LOCUS       NM_012281               5830 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily D member 2
            (KCND2), mRNA.
ACCESSION   NM_012281
VERSION     NM_012281.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5830)
  AUTHORS   Ye,W., Zhao,H., Dai,Y., Wang,Y., Lo,Y.H., Jan,L.Y. and Lee,C.H.
  TITLE     Activation and closed-state inactivation mechanisms of the human
            voltage-gated KV4 channel complexes
  JOURNAL   Mol Cell 82 (13), 2427-2442 (2022)
   PUBMED   35597238
REFERENCE   2  (bases 1 to 5830)
  AUTHORS   Zhang,Y., Tachtsidis,G., Schob,C., Koko,M., Hedrich,U.B.S.,
            Lerche,H., Lemke,J.R., van Haeringen,A., Ruivenkamp,C.,
            Prescott,T., Tveten,K., Gerstner,T., Pruniski,B., DiTroia,S.,
            VanNoy,G.E., Rehm,H.L., McLaughlin,H., Bolz,H.J., Zechner,U.,
            Bryant,E., McDonough,T., Kindler,S. and Bahring,R.
  TITLE     KCND2 variants associated with global developmental delay
            differentially impair Kv4.2 channel gating
  JOURNAL   Hum Mol Genet 30 (23), 2300-2314 (2021)
   PUBMED   34245260
  REMARK    GeneRIF: KCND2 variants associated with global developmental delay
            differentially impair Kv4.2 channel gating.
REFERENCE   3  (bases 1 to 5830)
  AUTHORS   Kise,Y., Kasuya,G., Okamoto,H.H., Yamanouchi,D., Kobayashi,K.,
            Kusakizako,T., Nishizawa,T., Nakajo,K. and Nureki,O.
  TITLE     Structural basis of gating modulation of Kv4 channel complexes
  JOURNAL   Nature 599 (7883), 158-164 (2021)
   PUBMED   34552243
  REMARK    GeneRIF: Structural basis of gating modulation of Kv4 channel
            complexes.
REFERENCE   4  (bases 1 to 5830)
  AUTHORS   Lu,X., Li,K. and Yang,J.
  TITLE     Potassium voltage-gated channel subfamily D member 2 induces an
            aggressive phenotype in lung adenocarcinoma
  JOURNAL   Neoplasma 68 (1), 135-143 (2021)
   PUBMED   32977724
  REMARK    GeneRIF: Potassium voltage-gated channel subfamily D member 2
            induces an aggressive phenotype in lung adenocarcinoma.
REFERENCE   5  (bases 1 to 5830)
  AUTHORS   Seifert,C., Storch,S. and Bahring,R.
  TITLE     Modulation of Kv4.2/KChIP3 interaction by the ceroid lipofuscinosis
            neuronal 3 protein CLN3
  JOURNAL   J Biol Chem 295 (34), 12099-12110 (2020)
   PUBMED   32641494
  REMARK    GeneRIF: Modulation of Kv4.2/KChIP3 interaction by the ceroid
            lipofuscinosis neuronal 3 protein CLN3.
REFERENCE   6  (bases 1 to 5830)
  AUTHORS   An,W.F., Bowlby,M.R., Betty,M., Cao,J., Ling,H.P., Mendoza,G.,
            Hinson,J.W., Mattsson,K.I., Strassle,B.W., Trimmer,J.S. and
            Rhodes,K.J.
  TITLE     Modulation of A-type potassium channels by a family of calcium
            sensors
  JOURNAL   Nature 403 (6769), 553-556 (2000)
   PUBMED   10676964
REFERENCE   7  (bases 1 to 5830)
  AUTHORS   Kurschner,C. and Yuzaki,M.
  TITLE     Neuronal interleukin-16 (NIL-16): a dual function PDZ domain
            protein
  JOURNAL   J Neurosci 19 (18), 7770-7780 (1999)
   PUBMED   10479680
REFERENCE   8  (bases 1 to 5830)
  AUTHORS   Zhu,X.R., Wulf,A., Schwarz,M., Isbrandt,D. and Pongs,O.
