LOCUS       NM_002233               4190 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily A member 4
            (KCNA4), mRNA.
ACCESSION   NM_002233
VERSION     NM_002233.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4190)
  AUTHORS   Kang,G.J., Xie,A., Kim,E. and Dudley,S.C. Jr.
  TITLE     miR-448 regulates potassium voltage-gated channel subfamily A
            member 4 (KCNA4) in ischemia and heart failure
  JOURNAL   Heart Rhythm 20 (5), 730-736 (2023)
   PUBMED   36693615
  REMARK    GeneRIF: miR-448 regulates potassium voltage-gated channel
            subfamily A member 4 (KCNA4) in ischemia and heart failure.
REFERENCE   2  (bases 1 to 4190)
  AUTHORS   Nilsson,M., Lindstrom,S.H., Kaneko,M., Wang,K., Minguez-Vinas,T.,
            Angelini,M., Steccanella,F., Holder,D., Ottolia,M., Olcese,R. and
            Pantazis,A.
  TITLE     An epilepsy-associated KV1.2 charge-transfer-center mutation
            impairs KV1.2 and KV1.4 trafficking
  JOURNAL   Proc Natl Acad Sci U S A 119 (17), e2113675119 (2022)
   PUBMED   35439054
  REMARK    GeneRIF: An epilepsy-associated KV1.2 charge-transfer-center
            mutation impairs KV1.2 and KV1.4 trafficking.
REFERENCE   3  (bases 1 to 4190)
  AUTHORS   Enyeart,J.J. and Enyeart,J.A.
  TITLE     Human adrenal glomerulosa cells express K2P and GIRK potassium
            channels that are inhibited by ANG II and ACTH
  JOURNAL   Am J Physiol Cell Physiol 321 (1), C158-C175 (2021)
   PUBMED   34038243
  REMARK    GeneRIF: Human adrenal glomerulosa cells express K2P and GIRK
            potassium channels that are inhibited by ANG II and ACTH.
REFERENCE   4  (bases 1 to 4190)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4190)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4190)
  AUTHORS   Gessler,M., Grupe,A., Grzeschik,K.H. and Pongs,O.
  TITLE     The potassium channel gene HK1 maps to human chromosome 11p14.1,
            close to the FSHB gene
  JOURNAL   Hum Genet 90 (3), 319-321 (1992)
   PUBMED   1487251
REFERENCE   7  (bases 1 to 4190)
  AUTHORS   Scott,H.S., Litjens,T., Hopwood,J.J. and Morris,C.P.
  TITLE     PCR detection of two RFLPs in exon I of the alpha-L-iduronidase
            (IDUA) gene
  JOURNAL   Hum Genet 90 (3), 327 (1992)
   PUBMED   1362562
REFERENCE   8  (bases 1 to 4190)
  AUTHORS   Tamkun,M.M., Knoth,K.M., Walbridge,J.A., Kroemer,H., Roden,D.M. and
            Glover,D.M.
  TITLE     Molecular cloning and characterization of two voltage-gated K+
            channel cDNAs from human ventricle
  JOURNAL   FASEB J 5 (3), 331-337 (1991)
   PUBMED   2001794
REFERENCE   9  (bases 1 to 4190)
  AUTHORS   Philipson,L.H., Hice,R.E., Schaefer,K., LaMendola,J., Bell,G.I.,
            Nelson,D.J. and Steiner,D.F.
  TITLE     Sequence and functional expression in Xenopus oocytes of a human
            insulinoma and islet potassium channel
  JOURNAL   Proc Natl Acad Sci U S A 88 (1), 53-57 (1991)
   PUBMED   1986382
REFERENCE   10 (bases 1 to 4190)
  AUTHORS   Philipson,L.H., Schaefer,K., LaMendola,J., Bell,G.I. and
            Steiner,D.F.
  TITLE     Sequence of a human fetal skeletal muscle potassium channel cDNA
            related to RCK4
  JOURNAL   Nucleic Acids Res 18 (23), 7160 (1990)
   PUBMED   2263489
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA328650.1, AK311228.1,
            M60450.1, BE467209.1 and AC124657.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002233.3.
