LOCUS       NM_002232               2476 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily A member 3
            (KCNA3), transcript variant 1, mRNA.
ACCESSION   NM_002232
VERSION     NM_002232.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2476)
  AUTHORS   Melis,M., Mastinu,M. and Sollai,G.
  TITLE     Effect of the rs2821557 Polymorphism of the Human Kv1.3 Gene on
            Olfactory Function and BMI in Different Age Groups
  JOURNAL   Nutrients 16 (6), 821 (2024)
   PUBMED   38542732
  REMARK    GeneRIF: Effect of the rs2821557 Polymorphism of the Human Kv1.3
            Gene on Olfactory Function and BMI in Different Age Groups.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2476)
  AUTHORS   Soldovieri,M.V., Ambrosino,P., Mosca,I., Servettini,I.,
            Pietrunti,F., Belperio,G., Syrbe,S., Taglialatela,M. and Lemke,J.R.
  CONSRTM   KCNA3 study group
  TITLE     De novo variants in KCNA3 cause developmental and epileptic
            encephalopathy
  JOURNAL   Ann Neurol 95 (2), 365-376 (2024)
   PUBMED   37964487
  REMARK    GeneRIF: De novo variants in KCNA3 cause developmental and
            epileptic encephalopathy.
REFERENCE   3  (bases 1 to 2476)
  AUTHORS   Melis,M., Tomassini Barbarossa,I., Crnjar,R. and Sollai,G.
  TITLE     Olfactory Sensitivity Is Associated with Body Mass Index and
            Polymorphism in the Voltage-Gated Potassium Channels Kv1.3
  JOURNAL   Nutrients 14 (23), 4986 (2022)
   PUBMED   36501016
  REMARK    GeneRIF: Olfactory Sensitivity Is Associated with Body Mass Index
            and Polymorphism in the Voltage-Gated Potassium Channels Kv1.3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2476)
  AUTHORS   Selvakumar,P., Fernandez-Marino,A.I., Khanra,N., He,C.,
            Paquette,A.J., Wang,B., Huang,R., Smider,V.V., Rice,W.J.,
            Swartz,K.J. and Meyerson,J.R.
  TITLE     Structures of the T cell potassium channel Kv1.3 with
            immunoglobulin modulators
  JOURNAL   Nat Commun 13 (1), 3854 (2022)
   PUBMED   35788586
  REMARK    GeneRIF: Structures of the T cell potassium channel Kv1.3 with
            immunoglobulin modulators.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2476)
  AUTHORS   Sebestyen,V., Nagy,E., Mocsar,G., Volko,J., Szilagyi,O.,
            Kenesei,A., Panyi,G., Toth,K., Hajdu,P. and Vamosi,G.
  TITLE     Role of C-Terminal Domain and Membrane Potential in the Mobility of
            Kv1.3 Channels in Immune Synapse Forming T Cells
  JOURNAL   Int J Mol Sci 23 (6), 3313 (2022)
   PUBMED   35328733
  REMARK    GeneRIF: Role of C-Terminal Domain and Membrane Potential in the
            Mobility of Kv1.3 Channels in Immune Synapse Forming T Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2476)
  AUTHORS   Folander,K., Douglass,J. and Swanson,R.
  TITLE     Confirmation of the assignment of the gene encoding Kv1.3, a
            voltage-gated potassium channel (KCNA3) to the proximal short arm
            of human chromosome 1
  JOURNAL   Genomics 23 (1), 295-296 (1994)
   PUBMED   7829094
REFERENCE   7  (bases 1 to 2476)
  AUTHORS   Attali,B., Romey,G., Honore,E., Schmid-Alliana,A., Mattei,M.G.,
            Lesage,F., Ricard,P., Barhanin,J. and Lazdunski,M.
  TITLE     Cloning, functional expression, and regulation of two K+ channels
            in human T lymphocytes
  JOURNAL   J Biol Chem 267 (12), 8650-8657 (1992)
   PUBMED   1373731
REFERENCE   8  (bases 1 to 2476)
  AUTHORS   Cai,Y.C., Osborne,P.B., North,R.A., Dooley,D.C. and Douglass,J.