  TITLE     Characterization of human Kv4.2 mediating a rapidly-inactivating
            transient voltage-sensitive K+ current
  JOURNAL   Recept Channels 6 (5), 387-400 (1999)
   PUBMED   10551270
REFERENCE   9  (bases 1 to 5830)
  AUTHORS   Kong,W., Po,S., Yamagishi,T., Ashen,M.D., Stetten,G. and
            Tomaselli,G.F.
  TITLE     Isolation and characterization of the human gene encoding Ito:
            further diversity by alternative mRNA splicing
  JOURNAL   Am J Physiol 275 (6), H1963-H1970 (1998)
   PUBMED   9843794
REFERENCE   10 (bases 1 to 5830)
  AUTHORS   Brugada,R., Campuzano,O., Sarquella-Brugada,G., Brugada,P.,
            Brugada,J. and Hong,K.
  TITLE     Brugada Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301690
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004946.1, AC092020.3,
            BC110449.1 and AC004888.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_012281.2.
            
            Summary: Voltage-gated potassium (Kv) channels represent the most
            complex class of voltage-gated ion channels from both functional
            and structural standpoints. Their diverse functions include
            regulating neurotransmitter release, heart rate, insulin secretion,
            neuronal excitability, epithelial electrolyte transport, smooth
            muscle contraction, and cell volume. Four sequence-related
            potassium channel genes - shaker, shaw, shab, and shal - have been
            identified in Drosophila, and each has been shown to have human
            homolog(s). This gene encodes a member of the potassium channel,
            voltage-gated, shal-related subfamily, members of which form
            voltage-activated A-type potassium ion channels and are prominent
            in the repolarization phase of the action potential. This member
            mediates a rapidly inactivating, A-type outward potassium current
            which is not under the control of the N terminus as it is in Shaker
            channels. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.107642.1,
                                           SRR1660809.83254.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331113.9/ ENSP00000333496.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC004946.1         105013-105102
            91-839              AC092020.3         1-749
            840-3611            BC110449.1         1-2772
            3612-5830           AC004888.1         131541-133759
FEATURES             Location/Qualifiers
     source          1..5830
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.31"
     gene            1..5830
                     /gene="KCND2"
                     /gene_synonym="KV4.2; RK5"
                     /note="potassium voltage-gated channel subfamily D member
                     2"
                     /db_xref="GeneID:3751"
                     /db_xref="HGNC:HGNC:6238"
                     /db_xref="MIM:605410"
     exon            1..2573
                     /gene="KCND2"
                     /gene_synonym="KV4.2; RK5"
                     /inference="alignment:Splign:2.1.0"
     CDS             1459..3351
                     /gene="KCND2"
                     /gene_synonym="KV4.2; RK5"
                     /note="voltage-sensitive potassium channel; voltage-gated