            
            Summary: Potassium channels represent the most complex class of
            voltage-gated ion channels from both functional and structural
            standpoints. Their diverse functions include regulating
            neurotransmitter release, heart rate, insulin secretion, neuronal
            excitability, epithelial electrolyte transport, smooth muscle
            contraction, and cell volume. Four sequence-related potassium
            channel genes - shaker, shaw, shab, and shal - have been identified
            in Drosophila, and each has been shown to have human homolog(s).
            This gene encodes a member of the potassium channel, voltage-gated,
            shaker-related subfamily. This member contains six
            membrane-spanning domains with a shaker-type repeat in the fourth
            segment. It belongs to the A-type potassium current class, the
            members of which may be important in the regulation of the fast
            repolarizing phase of action potentials in heart and thus may
            influence the duration of cardiac action potential.[provided by
            RefSeq, Mar 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA328650.1, SRR1660803.27947.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328224.7/ ENSP00000328511.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DA328650.1         1-7
            8-944               AK311228.1         1-937
            945-3389            M60450.1           1-2445
            3390-3702           BE467209.1         1-313               c
            3703-4190           AC124657.5         135446-135933
FEATURES             Location/Qualifiers
     source          1..4190
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.1"
     gene            1..4190
                     /gene="KCNA4"
                     /gene_synonym="HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8;
                     KV1.4; MCIDDS; PCN2"
                     /note="potassium voltage-gated channel subfamily A member
                     4"
                     /db_xref="GeneID:3739"
                     /db_xref="HGNC:HGNC:6222"
                     /db_xref="MIM:176266"
     exon            1..459
                     /gene="KCNA4"
                     /gene_synonym="HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8;
                     KV1.4; MCIDDS; PCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            460..4190
                     /gene="KCNA4"
                     /gene_synonym="HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8;
                     KV1.4; MCIDDS; PCN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1242..3203
                     /gene="KCNA4"
                     /gene_synonym="HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8;
                     KV1.4; MCIDDS; PCN2"
                     /note="shaker-related potassium channel Kv1.4; type A
                     potassium channel; rapidly inactivating potassium channel;
                     potassium channel, voltage gated shaker related subfamily
                     A, member 4; fetal skeletal muscle potassium channel;
                     cardiac potassium channel; potassium channel 2;
                     voltage-gated K(+) channel HuKII; voltage-gated potassium
                     channel HK1; voltage-gated potassium channel HBK4;
                     voltage-gated potassium channel subunit Kv1.4"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily A
                     member 4"
                     /protein_id="NP_002224.1"
                     /db_xref="CCDS:CCDS41629.1"
                     /db_xref="GeneID:3739"
                     /db_xref="HGNC:HGNC:6222"
