LOCUS       NM_004977               6747 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily C member 3
            (KCNC3), transcript variant 1, mRNA.
ACCESSION   NM_004977
VERSION     NM_004977.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6747)
  AUTHORS   Khare,S., Galeano,K., Zhang,Y., Nick,J.A., Nick,H.S.,
            Subramony,S.H., Sampson,J., Kaczmarek,L.K. and Waters,M.F.
  TITLE     C-terminal proline deletions in KCNC3 cause delayed channel
            inactivation and an adult-onset progressive SCA13 with spasticity
  JOURNAL   Cerebellum 17 (5), 692-697 (2018)
   PUBMED   29949095
  REMARK    GeneRIF: Study expanded the genotype-phenotype-pathophysiology
            repertoire of SCA13 by addition of a causative KCNC3 mutation,
            p.Pro583_Pro585del, its associated phenotype of profound
            spasticity, and the decreased inactivation rate of the mutant
            channel.
REFERENCE   2  (bases 1 to 6747)
  AUTHORS   Khare,S., Nick,J.A., Zhang,Y., Galeano,K., Butler,B.,
            Khoshbouei,H., Rayaprolu,S., Hathorn,T., Ranum,L.P.W., Smithson,L.,
            Golde,T.E., Paucar,M., Morse,R., Raff,M., Simon,J.,
            Nordenskjold,M., Wirdefeldt,K., Rincon-Limas,D.E., Lewis,J.,
            Kaczmarek,L.K., Fernandez-Funez,P., Nick,H.S. and Waters,M.F.
  TITLE     A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13
            subtype associated with dominant negative effects and aberrant EGFR
            trafficking
  JOURNAL   PLoS One 12 (5), e0173565 (2017)
   PUBMED   28467418
  REMARK    GeneRIF: results therefore confirm the KCNC3R423H allele as
            causative for SCA13, through a dominant negative effect on KCNC3WT
            and links with EGFR that account for dominant inheritance,
            congenital onset, and disease pathology
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6747)
  AUTHORS   Zhang,Y. and Kaczmarek,L.K.
  TITLE     Kv3.3 potassium channels and spinocerebellar ataxia
  JOURNAL   J Physiol 594 (16), 4677-4684 (2016)
   PUBMED   26442672
  REMARK    GeneRIF: This review covers the localization and physiological
            function of Kv3.3 in the central nervous system and how the normal
            function of the channel is altered by the disease-causing mutations
            Review article
REFERENCE   4  (bases 1 to 6747)
  AUTHORS   Zhang,Y., Zhang,X.F., Fleming,M.R., Amiri,A., El-Hassar,L.,
            Surguchev,A.A., Hyland,C., Jenkins,D.P., Desai,R., Brown,M.R.,
            Gazula,V.R., Waters,M.F., Large,C.H., Horvath,T.L., Navaratnam,D.,
            Vaccarino,F.M., Forscher,P. and Kaczmarek,L.K.
  TITLE     Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local
            Actin Network that Regulates Channel Gating
  JOURNAL   Cell 165 (2), 434-448 (2016)
   PUBMED   26997484
  REMARK    GeneRIF: Kv3.3 regulates Arp2/3-dependent cortical actin nucleation
            mediated by Hax-1; resulting cortical actin structures interact
            with the channel's gating machinery to slow its inactivation rate
            during sustained membrane depolarizations; a mutation that leads to
            late-onset spinocerebellar ataxia type 13.
REFERENCE   5  (bases 1 to 6747)
  AUTHORS   Song,M.S., Choi,S.Y., Ryu,P.D. and Lee,S.Y.
  TITLE     Voltage-Gated K+ Channel, Kv3.3 Is Involved in Hemin-Induced K562
            Differentiation
  JOURNAL   PLoS One 11 (2), e0148633 (2016)
   PUBMED   26849432
  REMARK    GeneRIF: The Kv channels, or at least Kv3.3, appear to be
            associated with cell differentiation
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6747)
  AUTHORS   Wang,D., Youngson,C., Wong,V., Yeger,H., Dinauer,M.C., Vega-Saenz
            Miera,E., Rudy,B. and Cutz,E.
  TITLE     NADPH-oxidase and a hydrogen peroxide-sensitive K+ channel may
            function as an oxygen sensor complex in airway chemoreceptors and
            small cell lung carcinoma cell lines
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 13182-13187 (1996)
   PUBMED   8917565
REFERENCE   7  (bases 1 to 6747)
  AUTHORS   Haas,M., Ward,D.C., Lee,J., Roses,A.D., Clarke,V., D'Eustachio,P.,
            Lau,D., Vega-Saenz de Miera,E. and Rudy,B.
