LOCUS       NM_001378969            7619 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily D member 3
            (KCND3), transcript variant 3, mRNA.
ACCESSION   NM_001378969 XM_005270851
VERSION     NM_001378969.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7619)
  AUTHORS   Ma,D., Zhao,C., Wang,X., Li,X., Zha,Y., Zhang,Y., Fu,G., Liang,P.,
            Guo,J. and Lai,D.
  TITLE     Structural basis for the gating modulation of Kv4.3 by auxiliary
            subunits
  JOURNAL   Cell Res 32 (4), 411-414 (2022)
   PUBMED   34997220
REFERENCE   2  (bases 1 to 7619)
  AUTHORS   Zanni,G., Hsiao,C.T., Fu,S.J., Tang,C.Y., Capuano,A., Bosco,L.,
            Graziola,F., Bellacchio,E., Servidei,S., Primiano,G., Soong,B.W.
            and Jeng,C.J.
  TITLE     Novel KCND3 Variant Underlying Nonprogressive Congenital Ataxia or
            SCA19/22 Disrupt KV4.3 Protein Expression and K+ Currents with
            Variable Effects on Channel Properties
  JOURNAL   Int J Mol Sci 22 (9), 4986 (2021)
   PUBMED   34067185
  REMARK    GeneRIF: Novel KCND3 Variant Underlying Nonprogressive Congenital
            Ataxia or SCA19/22 Disrupt KV4.3 Protein Expression and K+ Currents
            with Variable Effects on Channel Properties.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7619)
  AUTHORS   Clatot,J., Neyroud,N., Cox,R., Souil,C., Huang,J., Guicheney,P. and
            Antzelevitch,C.
  TITLE     Inter-Regulation of Kv4.3 and Voltage-Gated Sodium Channels
            Underlies Predisposition to Cardiac and Neuronal Channelopathies
  JOURNAL   Int J Mol Sci 21 (14), 5057 (2020)
   PUBMED   32709127
  REMARK    GeneRIF: Inter-Regulation of Kv4.3 and Voltage-Gated Sodium
            Channels Underlies Predisposition to Cardiac and Neuronal
            Channelopathies.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7619)
  AUTHORS   Li,X., Li,Z., Wang,D.W.W., Wang,D.W. and Wang,Y.
  TITLE     A Novel Gain-of-Function KCND3 Variant Associated with Brugada
            Syndrome
  JOURNAL   Cardiology 145 (10), 623-632 (2020)
   PUBMED   32818936
  REMARK    GeneRIF: A Novel Gain-of-Function KCND3 Variant Associated with
            Brugada Syndrome.
REFERENCE   5  (bases 1 to 7619)
  AUTHORS   Isbrandt,D., Leicher,T., Waldschutz,R., Zhu,X., Luhmann,U.,
            Michel,U., Sauter,K. and Pongs,O.
  TITLE     Gene structures and expression profiles of three human KCND (Kv4)
            potassium channels mediating A-type currents I(TO) and I(SA)
  JOURNAL   Genomics 64 (2), 144-154 (2000)
   PUBMED   10729221
REFERENCE   6  (bases 1 to 7619)
  AUTHORS   Dilks,D., Ling,H.P., Cockett,M., Sokol,P. and Numann,R.
  TITLE     Cloning and expression of the human kv4.3 potassium channel
  JOURNAL   J Neurophysiol 81 (4), 1974-1977 (1999)
   PUBMED   10200233
REFERENCE   7  (bases 1 to 7619)
  AUTHORS   Kong,W., Po,S., Yamagishi,T., Ashen,M.D., Stetten,G. and
            Tomaselli,G.F.
  TITLE     Isolation and characterization of the human gene encoding Ito:
            further diversity by alternative mRNA splicing
  JOURNAL   Am J Physiol 275 (6), H1963-H1970 (1998)
   PUBMED   9843794
REFERENCE   8  (bases 1 to 7619)
  AUTHORS   Serodio,P., Vega-Saenz de Miera,E. and Rudy,B.
