) channels represent the most
            complex class of voltage-gated ion channels from both functional
            and structural standpoints. Their diverse functions include
            regulating neurotransmitter release, heart rate, insulin secretion,
            neuronal excitability, epithelial electrolyte transport, smooth
            muscle contraction, and cell volume. This gene encodes a member of
            the potassium channel, voltage-gated, isk-related subfamily. This
            member is a type I membrane protein, and a beta subunit that
            assembles with a potassium channel alpha-subunit to modulate the
            gating kinetics and enhance stability of the multimeric complex.
            This gene is prominently expressed in the embryo and in adult
            uterus. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.244530.1,
                                           SRR18074969.3507538.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281830.4/ ENSP00000281830.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AC017014.4         33298-33382
            86-2915             AC017014.4         33916-36745
FEATURES             Location/Qualifiers
     source          1..2915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.1"
     gene            1..2915
                     /gene="KCNE4"
                     /gene_synonym="MIRP3"
                     /note="potassium voltage-gated channel subfamily E
                     regulatory subunit 4"
                     /db_xref="GeneID:23704"
                     /db_xref="HGNC:HGNC:6244"
                     /db_xref="MIM:607775"
     exon            1..85
                     /gene="KCNE4"
                     /gene_synonym="MIRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            86..2915
                     /gene="KCNE4"
                     /gene_synonym="MIRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..621
                     /gene="KCNE4"
                     /gene_synonym="MIRP3"
                     /note="MINK-related peptide 3; minimum potassium ion
                     channel-related peptide 3; cardiac voltage-gated potassium
                     channel accessory subunit 4; potassium voltage-gated
                     channel, Isk-related family, member 4; potassium channel
                     subunit beta MiRP3; potassium channel, voltage gated
                     subfamily E regulatory beta subunit 4"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily E
                     member 4"
                     /protein_id="NP_542402.4"
                     /db_xref="CCDS:CCDS2456.3"
                     /db_xref="GeneID:23704"
                     /db_xref="HGNC:HGNC:6244"
                     /db_xref="MIM:607775"
                     /translation="MLKMEPLNSTHPGTAASSSPLESRAAGGGSGNGNEYFYILVVMS
                     FYGIFLIGIMLGYMKSKRREKKSSLLLLYKDEERLWGEAMKPLPVVSGLRSVQVPLML
                     NMLQESVAPALSCTLCSMEGDSVSSESSSPDVHLTIQEEGADDELEETSETPLNESSE
                     GSSENIHQNS"
     regulatory      2880..2885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNE4"
                     /gene_synonym="MIRP3"
                     /note="hexamer: AATAAA"
     polyA_site      2915
                     /gene="KCNE4"
                     /gene_synonym="MIRP3"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcaga gccggacaga gcagaagaac cctcttggac tggacgattt gggaattcaa
       61 aacttgggac aaactgtcag ccttgcccct gctgtggagg cagcctcaat gctgaaaatg