  TITLE     Localization of Shaw-related K+ channel genes on mouse and human
            chromosomes
  JOURNAL   Mamm Genome 4 (12), 711-715 (1993)
   PUBMED   8111118
REFERENCE   8  (bases 1 to 6747)
  AUTHORS   Waters,M.F.
  TITLE     Spinocerebellar Ataxia Type 13
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301404
REFERENCE   9  (bases 1 to 6747)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
REFERENCE   10 (bases 1 to 6747)
  AUTHORS   Ghanshani,S., Pak,M., McPherson,J.D., Strong,M., Dethlefs,B.,
            Wasmuth,J.J., Salkoff,L., Gutman,G.A. and Chandy,K.G.
  TITLE     Genomic organization, nucleotide sequence, and cellular
            distribution of a Shaw-related potassium channel gene, Kv3.3, and
            mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1
  JOURNAL   Genomics 12 (2), 190-196 (1992)
   PUBMED   1740329
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF055989.1 and AC008655.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 29, 2019 this sequence version replaced NM_004977.2.
            
            Summary: The Shaker gene family of Drosophila encodes components of
            voltage-gated potassium channels and is comprised of four
            subfamilies. Based on sequence similarity, this gene is similar to
            one of these subfamilies, namely the Shaw subfamily. The protein
            encoded by this gene belongs to the delayed rectifier class of
            channel proteins and is an integral membrane protein that mediates
            the voltage-dependent potassium ion permeability of excitable
            membranes. Alternate splicing results in several transcript
            variants. [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF055989.1, ERR4352444.355292.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000477616.2/ ENSP00000434241.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               AF055989.1         1-482
            483-483             AC008655.7         48189-48189         c
            484-3039            AF055989.1         484-3039
            3040-6747           AC008655.7         31231-34938         c
FEATURES             Location/Qualifiers
     source          1..6747
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..6747
                     /gene="KCNC3"
                     /gene_synonym="KSHIIID; KV3.3; SCA13"
                     /note="potassium voltage-gated channel subfamily C member
                     3"
                     /db_xref="GeneID:3748"
                     /db_xref="HGNC:HGNC:6235"
                     /db_xref="MIM:176264"
     exon            1..1165
                     /gene="KCNC3"
                     /gene_synonym="KSHIIID; KV3.3; SCA13"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..2569
                     /gene="KCNC3"
                     /gene_synonym="KSHIIID; KV3.3; SCA13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     voltage-gated potassium channel protein KV3.3;
                     Shaw-related voltage-gated potassium channel protein 3;
                     voltage-gated potassium channel subunit Kv3.3; potassium
                     voltage-gated channel, Shaw-related subfamily, member 3;
                     potassium channel, voltage gated Shaw related subfamily C,
                     member 3; voltage-gated potassium channel KCNC3"
                     /codon_start=1
                     /product="voltage-gated potassium channel KCNC3 isoform 1"
                     /protein_id="NP_004968.2"
                     /db_xref="CCDS:CCDS12793.1"
