LOCUS       NM_001039574            4139 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily C member 4
            (KCNC4), transcript variant 3, mRNA.
ACCESSION   NM_001039574
VERSION     NM_001039574.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4139)
  AUTHORS   Alexander,T.D., Muqeem,T., Zhi,L., Tymanskyj,S.R. and
            Covarrubias,M.
  TITLE     Tunable Action Potential Repolarization Governed by Kv3.4 Channels
            in Dorsal Root Ganglion Neurons
  JOURNAL   J Neurosci 42 (46), 8647-8657 (2022)
   PUBMED   36198500
  REMARK    GeneRIF: Tunable Action Potential Repolarization Governed by Kv3.4
            Channels in Dorsal Root Ganglion Neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4139)
  AUTHORS   Zemel,B.M., Zhi,L., Brown,E.V., Tymanskyj,S.R., Liang,Q. and
            Covarrubias,M.
  TITLE     PKCepsilon associates with the Kv3.4 channel to promote its
            expression in a kinase activity-dependent manner
  JOURNAL   FASEB J 35 (1), e21241 (2021)
   PUBMED   33368632
  REMARK    GeneRIF: PKCepsilon associates with the Kv3.4 channel to promote
            its expression in a kinase activity-dependent manner.
REFERENCE   3  (bases 1 to 4139)
  AUTHORS   Qian,C., Dai,Y., Xu,X. and Jiang,Y.
  TITLE     HIF-1alpha Regulates Proliferation and Invasion of Oral Cancer
            Cells through Kv3.4 Channel
  JOURNAL   Ann Clin Lab Sci 49 (4), 457-467 (2019)
   PUBMED   31471334
  REMARK    GeneRIF: HIF-1alpha regulates the invasion, migration and
            proliferation of oral cancer cells by regulating Kv3.4 expression.
REFERENCE   4  (bases 1 to 4139)
  AUTHORS   Hartmann,S., Zheng,F., Kyncl,M.C., Karch,S., Voelkl,K., Zott,B.,
            D'Avanzo,C., Lomoio,S., Tesco,G., Kim,D.Y., Alzheimer,C. and
            Huth,T.
  TITLE     beta-Secretase BACE1 Promotes Surface Expression and Function of
            Kv3.4 at Hippocampal Mossy Fiber Synapses
  JOURNAL   J Neurosci 38 (14), 3480-3494 (2018)
   PUBMED   29507146
REFERENCE   5  (bases 1 to 4139)
  AUTHORS   Fernandez-Valle,A., Rodrigo,J.P., Garcia-Pedrero,J.M.,
            Rodriguez-Santamarta,T., Allonca,E., Lequerica-Fernandez,P. and de
            Vicente,J.C.
  TITLE     Expression of the voltage-gated potassium channel Kv3.4 in oral
            leucoplakias and oral squamous cell carcinomas
  JOURNAL   Histopathology 69 (1), 91-98 (2016)
   PUBMED   26648458
  REMARK    GeneRIF: This study provides original evidence to demonstrate the
            early occurrence and high prevalence of abnormal Kv3.4 expression
            in oral leucoplakias. Our results support a role for Kv3.4
            potassium channel in OSCC tumorigenesis rather than tumour
            progression and disease outcome.
REFERENCE   6  (bases 1 to 4139)
  AUTHORS   Angulo,E., Noe,V., Casado,V., Mallol,J., Gomez-Isla,T., Lluis,C.,
            Ferrer,I., Ciudad,C.J. and Franco,R.
  TITLE     Up-regulation of the Kv3.4 potassium channel subunit in early
            stages of Alzheimer's disease
  JOURNAL   J Neurochem 91 (3), 547-557 (2004)
   PUBMED   15485486
  REMARK    GeneRIF: Kv3.4 was overexpressed in early stages of Alzheimer
            disease and in advanced stages was present at high levels in
            neurodegenerative structures. This subunit regulates
            delayed-rectifier currents, primary determinants of spike
            repolarization in neurones
REFERENCE   7  (bases 1 to 4139)
  AUTHORS   Beck,E.J., Sorensen,R.G., Slater,S.J. and Covarrubias,M.
  TITLE     Interactions between multiple phosphorylation sites in the
            inactivation particle of a K+ channel. Insights into the molecular
            mechanism of protein kinase C action
  JOURNAL   J Gen Physiol 112 (1), 71-84 (1998)
   PUBMED   9649584
REFERENCE   8  (bases 1 to 4139)
  AUTHORS   Covarrubias,M., Wei,A., Salkoff,L. and Vyas,T.B.
