LOCUS       NM_004770               3748 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily B member 2
            (KCNB2), mRNA.
ACCESSION   NM_004770
VERSION     NM_004770.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3748)
  AUTHORS   Li,Z., Dong,W., Zhang,X., Lu,J.M., Mei,Y.A. and Hu,C.
  TITLE     Protein Kinase C Controls the Excitability of Cortical Pyramidal
            Neurons by Regulating Kv2.2 Channel Activity
  JOURNAL   Neurosci Bull 38 (2), 135-148 (2022)
   PUBMED   34542799
  REMARK    GeneRIF: Protein Kinase C Controls the Excitability of Cortical
            Pyramidal Neurons by Regulating Kv2.2 Channel Activity.
REFERENCE   2  (bases 1 to 3748)
  AUTHORS   Maverick,E.E., Leek,A.N. and Tamkun,M.M.
  TITLE     Kv2 channel-AMIGO beta-subunit assembly modulates both channel
            function and cell adhesion molecule surface trafficking
  JOURNAL   J Cell Sci 134 (12) (2021)
   PUBMED   34137443
  REMARK    GeneRIF: Kv2 channel-AMIGO beta-subunit assembly modulates both
            channel function and cell adhesion molecule surface trafficking.
REFERENCE   3  (bases 1 to 3748)
  AUTHORS   Di Mattia,T., Martinet,A., Ikhlef,S., McEwen,A.G., Nomine,Y.,
            Wendling,C., Poussin-Courmontagne,P., Voilquin,L., Eberling,P.,
            Ruffenach,F., Cavarelli,J., Slee,J., Levine,T.P., Drin,G.,
            Tomasetto,C. and Alpy,F.
  TITLE     FFAT motif phosphorylation controls formation and lipid transfer
            function of inter-organelle contacts
  JOURNAL   EMBO J 39 (23), e104369 (2020)
   PUBMED   33124732
REFERENCE   4  (bases 1 to 3748)
  AUTHORS   Fu,J., Dai,X., Plummer,G., Suzuki,K., Bautista,A., Githaka,J.M.,
            Senior,L., Jensen,M., Greitzer-Antes,D., Manning Fox,J.E.,
            Gaisano,H.Y., Newgard,C.B., Touret,N. and MacDonald,P.E.
  TITLE     Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues
            Human beta-Cell Dysfunction
  JOURNAL   Diabetes 66 (7), 1890-1900 (2017)
   PUBMED   28607108
  REMARK    GeneRIF: Kv2.1, but not Kv2.2 (KCNB2), forms clusters of 6-12
            tetrameric channels at the plasma membrane and facilitates insulin
            exocytosis
REFERENCE   5  (bases 1 to 3748)
  AUTHORS   Naranjo,D., Moldenhauer,H., Pincuntureo,M. and Diaz-Franulic,I.
  TITLE     Pore size matters for potassium channel conductance
  JOURNAL   J Gen Physiol 148 (4), 277-291 (2016)
   PUBMED   27619418
  REMARK    Review article
REFERENCE   6  (bases 1 to 3748)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   7  (bases 1 to 3748)
  AUTHORS   Gutman,G.A., Chandy,K.G., Grissmer,S., Lazdunski,M., McKinnon,D.,
            Pardo,L.A., Robertson,G.A., Rudy,B., Sanguinetti,M.C., Stuhmer,W.
            and Wang,X.
  TITLE     International Union of Pharmacology. LIII. Nomenclature and
            molecular relationships of voltage-gated potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 473-508 (2005)
   PUBMED   16382104
  REMARK    Review article
REFERENCE   8  (bases 1 to 3748)
  AUTHORS   Yan,L., Figueroa,D.J., Austin,C.P., Liu,Y., Bugianesi,R.M.,
            Slaughter,R.S., Kaczorowski,G.J. and Kohler,M.G.
  TITLE     Expression of voltage-gated potassium channels in human and rhesus
            pancreatic islets
  JOURNAL   Diabetes 53 (3), 597-607 (2004)
   PUBMED   14988243
REFERENCE   9  (bases 1 to 3748)
  AUTHORS   Schmalz,F., Kinsella,J., Koh,S.D., Vogalis,F., Schneider,A.,
            Flynn,E.R., Kenyon,J.L. and Horowitz,B.
  TITLE     Molecular identification of a component of delayed rectifier
            current in gastrointestinal smooth muscles
  JOURNAL   Am J Physiol 274 (5), G901-G911 (1998)
   PUBMED   9612272
REFERENCE   10 (bases 1 to 3748)
  AUTHORS   Hugnot,J.P., Salinas,M., Lesage,F., Guillemare,E., de Weille,J.,
            Heurteaux,C., Mattei,M.G. and Lazdunski,M.
  TITLE     Kv8.1, a new neuronal potassium channel subunit with specific
            inhibitory properties towards Shab and Shaw channels
  JOURNAL   EMBO J 15 (13), 3322-3331 (1996)
   PUBMED   8670833
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011131.6 and AC022893.6.