                     /db_xref="GeneID:3748"
                     /db_xref="HGNC:HGNC:6235"
                     /db_xref="MIM:176264"
                     /translation="MLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPA
                     QPGPAASPAGPPAPRGPGDRRAEPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETY
                     RSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPA
                     DVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAG
                     AHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRV
                     WALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPP
                     ENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPF
                     YLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLL
                     LIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGD
                     MYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRP
                     PQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVAGAYPAGPHTHPGLL
                     RGGAGGLGIMGLPPLPAPGEPCPLAQEEVIEINRADPRPNGDPAAAALAHEDCPAIDQ
                     PAMSPEDKSPITPGSRGRYSRDRACFLLTDYAPSPDGSIRKATGAPPLPPQDWRKPGP
                     PSFLPDLNANAAAWISP"
     exon            1166..2273
                     /gene="KCNC3"
                     /gene_synonym="KSHIIID; KV3.3; SCA13"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2465
                     /gene="KCNC3"
                     /gene_synonym="KSHIIID; KV3.3; SCA13"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2592
                     /gene="KCNC3"
                     /gene_synonym="KSHIIID; KV3.3; SCA13"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..6747
                     /gene="KCNC3"
                     /gene_synonym="KSHIIID; KV3.3; SCA13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6721..6726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNC3"
                     /gene_synonym="KSHIIID; KV3.3; SCA13"
                     /note="hexamer: AATAAA"
     polyA_site      6747
                     /gene="KCNC3"
                     /gene_synonym="KSHIIID; KV3.3; SCA13"
                     /note="major polyA site"
ORIGIN      
        1 accggtcccg cctcccttga cgccccgccc cgcccctcct ccctgctctc ttagaaagag
       61 ccaatcgctc cgtctcattg gcggccccga ctcgtccagc tgggtcgcgt tagagtgccc
      121 gccccactcc tcccagccac agccccgccc cacctccccc aggccaatca gtttggttcc
      181 tctcccctaa gccacgcccc cgctacctcg ctcctcctcc cacccaatcc cgtcggtctc
      241 tccccccgtg tccccgcccc tgcgtccccg cccctcccgc cccgcccccc gtccaatgct
      301 gagctcagtc tgcgtctcgt ccttccgcgg gcgccagggg gccagcaagc agcagccggc
      361 gccaccgccg cagccgcccg agtccccgcc gccgccaccg ctgccgccgc agcagcagca
      421 gcctgcgcag cccggccccg ccgcgtcccc ggcgggcccc ccggcacccc gcgggcccgg
      481 ggaccggcgc gccgagccat gccccgggct gccggcggcg gccatggggc ggcacggcgg
      541 cggcggtggc gacagcggca agatcgtgat caacgtgggc ggcgtgcgcc atgagacgta
      601 ccgctcgacg ctgcgcaccc tgccggggac gcggctggcc ggcctgacgg agcccgaggc
      661 ggcggcacgc ttcgactacg acccgggcgc cgacgagttc ttctttgacc ggcacccggg
      721 agtcttcgcg tacgtgctca actactaccg caccggcaag ctgcactgcc cagccgacgt
      781 gtgcgggccc ctgtttgagg aggagctcgg cttctggggc atcgacgaga ccgacgtgga
      841 ggcctgctgc tggatgacct accggcagca tcgcgacgct gaggaggcgc tcgactcctt
      901 cgaggcgccc gaccccgcgg gcgccgccaa cgccgccaac gccgcaggcg cccacgacgg
      961 aggcctggac gacgaggcgg gcgcgggcgg cggcggcctg gacggagcgg gcggcgagct
     1021 caagcgcctc tgcttccagg acgcgggcgg cggcgccggg gggccgccag ggggcgcggg
