LOCUS       NP_002226                529 aa            linear   PRI 30-APR-2025
DEFINITION  potassium voltage-gated channel subfamily A member 6 [Homo
            sapiens].
ACCESSION   NP_002226
VERSION     NP_002226.1
DBSOURCE    REFSEQ: accession NM_002235.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 529)
  AUTHORS   Salpietro,V., Galassi Deforie,V., Efthymiou,S., O'Connor,E.,
            Marce-Grau,A., Maroofian,R., Striano,P., Zara,F., Morrow,M.M.,
            Reich,A., Blevins,A., Sala-Coromina,J., Accogli,A., Fortuna,S.,
            Alesandrini,M., Au,P.Y.B., Singhal,N.S., Cogne,B., Isidor,B.,
            Hanna,M.G., Macaya,A., Kullmann,D.M., Houlden,H. and Mannikko,R.
  CONSRTM   SYNAPS Study Group
  TITLE     De novo KCNA6 variants with attenuated KV 1.6 channel deactivation
            in patients with epilepsy
  JOURNAL   Epilepsia 64 (2), 443-455 (2023)
   PUBMED   36318112
  REMARK    GeneRIF: De novo KCNA6 variants with attenuated KV 1.6 channel
            deactivation in patients with epilepsy.
REFERENCE   2  (residues 1 to 529)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 529)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 529)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (residues 1 to 529)
  AUTHORS   Naranjo,D., Moldenhauer,H., Pincuntureo,M. and Diaz-Franulic,I.
  TITLE     Pore size matters for potassium channel conductance
  JOURNAL   J Gen Physiol 148 (4), 277-291 (2016)
   PUBMED   27619418
  REMARK    Review article
REFERENCE   6  (residues 1 to 529)
  AUTHORS   Yusifov,T., Savalli,N., Gandhi,C.S., Ottolia,M. and Olcese,R.
  TITLE     The RCK2 domain of the human BKCa channel is a calcium sensor
  JOURNAL   Proc Natl Acad Sci U S A 105 (1), 376-381 (2008)
   PUBMED   18162557
  REMARK    GeneRIF: analysis of how the RCK2 domain of the human BKCa channel
            is a calcium sensor
REFERENCE   7  (residues 1 to 529)
  AUTHORS   Gutman,G.A., Chandy,K.G., Grissmer,S., Lazdunski,M., McKinnon,D.,
            Pardo,L.A., Robertson,G.A., Rudy,B., Sanguinetti,M.C., Stuhmer,W.
            and Wang,X.
  TITLE     International Union of Pharmacology. LIII. Nomenclature and
            molecular relationships of voltage-gated potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 473-508 (2005)
   PUBMED   16382104
  REMARK    Review article
REFERENCE   8  (residues 1 to 529)
  AUTHORS   Guihard,G., Bellocq,C., Grelet,E. and Escande,D.
  TITLE     Human Kv1.6 current displays a C-type-like inactivation when
            re-expressed in cos-7 cells
  JOURNAL   Biochem Biophys Res Commun 311 (1), 83-89 (2003)
   PUBMED   14575698
REFERENCE   9  (residues 1 to 529)
  AUTHORS   Albrecht,B., Weber,K. and Pongs,O.
  TITLE     Characterization of a voltage-activated K-channel gene cluster on
            human chromosome 12p13
  JOURNAL   Recept Channels 3 (3), 213-220 (1995)
   PUBMED   8821794
REFERENCE   10 (residues 1 to 529)
  AUTHORS   Grupe,A., Schroter,K.H., Ruppersberg,J.P., Stocker,M., Drewes,T.,
            Beckh,S. and Pongs,O.
  TITLE     Cloning and expression of a human voltage-gated potassium channel.
            A novel member of the RCK potassium channel family
  JOURNAL   EMBO J 9 (6), 1749-1756 (1990)
   PUBMED   2347305
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005833.1.
            
            Summary: Potassium channels represent the most complex class of
            voltage-gated ion channels from both functional and structural
            standpoints. Their diverse functions include regulating
            neurotransmitter release, heart rate, insulin secretion, neuronal
            excitability, epithelial electrolyte transport, smooth muscle
            contraction, and cell volume. Four sequence-related potassium
            channel genes - shaker, shaw, shab, and shal - have been identified
            in Drosophila, and each has been shown to have human homolog(s).
