LOCUS       NM_001199862            4176 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily A regulatory
            beta subunit 2 (KCNAB2), transcript variant 5, mRNA.
ACCESSION   NM_001199862
VERSION     NM_001199862.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4176)
  AUTHORS   Lyu,Y., Wang,Q., Liang,J., Zhang,L. and Zhang,H.
  TITLE     The Ion Channel Gene KCNAB2 Is Associated with Poor Prognosis and
            Loss of Immune Infiltration in Lung Adenocarcinoma
  JOURNAL   Cells 11 (21), 3438 (2022)
   PUBMED   36359834
  REMARK    GeneRIF: The Ion Channel Gene KCNAB2 Is Associated with Poor
            Prognosis and Loss of Immune Infiltration in Lung Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4176)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4176)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4176)
  AUTHORS   Ashton,C., Rhie,S.K., Carmichael,J.D. and Zada,G.
  TITLE     Role of KCNAB2 expression in modulating hormone secretion in
            somatotroph pituitary adenoma
  JOURNAL   J Neurosurg 134 (3), 787-793 (2020)
   PUBMED   32109873
  REMARK    GeneRIF: Role of KCNAB2 expression in modulating hormone secretion
            in somatotroph pituitary adenoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4176)
  AUTHORS   Portero,V., Le Scouarnec,S., Es-Salah-Lamoureux,Z., Burel,S.,
            Gourraud,J.B., Bonnaud,S., Lindenbaum,P., Simonet,F., Violleau,J.,
            Baron,E., Moreau,E., Scott,C., Chatel,S., Loussouarn,G., O'Hara,T.,
            Mabo,P., Dina,C., Le Marec,H., Schott,J.J., Probst,V., Baro,I.,
            Marionneau,C., Charpentier,F. and Redon,R.
  TITLE     Dysfunction of the Voltage-Gated K+ Channel beta2 Subunit in a
            Familial Case of Brugada Syndrome
  JOURNAL   J Am Heart Assoc 5 (6), e003122 (2016)
   PUBMED   27287695
  REMARK    GeneRIF: The results show that KvBeta 2 dysregulation of Kv4.3 is
            involved in the pathogenesis of Brugada Syndrome. This new finding
            also expands the list of genes associated with susceptibility to
            BrS and may contribute to improve molecular diagnosis of this
            cardiac arrhythmia disorder.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4176)
  AUTHORS   Kaab,S., Dixon,J., Duc,J., Ashen,D., Nabauer,M., Beuckelmann,D.J.,
            Steinbeck,G., McKinnon,D. and Tomaselli,G.F.
  TITLE     Molecular basis of transient outward potassium current
            downregulation in human heart failure: a decrease in Kv4.3 mRNA
            correlates with a reduction in current density
  JOURNAL   Circulation 98 (14), 1383-1393 (1998)
   PUBMED   9760292
REFERENCE   7  (bases 1 to 4176)
  AUTHORS   Nakahira,K., Shi,G., Rhodes,K.J. and Trimmer,J.S.
  TITLE     Selective interaction of voltage-gated K+ channel beta-subunits
            with alpha-subunits
  JOURNAL   J Biol Chem 271 (12), 7084-7089 (1996)
   PUBMED   8636142
REFERENCE   8  (bases 1 to 4176)
  AUTHORS   Schultz,D., Litt,M., Smith,L., Thayer,M. and McCormack,K.
  TITLE     Localization of two potassium channel beta subunit genes, KCNA1B
            and KCNA2B
  JOURNAL   Genomics 31 (3), 389-391 (1996)
   PUBMED   8838324
REFERENCE   9  (bases 1 to 4176)
  AUTHORS   McCormack,K., McCormack,T., Tanouye,M., Rudy,B. and Stuhmer,W.