                     potassium channel subunit Kv4.2; potassium channel,
                     voltage gated Shal related subfamily D, member 2"
                     /codon_start=1
                     /product="A-type voltage-gated potassium channel KCND2"
                     /protein_id="NP_036413.1"
                     /db_xref="CCDS:CCDS5776.1"
                     /db_xref="GeneID:3751"
                     /db_xref="HGNC:HGNC:6238"
                     /db_xref="MIM:605410"
                     /translation="MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIV
                     LNVSGTRFQTWQDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTG
                     KLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGES
                     ALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKE
                     LPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIG
                     LVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMA
                     IIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSL
                     SGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRN
                     GLLSNQLQSSEDEQAFVSKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVAT
                     VNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRIPNANVSGSHQGSIQELSTIQIRCVER
                     TPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISIPTPPVTTPEGDDRPESPEYSGGNI
                     VRVSAL"
     exon            2574..2736
                     /gene="KCND2"
                     /gene_synonym="KV4.2; RK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2832
                     /gene="KCND2"
                     /gene_synonym="KV4.2; RK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..2925
                     /gene="KCND2"
                     /gene_synonym="KV4.2; RK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3173
                     /gene="KCND2"
                     /gene_synonym="KV4.2; RK5"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..5830
                     /gene="KCND2"
                     /gene_synonym="KV4.2; RK5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5798..5803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCND2"
                     /gene_synonym="KV4.2; RK5"
                     /note="hexamer: AATAAA"
     polyA_site      5830
                     /gene="KCND2"
                     /gene_synonym="KV4.2; RK5"
                     /note="major polyA site"
ORIGIN      
        1 ctaacctgcg tggcggggcg tgcgcgcggt tatttattta ttttctcctt atttattgat
       61 cgcactagca gagcagcgcg gggagcccgg ggagatgcag gaccacccac tggcggggaa
      121 gcagctagca gccctcccgc gcccccgcgc tgccgagcgc cttctgcctc cgcgctcgga
      181 cgagagcccg tgccggcccc ggccccggcc ccaccgcgcc aacgccgccc gcccggccgc
      241 cccgcagccc cgccgccccg cagccccgca ccgcgctggc caggctcccg cgacagtggc
      301 cccgcagtaa gttggcagga gcgagtcccc tccgttctcg cctcccccgc accttttgaa
      361 cttgttgctg ctgctctgct cgcctgcgcc tggcttttgg aaggtgaaaa ggaggaggga
      421 ggcacggagg gatgggggaa gggaaagaag agctcgcttg agctttattt atgctctctc
      481 ggcgcatcgg attcggctgc tcgcgagctg ctttctctcc tcttcccttt ccgggtgcac
      541 ggcgaggaga aagtctctat gcaactaagc cccggcgcgc acttggccag gtatgtaccg
