LOCUS       NM_004974              11829 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily A member 2
            (KCNA2), transcript variant 1, mRNA.
ACCESSION   NM_004974
VERSION     NM_004974.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11829)
  AUTHORS   Xie,C., Kessi,M., Yin,F. and Peng,J.
  TITLE     Roles of KCNA2 in Neurological Diseases: from Physiology to
            Pathology
  JOURNAL   Mol Neurobiol 61 (11), 8491-8517 (2024)
   PUBMED   38517617
  REMARK    GeneRIF: Roles of KCNA2 in Neurological Diseases: from Physiology
            to Pathology.
            Review article
REFERENCE   2  (bases 1 to 11829)
  AUTHORS   Arlt,F.A., Miske,R., Machule,M.L., Broegger Christensen,P.,
            Mindorf,S., Teegen,B., Borowski,K., Buthut,M., Rossling,R.,
            Sanchez-Sendin,E., van Hoof,S., Cordero-Gomez,C., Bunger,I.,
            Radbruch,H., Kraft,A., Ayzenberg,I., Klausewitz,J., Hansen,N.,
            Timaus,C., Kortvelyessy,P., Postert,T., Baur-Seack,K., Rost,C.,
            Brunkhorst,R., Doppler,K., Haigis,N., Hamann,G., Kunze,A.,
            Stutzer,A., Maschke,M., Melzer,N., Rosenow,F., Siebenbrodt,K.,
            Stenor,C., Dichgans,M., Georgakis,M.K., Fang,R., Petzold,G.C.,
            Gortler,M., Zerr,I., Wunderlich,S., Mihaljevic,I., Turko,P.,
            Schmidt Ettrup,M., Buchholz,E., Foverskov Rasmussen,H., Nasouti,M.,
            Talucci,I., Maric,H.M., Heinemann,S.H., Endres,M., Komorowski,L.
            and Pruss,H.
  CONSRTM   DEMDAS study group
  TITLE     KCNA2 IgG autoimmunity in neuropsychiatric diseases
  JOURNAL   Brain Behav Immun 117, 399-411 (2024)
   PUBMED   38309639
  REMARK    GeneRIF: KCNA2 IgG autoimmunity in neuropsychiatric diseases.
REFERENCE   3  (bases 1 to 11829)
  AUTHORS   Minguez-Vinas,T., Prakash,V., Wang,K., Lindstrom,S.H., Pozzi,S.,
            Scott,S.A., Spiteri,E., Stevenson,D.A., Ashley,E.A., Gunnarsson,C.
            and Pantazis,A.
  TITLE     Two epilepsy-associated variants in KCNA2 (KV 1.2) at position H310
            oppositely affect channel functional expression
  JOURNAL   J Physiol 601 (23), 5367-5389 (2023)
   PUBMED   37883018
  REMARK    GeneRIF: Two epilepsy-associated variants in KCNA2 (KV 1.2) at
            position H310 oppositely affect channel functional expression.
REFERENCE   4  (bases 1 to 11829)
  AUTHORS   Nilsson,M., Lindstrom,S.H., Kaneko,M., Wang,K., Minguez-Vinas,T.,
            Angelini,M., Steccanella,F., Holder,D., Ottolia,M., Olcese,R. and
            Pantazis,A.
  TITLE     An epilepsy-associated KV1.2 charge-transfer-center mutation
            impairs KV1.2 and KV1.4 trafficking
  JOURNAL   Proc Natl Acad Sci U S A 119 (17), e2113675119 (2022)
   PUBMED   35439054
  REMARK    GeneRIF: An epilepsy-associated KV1.2 charge-transfer-center
            mutation impairs KV1.2 and KV1.4 trafficking.
REFERENCE   5  (bases 1 to 11829)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 11829)
  AUTHORS   Nakahira,K., Shi,G., Rhodes,K.J. and Trimmer,J.S.
  TITLE     Selective interaction of voltage-gated K+ channel beta-subunits
            with alpha-subunits
  JOURNAL   J Biol Chem 271 (12), 7084-7089 (1996)
   PUBMED   8636142
REFERENCE   7  (bases 1 to 11829)
  AUTHORS   Kim,E., Niethammer,M., Rothschild,A., Jan,Y.N. and Sheng,M.