  TITLE     Elimination of rapid potassium channel inactivation by
            phosphorylation of the inactivation gate
  JOURNAL   Neuron 13 (6), 1403-1412 (1994)
   PUBMED   7993631
REFERENCE   9  (bases 1 to 4139)
  AUTHORS   Ghanshani,S., Pak,M., McPherson,J.D., Strong,M., Dethlefs,B.,
            Wasmuth,J.J., Salkoff,L., Gutman,G.A. and Chandy,K.G.
  TITLE     Genomic organization, nucleotide sequence, and cellular
            distribution of a Shaw-related potassium channel gene, Kv3.3, and
            mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1
  JOURNAL   Genomics 12 (2), 190-196 (1992)
   PUBMED   1740329
REFERENCE   10 (bases 1 to 4139)
  AUTHORS   Rudy,B., Sen,K., Vega-Saenz de Miera,E., Lau,D., Ried,T. and
            Ward,D.C.
  TITLE     Cloning of a human cDNA expressing a high voltage-activating,
            TEA-sensitive, type-A K+ channel which maps to chromosome 1 band
            p21
  JOURNAL   J Neurosci Res 29 (3), 401-412 (1991)
   PUBMED   1920536
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL137790.4, DA404087.1,
            DA111555.1, AK310193.1, CK823243.1, BX098184.1 and BC025377.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001039574.2.
            
            Summary: The Shaker gene family of Drosophila encodes components of
            voltage-gated potassium channels and is comprised of four
            subfamilies. Based on sequence similarity, this gene is similar to
            the Shaw subfamily. The protein encoded by this gene belongs to the
            delayed rectifier class of channel proteins and is an integral
            membrane protein that mediates the voltage-dependent potassium ion
            permeability of excitable membranes. It generates atypical
            voltage-dependent transient current that may be important for
            neuronal excitability. Multiple transcript variants have been found
            for this gene. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (3) uses an alternate splice site
            that results in a frameshift in the 3' coding region, compared to
            variant 1. The encoded isoform (c) has a shorter and distinct
            C-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.155210.1,
                                           SRR1803617.119651.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000438661.3/ ENSP00000393655.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               AL137790.4         21530-21929
            401-663             DA404087.1         1-263
            664-975             DA111555.1         99-410
            976-2648            AK310193.1         1-1673
            2649-2925           CK823243.1         317-593
            2926-3326           BX098184.1         188-588
            3327-4139           BC025377.1         735-1547
FEATURES             Location/Qualifiers
     source          1..4139
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..4139
                     /gene="KCNC4"
                     /gene_synonym="C1orf30; HKSHIIIC; KSHIIIC; KV3.4"
                     /note="potassium voltage-gated channel subfamily C member
                     4"
                     /db_xref="GeneID:3749"
                     /db_xref="HGNC:HGNC:6236"
                     /db_xref="MIM:176265"
     exon            1..1864
                     /gene="KCNC4"
                     /gene_synonym="C1orf30; HKSHIIIC; KSHIIIC; KV3.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1187..3067
                     /gene="KCNC4"
                     /gene_synonym="C1orf30; HKSHIIIC; KSHIIIC; KV3.4"
                     /note="isoform c is encoded by transcript variant 3;
                     voltage-gated potassium channel subunit KV3.4; K+ channel