            This gene encodes a member of the potassium channel, voltage-gated,
            shaker-related subfamily. This member contains six
            membrane-spanning domains with a shaker-type repeat in the fourth
            segment. It belongs to the delayed rectifier class. The coding
            region of this gene is intronless, and the gene is clustered with
            genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (4) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: X17622.1, BC069355.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280684.4/ ENSP00000280684.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.32"
     Protein         1..529
                     /product="potassium voltage-gated channel subfamily A
                     member 6"
                     /note="voltage-gated potassium channel protein Kv1.6;
                     human brain potassium channel-2; protein phosphatase 1,
                     regulatory subunit 96; potassium voltage-gated channel,
                     shaker-related subfamily, member 6; voltage-gated
                     potassium channel HBK2; voltage-gated potassium channel
                     subunit Kv1.6; potassium channel, voltage gated shaker
                     related subfamily A, member 6"
                     /calculated_mol_wt=58598
     Region          1..33
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P17658.1)"
     Site            3
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q61923; propagated from
                     UniProtKB/Swiss-Prot (P17658.1)"
     Region          41..170
                     /region_name="BTB_POZ_KCNA6"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in potassium
                     voltage-gated channel subfamily A member 6 (KCNA6);
                     cd18407"
                     /db_xref="CDD:349714"
     Site            order(41,74,77,79..80,82,84)
                     /site_type="other"
                     /note="putative beta subunit interface [polypeptide
                     binding]"
                     /db_xref="CDD:349714"
     Site            order(42,46,48..55,58,78,81,85,87..88,90..91,94,98,101,
                     105,107,111,115..116,119)
                     /site_type="other"
                     /note="putative tetramer interface [polypeptide binding]"
                     /db_xref="CDD:349714"
     Site            172..193
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P17658.1)"
     Region          210..233
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P17658.1)"
     Region          259..468
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Site            263..284
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P17658.1)"
     Site            296..316
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P17658.1)"
     Site            338..358
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P17658.1)"
     Region          360..373
                     /region_name="S4-S5 linker.
                     /evidence=ECO:0000250|UniProtKB:P63142"
                     /note="propagated from UniProtKB/Swiss-Prot (P17658.1)"
     Site            374..395
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P17658.1)"
     Region          422..427
                     /region_name="Selectivity filter.
                     /evidence=ECO:0000250|UniProtKB:P63142"
                     /note="propagated from UniProtKB/Swiss-Prot (P17658.1)"
     Site            437..465
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P17658.1)"
     Region          488..513
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P17658.1)"
     Site            511
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000305;
                     propagated from UniProtKB/Swiss-Prot (P17658.1)"
     Region          527..529
                     /region_name="PDZ-binding. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P17658.1)"
     CDS             1..529
                     /gene="KCNA6"
                     /gene_synonym="HBK2; KV1.6; PPP1R96"
                     /coded_by="NM_002235.5:709..2298"
                     /db_xref="CCDS:CCDS8534.1"
                     /db_xref="GeneID:3742"
                     /db_xref="HGNC:HGNC:6225"
                     /db_xref="MIM:176257"
ORIGIN      
        1 mrseksltla apgevrgpeg eqqdagdfpe agggggccss erlvinisgl rfetqlrtls
       61 lfpdtllgdp grrvrffdpl rneyffdrnr psfdailyyy qsggrlrrpv nvpldiflee
      121 irfyqlgdea laafredegc lpeggedekp lpsqpfqrqv wllfeypess gpargiaivs
      181 vlvilisivi fcletlpqfr vdgrggnngg vsrvspvsrg sqeeeededd sytfhhgitp
      241 gemgtggsss lstlggsfft dpfflvetlc ivwftfellv rfsacpskpa ffrnimniid
      301 lvaifpyfit lgtelvqqqe qqpasggggq ngqqamslai lrvirlvrvf rifklsrhsk
      361 glqilgktlq asmrelglli fflfigvilf ssavyfaead dddslfpsip dafwwavvtm
      421 ttvgygdmyp mtvggkivgs lcaiagvlti alpvpvivsn fnyfyhrete qeeqgqythv
      481 tcgqpapdlr atdnglgkpd fpeanrerrp sylptphray aekrmltev
//