  TITLE     Clustering of Shaker-type K+ channels by interaction with a family
            of membrane-associated guanylate kinases
  JOURNAL   Nature 378 (6552), 85-88 (1995)
   PUBMED   7477295
REFERENCE   8  (bases 1 to 11829)
  AUTHORS   Ramaswami,M., Tanouy,M. and Mathew,M.K.
  TITLE     Facile formation of heteromultimeric potassium channels by
            expression of cloned human cDNAs
  JOURNAL   Indian J Biochem Biophys 31 (4), 254-260 (1994)
   PUBMED   8002006
REFERENCE   9  (bases 1 to 11829)
  AUTHORS   Klocke,R., Roberds,S.L., Tamkun,M.M., Gronemeier,M., Augustin,A.,
            Albrecht,B., Pongs,O. and Jockusch,H.
  TITLE     Chromosomal mapping in the mouse of eight K(+)-channel genes
            representing the four Shaker-like subfamilies Shaker, Shab, Shaw,
            and Shal
  JOURNAL   Genomics 18 (3), 568-574 (1993)
   PUBMED   7905852
REFERENCE   10 (bases 1 to 11829)
  AUTHORS   Grissmer,S., Dethlefs,B., Wasmuth,J.J., Goldin,A.L., Gutman,G.A.,
            Cahalan,M.D. and Chandy,K.G.
  TITLE     Expression and chromosomal localization of a lymphocyte K+ channel
            gene
  JOURNAL   Proc Natl Acad Sci U S A 87 (23), 9411-9415 (1990)
   PUBMED   2251283
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL365361.12, AK290061.1,
            BC043564.1 and BM682747.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004974.3.
            
            Summary: Potassium channels represent the most complex class of
            voltage-gated ion channels from both functional and structural
            standpoints. Their diverse functions include regulating
            neurotransmitter release, heart rate, insulin secretion, neuronal
            excitability, epithelial electrolyte transport, smooth muscle
            contraction, and cell volume. Four sequence-related potassium
            channel genes - shaker, shaw, shab, and shal - have been identified
            in Drosophila, and each has been shown to have human homolog(s).
            This gene encodes a member of the potassium channel, voltage-gated,
            shaker-related subfamily. This member contains six
            membrane-spanning domains with a shaker-type repeat in the fourth
            segment. It belongs to the delayed rectifier class, members of
            which allow nerve cells to efficiently repolarize following an
            action potential. The coding region of this gene is intronless, and
            the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290061.1, DA341137.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316361.10/ ENSP00000314520.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL365361.12        53224-53228         c
            6-1313              AK290061.1         1-1308
            1314-1325           BC043564.1         1263-1274
            1326-2155           AK290061.1         1321-2150
            2156-2210           BM682747.1         64-118              c
            2211-2255           BM682747.1         18-62               c
            2256-11829          AL365361.12        40450-50023         c
FEATURES             Location/Qualifiers