  TITLE     Cloning of a novel component of A-type K+ channels operating at
            subthreshold potentials with unique expression in heart and brain
  JOURNAL   J Neurophysiol 75 (5), 2174-2179 (1996)
   PUBMED   8734615
REFERENCE   9  (bases 1 to 7619)
  AUTHORS   Brugada,R., Campuzano,O., Sarquella-Brugada,G., Brugada,P.,
            Brugada,J. and Hong,K.
  TITLE     Brugada Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301690
REFERENCE   10 (bases 1 to 7619)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512665.11, AL450997.5 and
            AL049557.19.
            
            On Mar 17, 2020 this sequence version replaced XM_005270851.4.
            
            Summary: Voltage-gated potassium (Kv) channels represent the most
            complex class of voltage-gated ion channels from both functional
            and structural standpoints. Their diverse functions include
            regulating neurotransmitter release, heart rate, insulin secretion,
            neuronal excitability, epithelial electrolyte transport, smooth
            muscle contraction, and cell volume. Four sequence-related
            potassium channel genes - shaker, shaw, shab, and shal - have been
            identified in Drosophila, and each has been shown to have human
            homolog(s). This gene encodes a member of the potassium channel,
            voltage-gated, shal-related subfamily, members of which form
            voltage-activated A-type potassium ion channels and are prominent
            in the repolarization phase of the action potential. This member
            includes two isoforms with different sizes, which are encoded by
            alternatively spliced transcript variants of this gene. [provided
            by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF205857.1, AF187963.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302127.5/ ENSP00000306923.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AL512665.11        22085-22248         c
            165-1342            AL512665.11        14201-15378         c
            1343-1505           AL450997.5         10106-10268         c
            1506-1607           AL450997.5         3852-3953           c
            1608-1697           AL450997.5         3387-3476           c
            1698-1754           AL450997.5         1598-1654           c
            1755-2002           AL450997.5         188-435             c
            2003-7619           AL049557.19        122103-127719       c
FEATURES             Location/Qualifiers
     source          1..7619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..7619
                     /gene="KCND3"
                     /gene_synonym="BRGDA9; KCND3L; KCND3S; KSHIVB; KV4.3;
                     SCA19; SCA22"
                     /note="potassium voltage-gated channel subfamily D member
                     3"
                     /db_xref="GeneID:3752"
                     /db_xref="HGNC:HGNC:6239"
                     /db_xref="MIM:605411"
     exon            1..164
                     /gene="KCND3"
                     /gene_synonym="BRGDA9; KCND3L; KCND3S; KSHIVB; KV4.3;
                     SCA19; SCA22"
                     /inference="alignment:Splign:2.1.0"
     exon            165..1342
                     /gene="KCND3"
                     /gene_synonym="BRGDA9; KCND3L; KCND3S; KSHIVB; KV4.3;
