LOCUS       NM_031886               4151 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily A member 7
            (KCNA7), mRNA.
ACCESSION   NM_031886
VERSION     NM_031886.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4151)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 4151)
  AUTHORS   Atsem,S., Reichenbach,J., Potabattula,R., Dittrich,M., Nava,C.,
            Depienne,C., Bohm,L., Rost,S., Hahn,T., Schorsch,M., Haaf,T. and El
            Hajj,N.
  TITLE     Paternal age effects on sperm FOXK1 and KCNA7 methylation and
            transmission into the next generation
  JOURNAL   Hum Mol Genet 25 (22), 4996-5005 (2016)
   PUBMED   28171595
  REMARK    GeneRIF: For FOXK1 and KCNA7, the age effect on the sperm epigenome
            was replicated in an independent cohort of 188 sperm samples.
REFERENCE   3  (bases 1 to 4151)
  AUTHORS   Finol-Urdaneta,R.K., Remedi,M.S., Raasch,W., Becker,S., Clark,R.B.,
            Struver,N., Pavlov,E., Nichols,C.G., French,R.J. and Terlau,H.
  TITLE     Block of Kv1.7 potassium currents increases glucose-stimulated
            insulin secretion
  JOURNAL   EMBO Mol Med 4 (5), 424-434 (2012)
   PUBMED   22438204
  REMARK    GeneRIF: The authors conclude that K(v) 1.7 contributes to the
            membrane-repolarizing current of beta cells during
            glucose-stimulated insulin.
REFERENCE   4  (bases 1 to 4151)
  AUTHORS   Gutman,G.A., Chandy,K.G., Grissmer,S., Lazdunski,M., McKinnon,D.,
            Pardo,L.A., Robertson,G.A., Rudy,B., Sanguinetti,M.C., Stuhmer,W.
            and Wang,X.
  TITLE     International Union of Pharmacology. LIII. Nomenclature and
            molecular relationships of voltage-gated potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 473-508 (2005)
   PUBMED   16382104
  REMARK    Review article
REFERENCE   5  (bases 1 to 4151)
  AUTHORS   Ding,Q., Zhao,Y.Y., Dong,L.Y., Sun,Z.J. and Guo,L.
  TITLE     [Distribution and significance of cSNP in KCNA7 gene as a novel
            NIDDM candidate gene in the population of northeast China]
  JOURNAL   Yi Chuan 25 (2), 129-132 (2003)
   PUBMED   15639836
  REMARK    GeneRIF: Observational study of genotype prevalence. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4151)
  AUTHORS   Bardien-Kruger,S., Wulff,H., Arieff,Z., Brink,P., Chandy,K.G. and
            Corfield,V.
  TITLE     Characterisation of the human voltage-gated potassium channel gene,
            KCNA7, a candidate gene for inherited cardiac disorders, and its
            exclusion as cause of progressive familial heart block I (PFHBI)
  JOURNAL   Eur J Hum Genet 10 (1), 36-43 (2002)
   PUBMED   11896454
  REMARK    GeneRIF: Expressed in heart, but not the cause of progressive
            familial heart block I.
REFERENCE   7  (bases 1 to 4151)
  AUTHORS   Kashuba,V.I., Kvasha,S.M., Protopopov,A.I., Gizatullin,R.Z.,
            Rynditch,A.V., Wahlestedt,C., Wasserman,W.W. and Zabarovsky,E.R.
  TITLE     Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a
            member of the voltage-gated potassium channel gene family
  JOURNAL   Gene 268 (1-2), 115-122 (2001)
   PUBMED   11368907
REFERENCE   8  (bases 1 to 4151)
  AUTHORS   Kalman,K., Nguyen,A., Tseng-Crank,J., Dukes,I.D., Chandy,G.,
            Hustad,C.M., Copeland,N.G., Jenkins,N.A., Mohrenweiser,H.,
            Brandriff,B., Cahalan,M., Gutman,G.A. and Chandy,K.G.