     source          1..11829
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..11829
                     /gene="KCNA2"
                     /gene_synonym="DEE32; EIEE32; HBK5; HK4; HUKIV; KV1.2;
                     MK2; NGK1; RBK2"
                     /note="potassium voltage-gated channel subfamily A member
                     2"
                     /db_xref="GeneID:3737"
                     /db_xref="HGNC:HGNC:6220"
                     /db_xref="MIM:176262"
     exon            1..131
                     /gene="KCNA2"
                     /gene_synonym="DEE32; EIEE32; HBK5; HK4; HUKIV; KV1.2;
                     MK2; NGK1; RBK2"
                     /inference="alignment:Splign:2.1.0"
     exon            132..463
                     /gene="KCNA2"
                     /gene_synonym="DEE32; EIEE32; HBK5; HK4; HUKIV; KV1.2;
                     MK2; NGK1; RBK2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..11829
                     /gene="KCNA2"
                     /gene_synonym="DEE32; EIEE32; HBK5; HK4; HUKIV; KV1.2;
                     MK2; NGK1; RBK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             627..2126
                     /gene="KCNA2"
                     /gene_synonym="DEE32; EIEE32; HBK5; HK4; HUKIV; KV1.2;
                     MK2; NGK1; RBK2"
                     /note="isoform a is encoded by transcript variant 1;
                     voltage-gated potassium channel protein Kv1.2; potassium
                     voltage-gated channel, shaker-related subfamily, member 2;
                     voltage-gated K(+) channel HuKIV; voltage-gated potassium
                     channel HBK5; voltage-gated potassium channel subunit
                     Kv1.2; potassium channel, voltage gated shaker related
                     subfamily A, member 2"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily A
                     member 2 isoform a"
                     /protein_id="NP_004965.1"
                     /db_xref="CCDS:CCDS827.1"
                     /db_xref="GeneID:3737"
                     /db_xref="HGNC:HGNC:6220"
                     /db_xref="MIM:176262"
                     /translation="MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRF
                     ETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPV
                     NVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSG
                     PARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSF
                     TDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAE
                     KPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFF
                     LFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGS
                     LCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSA
                     STISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV"
     regulatory      9171..9176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNA2"
                     /gene_synonym="DEE32; EIEE32; HBK5; HK4; HUKIV; KV1.2;
                     MK2; NGK1; RBK2"
                     /note="hexamer: AATAAA"
