LOCUS       NM_004732               2879 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily A regulatory
            beta subunit 3 (KCNAB3), mRNA.
ACCESSION   NM_004732
VERSION     NM_004732.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2879)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2879)
  AUTHORS   Ding,J., Miao,Q.F., Zhang,J.W., Guo,Y.X., Zhang,Y.X., Zhai,Q.X. and
            Chen,Z.H.
  TITLE     H258R mutation in KCNAB3 gene in a family with genetic epilepsy and
            febrile seizures plus
  JOURNAL   Brain Behav 10 (12), e01859 (2020)
   PUBMED   32990398
  REMARK    GeneRIF: H258R mutation in KCNAB3 gene in a family with genetic
            epilepsy and febrile seizures plus.
REFERENCE   3  (bases 1 to 2879)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2879)
  AUTHORS   Leicher,T., Bahring,R., Isbrandt,D. and Pongs,O.
  TITLE     Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel
            A-type potassium channel
  JOURNAL   J Biol Chem 273 (52), 35095-35101 (1998)
   PUBMED   9857044
REFERENCE   5  (bases 1 to 2879)
  AUTHORS   McCormack,K., McCormack,T., Tanouye,M., Rudy,B. and Stuhmer,W.
  TITLE     Alternative splicing of the human Shaker K+ channel beta 1 gene and
            functional expression of the beta 2 gene product
  JOURNAL   FEBS Lett 370 (1-2), 32-36 (1995)
   PUBMED   7649300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104581.22.
            
            On Sep 16, 2020 this sequence version replaced NM_004732.3.
            
            Summary: This gene encodes a member of the potassium channel,
            voltage-gated, shaker-related subfamily. The encoded protein is one
            of the beta subunits, which are auxiliary proteins associating with
            functional Kv-alpha subunits. The encoded protein forms a
            heterodimer with the potassium voltage-gated channel,
            shaker-related subfamily, member 5 gene product and regulates the
            activity of the alpha subunit. [provided by RefSeq, May 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.3424782.1,
                                           SRR18074969.2493385.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303790.3/ ENSP00000302719.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-663               AC104581.22        92431-93093         c
            664-707             AC104581.22        91020-91063         c
            708-745             AC104581.22        90894-90931         c
            746-825             AC104581.22        90581-90660         c
            826-870             AC104581.22        89296-89340         c
            871-915             AC104581.22        89168-89212         c
            916-959             AC104581.22        88920-88963         c
            960-1046            AC104581.22        88334-88420         c
            1047-1132           AC104581.22        87652-87737         c
            1133-1253           AC104581.22        87382-87502         c
            1254-1348           AC104581.22        87205-87299         c
            1349-1469           AC104581.22        86948-87068         c
            1470-1558           AC104581.22        86693-86781         c
            1559-2879           AC104581.22        85096-86416         c
FEATURES             Location/Qualifiers
     source          1..2879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2879
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /note="potassium voltage-gated channel subfamily A
                     regulatory beta subunit 3"
                     /db_xref="GeneID:9196"
                     /db_xref="HGNC:HGNC:6230"
                     /db_xref="MIM:604111"
     exon            1..663
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..1636
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /note="potassium channel, voltage-dependent, beta-3
                     subunit; potassium voltage-gated channel, shaker-related
                     subfamily, beta member 3; K(+) channel subunit beta-3;
                     potassium channel, voltage gated subfamily A regulatory
                     beta subunit 3"
                     /codon_start=1
                     /product="voltage-gated potassium channel subunit beta-3"
                     /protein_id="NP_004723.2"
                     /db_xref="CCDS:CCDS11124.1"
                     /db_xref="GeneID:9196"
                     /db_xref="HGNC:HGNC:6230"
                     /db_xref="MIM:604111"
                     /translation="MQVSIACTEQNLRSRSSEDRLCGPRPGPGGGNGGPAGGGHGNPP
                     GGGGSGPKARAALVPRPPAPAGALRESTGRGTGMKYRNLGKSGLRVSCLGLGTWVTFG
                     SQISDETAEDVLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVITTKI
                     FWGGQAETERGLSRKHIIEGLRGSLERLQLGYVDIVFANRSDPNCPMEEIVRAMTYVI
                     NQGLALYWGTSRWGAAEIMEAYSMARQFNLIPPVCEQAEHHLFQREKVEMQLPELYHK
                     IGVGSVTWYPLACGLITSKYDGRVPDTCRASIKGYQWLKDKVQSEDGKKQQAKVMDLL