                     SCA19; SCA22"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..2204
                     /gene="KCND3"
                     /gene_synonym="BRGDA9; KCND3L; KCND3S; KSHIVB; KV4.3;
                     SCA19; SCA22"
                     /note="isoform 1 is encoded by transcript variant 3;
                     sha1-related potassium channel Kv4.3; voltage-gated K+
                     channel; potassium ionic channel Kv4.3; potassium
                     voltage-gated channel, Shal-related subfamily, member 3;
                     potassium voltage-gated channel long; voltage-gated
                     potassium channel subunit Kv4.3; potassium channel,
                     voltage gated Shal related subfamily D, member 3; A-type
                     voltage-gated potassium channel KCND3"
                     /codon_start=1
                     /product="A-type voltage-gated potassium channel KCND3
                     isoform 1"
                     /protein_id="NP_001365898.1"
                     /db_xref="CCDS:CCDS843.1"
                     /db_xref="GeneID:3752"
                     /db_xref="HGNC:HGNC:6239"
                     /db_xref="MIM:605411"
                     /translation="MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVL
                     NVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGK
                     LHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESM
                     PSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPC
                     GERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVM
                     TNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIII
                     FATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGV
                     LVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLL
                     NEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNH
                     EFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTHLPNSNLPATR
                     LRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALT
                     PEGESRPPPASPGPNTNIPSIASNVVKVSAL"
     exon            1343..1505
                     /gene="KCND3"
                     /gene_synonym="BRGDA9; KCND3L; KCND3S; KSHIVB; KV4.3;
                     SCA19; SCA22"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1607
                     /gene="KCND3"
                     /gene_synonym="BRGDA9; KCND3L; KCND3S; KSHIVB; KV4.3;
                     SCA19; SCA22"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1697
                     /gene="KCND3"
                     /gene_synonym="BRGDA9; KCND3L; KCND3S; KSHIVB; KV4.3;
                     SCA19; SCA22"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1754
                     /gene="KCND3"
                     /gene_synonym="BRGDA9; KCND3L; KCND3S; KSHIVB; KV4.3;
                     SCA19; SCA22"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..2002
                     /gene="KCND3"
                     /gene_synonym="BRGDA9; KCND3L; KCND3S; KSHIVB; KV4.3;
                     SCA19; SCA22"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..7619
                     /gene="KCND3"
                     /gene_synonym="BRGDA9; KCND3L; KCND3S; KSHIVB; KV4.3;