     polyA_site      9191
                     /gene="KCNA2"
                     /gene_synonym="DEE32; EIEE32; HBK5; HK4; HUKIV; KV1.2;
                     MK2; NGK1; RBK2"
     regulatory      11810..11815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNA2"
                     /gene_synonym="DEE32; EIEE32; HBK5; HK4; HUKIV; KV1.2;
                     MK2; NGK1; RBK2"
                     /note="hexamer: AATAAA"
     polyA_site      11829
                     /gene="KCNA2"
                     /gene_synonym="DEE32; EIEE32; HBK5; HK4; HUKIV; KV1.2;
                     MK2; NGK1; RBK2"
                     /note="major polyA site"
ORIGIN      
        1 attctgtgct ccctgccgag gagatgtgag ggattttctc ttgggggaga aatcagtggt
       61 cgagcgcctg cccagctcaa atgccacccg gctcagaggg aggcctgcgg cccagggatc
      121 ccggagggag agcaacgtca cacctcctga ggacagccag gactccagct tttgctgagc
      181 tttgcatctt gcctccttcc ttcaaaaggc tccaggccca tgctcggctg tcttcaagtc
      241 ccgcatgccc ctggccaggc acctcaccgc ccctccagcc cagcccaatc ctagagctca
      301 cctccaggac ccagagtctg cccttctgcc cagaatgact caccattatt tctagctcga
      361 gtgagaagac gtgatgagga gttgggctgc ctgttggtgc atctcagatt cctgcagcat
      421 ctgatcagct ctgcaaggaa gagagcttca cgtctctggt cagccaagcg aggctgtctc
      481 tccagctctc agagagctct cggggctctc ctgcaggaga ccaggccaat gctcctgtgc
      541 ttcctggggc cagtagcagc accctgagct ccctgccacc aggcagctga aaggcatagc
      601 gtgaggtgct tctctcagtc ccaattatga cagtggccac cggagaccca gcagacgagg
      661 ctgctgccct ccctgggcac ccacaggaca cctatgaccc agaggcagac cacgagtgct
      721 gtgagagggt ggtgatcaac atctcagggc tgcggtttga gacccagcta aagaccttag
      781 cccagtttcc agagaccctc ttaggggacc caaagaaacg aatgaggtac tttgaccccc
      841 tccgaaatga gtactttttc gatcggaacc gccctagctt tgatgccatt ttgtactact
      901 accagtcagg gggccgattg aggcgacctg tgaatgtgcc cttagatata ttctctgaag
      961 aaattcggtt ttatgagctg ggagaagaag cgatggagat gtttcgggaa gatgaaggct
     1021 acatcaagga ggaagagcgt cctctgcctg aaaatgagtt tcagagacaa gtgtggcttc
     1081 tctttgaata cccagagagc tcagggcctg ccaggattat agctattgtg tctgtcatgg
     1141 tgattctgat ctcaattgtc agcttctgtc tggaaacatt gcccatcttc cgggatgaga
     1201 atgaagacat gcatggtagt ggggtgacct tccacaccta ttccaacagc accatcgggt
     1261 accagcagtc cacttccttc acagaccctt tcttcattgt agagacactc tgcatcatct
     1321 ggttctcctt tgaattcttg gtgaggttct ttgcctgtcc cagcaaagcc ggcttcttca
     1381 ccaacatcat gaacatcatt gacattgtgg ccatcatccc ctacttcatc accctgggga
     1441 cagagttggc tgagaagcca gaggacgctc agcaaggcca gcaggccatg tcactggcca
     1501 tcctccgtgt catccggttg gtaagagtct ttaggatttt caagttgtcc agacactcca
     1561 aaggtctcca gattctaggt cagaccctca aagccagcat gagagaattg ggcctcctga
     1621 tattctttct cttcataggg gtcatccttt tctctagtgc tgtgtatttt gcagaggccg
     1681 atgagcgaga gtcccagttc cccagcatcc cagatgcctt ctggtgggca gtcgtctcca
     1741 tgacaactgt aggctatgga gacatggttc cgactaccat tgggggaaag atagtgggtt
     1801 ccctatgtgc gattgcaggt gtgttaacta ttgccttacc ggtccctgtc attgtgtcca
     1861 atttcaacta cttctaccac cgggagacag agggagagga acaggcccaa tacttgcaag