                     /db_xref="MIM:176266"
                     /translation="MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAV
                     AAATAAVEGSGGSGGGSHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSF
                     PHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQD
                     EGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNE
                     YFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFV
                     REEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRD
                     DRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFA
                     CPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVR
                     VFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHF
                     QSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF
                     YHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCA
                     KEEKCQGKGDDSETDKNNCSNAKAVETDV"
     regulatory      3370..3375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNA4"
                     /gene_synonym="HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8;
                     KV1.4; MCIDDS; PCN2"
                     /note="hexamer: AATAAA"
     polyA_site      3394
                     /gene="KCNA4"
                     /gene_synonym="HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8;
                     KV1.4; MCIDDS; PCN2"
                     /note="major polyA site"
     polyA_site      4039
                     /gene="KCNA4"
                     /gene_synonym="HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8;
                     KV1.4; MCIDDS; PCN2"
                     /note="major polyA site"
     regulatory      4161..4166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNA4"
                     /gene_synonym="HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8;
                     KV1.4; MCIDDS; PCN2"
                     /note="hexamer: AGTAAA"
     polyA_site      4190
                     /gene="KCNA4"
                     /gene_synonym="HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8;
                     KV1.4; MCIDDS; PCN2"
ORIGIN      
        1 agagcgcgtt cgcggccagg ggaggcgtgt gctgctcccg cagccagcga gagcgagaga
       61 gggatggatg ttggaggagg aattcgggct taacaagtga tcgctgctgt ctaggatttt
      121 gtttcttttc gggggaacct tgacttcctt tcccaggcaa tccctcctgt gctgaactcc
      181 agaggaacca ggagtcttgg ggtcttctct ggggcagccc caacccccac ccccaggctc
      241 cagccgcgag gactctgtgc acccctcggg ccaggcaaca gaacttgttc cgtggatatt
      301 tggagcctcc acctgccaaa cccgagtgat tccttttacc accccccgcc ccccacccag
      361 gatcattctt cccctcctcc agctgttgca gcttgagggg gaaaaacaag ccagccggtg
      421 gattttcttt atttttattt ttcgccccgc cggggaacgg tgaagtgctt cttctgcatg
      481 attttggctg aagaatgctc tgcatttcct tgatttctat ggagacctca gagctggttt
      541 tgcttctgct gacacctcat ctagcacctt ctctacctcc cagggtcttt gcctctatct
      601 gtggtttggc attgtacctg ggtacaggaa gcctttgatg aacttaaaag gagagcctgg
      661 agaatcatcc tgatagactt tgagtagaaa tggctggaca tacttcaaac cacatcttaa
      721 catggttcga gccatcacta gaaggcaagt gctaacagta aaggcttatt tgcattttat
      781 ttacatttaa tggactgagc attggccaat ttccatggca gaaaaatata tttcattttc
      841 taggcacaac ttctggctgt cagacacttg ctgcctttga atcttgcagc aacatcacta
      901 accacatccc agacatattt ccaaatttca acatctaccc ccaaaacata ggtgtctgag
      961 agactccagc attttcggac ttcttagtct tgagagtgcc aggctattta tctcgaccag
     1021 ccaagctctg gagagcaatg ttgaatccct gagaagagag agcatggggc gtgctgattt
     1081 aaaaacagaa aatgcaaagt tggactgaaa atatccttag tcttccaagc aatctgctta
     1141 agggttccaa acttacctta atttggtgag aaaagaagct gccctatttt tctttcttct