  TITLE     Alternative splicing of the human Shaker K+ channel beta 1 gene and
            functional expression of the beta 2 gene product
  JOURNAL   FEBS Lett 370 (1-2), 32-36 (1995)
   PUBMED   7649300
REFERENCE   10 (bases 1 to 4176)
  AUTHORS   McCormack,T. and McCormack,K.
  TITLE     Shaker K+ channel beta subunits belong to an NAD(P)H-dependent
            oxidoreductase superfamily
  JOURNAL   Cell 79 (7), 1133-1135 (1994)
   PUBMED   8001150
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL035406.25, AK131252.1 and
            AW327942.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001199862.1.
            
            Summary: Voltage-gated potassium (Kv) channels represent the most
            complex class of voltage-gated ion channels from both functional
            and structural standpoints. Their diverse functions include
            regulating neurotransmitter release, heart rate, insulin secretion,
            neuronal excitability, epithelial electrolyte transport, smooth
            muscle contraction, and cell volume. Four sequence-related
            potassium channel genes - shaker, shaw, shab, and shal - have been
            identified in Drosophila, and each has been shown to have human
            homolog(s). This gene encodes a member of the potassium channel,
            voltage-gated, shaker-related subfamily. This member is one of the
            beta subunits, which are auxiliary proteins associating with
            functional Kv-alpha subunits. This member alters functional
            properties of the KCNA4 gene product. Alternative splicing of this
            gene results in multiple transcript variants encoding distinct
            isoforms. [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (5) lacks three exons from the 5'
            end and contains two alternate 5' exons and an additional internal
            in-frame exon, as compared to variant 1. The resulting isoform (3)
            has a longer and distinct N-terminus and an additional internal
            segment, as compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131252.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378083.8/ ENSP00000367323.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AL035406.25        97525-97557         c
            34-1497             AK131252.1         1-1464
            1498-4152           AL035406.25        42289-44943         c
            4153-4176           AW327942.1         30-53               c
FEATURES             Location/Qualifiers
     source          1..4176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..4176
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /note="potassium voltage-gated channel subfamily A
                     regulatory beta subunit 2"
                     /db_xref="GeneID:8514"
                     /db_xref="HGNC:HGNC:6229"
                     /db_xref="MIM:601142"
     exon            1..296
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            297..540
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..1570
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /note="isoform 3 is encoded by transcript variant 5; K(+)
                     channel subunit beta-2; potassium voltage-gated channel,
                     shaker-related subfamily, beta member 2; potassium
                     channel, voltage gated subfamily A regulatory beta subunit
                     2"
                     /codon_start=1
                     /product="voltage-gated potassium channel subunit beta-2
                     isoform 3"
                     /protein_id="NP_001186791.1"
                     /db_xref="CCDS:CCDS55570.1"