      601 cgggagcggc gcgttctgcg cggaagcaga tgctgctgcc gccacggcgg cggcggctgc
      661 cagctcctga gctctgtaac tgtcacactg cacctgagct gaacttgaaa agagagtgaa
      721 ggggcgattg ggcgaacgct tttggcagac acagagggtg tttgtagacg tgggggagga
      781 gaatctctat taacgccccc caccgtaacc actgcacatc acctccatct ctgcaaatac
      841 agcccgagga gtagaggcag cagcagctgg acccccaaag agagacgtgg ggcagcggct
      901 gtgaccgcat ctcctgagct acaacaacag gtcgcctttt tgagactcct ttggcgggaa
      961 gggctacttg gaaaggaagg tttgaaagag tgagaagggt aggtgtaagg gttccctaat
     1021 tcgtcgaaag aattctattg ggtgactctc gttcgtcttc tctatcctac actccacata
     1081 ctgaccctat attatccaga ctgtgccggg gagaaatcaa aaacacctgt ttgaagaaac
     1141 ggctgcacct gtgtgcttat ttgtgccaga gggtggccta gcccacctgc aggaagagat
     1201 ttggctgggt tctgttgagg gtgattgtta ggacgttgta ttttgttgcc attattccaa
     1261 atacctgtct tggagggaaa gttgcccttc tgagaactgt gactttacca ggagccctat
     1321 cttggaataa gagttacacc tctggaccac gtttctcact agtactttgc ttgactggag
     1381 gaagtgggtg acttttggct gcttcggtga cccattgtag acgcctcgtt acccttcttc
     1441 cttccgcttc aagtaatcat ggcggcgggg gtggcagcgt ggctgccttt tgcaagggca
     1501 gcggctatcg ggtggatgcc tgtggcctcg gggcctatgc cggctccccc gaggcaggag
     1561 aggaaaagga cccaagatgc tctcattgtg ctgaatgtga gtggcacccg cttccagacg
     1621 tggcaggaca ccctggaacg ttacccagac actctactgg gcagttctga gagggacttt
     1681 ttctaccacc cagaaactca gcagtatttc tttgaccgtg acccagacat cttccgccac
     1741 atcctgaatt tctaccgcac tgggaagctc cactatcctc gccacgagtg catctctgct
     1801 tacgatgaag aactggcctt ctttggcctc atcccggaaa tcatcggcga ctgctgttat
     1861 gaggagtaca aggatcgcag gcgagagaac gccgagcgcc tgcaggacga cgcggatacc
     1921 gacaccgctg gggagagcgc cttgcccacc atgactgcaa ggcagagggt ctggagggcc
     1981 ttcgagaacc cccacaccag cacgatggcc ctggtgttct actatgtcac ggggtttttc
     2041 attgccgtct ctgtcatcgc gaatgtggtg gaaacagtgc cgtgcggatc aagcccaggt
     2101 cacattaaag aactgccctg tggagagcgg tatgctgtgg ccttcttctg cttggacacg
     2161 gcctgcgtca tgatcttcac agttgagtat ttgcttcgcc tggctgcagc gcctagtcgt
     2221 taccgttttg tgcgtagtgt catgagtatc atcgacgtgg tggccatcct gccttattac
     2281 attgggctgg tgatgacaga caatgaggac gtcagcggag cctttgtcac actccgagtc
     2341 ttccgggtct tcaggatctt taagttttcc cgccactctc aaggcctgcg catcctgggg
     2401 tacacactga agagttgtgc ctcagaattg ggcttcttgc ttttctcgct caccatggct
     2461 atcatcatct tcgctacagt tatgttctac gcagagaagg ggtcttcggc tagcaagttc
     2521 accagcatcc ctgcagcctt ctggtatacc atcgtcacca tgacaacact agggtatggt
     2581 gacatggtgc caaaaaccat agcagggaag atttttggtt ctatctgttc gctgagtggg
     2641 gtcttggtca ttgctctacc tgttccggtg attgtatcca acttcagtcg catctaccac
     2701 cagaatcaac gagcagacaa acgaagggca caaaagaaag ctagactggc caggatccgg
     2761 gcagccaaaa gcggaagcgc aaatgcttac atgcagagca aacggaatgg tttactcagt
     2821 aatcagctgc agtcctcaga ggatgagcag gcttttgtta gcaaatccgg ctccagcttt
     2881 gaaacccagc accaccacct gcttcactgc ctggaaaaaa ccacgaatca cgagtttgtg
     2941 gacgaacaag tctttgaaga aagctgcatg gaagttgcaa ctgttaatcg tccttcaagt
     3001 cacagtcctt cactgtcttc acaacaagga gtcaccagca cctgctgttc acgacgacac
     3061 aaaaaaactt ttcgcatccc aaatgccaat gtatcaggaa gccatcaagg tagtatacaa
     3121 gaactcagca cgattcagat cagatgtgtg gagagaacac ctctgtctaa cagccgatcc
     3181 agtttaaatg ccaaaatgga agagtgtgtt aaactaaact gtgaacaacc ttatgtgact