                     PVAHQLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLIEHLGALQVLSQLTPQTVMEI
                     DGLLGNKPHSKK"
     exon            664..707
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            708..745
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            746..825
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            826..870
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            871..915
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            916..959
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1046
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1132
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1253
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1348
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1469
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1558
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..2879
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2535..2540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /note="hexamer: AATAAA"
     polyA_site      2557
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
                     /note="major polyA site"
     polyA_site      2879
                     /gene="KCNAB3"
                     /gene_synonym="AKR6A9; KCNA3.1B; KCNA3B; KV-BETA-3"
ORIGIN      
        1 gagctgggcc cgctgccgac gcggctggga gcccagcggg tcccgcagcg gttcgcgctg
       61 aagtggcatc tctctcccgc cccgcttccc cctgggtcct tatcctccga gacctttacc
      121 tcatcctcga cctttaccct catccatttc cccctcctaa tccttgctcc tgtgtccccc
      181 gtaactgaat atctccactc ctggcgcccc ccacgtttct tccctcccgc cgcaaacctc
      241 gcgacctcca gcagcccgcc cccgcgggcc cgatcctgcc tggcggctcc cgccgcagcc
      301 tcctcagcct tcccgctctg ccggggttcg ccccactacg cccccggtcg tcagccctcg
      361 ggcttccctg ctcccccctc ccgtcccctc ggagccccct cccccgcctc ggccagccag
      421 catgcaggtg tctatcgcgt gtaccgagca gaaccttcgc agccggagca gtgaggaccg
      481 tctgtgtgga ccccggccgg gccccggggg cggtaatggt gggccggccg gcggggggca
      541 cgggaatcct ccggggggtg gagggtctgg ccccaaggcc cgagctgcac tggttccccg
      601 acccccagcg cccgctgggg ccctccgaga gagcaccggc cgaggcactg gcatgaaata
      661 caggaaccta gggaagtctg gtcttcgggt atcctgtctt ggcctaggta cctgggtcac
      721 atttggttct cagatctcag atgagacagc agaggatgtg ctgactgtag cctatgagca
      781 tggtgtaaac ctgtttgaca ccgccgaagt gtacgcagca ggaaaggctg aaagaaccct
      841 agggaacatc ctcaagagca aaggttggag gagatcaagc tatgtcatca ctaccaagat
      901 tttttgggga ggacaggcag aaaccgagcg aggtttaagc cgaaagcaca tcattgaggg
      961 cttgcgagga tccctggaac gcctccagct gggatacgtg gacattgtct ttgccaatcg
     1021 ctcagacccc aactgtccta tggaggagat tgtgcgagcc atgacctatg tcatcaacca
     1081 gggcctggcc ctatactggg ggacatcccg atggggggct gcagaaatca tggaggccta
     1141 ctccatggcc agacagttca atctgattcc tccagtgtgt gaacaagcgg agcaccatct
     1201 gtttcagagg gagaaggtgg agatgcagct gccagagctc taccacaaga ttggagttgg
     1261 atcagtcact tggtaccctc tagcctgtgg tctcattact agcaagtatg atgggcgagt
     1321 cccagatact tgcagggcct ccatcaaggg ctaccagtgg ctcaaggaca aagtgcagag
     1381 tgaagatggc aagaagcaac aagccaaagt catggacctt cttcctgtcg ctcaccagct
     1441 gggctgcacc gtggcccagc ttgctattgc gtggtgtctc cgcagtgagg gtgtcagctc
     1501 tgtcttgctg ggggtgtcga gtgcggagca gttgatagaa cacctgggcg cgctacaggt
     1561 gctgagccag ctgaccccgc agacagtgat ggaaatagac gggctcctgg gaaacaagcc
     1621 gcattccaag aagtagtctg tcgcgggcgc agggacccaa cccggtgtcg ctgcacccgc
     1681 ccgagccccg ctcctcgcag ccgcctctcc cgctccggat ccctccacgc agcggccgga
     1741 gccagactag ccccgcccac caacgagtcc cggcttcgag tagtgatacg catgaacaaa
     1801 gccatatcct tttgcagtgg ggtcgagaga gaaagtagca cgcccgcccc ctgctgcgtc
     1861 tttctaggcc cttcttgcaa atcccgggca tgagctactc gccgtcggct ctctgccact
     1921 tcgtctcgct ccctactctc ctccccttat tcccgaggcc cagaaaagaa aacaaaaaca
     1981 aaaacccagc acatacaaga aacatacagt gtacctcaaa aggggccctt gaaatgtcat
     2041 caaagggtaa taacctagtg agtgagttgt gatgtcatct ggaacatagg aaatggggct
     2101 cttagcgtat tcggtacgaa ggaagccagg ctggtcctgg caggaagtaa atgataatct
     2161 ttgggaaacc aggaccctgc ctcccagccc agaggtggag gagggcggtc agggtggggt
     2221 ctacagtggc acagcactga caaaggtaga gggaaatgta atagcacatc tacgctgcag
     2281 tctggtgaaa gtggccgggg tggtccttgg aaaacagttg ggctgttctt ggcaggaatt
     2341 agtgacagcc tttccgtcac gggcagggac gccttgattt aaaaaaaata aataaataaa
     2401 acgtctgggt atagactttt gagccttgag cagggcctcc tacctggcag tggggaactg
     2461 cagtcttcct cctggcaata aacctaaagc aataatgatg gccccttctc tgtaagactt
     2521 cccaggtaac tgtaaataaa cctcagcttg atcctcacag tgtctaaagt tgcaggggct
     2581 tgggaggtta gggtcacagt ctcacttgtc tggccctctc gccccctaac attagaaatc
     2641 tgctagcatt agctttctct ccattgctca ttcaccttgg tgacccaggc atcgggctcc
     2701 tagtcactgt tctcatcaag gaccaagaca ccagataccc caggccccag ttttcttcct
     2761 tcagctacca cattccttag aacccagaaa tctggcttca taattttgtt cctcctcttt
     2821 ctatgaaaga cttagctatc tgcctttatt tgtttgtatt taaagtaata ttagccata
//