                     /db_xref="GeneID:8514"
                     /db_xref="HGNC:HGNC:6229"
                     /db_xref="MIM:601142"
                     /translation="MLSMTYSESLRSVSSRCHSEWALHPVRQTDTLELQRLREVRAAA
                     QARNMESFLRMHGLSLDGCTAQRTGMKYRNLGKSGLRVSCLGLGTWVTFGGQITDEMA
                     EQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAET
                     ERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEGDPFSSSKSRTFIIEETV
                     RAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQ
                     LPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQ
                     AKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLS
                     SSIIHEIDSILGNKPYSKKDYRS"
     exon            541..584
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            585..622
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            623..702
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            703..747
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            748..792
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            793..836
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            837..923
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            924..968
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1054
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1175
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1270
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1391
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1480
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..4176
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4160..4165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /note="hexamer: AATAAA"
     polyA_site      4176
                     /gene="KCNAB2"
                     /gene_synonym="AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2;
                     KCNA2B; KV-BETA-2"
                     /note="major polyA site"
ORIGIN      
        1 agtcagcctt gccaggttgc agcacggaac tgcacttccc gagcttttag gggaagaggc
       61 actcgtgaat aattcagcct ctttcactga gatgaaaacg ccctaataga actaatggac
      121 tcgctgcctc aaaactcgac tctggtggga ctcatctcat tcaccaattg cttctgacgt
      181 cctgcagtga cactccctaa tgaaaaagcc gctgtgccag atccttagag tgtctggtga
      241 tccctaataa accagactgt ggccttttta acgagcagac gcccccacga aggcagtggc
      301 agctcccaag ccaggcggca ccatgctgtc catgacgtac agcgagagtc tgcggagcgt
      361 gagcagcagg tgccactctg aatgggccct gcaccccgtc cgccagacgg acacgctgga
      421 actgcagcgg ctgcgggagg tgcgggcggc tgcccaggcc aggaacatgg agagcttcct
      481 ccgcatgcac ggcctttccc tggacggctg caccgcccag cgcacaggca tgaagtatcg
      541 gaacctgggc aagtctggcc tgcgggtctc ctgcctggga cttggaacat gggtgacctt
      601 cggaggccag atcaccgatg agatggcaga gcagctcatg accttggcct atgataatgg
      661 catcaacctc ttcgatacag cagaagtcta cgcagccggc aaggctgaag tggtactggg
      721 aaacatcatt aagaagaaag gatggaggcg gtccagcctc gtcatcacca ccaagatctt
      781 ctggggcgga aaggcggaga cggagcgggg cctgtccagg aagcacataa tcgaaggtct
      841 gaaagcttcc ctggagcgac tgcagctgga gtacgtggat gtggtgtttg ccaaccgccc
      901 ggaccccaac accccgatgg aaggggaccc atttagttcc tccaagtcaa ggacattcat
      961 catagaagag accgtccgcg ccatgaccca cgtcatcaac caggggatgg ccatgtactg
     1021 gggcacgtca cgctggagct ccatggagat catggaggcc tactccgtgg cccggcagtt
     1081 caacctgacc ccgcccatct gcgagcaggc tgagtaccac atgttccagc gtgagaaagt
     1141 ggaggtgcag ctgccggagc tgttccacaa gataggagtg ggcgccatga cctggtcccc
     1201 tctggcctgt ggcattgttt ctggcaagta cgacagtggc atcccaccct actcaagagc