     1921 tgacaagctg tccaaagatc ccatcctccc ctgacctaaa gaaaagtaga agtgcctcta
     1981 ccattagtaa gtctgattac atggagatcc aggagggtgt aaataacagt aatgaggact
     2041 ttagagagga aaacttgaaa acagccaact gtaccttggc taacacaaac tatgtgaata
     2101 ttaccaaaat gttaactgat gtctgattga aacctattac cgtactcaca gctcaatgga
     2161 actaatgcag atgttgcata atagcctgca ttgtagtcag tgtgttctac agtgtgtatc
     2221 tggttctgca tggaaagcaa tagttgtgca agtgactttt gatcttttga cttttgattt
     2281 agaacacaga atatctatca tggctttcat gcacatcctc atcaccggct tatgaacttc
     2341 caaagacggg agtcacctat caagctagga tttcagatag acacgttgag gccacctcat
     2401 atcccataca cagtgcacca tatcagtgcc atcattcctt cctaatgaaa tgcacacaac
     2461 atccaagaga tgcactcccc tccccaccat cccaccacct tatttgagcc cacctgccct
     2521 ttcacagagg aacacaatca tggcttagct ttaaatagct ggtgtttgtt caaaaggtca
     2581 tactcatttt tgcattgaaa agaacacaca gtcctgtgtg ttggaattac tttctgtgtc
     2641 acaggctgga gtttgtgaat tgcagttgcc aagtagatgc tctggaggct tgtgtttcat
     2701 aacggaaaat gctgcattct gctttttctc tgcagtgtcg atgtgaggga agcccggggg
     2761 agggacagtt agtatgaccg aatatgagtt gtcaagtttc acatttgttc ccttaggcct
     2821 atggggagaa gctaacaaac caacagacct ctaagcctct gatttcacca tttttgcagg
     2881 ctccagggtc acaaaaacat gtctggtttc ttactggagt ttgcagacat ctgctttccc
     2941 actgatgtgg cccagctaca ctgacactgc agtgaaattt accagtgatg caatagagct
     3001 gcatgggtgt ttgttgcatg aatctcaata tttaaaacac aggagataac ctattttcct
     3061 agtagcctac acagtgttaa tatttagagt attaataggc ttggaatggt cttgaactag
     3121 gggttttttt cccatcagaa ggcaaaaatc cctccatcag gggaaaaaaa atagactatt
     3181 tggaatggaa ctaaaacttc tggcccccca gcctacctat ccctgttctt ctaaacagga
     3241 acgcagacct ctgcaaagcc agaagagtaa gcggggaagg cagcatctga acacctcaca
     3301 tgactgcacc ttaggaatta acctagtcgc gggcatgact gtacagtgga ccagggcatc
     3361 tggtcctgat gacaggcagg tctgtggatc cagtgtatat aaatatatat cgagtatctc
     3421 tctttcacgc gttcctctac ctagctagtg atagaaaaga aattgcattt gaacattgta
     3481 caagcttatg caatattttt gacaaagggc aatttatgca tgtgtttgac tatgtgcact
     3541 agggtgtata tatatacata catatgtgtg tatatgtata cacacacaca cacacacaca
     3601 cacacacaca cacatatata tatatatata ttcattttct ggagttcagg ttcaggagca
     3661 aatccactgc ttggtgggtt ggctgtctaa gaggcctaat gggttaattt gtctcattgg
     3721 taaccccact gggcctgggt ttgctgccat tgcctcagac actccggtat ccatggattc
     3781 ctagacgtta gaattgtctt tctgccctcc atgtgctgca gcttcagttc ccatggctga
     3841 agcttgtctt actgagtgca caagggccct gtggccctca cagttccagc tgtcctgggc
     3901 cagacccacc ccgggcctcc tctctacagt tcatcctgtt catcatctcc attttcacct
     3961 cttcccttgc cacttggatc ttattatcat ttggctctgc atccgtcact ttcacaaacc
     4021 tttcgctaaa gagccagaat ggatcccctg ctttgaaacc aaggacacca aggagtagga
     4081 ctccctggga ccaaattcca ctgatctgga cctaaaggga gcctcctcta tgtggaaatg
     4141 tctgaagtcc gggactaagt gatggagtcc ctagatgatc caaaggcatc attttgatct
     4201 ccagacccaa actctctccc cattaaactg gcaaccagag ctgcttttta aaaagaacca
     4261 aaggatgggt aaagaatcat ttcccacccc ccagaagaag tagagtgcaa atgagcactg
     4321 cacagcctaa aggtagacag taggttgacc ctgaaatggc ttcaggtagg gggcttttaa
     4381 ctcaccagac tgggcgtctt tgccttttga cggagtagct taattttccc aaacagtgaa