                     SCA19; SCA22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7592..7597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCND3"
                     /gene_synonym="BRGDA9; KCND3L; KCND3S; KSHIVB; KV4.3;
                     SCA19; SCA22"
                     /note="hexamer: AACAAA"
     polyA_site      7619
                     /gene="KCND3"
                     /gene_synonym="BRGDA9; KCND3L; KCND3S; KSHIVB; KV4.3;
                     SCA19; SCA22"
                     /note="major polyA site"
ORIGIN      
        1 agcgagcgag actgcgctgg cgaggaggag ccgcgcgagc ggcggctgct gggcgcttcc
       61 ccgcgctgct gggcgctcgg cgcctccgcg gccccggctc ccggccgcag cttcctcgcg
      121 cgcgcggggc gccgggcgcg gggcccgggc tggcttcgcg gaagggtttg ctgaactaac
      181 tccaagctgg tgtgcctagc gtccgcgcgg ctgccggccc aagagctgga gtcaccatgg
      241 cggccggagt tgcggcctgg ctgccttttg cccgggctgc ggccatcggg tggatgccgg
      301 tggccaactg ccccatgccc ctggccccgg ccgacaagaa caagcggcag gatgagctga
      361 ttgtcctcaa cgtgagtggg cggaggttcc agacctggag gaccacgctg gagcgctacc
      421 cggacaccct gctgggcagc acggagaagg agttcttctt caacgaggac accaaggagt
      481 acttcttcga ccgggacccc gaggtgttcc gctgcgtgct caacttctac cgcacgggga
      541 agctgcacta cccgcgctac gagtgcatct ctgcctacga cgacgagctg gccttctacg
      601 gcatcctccc ggagatcatc ggggactgct gctacgagga gtacaaggac cgcaagaggg
      661 agaacgccga gcggctcatg gacgacaacg actcggagaa caaccaggag tccatgccct
      721 cgctcagctt ccgccagacc atgtggcggg ccttcgagaa cccccacacc agcacgctgg
      781 ccctggtctt ctactacgtg actggcttct tcatcgctgt ctcggtcatc accaacgtgg
      841 tggagacggt gccgtgcggc acggtcccgg gcagcaagga gctgccgtgc ggggagcgct
      901 actcggtggc cttcttctgc ctggacacgg cgtgcgtcat gatcttcacc gtggagtacc
      961 tcctgcggct cttcgcggct cccagccgct accgcttcat ccgcagcgtc atgagcatca
     1021 tcgacgtggt ggccatcatg ccctactaca tcggtctggt catgaccaac aacgaggacg
     1081 tgtccggcgc cttcgtcacg ctccgggtct tccgcgtctt caggatcttc aagttttccc
     1141 gccactccca gggcctgcgg atcctgggct acacactgaa gagctgtgcc tccgaactgg
     1201 gctttcttct cttctccctc accatggcca tcatcatctt tgccactgtg atgttttatg
     1261 ccgagaaggg ctcctcggcc agcaagttca caagcatccc tgcctcgttt tggtacacca
     1321 ttgtcaccat gaccacactg ggatacggag acatggtgcc taagacgatt gcagggaaga
     1381 tcttcggctc catctgctcc ttgagtggcg tcctggtcat tgccctgcca gtccctgtga
     1441 ttgtttccaa ctttagccgg atttaccacc agaatcagag agctgataaa cgcagggcac
     1501 aaaagaaggc ccgccttgcc aggatccgtg tggccaaaac aggcagttcg aatgcatacc
     1561 tgcacagcaa gcgcaacggg ctcctcaacg aggcgctgga gctgacgggc accccagaag
     1621 aggagcacat gggcaagacc acctcactca tcgagagcca gcatcatcac ctgctgcact
     1681 gcctggaaaa aaccactggg ttgtcctatc ttgtggatga tcccctgtta tctgtacgaa
     1741 cctccaccat caagaaccac gagtttattg atgagcagat gtttgagcag aactgcatgg
     1801 agagttcaat gcagaactac ccatccacaa gaagtccctc actgtccagc cacccaggcc
     1861 tcactaccac ctgctgctcc cgtcgtagta agaagaccac acacctgccc aattctaacc
     1921 tgccagctac tcgcctgcgc agcatgcaag agctcagcac gatccacatc cagggcagtg
     1981 agcagccctc cctcacaacc agtcgctcca gccttaattt gaaagcagac gacggactga
     2041 gaccaaactg caaaacatcc cagatcacca cagccatcat cagcatcccc actcccccag
     2101 cgctaacccc agagggggaa agtcggccac cccctgccag cccaggcccc aacacgaaca
     2161 ttccttccat agccagcaat gttgtcaagg tctccgcctt gtaaaaccac tggacagagg
     2221 gccagagtgg gtagtgggga atgaagggga ctggcatgtt ggtgggtggt cactgagacc
