LOCUS       NM_172160               3152 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily A regulatory
            beta subunit 1 (KCNAB1), transcript variant 1, mRNA.
ACCESSION   NM_172160
VERSION     NM_172160.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3152)
  AUTHORS   Quintanilha,J.C.F., Wang,J., Sibley,A.B., Jiang,C., Etheridge,A.S.,
            Shen,F., Jiang,G., Mulkey,F., Patel,J.N., Hertz,D.L., Dees,E.C.,
            McLeod,H.L., Bertagnolli,M., Rugo,H., Kindler,H.L., Kelly,W.K.,
            Ratain,M.J., Kroetz,D.L., Owzar,K., Schneider,B.P., Lin,D. and
            Innocenti,F.
  TITLE     Bevacizumab-induced hypertension and proteinuria: a genome-wide
            study of more than 1000 patients
  JOURNAL   Br J Cancer 126 (2), 265-274 (2022)
   PUBMED   34616010
  REMARK    GeneRIF: Bevacizumab-induced hypertension and proteinuria: a
            genome-wide study of more than 1000 patients.
            Erratum:[Br J Cancer. 2022 Jan;126(1):162. doi:
            10.1038/s41416-021-01617-1.. PMID: 34853435]
REFERENCE   2  (bases 1 to 3152)
  AUTHORS   Macias,A., de la Cruz,A., Peraza,D.A., Benito-Bueno,A., Gonzalez,T.
            and Valenzuela,C.
  TITLE     KV1.5-KVbeta1.3 Recycling Is PKC-Dependent
  JOURNAL   Int J Mol Sci 22 (3), 1336 (2021)
   PUBMED   33572906
  REMARK    GeneRIF: KV1.5-KVbeta1.3 Recycling Is PKC-Dependent.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3152)
  AUTHORS   Cho,I.H., Panzera,L.C., Chin,M., Alpizar,S.A., Olveda,G.E.,
            Hill,R.A. and Hoppa,M.B.
  TITLE     The potassium channel subunit Kvbeta1 serves as a major control
            point for synaptic facilitation
  JOURNAL   Proc Natl Acad Sci U S A 117 (47), 29937-29947 (2020)
   PUBMED   33168717
  REMARK    GeneRIF: The potassium channel subunit Kvbeta1 serves as a major
            control point for synaptic facilitation.
REFERENCE   4  (bases 1 to 3152)
  AUTHORS   Liao,J., Su,X., Chen,P., Wang,X., Xu,L., Li,X., Thean,L., Tan,C.,
            Tan,A.G., Tay,W.T., Jun,G., Zheng,Y., Chew,M., Wang,Y.X., Tan,Q.S.,
            Barathi,V.A., Klein,B.E., Saw,S.M., Vithana,E.N., Tai,E.S.,
            Iyengar,S.K., Mitchell,P., Khor,C.C., Aung,T., Wang,J.J.,
            Jonas,J.B., Teo,Y.Y., Wong,T.Y. and Cheng,C.Y.
  TITLE     Meta-analysis of genome-wide association studies in multiethnic
            Asians identifies two loci for age-related nuclear cataract
  JOURNAL   Hum Mol Genet 23 (22), 6119-6128 (2014)
   PUBMED   24951543
  REMARK    GeneRIF: Genetic variations of KCNAB1 and CRYAA are associated with
            age-related nuclear cataract.
REFERENCE   5  (bases 1 to 3152)
  AUTHORS   Macias,A., de la Cruz,A., Prieto,A., Peraza,D.A., Tamkun,M.M.,
            Gonzalez,T. and Valenzuela,C.
  TITLE     PKC inhibition results in a Kv 1.5 + Kv beta1.3 pharmacology closer
            to Kv 1.5 channels
  JOURNAL   Br J Pharmacol 171 (21), 4914-4926 (2014)
   PUBMED   24946104
  REMARK    GeneRIF: Protein kinase C inhibition results in a Kv 1.5 and Kv
            beta 1.3 pharmacology closer to Kv 1.5 channels
REFERENCE   6  (bases 1 to 3152)
  AUTHORS   England,S.K., Uebele,V.N., Kodali,J., Bennett,P.B. and Tamkun,M.M.
  TITLE     A novel K+ channel beta-subunit (hKv beta 1.3) is produced via
            alternative mRNA splicing
  JOURNAL   J Biol Chem 270 (48), 28531-28534 (1995)
   PUBMED   7499366
REFERENCE   7  (bases 1 to 3152)
  AUTHORS   McCormack,K., McCormack,T., Tanouye,M., Rudy,B. and Stuhmer,W.
  TITLE     Alternative splicing of the human Shaker K+ channel beta 1 gene and
            functional expression of the beta 2 gene product
  JOURNAL   FEBS Lett 370 (1-2), 32-36 (1995)
   PUBMED   7649300
REFERENCE   8  (bases 1 to 3152)
  AUTHORS   England,S.K., Uebele,V.N., Shear,H., Kodali,J., Bennett,P.B. and
            Tamkun,M.M.