     1201 tcttctacaa ctggaaccag ccatttccga aaaccaccac catggaggtt gcaatggtga
     1261 gtgcggagag ctcagggtgc aacagtcaca tgccttatgg ttatgctgcc caggcccggg
     1321 cccgggagcg ggagaggctt gctcactcca gggcagctgc agcagctgct gttgcagcgg
     1381 ccacagctgc tgtcgaaggt agcgggggtt ctggtggggg ctcccaccac caccaccagt
     1441 cacgcggggc ctgtacctcc catgaccctc agagcagccg gggtagtcgg aggaggaggc
     1501 gacagcggtc tgagaagaag aaagcccact accggcagag cagcttccct cattgctctg
     1561 acctgatgcc cagtggctct gaggagaaga tcctgaggga gctgagtgag gaggaggaag
     1621 atgaggagga ggaggaagag gaggaagagg agggaaggtt ttactatagt gaagatgacc
     1681 atggtgatga gtgttcctac acggatctgc tgcctcagga tgagggcggt ggcggctaca
     1741 gttcagtccg ctacagtgac tgttgtgaac gtgtggtgat aaatgtgtca ggcctacgct
     1801 ttgagaccca aatgaaaact ctggcccagt ttccagagac tttgttggga gaccctgaaa
     1861 agaggactca gtactttgac cctttgcgca atgagtattt ttttgacagg aaccgcccca
     1921 gctttgatgc catcttgtat tattatcaat caggaggccg cctgaagagg ccagtcaatg
     1981 tcccctttga tatcttcact gaggaggtga agttctatca gttgggggag gaggccctgt
     2041 tgaagtttcg ggaggacgag ggctttgtga gagaagagga agacagggcc ctccccgaga
     2101 atgaatttaa aaagcagatt tggctcctct ttgaatatcc agagagctcc agtcctgcaa
     2161 ggggcatagc cattgtgtcc gtcctggtca tcttaatctc cattgtcatc ttttgcctgg
     2221 aaaccttgcc tgagtttagg gacgacaggg atctcgtcat ggcactgagt gctggcgggc
     2281 atggtgggtt gttgaatgat acttcagcac cccatctgga gaactcaggg cacacaatat
     2341 tcaatgaccc cttcttcatc gtggaaacag tctgtattgt atggttttcc tttgagtttg
     2401 tggttcgctg ctttgcttgt cccagccaag cactcttctt caaaaacatc atgaacatca
     2461 ttgacattgt ctccattttg ccttacttca tcacactggg cactgacctg gcccagcaac
     2521 aggggggtgg caatggtcag cagcagcagg ccatgtcctt tgccatcctc agaatcattc
     2581 gtctggtccg agtattccgg atcttcaaac tctccaggca ctccaaaggc ctgcagatcc
     2641 tgggccacac cctcagagcc agcatgcggg aactgggcct tctgatcttc ttcctcttca
     2701 ttggggtcat cctcttttct agtgctgtgt attttgcaga ggcggatgaa cctactaccc
     2761 atttccaaag catcccagat gcattttggt gggctgtggt gaccatgaca actgtgggct
     2821 atggggacat gaagcccatc actgtagggg gcaagattgt cgggtccctg tgtgccattg
     2881 cgggtgtctt aaccattgct ttgccagtgc cagtgattgt ctctaacttt aactatttct
     2941 accacagaga gactgaaaat gaggaacaga cacagctaac gcagaatgca gtcagttgtc
     3001 catacctccc ctctaatttg ctcaagaaat ttcggagctc tacttcttct tccctggggg
     3061 acaagtcaga gtatctagag atggaagaag gagttaagga atctctgtgt gcaaaggagg
     3121 agaagtgtca gggaaagggg gatgacagtg agacagataa aaacaactgt tctaatgcaa
     3181 aggctgtgga gactgatgtg tgaatctttt tccacctgcc actgctcccc cctcagcatc
     3241 tccaaatata tttatgcata gagagtgcag ttatgaaaat gaaatatgca aatgatccaa
     3301 tgcatacagt agtacactat ttaatggtta tacatggcat aattgttact aaacttgtat
     3361 tacatatcaa ataaatgata catcttggag aagagggagg aataggagca aatctatctt
     3421 tatattttta ttagaatgca agaattttgc acattaactg gaaaagatgt taacagtaaa
     3481 gatggagaga gagagtgtgt gcgtgtgtgt gtatatgtgt gtgtgtgtga agtaaattgt
     3541 caatgttagt aattgtgcag tgaagggaaa agttggcatt ttgaagtatt tactatgtaa
     3601 gaactaatga atctgagcag tcatttatca gtgctttaac agcatatcgt atgtctttgg
     3661 attctgtagt tgttttttaa aaattgtaag aaatactgtg tagagaaaaa agaaagtaaa
     3721 ttatttaata gactataggt cacaatttta tcttggattt aattaaaatt tatttttaac
     3781 tggaaattaa cttttaaaaa ggctgcaagg gcctttagaa attgattata ttttgttatt
     3841 aattttggga agacttaaca gcaaatgtct aacattatag aataagtgaa attggagaat
     3901 atgtaataag ttttgtttgc aggtaacagg actggatttt tttttctttg cactacttta
     3961 tatgctggag attgagagag acttcaaact gtgaatgttt actaatgtaa cagttcaatg
     4021 acaatcattg gaagaatgat ttctttagtc ttattttatt gttttctttt cattgtgtga
     4081 gactaatgat catgcagata acatcacagg attctctcct cttttaaaat ctaaataact
     4141 gattgacaaa ggaattatga agtaaaattt agcaactgaa tcttttgaaa
//