     1261 ctccttgaag ggctaccagt ggctgaagga caagatcctc agtgaggagg gccggcgcca
     1321 gcaagccaag ctgaaggagc tgcaggccat cgccgagcgc ctgggctgca ccctgcccca
     1381 gctggccata gcctggtgcc tgaggaatga gggagtcagc tccgtgctcc tgggggcctc
     1441 caatgcggac cagctcatgg agaacattgg ggcaatacag gtccttccga aactgtcatc
     1501 ttccattatc cacgagattg atagtatttt gggcaataaa ccctacagca aaaaggacta
     1561 cagatcctaa gccgcccccg cccgcctgct cggacagttt ccgttccctc ctagtctctg
     1621 ttcgctcgct taagctgttt tgaagccaag tgaagagtgt ggtttgcatc caagagaaaa
     1681 caccacactg tgatgtcatc gggaaatgat ctcccaagtc gctgccagac accacccact
     1741 gcttcgccgg acaatgtcga agtccagtct gtgccgggga aggcactggt taggaaggat
     1801 gttcaaacgg tcccacccaa gcctgtcacc tctgctcatc ctccaagacc acccagcttt
     1861 ctcccagcca cagccaagat tcccaaagtc aaggcccaaa gatttccaag gttcccaaag
     1921 tcaaggccag gccaaggcct ggttgggtcc ttggggcggg cagggccagc ctctcctctg
     1981 ctgagaatcc ccacttggtg tagggggaga ggggaaaggg gtctggccca tcgaggggcc
     2041 ccttctgcca gggccttggt tgctggggca gggcctcccc actgggggtc ttcctccacc
     2101 tcccactttc caagggctcc aggaatctgg ggcctgacca cagattcctc tcccatcctt
     2161 ttctgctcca acctgcccca ctgggtcccg gcaggggcca tgcctaccaa gctcgagctg
     2221 gcccttgacc cccacccacc cccacccttg ctggcagggg cagggacccc agggggattg
     2281 actctgcagt ttgggagcca caaaaagcgt agcggtgtga tttctagctc agcctcccac
     2341 cgtcttcctc ctacacacca atgatgagcc tcatgccagt gaggcccgga gcgcttggga
     2401 ggggtcccag tggggcaggc ccctctgtct ggccacccct ctgtcctggc cccggaaggc
     2461 cctgtggtca tgtgctccta gctgcacggt ggctgctggc cacaccacgg caagtggcag
     2521 caggggccgg ccctgtgcac aaggatgcac tcctctcggc ccctgtagac tttctctaaa
     2581 gccgcccgcc agcccaggcc gctgctctgc accgagctgg tgggcttggg ttttgtggag
     2641 cgcatgcttg gaccctttca gtaaggaagg gtctttgggg ttttctgtgc ccatgacttg
     2701 ggggctgcac ccccacagca cccccacaat gtaggaaaag acctcaggga acctctccct
     2761 ggaaagacgg gcagggctgg ttagcccctc ccactgcctg acacctggga caggctgggc
     2821 agaggggaga gagggcagga caggccagag tgacgccccc gtgcagcttg ggccggaggg
     2881 caagggatgc cagtaagtct gcaggtgcgg ggtgccacct acaggcccag gcctgtgtcc
     2941 caagcagtac ccaggctttg cagaccacgc ggggcagggc tccactgaag ccacccccac
     3001 ccctcgccag ctagctccat agggaagcct gtgtctcctg cccccagggc gcaccctcag
     3061 tgcaggcacc tctgttcccg ctttgcccct ggaggagcca ctattccaga aggctccacc
     3121 ctgccgtcct gcgggagcct gctgtccagt cctggccggg ccaaggcctg ggaaactgtg
     3181 aaagtcagaa aggccagcgg ggagaggctg gggcgagggg aggaggggga tcagcttctg
     3241 ctattaccga ccccccttca tgctgcccct ggcgcctaga acccttgccc ctcctcatag
     3301 accaagtccc gggggtctcc actcagtcct gctgcctgct tcaccagaag cagccctgtg
     3361 agtgtggggt ggggaagtcc cttcccaacg gaggtcccag cctatggccc tgggcccagg
     3421 tgggggtcgc ctgcttcctt cccggacagg gtcctgcagt ggccaatggt gccagagggc
     3481 aggtggccca ccctcgccat cagggagggt ggctggcccc atccccactg ccacccagcc
     3541 ccacccactg ttggaagagg gaccagcgcg aggtggtgcc cagggtgggc actgctgctt
     3601 aatgcgaggc acacctgggg cagctgagcc cccaaaggct gcgggtttgc caaacacaga
     3661 gaggccaggc cccagtgtca ggatgcagtc agcctctggc gcagctcttt ccacgacctg
     3721 gttcctggat gtcctgcttg ctccacaccc atctacaggg aggatgtgag ggggctctgc
     3781 ctcctagggc caggtccccc ctctcgggag gaggtattgg gtaggaccat ccaagaaagg
     3841 gcagaagacc aagggcagtc ggggtctaga aaggagggcg ctggccctgc tggacgcttc
     3901 ggagccccca ctgtttccca ctcagctttg tgctcagatc ccaggtccca aggagtgaca
     3961 ggggcttcct cccaccttct gtccttgtcc agtcatgtaa ataatgtgct ttttctctcc
     4021 ccgagtcttt ttttttaaac ctaccgtggt tcctcagcta actgcattcc ctacccaggc
     4081 agagactgtc ctatgcctcg agcttccaaa cgagactcag accgcgacac agccaccgta
     4141 tttatggaat gacaaaataa ataaagccca aaccca
//
