LOCUS       NP_002224                653 aa            linear   PRI 27-APR-2025
DEFINITION  potassium voltage-gated channel subfamily A member 4 [Homo
            sapiens].
ACCESSION   NP_002224
VERSION     NP_002224.1
DBSOURCE    REFSEQ: accession NM_002233.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 653)
  AUTHORS   Kang,G.J., Xie,A., Kim,E. and Dudley,S.C. Jr.
  TITLE     miR-448 regulates potassium voltage-gated channel subfamily A
            member 4 (KCNA4) in ischemia and heart failure
  JOURNAL   Heart Rhythm 20 (5), 730-736 (2023)
   PUBMED   36693615
  REMARK    GeneRIF: miR-448 regulates potassium voltage-gated channel
            subfamily A member 4 (KCNA4) in ischemia and heart failure.
REFERENCE   2  (residues 1 to 653)
  AUTHORS   Nilsson,M., Lindstrom,S.H., Kaneko,M., Wang,K., Minguez-Vinas,T.,
            Angelini,M., Steccanella,F., Holder,D., Ottolia,M., Olcese,R. and
            Pantazis,A.
  TITLE     An epilepsy-associated KV1.2 charge-transfer-center mutation
            impairs KV1.2 and KV1.4 trafficking
  JOURNAL   Proc Natl Acad Sci U S A 119 (17), e2113675119 (2022)
   PUBMED   35439054
  REMARK    GeneRIF: An epilepsy-associated KV1.2 charge-transfer-center
            mutation impairs KV1.2 and KV1.4 trafficking.
REFERENCE   3  (residues 1 to 653)
  AUTHORS   Enyeart,J.J. and Enyeart,J.A.
  TITLE     Human adrenal glomerulosa cells express K2P and GIRK potassium
            channels that are inhibited by ANG II and ACTH
  JOURNAL   Am J Physiol Cell Physiol 321 (1), C158-C175 (2021)
   PUBMED   34038243
  REMARK    GeneRIF: Human adrenal glomerulosa cells express K2P and GIRK
            potassium channels that are inhibited by ANG II and ACTH.
REFERENCE   4  (residues 1 to 653)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (residues 1 to 653)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (residues 1 to 653)
  AUTHORS   Gessler,M., Grupe,A., Grzeschik,K.H. and Pongs,O.
  TITLE     The potassium channel gene HK1 maps to human chromosome 11p14.1,
            close to the FSHB gene
  JOURNAL   Hum Genet 90 (3), 319-321 (1992)
   PUBMED   1487251
REFERENCE   7  (residues 1 to 653)
  AUTHORS   Scott,H.S., Litjens,T., Hopwood,J.J. and Morris,C.P.
  TITLE     PCR detection of two RFLPs in exon I of the alpha-L-iduronidase
            (IDUA) gene
  JOURNAL   Hum Genet 90 (3), 327 (1992)
   PUBMED   1362562
REFERENCE   8  (residues 1 to 653)
  AUTHORS   Tamkun,M.M., Knoth,K.M., Walbridge,J.A., Kroemer,H., Roden,D.M. and
            Glover,D.M.
  TITLE     Molecular cloning and characterization of two voltage-gated K+
            channel cDNAs from human ventricle
  JOURNAL   FASEB J 5 (3), 331-337 (1991)
   PUBMED   2001794
REFERENCE   9  (residues 1 to 653)
  AUTHORS   Philipson,L.H., Hice,R.E., Schaefer,K., LaMendola,J., Bell,G.I.,
            Nelson,D.J. and Steiner,D.F.
  TITLE     Sequence and functional expression in Xenopus oocytes of a human
            insulinoma and islet potassium channel
  JOURNAL   Proc Natl Acad Sci U S A 88 (1), 53-57 (1991)
   PUBMED   1986382
REFERENCE   10 (residues 1 to 653)
  AUTHORS   Philipson,L.H., Schaefer,K., LaMendola,J., Bell,G.I. and
            Steiner,D.F.
  TITLE     Sequence of a human fetal skeletal muscle potassium channel cDNA
            related to RCK4
  JOURNAL   Nucleic Acids Res 18 (23), 7160 (1990)
   PUBMED   2263489
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA328650.1, AK311228.1,
            M60450.1, BE467209.1 and AC124657.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Potassium channels represent the most complex class of
            voltage-gated ion channels from both functional and structural
            standpoints. Their diverse functions include regulating
            neurotransmitter release, heart rate, insulin secretion, neuronal
            excitability, epithelial electrolyte transport, smooth muscle
            contraction, and cell volume. Four sequence-related potassium
            channel genes - shaker, shaw, shab, and shal - have been identified
            in Drosophila, and each has been shown to have human homolog(s).