     2281 actccctccc ccctttcccc actatttctg cctgccccat tgtaccccta gcactgagac
     2341 ttgtgcctgg aaggaaaaag aggtagcaaa ggggcacctg aggttcacgc tgctagcgtg
     2401 gacatagccc tgtgatactg catctcactg gggccagagg aagggaggga gggtgggggg
     2461 gtcggggata ggccggggga tataggctat gtgccaggac agggcctgga tggaggagcc
     2521 tcagactcag accaaataac agtcgtttct ggagacccca gtgaggaaaa tacaagacca
     2581 agagcagcaa agaggccaag ttgtcacaag caaaacagga agaaaatata acactgtgta
     2641 tttaagcacc tttttcaagg ctcttaatgg ataatattta ttcatgggaa aaggtggaaa
     2701 acaaaaacac caacggattt ttgtgaaatg tttttctcca tggacccaac acctttgaac
     2761 caaaacaatg cattttgtga gggatttttt tttctccttt tatagcaaaa gcttttaggc
     2821 taagaagtca gttattgctg agttctctct ccattccccc aggtgggtga ggtcaactga
     2881 gcctgggccc ccactgccca gctgacctgt gcagagctgc caagtgacca cacggcaatc
     2941 cttacccttt gtctgtccct gtctcccttg tctctgtacc tctctgctta cccctagctg
     3001 tttctgtgtc cagccatctg tctctacctg gatcccaatg atcctgaaac acatcagtaa
     3061 agccttcttc atcactgcca cgcacaacag acttgtgcct gggagttcta tctgtgtgaa
     3121 tgcaactgca gaggaggaaa gagtgaagca aaaattggga gagtttaggg gtaagggaag
     3181 tctacctcac agaacagagg tacttccctt ggggttggaa ccactcgtgt ttgcagtttc
     3241 agtttctggg aaagaaaggg aatgaacaga tttatcacac tggaatcttg aaaaggcaaa
     3301 tcgccaacac ctgagacgcg gtcaactctg gtatgtgcca gtgaggggag aacggaagga
     3361 cccagggctc gcagcctcag ccggtcatta gggcaccttg ctatggaccc ttccttcaag
     3421 acccaccata aagcccatcc agagcccttc caagaggccc cgggagtagt tttctccaga
     3481 gagggcagtg gtacggggac caagattcct ctgacttata tcaaaccaga ggcaactccc
     3541 acacagaggc tgtggaaggg taagcctgtg tgcctcaaga aaaatgcttc aaagcaaaag
     3601 caagtaagag attctagatg attcttacct gctatgaaag atgccttgat gtctgaagag
     3661 gcttcggcct gatctccctg aagatgctga aatgggggag aagcctcatc acctctgtgc
     3721 aagcaaagga gtgaagatta tttcttgaac acctggacaa catatctatt caactagctt
     3781 gcaccctggt ggagctgggg gcagcatttc tggaatcctc ctaaccattg ttcactgctt
     3841 gtagcagagt aggtgggcct cagggttagt gacaagtcct ttcctgccct tcccaacacc
     3901 cagccacctt gctgcagtct ctgtagcctg ggctctgaaa tacatgagct cctcgggagc
     3961 tgcctatcca tcctacagct tagtggttag ctgtttaatt gtaggccaag aatttctctc
     4021 cccaccacag ccatctaaat gagttttact agccaggaac ctaaaaacac ccttcgtggg
     4081 cttccctatg accccagctc gattgaccct gtaggttcaa aaggtttcga ggtggcacct
     4141 aaccagaatg tgggcagaag gcagaggaga gggagccttc tttctgtctt tatctcttta
     4201 tgcttatcct cattgaccat gggctgagtt ctttctctgg gtcccctaat gtgggaatgg
     4261 agtggttctt gccctctgag cttacagact aagaaggcag aaaagcttta caactacaga
     4321 gtacatgtgt atacacacaa ccaacctaaa cacatcagag aatacatact taaatcaatt
     4381 cacttcatat acacatctca ttagaagacc aagctaaact tcacttagag ggcgggcaaa
     4441 ggactagaaa agaatttttc tcttaaaaaa aatgagtact agagcaaaat tatgagtgtc
     4501 taagtatctt agttatgctt cataagatct gactggggta agagataaag aggtaaatag
     4561 ggctgggcgc ggtggctcac atctgtaatc ccagcacttt gggaagccga ggtgaacaga
     4621 tcacctgaag tcaggagttg aagaccaact tggccaacat ggtgaaaccc catctctact
     4681 aaaaatacaa aaattagcca ggcatggtgg tggacccctg taatcccagc tacttggaag
     4741 gctgaggggg aggattgctt aaacccagga ggcagaggtt gcagtgagcc gtgattgcac
     4801 cactgcactc cagcccaggt gacacagcaa gactccgtct caaaaaaaaa aaaaagaaaa
     4861 gaaaaaaaaa aaggaggtaa attagaactg gttgcacaca catacaaact tcctgtgatg
     4921 aatttaagaa cagatcatta cagggttaga atagtgacag attcaacaaa ggatctgttt