     4441 ttgcaggggt cgggctatgc aggggtggct ccagcccagg cctcactgct gcctagttag
     4501 cacctacagt tgtcttgggg catggggcac cagctcaggg tgctaggccc agggtgctca
     4561 ttagtgcctg gtcacccaca tccccaggta tctgcagggc atcccatgcc cagcacaaag
     4621 cctctgtgct tctcttcctc tccttcatgg gaggtggtgc tgaatttcca aggcatgggg
     4681 tgggagggac acagatcttt ggaaaataga aggtaaagca acccatatct gaggcctagg
     4741 tcagggatag atatcttatc acagtgtcct tggcccagga ctctaaaatg ttcacataca
     4801 gtcatgcaca ttcaccacaa aataggtaca ctgttgtcac acacaaacat aaaacatgta
     4861 acgtgcaaaa tacagacaga ccaggttaac ataaaagcaa acacagaaga tatatggtta
     4921 taattgtata taaaatgcac actctgcaca gatatagaat ttacacagaa catacacaaa
     4981 agacaaacat acaccacata caaatataca acctgaaact cagatgcaaa atacataaaa
     5041 aactacatgg acaaaatgca tatgcatata agatacacaa aggctacttt accattgttt
     5101 ctacacataa aatacacaca aactcagtat atacacacga tgcattaact tataataggc
     5161 atacaagata catagcacac atgcccaaaa atatcgcaca atacacatga aatgcagaca
     5221 tatactcaga cccattgccc tgcccccaga gctatgaatt aacaggcaca aacaaaagat
     5281 cagatgtaat cacctttgcc tggcctgtgt ctatatcccc caggatcttt caaggaatct
     5341 ctttctctat tcttttctct cactaccaga tttcactcct gagaagtaac tcctaggttt
     5401 caagcaggag gatgggccac cacatcaagc agatatctga ctaagaccag gaattgcatg
     5461 gggtctctac caattcacct tcctcccacc agaaacctgg gtgcagggtg tgaaagtacc
     5521 tgggacagct ggtagcctaa tataggcctc cttgccatga cccttccttc cttccagcaa
     5581 atccgcacag acaacccaat agcccaggct ccccttctcc cagcacctgg gatctccaga
     5641 ttcagcccta ttctcttaaa agcagtaatg gctcaagaaa ctgcaggatc ttgagcccag
     5701 gaccagggta aagatgtccc caacattctc taagcccaca gattttattg cccttccatc
     5761 ctttgcagct ttgttggggg cacggtcagg aagttgagac cctatagaga cctgtctctt
     5821 aaaatgagcc acctttactt gcttgtggca tttcacttgc tcttgtgcat aagcccaaag
     5881 gggccaactc ctgattcccc tctgggtgtg ttcaatcccg ggcacgctct tccttttcct
     5941 cttgttgggc tcccctggat gccctgcctc ccatccaatt gctatgcaac ccagttcagc
     6001 ttaagtaaaa agtgattaag aacatacatc taaggctaag caagctaaca ctttttagag
     6061 ggcctgactt tatcctatat tctaaggcca tatttaaata ctttctaaga ttacccacca
     6121 ttttggatta ctcttggagc tggttcttcc cctaagtagg actagctgag agctgagtgc
     6181 attttagcaa aggcttcacc tacatcggaa gtaaagagtt gcagtcaggc tttggatcag
     6241 gcctcactcc tgatttctgc tcctgcagcc atcccgttgt gtctcactct cccttccagt
     6301 gatggtcgca gctcccagtc tctacagaaa aggtaacaac agtagggagt ggacatatgg
     6361 gtccaaaacg tgtgctttgc tggaaacttg tgtttccagg tcaaggtacc attcctgttg
     6421 gcttcatcaa gtgcctctgt ggattcattt tcaagaaact tggagttttc aggagaccga
     6481 aaaggaatag gcccaggaaa ggtggagaga ttgtcaggaa gagagagtgg ctgagtgggt
     6541 caaatttcag agtaaacttt ttaggagcca acatttaatt aagaaaataa ttaaggctct
     6601 gtgctttctg aaacttcagt aatatttgac atgctctctt ccttcttctc tgcttgcctc
     6661 tgtccctctc acctgtgttt ctgaggctag tgttggcatg tcaccatgag gttagccttt
     6721 taaaaggggc cccacgggag tgtgcctcta gattgcgtta gcctagtatg gaaagggctc
     6781 ccatggaagc tatgatggcc tgagacccca gcctgggtgt tcatgttgct gctccgtgtt
     6841 gggagggccc aggactagct tgttctacct attcttcctg gatctctcac tatattatag