            
            On Nov 26, 2018 this sequence version replaced NM_004770.2.
            
            Summary: Voltage-gated potassium (Kv) channels represent the most
            complex class of voltage-gated ion channels from both functional
            and structural standpoints. Their diverse functions include
            regulating neurotransmitter release, heart rate, insulin secretion,
            neuronal excitability, epithelial electrolyte transport, smooth
            muscle contraction, and cell volume. Four sequence-related
            potassium channel genes - shaker, shaw, shab, and shal - have been
            identified in Drosophila, and each has been shown to have human
            homolog(s). This gene encodes a member of the potassium channel,
            voltage-gated, shab-related subfamily. This member is a delayed
            rectifier potassium channel. The gene is expressed in
            gastrointestinal smooth muscle cells. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF338730.1, SRR1660803.155026.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000523207.2/ ENSP00000430846.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-661               AC011131.6         113199-113859
            662-1333            AC011131.6         143616-144287
            1334-3748           AC022893.6         142215-144629       c
FEATURES             Location/Qualifiers
     source          1..3748
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.11"
     gene            1..3748
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /note="potassium voltage-gated channel subfamily B member
                     2"
                     /db_xref="GeneID:9312"
                     /db_xref="HGNC:HGNC:6232"
                     /db_xref="MIM:607738"
     exon            1..661
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..1333
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             755..3490
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /note="delayed rectifier potassium channel protein;
                     potassium channel Kv2.2; voltage-gated potassium channel
                     subunit Kv2.2; potassium voltage-gated channel,
                     Shab-related subfamily, member 2; potassium channel,
                     voltage gated Shab related subfamily B, member 2"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily B
                     member 2"
                     /protein_id="NP_004761.2"
                     /db_xref="CCDS:CCDS6209.1"
                     /db_xref="GeneID:9312"
                     /db_xref="HGNC:HGNC:6232"
                     /db_xref="MIM:607738"
                     /translation="MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGL
                     NHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNF
                     YRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMR
                     EREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPEL
                     QETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILP
                     YYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNE
                     LGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTL
                     LGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIV
                     SMNLKDAFARSMELIDVAVEKAGESANTKDSADDNHLSPSRWKWARKALSETSSNKSF
                     ENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPER
                     PSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPP
                     SASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGPAARDGTLEYAPVDITVNLDASG
                     SQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFKENRGSAPQTPPSTARPLPVT
                     TADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGPSKGLSPRFPKQKLFPFSS
                     RERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSDGRDPLREEGSVGSSSP
                     QDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGDTGYCPTRETSM"
     exon            1334..3748
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3722..3727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /note="hexamer: AATAAA"
     polyA_site      3748
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /note="major polyA site"
ORIGIN      
        1 gcagccctgt gtgcgcgccg ggccggctag ctgcggggcg ggggagcggc gccccagagc
       61 gccccgccta gcctcccgcg cgcagcctct accctgctcc gccacagaca cacacccacc
      121 aagcacccac cgccctccgc cctccgccct ccgcccccgc ggccgccgcc gccgctgcgc