  TITLE     Characterization of a voltage-gated K+ channel beta subunit
            expressed in human heart
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6309-6313 (1995)
   PUBMED   7603988
REFERENCE   9  (bases 1 to 3152)
  AUTHORS   Morales,M.J., Castellino,R.C., Crews,A.L., Rasmusson,R.L. and
            Strauss,H.C.
  TITLE     A novel beta subunit increases rate of inactivation of specific
            voltage-gated potassium channel alpha subunits
  JOURNAL   J Biol Chem 270 (11), 6272-6277 (1995)
   PUBMED   7890764
REFERENCE   10 (bases 1 to 3152)
  AUTHORS   Majumder,K., De Biasi,M., Wang,Z. and Wible,B.A.
  TITLE     Molecular cloning and functional expression of a novel potassium
            channel beta-subunit from human atrium
  JOURNAL   FEBS Lett 361 (1), 13-16 (1995)
   PUBMED   7890032
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L47665.1, AK057059.1,
            AC092927.5 and BC043166.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 28, 2020 this sequence version replaced NM_172160.2.
            
            Summary: Potassium channels represent the most complex class of
            voltage-gated ion channels from both functional and structural
            standpoints. Their diverse functions include regulating
            neurotransmitter release, heart rate, insulin secretion, neuronal
            excitability, epithelial electrolyte transport, smooth muscle
            contraction, and cell volume. Four sequence-related potassium
            channel genes - shaker, shaw, shab, and shal - have been identified
            in Drosophila, and each has been shown to have human homolog(s).
            This gene encodes a member of the potassium channel, voltage-gated,
            shaker-related subfamily. This member includes distinct isoforms
            which are encoded by alternatively spliced transcript variants of
            this gene. Some of these isoforms are beta subunits, which form
            heteromultimeric complexes with alpha subunits and modulate the
            activity of the pore-forming alpha subunits. [provided by RefSeq,
            Apr 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1), which is also known as kvb1.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L47665.1, SRR1660805.176467.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000490337.6/ ENSP00000419952.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1396              L47665.1           20-1415
            1397-1582           AK057059.1         1963-2148
            1583-1845           AC092927.5         169055-169317       c
            1846-2446           BC043166.2         2626-3226
            2447-2857           AC092927.5         168043-168453       c
            2858-3152           BC043166.2         3637-3931
FEATURES             Location/Qualifiers
     source          1..3152
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.31"
     gene            1..3152
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /note="potassium voltage-gated channel subfamily A
                     regulatory beta subunit 1"
                     /db_xref="GeneID:7881"
                     /db_xref="HGNC:HGNC:6228"
                     /db_xref="MIM:601141"
     exon            1..309
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1294
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     potassium channel beta 3 chain; potassium channel beta3
                     subunit; potassium channel shaker chain beta 1a; K(+)
                     channel subunit beta-1; potassium voltage-gated channel,
                     shaker-related subfamily, beta member 1; K+ channel Beta1a
                     chain; potassium voltage-gated channel subfamily A member
                     regulatory beta subunit 1; potassium channel, voltage
                     gated subfamily A regulatory beta subunit 1"
                     /codon_start=1
                     /product="voltage-gated potassium channel subunit beta-1
                     isoform 1"
                     /protein_id="NP_751892.1"
                     /db_xref="CCDS:CCDS3174.1"
                     /db_xref="GeneID:7881"
                     /db_xref="HGNC:HGNC:6228"
                     /db_xref="MIM:601141"
                     /translation="MLAARTGAAGSQISEENTKLRRQSGFSVAGKDKSPKKASENAKD
                     SSLSPSGESQLRARQLALLREVEMNWYLKLCDLSSEHTTVCTTGMPHRNLGKSGLRVS
                     CLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGW
                     RRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPM
                     EEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREK
                     VEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKERIVSEEG
                     RKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVL
                     PKMTSHVVNEIDNILRNKPYSKKDYRS"
     exon            310..353
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            354..391
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            392..471