  TITLE     Genomic organization, chromosomal localization, tissue
            distribution, and biophysical characterization of a novel mammalian
            Shaker-related voltage-gated potassium channel, Kv1.7
  JOURNAL   J Biol Chem 273 (10), 5851-5857 (1998)
   PUBMED   9488722
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008687.5.
            
            On Sep 14, 2020 this sequence version replaced NM_031886.2.
            
            Summary: Potassium channels represent the most complex class of
            voltage-gated ion channels from both functional and structural
            standpoints. Their diverse functions include regulating
            neurotransmitter release, heart rate, insulin secretion, neuronal
            excitability, epithelial electrolyte transport, smooth muscle
            contraction, and cell volume. Four sequence-related potassium
            channel genes - shaker, shaw, shab, and shal - have been identified
            in Drosophila, and each has been shown to have human homolog(s).
            This gene encodes a member of the potassium channel, voltage-gated,
            shaker-related subfamily. This member contains six
            membrane-spanning domains with a shaker-type repeat in the fourth
            segment. The gene is expressed preferentially in skeletal muscle,
            heart and kidney. It is a candidate gene for inherited cardiac
            disorders. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ310479.1, BC140906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158188, SAMEA2158800
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221444.2/ ENSP00000221444.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-669               AC008687.5         83339-84007         c
            670-4151            AC008687.5         78705-82186         c
FEATURES             Location/Qualifiers
     source          1..4151
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..4151
                     /gene="KCNA7"
                     /gene_synonym="HAK6; KV1.7"
                     /note="potassium voltage-gated channel subfamily A member
                     7"
                     /db_xref="GeneID:3743"
                     /db_xref="HGNC:HGNC:6226"
                     /db_xref="MIM:176268"
     exon            1..669
                     /gene="KCNA7"
                     /gene_synonym="HAK6; KV1.7"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1485
                     /gene="KCNA7"
                     /gene_synonym="HAK6; KV1.7"
                     /note="voltage-gated potassium channel KCNA7;
                     voltage-dependent potassium channel Kv1.7; voltage-gated
                     potassium channel subunit Kv1.7; potassium voltage-gated
                     channel, shaker-related subfamily, member 7; potassium
                     channel, voltage gated shaker related subfamily A, member
                     7"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily A
                     member 7"
                     /protein_id="NP_114092.2"
                     /db_xref="CCDS:CCDS12755.1"
                     /db_xref="GeneID:3743"
                     /db_xref="HGNC:HGNC:6226"