  TITLE     Characterization and functional expression of genomic DNA encoding
            the human lymphocyte type n potassium channel
  JOURNAL   DNA Cell Biol 11 (2), 163-172 (1992)
   PUBMED   1547020
REFERENCE   9  (bases 1 to 2476)
  AUTHORS   Philipson,L.H., Hice,R.E., Schaefer,K., LaMendola,J., Bell,G.I.,
            Nelson,D.J. and Steiner,D.F.
  TITLE     Sequence and functional expression in Xenopus oocytes of a human
            insulinoma and islet potassium channel
  JOURNAL   Proc Natl Acad Sci U S A 88 (1), 53-57 (1991)
   PUBMED   1986382
REFERENCE   10 (bases 1 to 2476)
  AUTHORS   Grissmer,S., Dethlefs,B., Wasmuth,J.J., Goldin,A.L., Gutman,G.A.,
            Cahalan,M.D. and Chandy,K.G.
  TITLE     Expression and chromosomal localization of a lymphocyte K+ channel
            gene
  JOURNAL   Proc Natl Acad Sci U S A 87 (23), 9411-9415 (1990)
   PUBMED   2251283
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC035059.1, AL365361.12 and
            CA438434.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002232.4.
            
            Summary: Potassium channels represent the most complex class of
            voltage-gated ion channels from both functional and structural
            standpoints. Their diverse functions include regulating
            neurotransmitter release, heart rate, insulin secretion, neuronal
            excitability, epithelial electrolyte transport, smooth muscle
            contraction, and cell volume. Four sequence-related potassium
            channel genes - shaker, shaw, shab, and shal - have been identified
            in Drosophila, and each has been shown to have human homolog(s).
            This gene encodes a member of the potassium channel, voltage-gated,
            shaker-related subfamily. This member contains six
            membrane-spanning domains with a shaker-type repeat in the fourth
            segment. It belongs to the delayed rectifier class, members of
            which allow nerve cells to efficiently repolarize following an
            action potential. It plays an essential role in T-cell
            proliferation and activation. This gene appears to be intronless
            and it is clustered together with KCNA2 and KCNA10 genes on
            chromosome 1. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK314009.1, BC035059.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369769.4/ ENSP00000358784.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1165              BC035059.1         95-1259
            1166-1166           AL365361.12        120645-120645       c
            1167-2472           BC035059.1         1261-2566
            2473-2476           CA438434.1         31-34               c
FEATURES             Location/Qualifiers
     source          1..2476
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..2476
                     /gene="KCNA3"
                     /gene_synonym="HGK5; HLK3; HPCN3; HUKIII; KV1.3; MK3;
                     PCN3"
                     /note="potassium voltage-gated channel subfamily A member
                     3"
                     /db_xref="GeneID:3738"
                     /db_xref="HGNC:HGNC:6221"
                     /db_xref="MIM:176263"
     exon            1..2476
                     /gene="KCNA3"
                     /gene_synonym="HGK5; HLK3; HPCN3; HUKIII; KV1.3; MK3;
                     PCN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2456..2461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNA3"