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            472..516
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            517..561
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            562..605
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            606..692
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            693..778
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            779..899
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            900..994
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1115
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1204
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..3152
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3124..3129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /note="hexamer: AATAAA"
     polyA_site      3152
                     /gene="KCNAB1"
                     /gene_synonym="AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1;
                     Kvb1.3"
                     /note="major polyA site"
ORIGIN      
        1 agtgacttcc agtcttctct gaaagatctc cacgatgctg gcagcccgga caggggcagc
       61 ggggagtcag atctcagagg agaacaccaa gttaaggaga cagtctgggt tttctgtagc
      121 agggaaagac aaatctccca agaaagcctc agaaaacgct aaagacagca gccttagtcc
      181 ctcaggggaa agccagctca gggcgcgtca actggctctg ctgcgcgaag tggagatgaa
      241 ctggtaccta aagctctgcg acctgtccag cgagcacacc accgtctgca ccacaggcat
      301 gccgcacagg aatcttggaa aatcaggact cagagtttct tgcttgggtc ttggaacatg
      361 ggtgacattt ggaggtcaaa tttcagatga ggttgctgaa cggctgatga ccatcgccta
      421 tgaaagtggt gttaacctct ttgatactgc cgaagtctat gctgctggaa aggctgaagt
      481 gattctgggg agcatcatca agaagaaagg ctggaggagg tccagtctgg tcataacaac
      541 caaactctac tggggtggaa aagctgaaac agaaagaggg ctgtcaagaa agcatattat
      601 tgaaggattg aagggctccc tccagaggct gcagctcgag tatgtggatg tggtctttgc
      661 aaatcgaccg gacagtaaca ctcccatgga agaaattgtc cgagccatga cacatgtgat
      721 aaaccaaggc atggcgatgt actggggcac ctcgagatgg agtgctatgg agatcatgga
      781 agcctattct gtagcaagac agttcaatat gatcccaccg gtctgtgaac aagctgagta
      841 ccatcttttc cagagagaga aagtggaggt ccagctgcca gagctctacc acaaaatagg
      901 tgttggcgca atgacatggt ctccacttgc ctgtggaatc atctcaggaa aatacggaaa
      961 cggggtgcct gaaagttcca gggcttcact gaagtgctac cagtggttga aagaaagaat
     1021 tgtaagtgaa gaagggagaa aacagcaaaa caagctaaaa gacctttccc caattgcgga
     1081 gcgtctggga tgcacactac ctcagctagc tgttgcgtgg tgcctgagaa atgaaggtgt
     1141 gagttctgtg ctcctgggat catccactcc tgaacaactc attgaaaacc ttggtgccat
     1201 tcaggttctc ccaaagatga catcacatgt ggtaaatgag attgataaca tactgcgcaa
     1261 caagccctac agcaagaagg actatagatc ataaggcaat gcatgaacca cagaagctgc
     1321 atggttaaaa tagcggcctg tgcccagtac agaaaggtgt tactaaccag tcttttgaat
     1381 cacttagcag cttgctgctc aacctctagt gtccctccct ggattctttg aggtgtctgc
     1441 tgtcgctacc actgtgcaca tctgaaaact cacaaccaag aaaatccatt ctattttctt
     1501 atcttggact ggagtcacct attcttgcat tgctgtatac acctcatgct tatgcaatgg
     1561 gaagaatatg ggggccaggg ggtgtggtac taccttcagg catttggtaa ctcaaagaag
     1621 gctgtacaga tatatttttt caaaagaaca aaatccacag atgcaatgtg agttgcgtaa
     1681 gaaacagagt agatagacta aattcagtga aggaaaggaa ttgagagatt tttcttagta
     1741 aatagattat tgttaagtaa atagttatta aaaatatatc tcactgcaaa aaaaaaaaag
     1801 cagtatcttc actcaaaagt cttgcttgga agaataagca gaaataattt tatatatttt
     1861 ttttctattt tcacattcat actaacaagt tttgttccat ttgttattca ataaaacaaa
     1921 aatttctagg tatttgcttt attacctttc aaatatttac tgttgcttgg ccccaagaat
     1981 ggccttgtac aacttatcca gaatgtctat taggattcta atgttatgtc cacttacaag
     2041 tagagacagt aaaaggatga atacccaatc tttagtgaca atgcagctga tttatgaaag
     2101 agagggctac actgctatgg aaacttagct tcaaagaaaa tgcaatgtat ctgcaattag
     2161 gtgttcattt tttactacat tttattaaaa cctgctttat actttcaact gcttgtaggc
     2221 acaacttctg caagtttaaa tatttgagct ttacaaataa acatacacat gctcagtttt
     2281 ttaagtaaac ctgtaaaata cccaggaagg caaatgttca ttgtttaatt agcactggga
     2341 ttttataata taatgtttgg tatttttgag gcattgttaa catgaaagtc aaccactggc
     2401 tttgtgaaaa atgctatgtc actattcaga atatgctggg taaattgact tgcctagtga
     2461 aaagcaaaat gttaaagaaa gaacttctgg ttctataatc atattatatg cactaaacta
     2521 tatgcatgaa agttctttgc atggattaat ggggcttacc cttgttgcac tcgaaatctg
     2581 aggtgtatct agccctgcca ctattggcta cttaccctca ttaatatccc acttgagaaa
     2641 aattgtgaga ctatactgtg tcaatatctg taaaaagaga gaaaacatgt tttgtttttt
     2701 tttgaagggg gtggtgtggg agtggccctt taactctatt tggctatctg aggatgtaca
     2761 aaattctcat ttaattttct ggtcagcaag ttccccacac agaaatcact ctgaggttta
     2821 cagaagaact gtaatattat tttaaaatgc gatttttctg tcattagttc tagatatgta
     2881 cttcatggtt aaattctaaa tctgaaaatg ctagtgggag atatcaagaa attttctttt
     2941 tgattactag tacctgtatt ctaacagaga gtttgaattt tttgcccgtg ttatcagaat
     3001 gatggaaatt gatcattttc agttgttcat tgtgtattca atccagcgaa ctgctgtatg
     3061 tatagaggag ctgaggtgct gtctaatggg aaatgtgatt tgattgattt atttgcttag
     3121 agtaataaaa gcattttgtg cattcaatct ta
//