                     /db_xref="MIM:176268"
                     /translation="MEPRCPPPCGCCERLVLNVAGLRFETRARTLGRFPDTLLGDPAR
                     RGRFYDDARREYFFDRHRPSFDAVLYYYQSGGRLRRPAHVPLDVFLEEVAFYGLGAAA
                     LARLREDEGCPVPPERPLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVF
                     CLETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPGNPPRLPFNDPFFVVETLCIC
                     WFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMSLAI
                     LRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAE
                     VDRVDSHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPV
                     IVSNFSYFYHRETEGEEAGMFSHVDMQPCGPLEGKANGGLVDGEVPELPPPLWAPPGK
                     HLVTEV"
     exon            670..4151
                     /gene="KCNA7"
                     /gene_synonym="HAK6; KV1.7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4127..4132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNA7"
                     /gene_synonym="HAK6; KV1.7"
                     /note="hexamer: ATTAAA"
     polyA_site      4151
                     /gene="KCNA7"
                     /gene_synonym="HAK6; KV1.7"
                     /note="major polyA site"
ORIGIN      
        1 ggacaccggg ctggggcggc ggcggcggcg gccgaggcgg ccgaggcggg gccgcaccgg
       61 ggccgggcgt cggggccaca cgtcggttcg cgggtcgccg gggctgcgcg cgccatggag
      121 ccgcggtgcc cgccgccgtg cggctgctgc gagcggctgg tgctcaacgt ggccgggctg
      181 cgcttcgaga cgcgggcgcg cacgctgggc cgcttcccgg acactctgct aggggaccca
      241 gcgcgccgcg gccgcttcta cgacgacgcg cgccgcgagt atttcttcga ccggcaccgg
      301 cccagcttcg acgccgtgct ctactactac cagtccggtg ggcggctgcg gcggccggcg
      361 cacgtgccgc tcgacgtctt cctggaagag gtggccttct acgggctggg cgcggcggcc
      421 ctggcacgcc tgcgcgagga cgagggctgc ccggtgccgc ccgagcgccc cctgccccgc
      481 cgcgccttcg cccgccagct gtggctgctt ttcgagtttc ccgagagctc tcaggccgcg
      541 cgcgtgctcg ccgtagtctc cgtgctggtc atcctcgtct ccatcgtcgt cttctgcctc
      601 gagacgctgc ctgacttccg cgacgaccgc gacggcacgg ggcttgctgc tgcagccgca
      661 gccggcccgt tccccgctcc gctgaatggc tccagccaaa tgcctggaaa tccaccccgc
      721 ctgcccttca atgacccgtt cttcgtggtg gagacgctgt gtatttgttg gttctccttt
      781 gagctgctgg tacgcctcct ggtctgtcca agcaaggcta tcttcttcaa gaacgtgatg
      841 aacctcatcg attttgtggc tatccttccc tactttgtgg cactgggcac cgagctggcc
      901 cggcagcgag gggtgggcca gcaggccatg tcactggcca tcctgagagt catccgattg
      961 gtgcgtgtct tccgcatctt caagctgtcc cggcactcaa agggcctgca aatcttgggc
     1021 cagacgcttc gggcctccat gcgtgagctg ggcctcctca tctttttcct cttcatcggt
     1081 gtggtcctct tttccagcgc cgtctacttt gccgaagttg accgggtgga ctcccatttc
     1141 actagcatcc ctgagtcctt ctggtgggcg gtagtcacca tgactacagt tggctatgga
     1201 gacatggcac ccgtcactgt gggtggcaag atagtgggct ctctgtgtgc cattgcgggc
     1261 gtgctgacta tttccctgcc agtgcccgtc attgtctcca atttcagcta cttttatcac
     1321 cgggagacag agggcgaaga ggctgggatg ttcagccatg tggacatgca gccttgtggc
     1381 ccactggagg gcaaggccaa tggggggctg gtggacgggg aggtacctga gctaccacct
     1441 ccactctggg cacccccagg gaaacacctg gtcaccgaag tgtgaggaac agttgaggtc
     1501 tgcaggacct cacacctccc tagagggagg gagggagggc agggtggagg gcaaggctgg
     1561 ggggagggga ttgggtttag gaagagctag gttaagtcgt aacgagtggg gaaacactga