      181 ctcgggcagc cccagcgagc ggcaactccc gggctggcgc ggctcgcttt ctggctcctt
      241 ccgcgcggcg agctcagccc cgctcgattt ttcctcttct gttccagccc tctcttgtct
      301 gggtggctgt ggcggcggca gggggatggg gaccccgtgt ggggaagggg ttgaagatcg
      361 atgaagatta ttgttctttt aaaggatgcc ttagcttcct cccgccgcct ttcctctgag
      421 ccttcctact agagaccgtg aaccagagtc agggatgtaa agacaggggg aaagcacgcc
      481 gggagctcca gccagccggg gagaccctcc tctctgtgga ggggaggggg atttccagcg
      541 acaggtcatt ggcgaagggg atcgtcgcgg ggagaggctc cccggaggga gcggggaatc
      601 ccacagccct ttgtggtgcc cgagcccgtg ccgcctgctg agcggggtct gtgggagcta
      661 gctttgtcag tggaaatgcc tgccccagag ggatattgct tcagttgacc tcatttttta
      721 aggaccctgg ctctgcggct ttgtccagtt caaaatggca gaaaaggctc ccccgggctt
      781 aaacaggaag acttcaaggt cgacactttc ccttcctcca gagcctgtgg acattatccg
      841 gagcaaaaca tgctccagga gagttaagat caatgtgggg ggcctcaacc acgaagtcct
      901 gtggagaacg ctggacaggc tgcccaggac gcgcctgggg aagcttcgag actgcaacac
      961 acacgagagc ctcctggaag tgtgcgacga ctataatctg aacgagaacg agtatttctt
     1021 tgatcggcat ccaggagcct tcacttccat tttaaatttc taccggaccg ggaaactcca
     1081 tatgatggaa gaaatgtgtg cactttcgtt tggccaagaa cttgattact gggggattga
     1141 tgagatctac ttggagtcct gctgccaggc cagatatcat caaaaaaaag aacaaatgaa
     1201 cgaagaactg aggcgagagg cagagactat gcgagagcga gaaggagaag agtttgataa
     1261 tacctgctgc cctgataaaa ggaagaaact gtgggacttg ctggagaaac ctaactcatc
     1321 agtggctgca aagatcctgg ccatcgtgtc tatcctgttc attgtgcttt ccaccattgc
     1381 tttgtctctc aatacgctgc cggagctgca ggaaacggac gaatttggac aactcaatga
     1441 caaccgccaa ttagcacacg tggaggctgt gtgtattgca tggtttacca tggagtacct
     1501 tttgcgattc ttatcctcac caaataaatg gaagttcttc aaaggcccac tgaatgtcat
     1561 tgatttgctg gccatcttgc cgtactatgt caccattttt ctgacggagt ccaacaagag
     1621 cgtgctgcag ttccaaaacg tgaggcgcgt ggtccagatc ttccgaatca tgcgcatcct
     1681 caggatcctg aaactcgcca ggcattcgac aggcctgcag tctctgggtt tcacccttag
     1741 gcggagttac aatgaattgg gcttgttgat attgtttctg gccatgggga taatgatatt
     1801 ttccagcctg gtattttttg ctgagaagga tgaagatgct accaagttca ccagtatccc
     1861 tgcatcattt tggtgggcca ccatcaccat gaccactgtt ggctatggtg acatttaccc
     1921 taaaacatta ctagggaaaa ttgtgggagg tctgtgctgt attgctgggg ttctggttat
     1981 tgcccttcct atcccaatta ttgtgaacaa tttttctgag ttttacaagg agcagaaacg
     2041 ccaagagaaa gcaattaaaa ggagggaggc tcttgagcgg gccaaaagga acggaagcat
     2101 cgtttctatg aacttaaaag atgccttcgc tcgaagtatg gaactgatag atgtggctgt
     2161 tgagaaggcc ggagagtccg ccaacacaaa ggactccgcc gacgataatc acctgtcgcc
     2221 aagccggtgg aagtgggcca ggaaggctct gtcggaaaca agctccaaca agtctttcga
     2281 gaataagtac caggaggtta gccaaaaaga ctcccacgag cagctgaaca acacgtcttc
     2341 ctccagccca cagcatctga gtgcccagaa actggagatg ctatacaatg aaatcaccaa
     2401 gacacagcct cattctcacc caaacccaga ctgccaagaa aagcctgaga ggccatctgc
     2461 atatgaagaa gagattgaaa tggaagaagt ggtgtgtcca caggagcagc tggccgtggc
     2521 acagaccgag gtcattgtgg acatgaagag cacctccagc atcgacagct tcaccagctg
     2581 tgccaccgac ttcacagaga cagagagatc gccgctgccg ccgccctccg cctctcactt
     2641 gcagatgaag ttcccaaccg acctcccagg gacagaagag caccaaagag ctaggggccc
     2701 cccgtttcta actctatcca gagagaaagg acctgctgcc agggatggca cgctggagta
     2761 tgccccagtt gacataactg tgaacctcga tgccagtggc tcccagtgtg ggctacatag
     2821 tcctttgcag tctgacaatg ccaccgacag tcctaagagc tctctaaaag gcagcaaccc
     2881 actaaagtcc agatccctca aagtgaactt taaggaaaat agaggcagtg caccacagac
     2941 cccgcccagc acagccaggc cactgccagt caccacagct gacttttcgc tcactacccc
     3001 gcagcacatc agtaccatcc tcttagaaga aaccccctcc cagggagaca gacccttgct
     3061 gggcactgag gtttcagcgc cttgtcaggg accttccaaa gggctgtccc ccaggtttcc
     3121 caagcagaaa ctgttccctt tctcttcaag agagaggagg agcttcactg aaatagatac
     3181 tggtgacgac gaagacttct tagagctccc aggggcaagg gaggagaagc aggtggactc
     3241 cagcccaaat tgctttgcag ataagcctag tgatgggaga gaccctttaa gagaagaggg
     3301 cagtgtgggc tcttcctccc cgcaggacac aggtcacaac tgtaggcaag acatttacca
     3361 tgctgtgagt gaagtcaaaa aggacagtag tcaagaaggg tgcaagatgg aaaatcactt
     3421 gtttgcccca gaaattcatt ccaacccagg agacacaggt tattgtccca cacgtgaaac
     3481 cagcatgtga ctagttacaa aagcaataaa ttgaaacaaa acaaaacaaa acaaaacttg
     3541 tttcttaaaa atgcggttaa taatgcctgt gaactaaaaa aatgggaagc cctccccaaa
     3601 aaaagtgcat aaaatgttat ttttgcatgg catgaacagt ttagcttaag tactgtttaa
     3661 ataatgagtc aagactgcat tttgtaacaa accaacaaaa atgactgaag aacagtgaac
     3721 aaataaaaag agctctatta ggaaccaa
//