     3241 acagcaataa taagcatccc aacacctcca gtaaccacac cagaaggaga cgataggcca
     3301 gaatcccctg agtactcagg aggaaatatt gtcagagttt ctgctttgta agacaattgg
     3361 aataaggtct aagagaattc gagccctggc tgtgaaaaga atctcaacat agaagaaaga
     3421 agaaacaata aatattctgc agattaatgc agcaaagaaa gaaggttggt agtgaaacac
     3481 aaagcttcca atcttaagga tgtgaataaa accaccaaat ggcatttcta gacagtttga
     3541 cctgttatac agagtaatat tctgtggccc tttgactttg tgaatgagca caatgaaatg
     3601 ccgcctactg atgcttctta tgatcagaac tcttttttaa taaaataaat aacataaatc
     3661 gttgaacata atgttccagt tgaatgcaaa acaaaaaaaa tatggaaaac attttgataa
     3721 aattttttcc tgttaaaacc atgaacattg gctatgatga agattattac atatgaaaaa
     3781 aaaactcaca caacatattt gtattgactg aaggaaacca tcataatgca tgctagaatt
     3841 ctttgaagca gtgatctcag tttccttatg ttgtcttcag aataggcatg ataaactata
     3901 attgtagaaa ggggtaattt ctgtgcactt acaacaagct gagtgttcat gttccatggt
     3961 gggctgtgca aataaactcc ttttagacct gcagtatttc tcatggggat gctcattagt
     4021 aaatctaaag tgttcagata gttcagtatt cattatcgtt taactttgca cctagatact
     4081 gttacaactg caataatttg ttgtacaact gttgtatcag gaatcaggat ttttttgttg
     4141 ttgtactttc cagatcctta tagatacggt aagagccaca ttcgtagaaa aacttctggt
     4201 gtggccaggt tttaggtaac tttttaatcc aaaactattg tgccataaat gtttttcagt
     4261 aatatttttt ggtccactgt attcctgtga cacagtgcat tatctgttct tgtatttcta
     4321 tagcacctct ctattgggtt tatcatcatc aacaagacta ctgtttactg tagttcaagt
     4381 gactttccta cttttgtatt tccaaaaaaa attatcttgt aagtagcttg tcatcaatcc
     4441 ccttgtcgaa aactagaaaa aaaggagttg acccatataa attatctcta acgtctttgt
     4501 tgtttatgga aaagcccaga tactggatat atcactatgt attttatgaa cagaattgac
     4561 tgggactaat atcacaggat caatcatctc agaatcttac ttgatgcatt atttattttg
     4621 ctttagatct tgaatacatt ttgagaataa ctaatgtgga ttgaaatgta gagatacact
     4681 ggagtgcttt atttagcaat atttgatgaa agcatgcttt ctacgccatt caggaaggca
     4741 gcacaaattt atctcagaaa ggttcctgtg tattgcaagg tacaattttc tccaataaat
     4801 caggagaaca ggagtttgat gatgcaaagt tgatctctgt acatttaagt gaaaagtctt
     4861 tataactttt cacccttaaa atatttcagc agacatgtct gcacatgaca gtgtaaaaaa
     4921 gtttaatgtc aaatgcaaag tttttattca ttccaagcca ccactgtaag gaataaagct
     4981 tagcttctgt acatggaaag agctaataat tatccctctg tcagagatga gatttttaaa
     5041 tgcttatgat atttaatcat aaaaagggat taatccaacc attttctagt aaagccagaa
     5101 attcttgctt cccatttcta gaatagtttc tagaacagtg ctatgcacat attagatctt
     5161 aataaacatt tgctgagtga aagtaagata aactcaacta tctcttggga agaactggct
     5221 tcattcctag tacatctttt aaaaagttac taattttcca gcagtacaaa tattaacaat
     5281 tatattaaca cctgcctcat gtcagtttat gcttctagag caatgtctag tgaaacttat
     5341 ctgatggcat ttattgaaaa ccttctaaaa agtagactaa ggaaaccata atcagaatta
     5401 ctatgtcttt tgattcccaa tgagaagttc tattttcatg ttcttaatat tacatacaag
     5461 aaaatgcagt taggttattt caattgacaa ttctgcctcc tcttttgatt tatcacttac
     5521 ccaaaattat taattttatt aggcttttgg aaaagaaaaa aaactttttg atgttttagg
     5581 tgatttaaaa atataccgtg ttggtggtga atgactattg atgactgtgt taagtgcatc
     5641 tgtattgtaa gtgaaatgta attatttctg tgtaccatat ggagtaacta aggtcattgt
     5701 ttttgacaat tttgtttgaa attcatatat cttatttcaa aggatagcat aatatctgca
     5761 ttatgctgga aaaaaataga cctttggaga atacttaaat aaaacatgtg catgcttgaa
     5821 caggacaaaa
//