                     /gene_synonym="HGK5; HLK3; HPCN3; HUKIII; KV1.3; MK3;
                     PCN3"
                     /note="hexamer: AATAAA"
     polyA_site      2476
                     /gene="KCNA3"
                     /gene_synonym="HGK5; HLK3; HPCN3; HUKIII; KV1.3; MK3;
                     PCN3"
                     /note="major polyA site"
ORIGIN      
        1 agacccagac agagcatcgc ggctttggct gcaacaggcg gtgggctcgg ctcgggggcg
       61 gaggcggcga aagggcgggg agcgcgagga ggagcgacct ggcctcaccg ctgccgcctc
      121 ttccccgccg catggacgag cgcctcagcc ttctgcgctc gccgccgccg ccctcagccc
      181 gccaccgcgc ccaccctcct cagcgcccag cgagcagcgg cggtgcccac acgctggtga
      241 accacggcta cgcggagccc gccgcaggcc gcgagctgcc gcccgacatg accgtggtgc
      301 ccggggacca cctgctggag ccggaggtgg ccgatggtgg aggggccccg cctcaaggcg
      361 gctgtggcgg cggcggctgc gaccgctacg agccgctgcc gccctcactg ccggccgcgg
      421 gcgagcagga ctgctgcggg gagcgcgtgg tcatcaacat ctccgggctg cgcttcgaga
      481 cgcagctgaa gaccctttgc cagttccccg agacgctgct gggcgacccc aagcggcgca
      541 tgaggtactt cgacccgctc cgcaacgagt acttcttcga ccgcaaccgg cccagcttcg
      601 acgccatcct ctactactat cagtccgggg gccgcatccg ccggccggtc aacgtgccca
      661 tcgacatttt ctccgaggag atccgcttct accagctggg cgaggaggcc atggagaagt
      721 tccgcgagga cgagggcttc ctgcgggagg aggagcggcc cttgccccgc cgcgacttcc
      781 agcgccaggt gtggctgctc ttcgagtacc ccgagagctc cgggccggcc cggggcatcg
      841 ccatcgtgtc cgtgctggtc atcctcatct ccattgtcat cttctgcctg gagacgctgc
      901 cggagttccg cgacgagaag gactaccccg cctcgacgtc gcaggactca ttcgaagcag
      961 ccggcaacag cacgtcgggg tcccgcgcag gagcctccag cttctccgat cccttcttcg
     1021 tggtggagac gctgtgcatc atctggttct ccttcgaact gctggtgcgg ttcttcgctt
     1081 gtcctagcaa agccaccttc tcgcgaaaca tcatgaacct gatcgacatt gtggccatca
     1141 ttccttattt tatcactctg ggtaccgagc tggccgaacg acagggcaat ggacagcagg
     1201 ccatgtctct ggccatcctg agggtcatcc gcctggtaag ggtcttccgc atcttcaagc
     1261 tgtcgcgcca ctccaagggg ctgcagatcc tcgggcaaac gctgaaggcg tccatgcggg
     1321 agctgggatt gctcatcttc ttcctcttta ttggggtcat ccttttctcc agcgcggtct
     1381 actttgccga ggcagacgac cccacttcag gtttcagcag catcccggat gccttctggt
     1441 gggcagtggt aaccatgaca acagtgggtt acggcgatat gcacccagtg accatagggg
     1501 gcaagattgt gggatctctc tgtgccatcg ccggtgtctt gaccatcgca ttgccagttc
     1561 ccgtgattgt ttccaacttc aattacttct accaccggga gacagaaggg gaagagcaat
     1621 cccagtacat gcacgtggga agttgccagc acctctcctc ttcagccgag gagctccgaa
     1681 aagcaaggag taactcgact ctgagtaagt cggagtatat ggtgatcgaa gaggggggta
     1741 tgaaccatag cgctttcccc cagacccctt tcaaaacggg caattccact gccacctgca
     1801 ccacgaacaa taatcccaac tcttgtgtca acatcaaaaa gatattcacc gatgtttaat
     1861 atgtgataca agtgacatgc tgtgctcagt attgtgtgga acgtgccccc ttggtctgcc
     1921 tatgcccttg ttttatacat ttccagacca ttcatcaagg aaaggacctg aagaagtgga
     1981 aagcacactt cattctccct ctccctgctg cttcatactg aaacaggtgc ctgttttgca
     2041 agtgggctgc attctctcag ctctcctttt ccctcttacc ctctctctct taacattgta
     2101 aacaacagac ttacgttaaa cttcatttct agtacacgcc ctatttaaaa aagagcagta
     2161 catcctggga ggaaatgaaa ctaaagaaca gttagagtaa ctgtttaacc tcagaatttt
     2221 aaaggcagtt gtttctttcc taagcacatc aattcgtagt aaatgatgct tcggtttgat
     2281 ggacctttca acgttattta ttgaatatgt atttcggttg cctaccctgt agatatgtgg
     2341 atgaagagtc taactagaat aatgacttgt aaacccacca tgagttattt ggtttttgac
     2401 ttaaattcct atttgaatcc cctttcccgg aattttaagt gtctctacaa ctttgaataa
     2461 agggaaatgc ccaaga
//