                     subunit; potassium voltage-gated channel, Shaw-related
                     subfamily, member 4; potassium channel, voltage gated Shaw
                     related subfamily C, member 4; voltage-gated potassium
                     channel KCNC4"
                     /codon_start=1
                     /product="voltage-gated potassium channel KCNC4 isoform c"
                     /protein_id="NP_001034663.1"
                     /db_xref="CCDS:CCDS44193.1"
                     /db_xref="GeneID:3749"
                     /db_xref="HGNC:HGNC:6236"
                     /db_xref="MIM:176265"
                     /translation="MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGG
                     TRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGV
                     FAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDI
                     FESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFED
                     PYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVE
                     TEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGL
                     SSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGV
                     LIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGM
                     LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYC
                     KSEETSPRDSTCSDTSPPAREEGMIERKRADSKQNGDANAVLSDEEGAGLTQPLASSP
                     TPEERRALRRSTTRDRNKKAAACFLLSTGDYACADGSVRKETCQDALSSNYAQAEVLT
                     LS"
     exon            1865..2801
                     /gene="KCNC4"
                     /gene_synonym="C1orf30; HKSHIIIC; KSHIIIC; KV3.4"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..3005
                     /gene="KCNC4"
                     /gene_synonym="C1orf30; HKSHIIIC; KSHIIIC; KV3.4"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..4139
                     /gene="KCNC4"
                     /gene_synonym="C1orf30; HKSHIIIC; KSHIIIC; KV3.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4099..4104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNC4"
                     /gene_synonym="C1orf30; HKSHIIIC; KSHIIIC; KV3.4"
                     /note="hexamer: AATAAA"
     polyA_site      4139
                     /gene="KCNC4"
                     /gene_synonym="C1orf30; HKSHIIIC; KSHIIIC; KV3.4"
                     /note="major polyA site"
ORIGIN      
        1 actggggcgt ggcggccgct gccagcgccg gagggagacc atgagcccct agggccccag
       61 cccaccggcg ccgaggcgcc ccctccccta tgccacctcg cgcccgcccc ctgccgcgcg
      121 cgagccaagg ccggcgcccc gcccggagat gggcagacgc gtagatggcg tggctcccag
      181 cgccgccaga tcgcaggaac caggcgccgg ggcgttgcgc tgaggctccc tctccgcgcg
      241 gcccgggaag cctgcaggtg tccttggccg ctcggccgcc gcccccggta caccttcgcc
      301 agtgcccaga gcccggctcc ccagagcggc cccgcccccc aggctcggcg ccgcgcagga
      361 cgccccgtct gaggcacccc cgccccagcg cggcccccgc agcgctgcgc ccggtccggc
      421 gcagctccca gccgcggacg caggacccga ggctcgctcc tgcgggcgcg cttgttttcc
      481 agctgccgcc tcgccctgcg cagcccccgc ccgcccggcc gccgctctct gctctgcccc
      541 gcctgccttc ctcgcccggc gctggattta tgaatggggg gaagaggcca catgccgccg
      601 ccgccgcctc gtgttgaccg caagcagccc gggcccacgg agctccggct gccgtgagag
      661 tgtcggcctg gccccggcag ccgctcggag gacttgttgc tgctgcgctg ccgccgctgc
      721 ggggaagccg gctattccgg ggcttggtgc ggtcttggag ccggagggtg gcccgtgtga
      781 gcgcgagcgc cccggacctt cgcggtgcgc gtggactgtg cgcttcctcg tctttggtcg
      841 gggtgaaggc gggggcgtgt ccccggccca gagcgtttgt gtgtcccgtc gtagcggggg
      901 accgcgtgtg tgcttgcttc tacttccccg ggtcctccct ctctgcgcct ccctctctcc
      961 ggagcttcct gccctaaccc caaccacctg tgtaccggag aaatccaact cctcccgctc
     1021 cgcgtcctag ggggataggc aggggcaagc ccaagccgca gagggggccg ccaccgcctc
     1081 ctgcctcctc ttcgtctcct ccccctcccc cgtctgacgc tgcctcctcg ggaagggtgt