     4981 gatagggcac caagggaaca ttttactggt tcccacaaaa attaataaat gttaaatatc
     5041 atgtcccaag caatttccca tgttttttta ttggtcctaa tcaacagaat gttttgtgtt
     5101 ccttccactt cacgttcaga gcccacgtca tgccacttcc taaaagacca ttagaccatc
     5161 cccttttcct ccatcctcca ctgtagcctt agccagagaa aagatccagc tcacttctgg
     5221 tccaaaaaat gtcaacgttt ggaaaatggc tcatctacac tacagaacac agccagatga
     5281 cactgctaaa gggtactgta agaaaacaca aggtccaaag tatgctgaat tggtttcata
     5341 agtctaactc attggccagt gactgaaaaa ccaggatatc aggattttct gggggccaat
     5401 agccatgacc cttgagcttt catagttcat gaaccacttt gacataataa aatattccca
     5461 aaaccaccta ttccattcag tcccactcag cattaagagg gggagggaaa aacaaaccaa
     5521 ccaaccaacc taacagttac attcaaatgt caaatgaatg tgaacctaga aaatgtagta
     5581 ttaagagcat atcagaacta gaaaagattt aagaatatct aattcatttt acagtataga
     5641 aaactgagac ccagagaaat taaatgactt gttcaaggtc atgcagttat ttaatgacag
     5701 atctgagacc agaacacgag tcttttggct attagtctaa tgcattttct accacaccca
     5761 ctgcctctga gagcagtgat gctttggaga agatccatca aagaatccat actgtaattg
     5821 gagacatagt cttatatgtc aatacgtata tgtcaatact acttggacac agcccttgga
     5881 aatcacctga ctgtaccaat acaaaccata ctttggaaac caccattctc tgggtagaaa
     5941 catctatgga ctatcaattt tgtcagaaat cagtgaacaa gtgaagagtc aatttttttt
     6001 agtcaaatat tttctcttct caatgaagag aagactagga cagtgacatt ttgaagcata
     6061 ccttttatac tccttgtggt tcttatgaca gtctgtgatg gtagtaggta aagtagctaa
     6121 atccttgatt cagagagggg aaaacatgtg gaaagaaact gaacgactta tccaagttca
     6181 catgacaagt tagtggcaga accattattg caatccagga cttaagacat cttgtcctag
     6241 gatttttcct ccacattata ttgcactgct ctgaggcttg cttatatttt tcatacctgg
     6301 atttccaggg tggtgacgtg ggggagggaa gtattcaatt cagaaccacc gtgaaccaag
     6361 atctctggaa acaaactctg tactatttct ccttcatctc ctattttcat aactagtgcc
     6421 aagctcagga ctaactgcat agactccctt tcaaaagacc aatagatatt ctcagtgaca
     6481 gttgaacaca ttagtttaca atcacacaga atttgaacag aacttaaagt tgacagttaa
     6541 tgccgatcta taattaacaa aaatgtcaac ttgtggatat gctgatgatt ttatccagtt
     6601 ttcaaaatat gattcctaca gttcaggata tcacttatta gattgtagac aaggaaaatg
     6661 tacattggga cattatgtac ttaagagttt ttccttaagt tttgcagagg aagtggttga
     6721 aaattgagct aacactagat ttcgaggtta ctaaagaatt ccagttttcc agtctcccac
     6781 ttcaattacc aggtaactat aaggcaaaaa tatcccaatg ctgtgaactt aaggcaatat
     6841 tcatttcctt tctacactac ttggcatggt aaccatgaca aacttttatt ttctctttct
     6901 gatttcctaa tgaaatctca ttatttgcaa agctttaaaa tgactagatg aaggaaaaac
     6961 attgttatga cccatgaccc tcggagccca aacagcacca tgaagagcat cattaaaact
     7021 aagagaaagt ggctatcaga aaatgaaaca gctttaaagg ggttcctttt aagtcttgtt
     7081 ttctattcag aatgttctgt gttttttctc aagtgtggga atgacattta tcttagcagg
     7141 ttactcaact acactggatg atgtcactct aaccagtgta cggcactgac ccaagtcctg
     7201 gggggctcct tggaccaatg gactatttta caaacctggg aggtgggagg gatggtatat
     7261 ttttgataat cagacattcc aatgtaatgt tttccttaga ggtcacaccc ttccccccat
     7321 taatgtcatc gtgagataca tcaagtgtgt tcttttctat tttcgtataa taaatgggct
     7381 ttgcttatca acatcacaat ggcaaagaag aaatatactg tacaaaactg caggaagata
     7441 aaacatgaaa actttctatg aaaaaaaaaa aacacccttg agtttcctgt cgtcttcttt
     7501 tgaaactgta gtgcatatgt taaaacatgt atatcattta cagtattgag tcgtgtgcca
     7561 ctgctgtacc tgatgtatcc aatctggatt aaacaaatta tgtgccacaa accctaaaa
//