     6901 tgaggactct atcagtatca acccatgtgg agagaggaca gcaccctctg aagctcctca
     6961 ggctggggat tcagcactgc ccacagtagt agagtcacag aggctgactc ccccctaagg
     7021 aaactataga acagtgtgca aattgcatat gaaggtggca ccactacccc tatgtcaggc
     7081 aggggagcac agtgctttga cttgtttact caagagaggg gatgatggtg ctgagctctg
     7141 ctccccagag ctttcctggg gcccattgtc ataataactt gtatgtgggt gatggccgcc
     7201 tcatctgcga gggctataat atccatggtg ctccttggtt gcacaatgga ggttccccta
     7261 gccttggcaa ggtatccatt gccgggtttg aactcatgac cttaacctca ttaacatcat
     7321 cagtcacctg agccaacgcg cagagagggg gatgctggga gctctctcag tagctattgt
     7381 gaccatcatc tatatcttca gacttagccc ttgttgagtc caaccctgtt cccctatcaa
     7441 agcaaccagc agggacagat ggaggtaggg gctcccctac atgcaggaag gttctcttcc
     7501 tcaaactaac ctagtttact tttccttttt ttctgcttcc cttcccacca aatctcagct
     7561 tcatctctca tagtttgtgt ttgaatattt ttaaagagga aaagtgcaat aaaataaata
     7621 gtgactgttt tctttagcaa tagctctttc aaaatcttgc tctcaggact gaaaagtgat
     7681 agatagtacc tggattatca gataatgccc ttgacttctg ggggctcatt cacagtctct
     7741 gtagtttctt cttcttccca cgtgttcaca tgactcctgt cctcttgaga tctgacctcc
     7801 ttctggaatg gacacatatg ctaagatgca gtgtatgcac aaggaaggcc tgtgagaggg
     7861 ctttgtcact ttgtctcctt cctgtgtgca cctctctgtc tccatgtgtg tctctgtccc
     7921 ctctccctct gtctccccat ttctgcctgc tgtcatacag catccttaca acctctaggc
     7981 atgaaaatcc taagtttgtg tgaccttttc agcccatttt gttgactttc cctcagtctg
     8041 gcagatgtaa tggaagccta cacgaaagca cttcccaata gataagaata aagcatcctg
     8101 agccattaca gaagatcatt tccatgcact aaaagccatt acttgatcct tttgcttccc
     8161 cttctccctt ccccagggag acggatgctg agggaatgtg gcctggaggt ttgcacttgg
     8221 gatcagtagc ctgggcagat ttgggaattg ccctctgact ctctttcaaa ataagctgac
     8281 ttgctcaacc aaagggactc cgtgagagct gcagaaggaa gcaggttctt gtgggtttca
     8341 gtagaagtct acagggatag aagtttgggt ggttagggca tgacattagt gaaataaaga
     8401 ctctaccacc cgctagagtg tgcagctgca caaatatttg cacacatagc caggggcttc
     8461 agaagagtcc cctttcctaa catctgtgag cttaaatgtt cagactggac aatcagggaa
     8521 ggctggcaac cccagggtcc cattccatcc ttttttgatc taccttgctc tatacacata
     8581 tgtacagcaa aacctcagtt aactgatggg gaaacctcag ggacaggaac atcctgattg
     8641 ctttgcaatt ttggttattt gagtgggaat gggaaagcat gtctggttca acctttgtta
     8701 ttgagaaaaa tatttcctaa gtaggttagc ataactttcc tgccttagtt aagtagagtg
     8761 tttgaagata acagggacct tgccttgctc agggtcaaca ttgtaaacct caatgcttat
     8821 tgtacagtag tggacatagg tagagaagac caaagagaca ggctgaatgg ctgctggcta
     8881 caagacaggc ctggaaatgg gccactgggg cacatcctgg ctcatcggag cccttgctgt
     8941 catttgcctc tttctactga aaggatagta agaaaacata attcttgtca atcgaggttt
     9001 tggttaattg gtcctgagtt tttagaggtt ttccatatat acatatattt atgtgtgtat
     9061 atatatatat atagtatatg tatatatgta tactattttt aaattataga attatacatt
     9121 gaccaatctc cttagtttca cttatgtgga ataaatttgg caatccaagg aataaactgc
     9181 atttatgtgc attttttgaa tgacctcctt tgcattcttt tcacctctcc agttctactc
     9241 tttttttttc tgcttaggga cctctctaga aggcagatct ttcataaaaa aagaacaggc
     9301 tacaggatca cctctttcct ttccctccca ggtggctgcc tgactcaggg ataaaaggga