      121 gagcctctga acagcacgca ccccggcacc gccgcctcca gcagccccct ggagtcccgt
      181 gcggccggcg gcggcagcgg caatggcaac gagtacttct acattctggt tgtcatgtcc
      241 ttctacggca ttttcttgat cggaatcatg ctgggctaca tgaaatccaa gaggcgggag
      301 aagaagtcca gcctcctgct gctgtacaaa gacgaggagc ggctctgggg ggaggccatg
      361 aagccgctgc ctgtggtgtc gggcctgagg tcggtgcagg tgcccctgat gctgaacatg
      421 ctgcaggaga gcgtggcgcc cgcgctgtcc tgcaccctct gttccatgga aggggacagc
      481 gtgagctccg agtcctcctc cccggacgtg cacctcacca ttcaggagga gggggcagac
      541 gatgagctgg aggagacctc ggagacgccc ctcaacgaga gcagcgaagg gtcctcggag
      601 aacatccatc agaattccta gcacccccgg gacccctgcc ggtggctcca tcagccagca
      661 accttagaga gaggaaagac agttttcaag tgtctggttt cactttcaca gtgcggctgc
      721 cactttgaag agacccttgg taaacccctg attcggggtg gggtggggga ctaggctcag
      781 ccggaaccag cacctccaag gagtccggga ggtgcctgtg gtttgcaccc accactgaaa
      841 aagccgcgga gatgcgcagc gcgtacactg actttggggc ctgggtgttg gggttctgat
      901 cagaatttgg cgggatgata tgtttgccat tttctcactg gatgccctgg gtagctcctg
      961 cagggtctgc ctgttcccag ggctgccgaa tgcttaggac acgctgagag actagttgtg
     1021 atttgctatt ttgcctagag ctttgtcctt ctagatctga ttggctgtaa gtatctctac
     1081 tgtgtacctg tggcattcct tcacagtggg ttacaagctt cttttggatt agagggggat
     1141 ttttgatggg agaaagctgg agatctgaac ccagcccatt tgcacactat aagaaaaaaa
     1201 agtaactttt aaacctgtta acattggccg gggttataag agatgatctt ctattttgac
     1261 cttttgtcta acttatgacc ttgaactctg acctgtgacc atgcagcatc acatgatggc
     1321 atgacgttct ttggatcaga agagcttccc cagaatctaa cctgcactcc cgatggtggt
     1381 tcaggagact cttcctgatc tttctagaag gggtaaagtg gggttgaaca aggccaagcc
     1441 gttagctctg ctgctgctca gtttcccagc ctagttttct gagctgggag aggacataat
     1501 gtggtatttc gtcacgtagc tgagacctag aagggcatac tcaggcggag attgcacaaa
     1561 gctgggctcc aagttctgtg cttcctgatc ccgagccctg acactcattt gctgtgtggt
     1621 cccgggcatg tcatcaagaa gctcgctgtc tgcatgaggc tcccgacgat ctccatcccc
     1681 agggggttgg gaggatgtct ttagatttta ggactctgtg ataaatattc cacagcctgg
     1741 tgtgaggaag cttggaccaa atgcttcccc tttggccggt tagtctgaac aaggatctgc
     1801 tgatttaaag gagcagttgg agattcagaa cacatataac tggggaattc agggcaagct
     1861 accaacccag ccctgctgta gttttcccag gactgaagga aagaggcaga caccacattc
     1921 tcctctgcaa agttctctgg agaatgtgtg atgttaacac tcccagctaa gggaaagcaa
     1981 agtctaaagg aaaacacaca ggaatgcttc caatgtctcc aagtattcct gtggtcaaca
     2041 gtttcgcaga tccgttaggc ccttaaagac aaggaggaag taaaaggtca aatttaaatc
     2101 tatttaaaaa aacttttaaa aaaattattt atttattatt attttttatt tttaagacag
     2161 aatctcgctc tgttgcccag gctggagtgc agtggtgcaa tcttggctca ctgcaacctc
     2221 cacctcctgg gtttcagcga ttctcctgcc tcagcctcct gagtagctgg gattacaggc
     2281 gcctgccacc acgcccagct aattttttga tttttagtag agatggggtt tcgccatttt
     2341 ggccaggctg gtctcaaact cctggcctta aatgatcctc ccacctcggc ctcccaaagt
     2401 gctgggatta caggcatgag ccactgcacc cggccacttt tttttttttt aaagaaaaat
     2461 gctctgcatg gattggagac acagcaataa ctactgttgc catggaaggg ttaacagtgt
     2521 aggagctggt ttatcagtcc gctttgacat acagctaaag gaaatttatg tttgggggaa
     2581 aaaggccctc tgttcacttt aaaattcagt gtggacttat gccaaagggg gctgtttaag
     2641 ttgaaagaag ccaagttaag tttggcctct tgcctggaat cacttgaatt ctgaaatttc
     2701 actgcgacgg acatgtgcct tgtcacattt tccattgctt aatcctgaag tttggtgcaa
     2761 gtctctctgc acctattaaa aagtgatgta tatacttcct tcttattctg ttgagttgta
     2821 tagaattgtc ttttgtattt aacactttgt aattttcaca atatttttta atttaaataa
     2881 ataaacacat tttttccctc ctgggaagtc atgaa
//