     1621 gtcttgttgg gtcttgggtt gtgtggtttg gtagctcctg tgggtacctc ctgaagcagc
     1681 agcgaatggc aatgggttgt gttgtgttaa tgaagactca attggttcat attactctga
     1741 gttgtgcaaa gctcatggag ccttttgggg tagtgttgag ataggtttgg tcgtatcatt
     1801 ttgtgagttt cctaggtcag tgttgggttt ggttgggttg tgagtctggg atagtgtggt
     1861 ccagctgcat tgtgtaggat tctgtggttt ggtgggtccc ctagggccat gttgggtcaa
     1921 gttagatggt cccccatggc attgttgaga tcgaatgtgt gtggtgttaa gtttcgttga
     1981 gacatggtgg aaattgtgta gctctgtgat tcttccaggg gcatgttatt ttaggttctg
     2041 tgaacttgcg agtcatgtag aaatgtgaag agtccagtgg tagaatttga gctttctagg
     2101 tcacattggg ttaagtttgt atgaccaaat gaatcttgta gggttctgtt gggcttaact
     2161 gtgtagaggt gtgtggctgg acatttttcg tggccacagc gagttgagtt gtgttgaatt
     2221 gtacaaccat atgagccttg taaggccagt tcagttgggt catgccactg tttgagtctc
     2281 atagggccat gctgaattga gttccattga gttgtgtcac tatgtgagtc ctacaggaag
     2341 ttgggttgag ttggactgtg cgaacgagtt ccatagggcc acatcgggct gttttgcatt
     2401 tagtggtagc accaggaccc aaaggaaata gcagtgggga agcatcatgt atctgggagc
     2461 atgcagtggc gagggctctg ggaggtgtgc cgagctggct ccccagctcg ctgtaggggg
     2521 cgggactgga ttctgtatcc atgggattgg gtgttcatcc agaggcgact gggtaaatta
     2581 ggaagaggtg gatgctcctc ctgtttaccc cacatccact tcattgtgct gttcactccc
     2641 attctcccct acagttttat gctcagacat ggaggtcaga gccacaaggg aaaggggaga
     2701 gggggagaaa actgtactct gtccagacat gatagaggga cagagccaaa aggatagaga
     2761 aagagaccca gaaaaaggaa gaggtggaaa cccagagaga cagagaccca aagggagaga
     2821 aacagagact cagggagagg gagacaatga cctggagggt ggggtatggc agagacgcag
     2881 aagagaggaa cagaaatcca gagtggggag acagagacca agagcagggg atagaagccg
     2941 ggcgaagtgg cccatgcctg taatctcagc actctgggag accgaggaag ggggattgat
     3001 tgaggccagg agttcaagac cagcctgggc aacatggtga gaccccatct ctacaaaaaa
     3061 tacaaaaatt agctgagtgt ggtggcacat gcctgtgatc ccagctactc aggaagctga
     3121 ggcagaaaga tcccttgacc ctgagaggta gaggctgcat tgagccatga ttgcaccact
     3181 gcactccagc ctgggcaaca gagggagccc ccgtctcaac aaacaaacaa aaagagccag
     3241 tgggggaggg agggacagag acccagaggg cagcgtcaga cacccagagt tggagacaga
     3301 acaacagagt ctcagggaaa gagaaccaca atagaaaaag gcagaaaagg ccgggcgcgg
     3361 tggctcatgc ctgtaacccc agcactttgg gaggccgagg tgggcaaatt acgaggtcag
     3421 gagatccaga ccatcctggc taacacggtg aaaccccgtc tctactaaaa atacaaaaaa
     3481 attagccggg tgcggtggcg ggcacctgta gtcccagcta ctcgggaggc tgaggcagga
     3541 gaatggcatg aacctgggag gcggagcttg cagtgagccg agattgcgcc actgcactcc
     3601 agcctgggca gcagagcaac actctgtctc aaaaaaaaaa agaaaagaaa agaaaaagcc
     3661 agaaaaagtt ggtgcccctg aacccaagag tgatgtacag tctattccat agaatcacag
     3721 aacaatcctg aaccaggcct gtcacctacc ctccctgcag ctcaggaagg ctgtcagaca
     3781 ggctgggggc ctcactctgt tttccagggg agaaacctga gtctcagagc aggggagtgg
     3841 cttcccaagg tctcacagct tgtccccagg ggccaggcag gctgtctgtc tgcttcacat
     3901 gtccccatca gcctgctggg acacacgggt cctcctgagt cccgtagcct catttcttac
     3961 agacggggaa actgaggctc agagcagcag gtgttaccca aggtcacaag gccgaacatt
     4021 ttcagaaatc tttcagaact caaagggcat ttagaggaag aaggctgaaa tcactaacac
     4081 atatagggct tcctttggta tcaaagtact ttacttgggt taatttatta aaacctatcc
     4141 agtggtttac a
//