     1081 cggcgcgggc ggcacatggt ggcgccgctg gcagccccgc gtgtgggcgc tcttcgagga
     1141 cccctactcg tcgcgggctg ccaggtatgt ggccttcgcc tccctcttct tcatcctcat
     1201 ctccatcacc accttctgcc tggaaaccca tgagggcttc atccatatta gcaacaagac
     1261 ggtgacccag gcctccccga tccccggggc acctccggag aacatcacca acgtggaggt
     1321 ggagacggag cccttcctga cctacgtgga gggggtgtgc gtggtctggt tcaccttcga
     1381 gttcctcatg cgcatcacct tctgcccaga caaggtggag tttcttaaaa gcagcctcaa
     1441 catcatcgac tgtgtggcca tcctgccctt ctatctcgag gtgggcctct cgggcctcag
     1501 ctccaaggcc gccaaagacg tgctgggctt cctgcgggtg gtccgcttcg tccgcatcct
     1561 gcgcatcttc aagctgaccc ggcacttcgt ggggctgcgc gtgctgggac acacgctccg
     1621 cgccagcacc aacgagttcc tgctgctcat catcttcctg gccctggggg tgctcatctt
     1681 cgccaccatg atttactacg ctgagcgcat tggcgccgac cccgatgaca tcctgggctc
     1741 caaccacacc tacttcaaga acatccccat tggcttctgg tgggctgtgg tcaccatgac
     1801 gaccctgggc tatggagaca tgtaccccaa gacgtggtcg gggatgctgg tcggggcgct
     1861 gtgtgccctg gcgggggtgc tgaccatcgc catgcctgtg cccgtcattg tcaacaactt
     1921 tggcatgtac tattcgctgg ccatggccaa gcagaagctg cccaagaaga agaacaaaca
     1981 catcccccgg cccccgcaac cgggctcgcc caactactgc aagcctgacc cacccccgcc
     2041 acccccgccc cacccgcacc acggcagcgg gggcatcagc ccgccgccac ccatcacccc
     2101 accctccatg ggggtgactg tggccggggc ctacccagcg gggccccaca cgcaccccgg
     2161 gctgctcagg gggggagcgg gtgggctggg gatcatgggg ctgcctcctc tgccagcccc
     2221 cggcgagcct tgcccgttgg ctcaggagga ggtgattgag atcaaccggg cagatcctcg
     2281 ccccaatggg gatccggcag cagctgcgct tgcccacgag gactgcccag ccattgacca
     2341 gcctgccatg tccccggaag acaagagccc catcacgcct ggaagccgtg gccgctatag
     2401 ccgggaccga gcctgcttcc tcctcaccga ctatgcccct tcccctgatg gctccatccg
     2461 aaaagccact ggtgctcccc cactgccccc ccaagactgg cgtaagccag gccccccaag
     2521 cttcttgccc gacctcaacg ccaacgccgc ggcctggata tccccctagt ggacgaaccc
     2581 cctccccccg ggctcttgtc accgcctgag acctcgcgag actttcggtc ccccccgccc
     2641 cttcccccca ggttagcaat tgggaatggc tgggaggggg tgtccccaag acactgggct
     2701 tcaaatctcc ccccaagccc tccctcctac gatcaagaca ccttttgtcc agacagctcc
     2761 cttagcgttg cctggaaaag ccacagagct ccctgcgggg gtgcagaacc ctgcaggcag
     2821 ccccaggctt tgcagaaacc acacacactg ttgctggatc ttgagtccca ttagctgtga
     2881 gatgcctgtg agagccttcc cgcacccgtc agaagctcag agccttcttg gaccctttaa
     2941 agatgtccct ctccccagcc ctccgcctca ccgcccccca cccccgaccc cgtccttaga
     3001 atcttctgga ggagcctccc tcccccccca ccccccccca ctgctcctgg agttctcatc
     3061 ggattcccca agggcactgc cagcttcgct ccactcagcc cccttgcaga ccccaccccc
     3121 tgcctgctct ctttccctac aactaggtca gcccccagcc ccgctacggc ggccgcaccg
     3181 ttccctgccc tctccgctgg ctgctcccac atgcattcca cccagcccct ccccacgccc
     3241 ctgccgccca ccatcccgcc ttgctgcccc ccaccttttg cctcaggtga ggggaccagt
     3301 ggaggggggg aagggcggtg gactgtggtg ggaatggggc gggggaggct cggtgggcac
     3361 caacctgcct cctaatccgg agtctctccc ccctccccga tgtctccccc tttctcatcg
     3421 atgttgactg actccccgat ttgttcactt tctctctcca tctccttggt ccatctctgt
     3481 ccatctgtct cttgtcatcc gtccttttgt gtctctgtct gcctgactct gtctgtcttg
     3541 ccttctctgt ctctctgggt atctgttgtc ctccccttcc atttctttct ctctctgtct
     3601 ctttctccct gccttgggtc tctctgtctg acccttccct gcaccccatc ttcgtgcttc
     3661 ccccctgtgt ctgcacacct ccccaccccc caggttacga gaaatcccgc agcctcagca
     3721 gcatcgcggg cctgagcggg gtgtccctgc gcctcgcgcc ccttgccacc ccccctggct
     3781 ctccccgggc cgcccgccgc gctcccccga ccctgccctc catcctttag cgctcccctc
     3841 ccccctgtgg ggggactcgg gggtgaccgg gaagaaggtc aaaggagctg ggggtggggg