     9361 agtctgatct aacagccagg tgctttagcc tttcttctgt ctgccctggt tggctataac
     9421 ctcatcactg aggatcagaa aagttattcc aaactttgta ctcgagggga gtggaaagct
     9481 tgaagacctg gcaaaggatt tatctattta gcattctctt tgtcattggt ggtgccctag
     9541 gtttgaggtt tgtgagatct gaaagtaaca ttccaatgaa gaactaaagc acatctctgc
     9601 cacacagaag gtgaggtttg tggcaatcaa tggaactaac aaatccattc tgttttttat
     9661 tatgactaaa cctaagttga gggtgtgggt attagagcag ctgaaattca gttgcctctt
     9721 tgggggtaag ctgtacacat cactcaagaa acagctggat gcaagctaaa acctgctctc
     9781 attctccctc ttgcctgcta gtgtgttaga tccatggaag acagtttctc tcagcctcac
     9841 ctcttgcatt tgactgttgc tttctaccta gatgggagtg ggagggattt ttcactgtat
     9901 ctggagcaat tgaagtggtg caggggtgtc tgccatctcc ccacacccac agaagccctc
     9961 cagtctggct atgttagttg tgatcaggca gcagaagccc ataacccaga cttgacatga
    10021 ccagctggtg cactgaggca gttgaggtgg cctgtctgga tggctacttc ttgtacttca
    10081 tgaacctcag catggaaatg gatataactt tctgtgctcc tctgcactcc taaaatagtc
    10141 taatatgttc cagatgagtt tgcagctgag aactccctgc atcattccac tgatggatgc
    10201 acagggcatg attatgtaat aatgtggaca gctactgcaa catctagatc attgagggca
    10261 gtgtagatgt ggctgtgtgc taggaccctt ggtagctatc cagaggactc agtctggtgt
    10321 ctttctgagt ctctgtgaga ggcctctaag ccctgcttct ccttgaaaat gattccctag
    10381 acaccgaatg ccttgtttgt atgagtgaat aaatgctctg ggctgctaga gaaagcaata
    10441 ggaggagctg ggaggaagag aatattcagg ggcgcacttt gctaccaaac aatttccatg
    10501 tcagctgcta acattactgc ctttttagcc tatgaagtgt agggcaagga ctttgacctg
    10561 ccaggtgggg ctggaaagga gcacatcagc tccaggctaa gaaatgggat agaaaagcaa
    10621 gaagagaggc ctggctggct ttggcggggg tgagtctcag ctcctgaggg tttgaacatg
    10681 ctctgtgctt gccccagttc tgccttcacg tgggatccag cgacccagtt tccttttgtt
    10741 gtcgtgcttg gatggttcct tcatttgaag ggccccagga agctggaaag tcccatgatc
    10801 aagctctagc ctgctgagca aacaataccc cagccaaatt ggcctcttcc tggttttctg
    10861 catccctgca cccctctctc cactaaggat aatcttggaa cagttgcgat taatggtgcc
    10921 agcaatcaag gaagattctc tagttttcat cagggacata gctgtaaagc tcatgagtgg
    10981 aggatgctat ttccttttcc agacctgtgt gcttatgtgc ttatataggc tgcctctgga
    11041 gactttatat tgtgtgtgat gtgtgtgtat atatatatac acacacatat atatatatat
    11101 gtatatatat atatagagag agagagagag aggaaatggc cgccactcac ttaggctcat
    11161 gcagcacaga ctccagttag ggtttgcact ggcttccttg ctgcttgtgc atgaatcttc
    11221 agctgccctc ccatgtcctg tctctaataa ttgctgaaaa ctcaaagagg tagataaata
    11281 agcctccttg ggatcaatag cagaaggaac tccaaggctg atggtaaagc ttcgtaagga
    11341 tgatgccgaa agggaactgg ggtctccatg gtgataagag gctggggacc aatgagagct
    11401 gaaggcggag caggacttgc ggggaagact catgggagtt gggagtcatt taactatttg
    11461 tttgcttctt gaaaatttag acaccagctg taactacatt gcacaggatg tattgatatt
    11521 atcattcttg ctgacatatt ctggaagctt tcagccccac caacactgcc ccacccagga
    11581 cttctgcagc tgagagttcc tgtgtcagta gggtctgata tttgtacata ggttatacat
    11641 atatgtgtac atatgtgcct caatgaacat tgcctgtcca cctgatcatg ggtgtacata
    11701 gacttcatag agctccacag tcttttgtaa atattgacac aagtaaataa gtatataaat
    11761 atatattact ggggatttat tttaacatca ttctgtgtga tatgaaaaaa ataaaatttt
    11821 tgacagaca
//