     1141 ttggagggca gcggccgccc caagccggag ccccgcagcg cttcttatga tcagctcggt
     1201 gtgtgtctcc tcctaccgcg ggcgcaagtc ggggaacaag cctccgtcca aaacatgtct
     1261 gaaggaggag atggccaagg gcgaggcgtc ggagaagatc atcatcaacg tgggcggcac
     1321 gcgacatgag acctaccgca gcaccctgcg caccctaccg ggaacccgcc tcgcctggct
     1381 ggccgacccc gacggcgggg gccggcccga gaccgatggc ggcggtgtgg gtagcagcgg
     1441 cagcagcggc ggcgggggct gcgagttctt cttcgacagg cacccgggcg tcttcgccta
     1501 cgtgctcaac tactaccgca ccggcaagct gcactgcccc gcggacgtgt gcgggccgct
     1561 cttcgaagag gagctcacct tctggggcat cgacgagacc gacgtggaac cctgctgctg
     1621 gatgacctac cggcagcacc gcgacgccga ggaggcgctc gacatcttcg agagcccgga
     1681 cggaggcggc agcggcgcgg ggcccagcga cgaggccggc gacgatgagc gggagctggc
     1741 cctgcagcga ctgggccccc acgagggagg cgcgggccat ggcgccgggt ctgggggctg
     1801 ccgcggctgg cagccccgca tgtgggcgct cttcgaggat ccctactcct cccgggccgc
     1861 tagggtagtg gcctttgcct ctctcttctt catcctggtc tccatcacca ctttctgcct
     1921 ggagacccat gaggccttta atatcgaccg caacgtgaca gagatcctcc gcgtagggaa
     1981 catcaccagc gtgcacttcc ggcgggaggt agagacagag cccatcctga cctacatcga
     2041 gggcgtatgt gtgctgtggt tcacactgga gttcctggtg cgcatcgtgt gctgccccga
     2101 cacgctggac ttcgtcaaga acctgctcaa catcatcgac tttgtggcca tcctgccctt
     2161 ctacctggag gtggggctga gcggcctgtc atccaaggcg gcccgcgacg tgctgggctt
     2221 cctgcgcgtg gtgcgcttcg tgcgcatcct gcgtatcttc aagctcacac gccacttcgt
     2281 ggggctacgc gtgctgggcc acaccctgag ggccagcacc aatgagttcc tgctgcttat
     2341 catcttcctg gccctgggtg tgctcatctt tgccaccatg atctactacg ctgagcgcat
     2401 tggggccagg ccctccgacc ctcggggtaa tgaccacacc gacttcaaga acatccccat
     2461 tggcttctgg tgggctgtgg tcaccatgac gacactgggc tacggagaca tgtaccccaa
     2521 gacgtggtca ggcatgctgg taggggcact gtgtgcactg gctggcgtgc tcaccatcgc
     2581 catgccggtg cctgtcatcg tcaacaactt cggcatgtac tactccctgg ccatggccaa
     2641 gcagaagctg cccaagaaac ggaagaagca cgtgccacgg ccggcgcagc tggagtcacc
     2701 catgtactgc aagtctgagg agacttcccc ccgggacagc acctgcagtg ataccagccc
     2761 ccctgcccgg gaagagggta tgatcgagag gaaacgggca gactctaagc agaatggcga
     2821 tgccaacgca gtgctgtctg atgaggaggg agctggcctc acccaacccc tggcctcctc
     2881 cccgaccccc gaggagcgcc gggccctgcg acgctccacc actcgagaca gaaacaagaa
     2941 ggcagctgcc tgcttcctgc tcagcactgg ggactatgcc tgcgccgatg gtagtgtccg
     3001 gaaagagacc tgccaagacg ccctctcgtc caactatgcc caggctgaag tcctcaccct
     3061 ctcttaaagc ggcaccaacg tgagagagac aggcagacag acagaaagcc agaggcttag
     3121 ggaaactctg gaacccagac aagaatcttt tcgctgggaa agactcagat atccttgttt
     3181 gcacaggact ggtggaaaat ctcccatgcg accctcgggg cccagagcca tctgggtctg
     3241 atgttctgtt ccattgtaca tcgaagagat atatatgcac atatagtatc tatattcata
     3301 catattatac tcttgtgtgt agtgcacgtg ctattggtgg tttgtcttct ttgttaggct
     3361 gtgtctccct aagcccttgc cccacccaga gtttcccgtc cccttcactg atttctgttg
     3421 tttctgctga ctgtgtgggt ggaatgtccc aagaaaagtg catctgggaa ttgccagtcc
     3481 agctgggtag tcccaggctc ctgtcttggg gatgtttccc ctgtcagcaa gtaacctggt
     3541 gaagtctatt gaaggccaga ctgcccccta gggtcactgc ttcactagcc gcaccccacc
     3601 ccagattggg gttctacctc ccaccccaca tcctcgttgt ggggggactt ccaggggctc
     3661 ctctgcagcc tcctccacta cttcctccac cccatctatg tccttgactt aggggggcat
     3721 tttgtctttt ttagatttga ttttgttctc tctcctttgt ctgtttgttg tcaaagatgc
     3781 tgctgggcag acaggcaggg aaaggatctg tctgcccatc tggcccaggg ggtccgagaa
     3841 gggaagcctt gggcaagagg agaccagttg caatactgta cttcctggtc agtggccaga
     3901 ggatgcgtgc aatagcagag gccaggtgac cccttcagcc ttggcctctg cccctccctt
     3961 ggccctccct ccctgctcct ccctggtgtt ggtcagtcct tttctaaagc tgtcccctcg
     4021 tgtgtgtctg gggcatgccc aggctgggcc ctgtgccctg tctgcatgcc tccaactgtc
     4081 atgctgtgct cgagccccaa taaagacatc tggagcatcc tgctgctcct gctgtgtga
//