            This gene encodes a member of the potassium channel, voltage-gated,
            shaker-related subfamily. This member contains six
            membrane-spanning domains with a shaker-type repeat in the fourth
            segment. It belongs to the A-type potassium current class, the
            members of which may be important in the regulation of the fast
            repolarizing phase of action potentials in heart and thus may
            influence the duration of cardiac action potential.[provided by
            RefSeq, Mar 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA328650.1, SRR1660803.27947.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328224.7/ ENSP00000328511.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..653
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.1"
     Protein         1..653
                     /product="potassium voltage-gated channel subfamily A
                     member 4"
                     /note="shaker-related potassium channel Kv1.4; type A
                     potassium channel; rapidly inactivating potassium channel;
                     potassium channel, voltage gated shaker related subfamily
                     A, member 4; fetal skeletal muscle potassium channel;
                     cardiac potassium channel; potassium channel 2;
                     voltage-gated K(+) channel HuKII; voltage-gated potassium
                     channel HK1; voltage-gated potassium channel HBK4;
                     voltage-gated potassium channel subunit Kv1.4"
                     /calculated_mol_wt=73127
     Region          1..>37
                     /region_name="K_channel_TID"
                     /note="Potassium channel Kv1.4 tandem inactivation domain;
                     pfam07941"
                     /db_xref="CDD:429748"
     Region          24..148
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P22459.2)"
     Site            90
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P22459.2)"
     Site            122
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q61423; propagated from
                     UniProtKB/Swiss-Prot (P22459.2)"
     Region          176..303
                     /region_name="BTB_POZ"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain superfamily; cl38908"
                     /db_xref="CDD:453885"
     Site            305..326
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P22459.2)"
     Region          306..570
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Site            352
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P22459.2)"
     Site            371..392
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P22459.2)"
     Site            404..424
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P22459.2)"
     Site            440..460
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P22459.2)"
     Region          462..475
                     /region_name="S4-S5 linker.
                     /evidence=ECO:0000250|UniProtKB:P63142"
                     /note="propagated from UniProtKB/Swiss-Prot (P22459.2)"
     Site            476..497
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P22459.2)"
     Region          524..529
                     /region_name="Selectivity filter.
                     /evidence=ECO:0000250|UniProtKB:P63142"
                     /note="propagated from UniProtKB/Swiss-Prot (P22459.2)"
     Site            539..567
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P22459.2)"
     Site            599
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P22459.2)"
     Region          629..653
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P22459.2)"
     Region          651..653
                     /region_name="PDZ-binding.
                     /evidence=ECO:0000250|UniProtKB:P15385"
                     /note="propagated from UniProtKB/Swiss-Prot (P22459.2)"
     CDS             1..653
                     /gene="KCNA4"
                     /gene_synonym="HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8;
                     KV1.4; MCIDDS; PCN2"
                     /coded_by="NM_002233.4:1242..3203"
                     /db_xref="CCDS:CCDS41629.1"
                     /db_xref="GeneID:3739"
                     /db_xref="HGNC:HGNC:6222"
                     /db_xref="MIM:176266"
ORIGIN      
        1 mevamvsaes sgcnshmpyg yaaqararer erlahsraaa aaavaaataa vegsggsggg
       61 shhhhqsrga ctshdpqssr gsrrrrrqrs ekkkahyrqs sfphcsdlmp sgseekilre
      121 lseeeedeee eeeeeeegrf yyseddhgde csytdllpqd eggggyssvr ysdccervvi
      181 nvsglrfetq mktlaqfpet llgdpekrtq yfdplrneyf fdrnrpsfda ilyyyqsggr
      241 lkrpvnvpfd ifteevkfyq lgeeallkfr edegfvreee dralpenefk kqiwllfeyp
      301 essspargia ivsvlvilis ivifcletlp efrddrdlvm alsagghggl lndtsaphle
      361 nsghtifndp ffivetvciv wfsfefvvrc facpsqalff knimniidiv silpyfitlg
      421 tdlaqqqggg ngqqqqamsf ailriirlvr vfrifklsrh skglqilght lrasmrelgl
      481 lifflfigvi lfssavyfae adeptthfqs ipdafwwavv tmttvgygdm kpitvggkiv
      541 gslcaiagvl tialpvpviv snfnyfyhre teneeqtqlt qnavscpylp snllkkfrss
      601 tssslgdkse ylemeegvke slcakeekcq gkgddsetdk nncsnakave tdv
//