     3901 gtggggaaaa gggttttttt aaaaaaaatc aaaaagtcat taataatatg caaccgagat
     3961 gacgatgcca gcagacaccc ccgggcccct cacccccaac ctgggccccc aggatggaga
     4021 gaggggccac agcccgtccc cccaactctt ccctccccaa aaaaagcctt ctcaggtctc
     4081 cacgagccat aggacatccc cctgccatca acttgtgtaa ataagtccaa attatgccag
     4141 ttacatcttg gggcacctcc ccccacacac tgcatgcctt ccctaacctg gagcccccac
     4201 tccaagtcca cctcagcaat aagccgccag gggccgcatg cgcgggtttg aggggcaggc
     4261 actctgggaa gggggtggca cctcccgggg gtcgggctgg cctttaaggt ctccagcctt
     4321 cccatccttc accccaggag gacaaccaac cctgtgcgtt gattaggaga aaacaaacca
     4381 gaaactagaa acagtgtagg ggaaggagga acagttaccc aagccccaga tcggagttga
     4441 gctcaggtgg cgggagggcg gggccgagtt gagctcaggt ggtgggaggg cggggcgggc
     4501 tttggacctg ctccctcagc ctttaggaga attcctctgg tgaatttcac cctctcatcc
     4561 gccccttccc ccagggacct gctcgcctct attcttgctg catggactca gacctcctat
     4621 cccagaattc ctgggatgat ctggccctag cacacgaaat tccccgacta tctccctcca
     4681 ttcccaggac atgagacctg cacccagaat tctgagactg accctggcac gccacatctc
     4741 ccaatcccca cacactcctg cgacttaacc tctgcacaca gaggctccct gaaccaccct
     4801 ccctccccac tcctgccacc ccaaacaccc ccaccaaatt ccctgaactg cgtcccagca
     4861 cttctcaaac ctccaagact tgacccagct cttttcagct caaattcagc ctttgggatg
     4921 ctccaaatcc ttcccacaac tgacatttct tggacacccc caaagcctca ggcctgttcc
     4981 gcacccatat ccccaaagcc ctaacagact tgtccagccc aggttccctt gatgctagaa
     5041 cttccaagat aggcgcaacc tgtctgcaat tccagggaac cagaccctcc ccaagcaccc
     5101 tctttgtctt acgcctaacc ctgagtctct tccctgagat ggtgccccaa aggtaccctc
     5161 ttcacagaca ccagtgtttc ccagagggtt gtatttgtac ctttggtggt gtgctaaggt
     5221 ttgaggcagt atgaggacaa acacttgttt taaaagtttt gtctctaata cgcattttgt
     5281 acagaagccg ataagtgcag gcatcgctgc ttggctagga cacggtttat ttaggttaag
     5341 agtgtttcca tttaaagtag tccacagatg atcacagagg ctgttcccga agggaggaac
     5401 actggagtat cagaagattg ggaaccgaca acacccagct cggctgggat cccagccccc
     5461 cttccccagc ggtcctcacc gcgtcacgct cgcgggtgga aaatcatttc ccacctccta
     5521 tcctggctca aggatgcgct acctccccca agcccagaga ccacaccggt cccagactct
     5581 ttagcggacc ccccttttgg agccggggtc ccacggaatt agccacctcc ctccctctgc
     5641 tcccacggcc tcaggaaccc cccacccgag ggtggatggg gggcgtcact gagcacgatt
     5701 ctcgatgcaa cgattcctat gcaaggggca ttttgagtcc cccccatcct tccctcggac
     5761 cctaaaccct ggtgaagcag gggtgagggg tggggcgggt tttggtgggg gcggggcaaa
     5821 gggctagggg ctccagacac cagggtacgg ggtggggact gattatattg ccaaagggtt
     5881 caacttcttt aacaagcccc cccgtttccc ctgaccttca cgaaagccga aggaggcggg
     5941 gaaagggggt gagggtcttt tccaaagggt actgacctct tcccaacgtc tccccctgct
     6001 cgccagtccg ccacacgtac ccagcttttg agttcagctt ttcaaaataa ccacaatcat
     6061 gataaacttc tacaaaacgt gattctcctc ccctcccacc ccatccccca agtcaatagt
     6121 gtgggattcg gggagggaga gagcgagcta aagggactct ttccaagtcc ggctccccct
     6181 tttccccccg gccgccaggg tgcctgcacc tacacgcatg cgctgcatga cgcgcccccc
     6241 acacgcatgt cgcacccctc ctgcgctccg ggaacgcacg gacacgggcc agggggcggg
     6301 gcgattgggg aggaatgaat ggcggggggt cttcctgagc tccgcggctc accctcccca
     6361 acacacacac acacacacac agagcaataa gtttctctca ctcaaatgtg ggcggggcgg
     6421 gcctagcctg tcgctggtgg ggggagtggt gagggggcgc tctcagggat gggggcgggg
     6481 ttcggagaca gtgtggggag gggaggtctg caaatcgtcc aactctggtg ctaatggcgg
     6541 gtcttctcag cccacccgca gggcagggag ggaggggtcg gcgtggcccc ttccccaagc
     6601 ctcccccacg cccaccctgg gtgcatgaac cgcccaatgc agaagctgcc gcatgtcacc
     6661 cccctctccc caaagaaaaa gtgtcatgcc cccttcccac ccaccctcac tccccaccaa
     6721 aataaacgtt tccttttcat ttaaaaa
//
