LOCUS       NP_004965                499 aa            linear   PRI 12-NOV-2024
DEFINITION  potassium voltage-gated channel subfamily A member 2 isoform a
            [Homo sapiens].
ACCESSION   NP_004965
VERSION     NP_004965.1
DBSOURCE    REFSEQ: accession NM_004974.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 499)
  AUTHORS   Xie,C., Kessi,M., Yin,F. and Peng,J.
  TITLE     Roles of KCNA2 in Neurological Diseases: from Physiology to
            Pathology
  JOURNAL   Mol Neurobiol 61 (11), 8491-8517 (2024)
   PUBMED   38517617
  REMARK    GeneRIF: Roles of KCNA2 in Neurological Diseases: from Physiology
            to Pathology.
            Review article
REFERENCE   2  (residues 1 to 499)
  AUTHORS   Arlt,F.A., Miske,R., Machule,M.L., Broegger Christensen,P.,
            Mindorf,S., Teegen,B., Borowski,K., Buthut,M., Rossling,R.,
            Sanchez-Sendin,E., van Hoof,S., Cordero-Gomez,C., Bunger,I.,
            Radbruch,H., Kraft,A., Ayzenberg,I., Klausewitz,J., Hansen,N.,
            Timaus,C., Kortvelyessy,P., Postert,T., Baur-Seack,K., Rost,C.,
            Brunkhorst,R., Doppler,K., Haigis,N., Hamann,G., Kunze,A.,
            Stutzer,A., Maschke,M., Melzer,N., Rosenow,F., Siebenbrodt,K.,
            Stenor,C., Dichgans,M., Georgakis,M.K., Fang,R., Petzold,G.C.,
            Gortler,M., Zerr,I., Wunderlich,S., Mihaljevic,I., Turko,P.,
            Schmidt Ettrup,M., Buchholz,E., Foverskov Rasmussen,H., Nasouti,M.,
            Talucci,I., Maric,H.M., Heinemann,S.H., Endres,M., Komorowski,L.
            and Pruss,H.
  CONSRTM   DEMDAS study group
  TITLE     KCNA2 IgG autoimmunity in neuropsychiatric diseases
  JOURNAL   Brain Behav Immun 117, 399-411 (2024)
   PUBMED   38309639
  REMARK    GeneRIF: KCNA2 IgG autoimmunity in neuropsychiatric diseases.
REFERENCE   3  (residues 1 to 499)
  AUTHORS   Minguez-Vinas,T., Prakash,V., Wang,K., Lindstrom,S.H., Pozzi,S.,
            Scott,S.A., Spiteri,E., Stevenson,D.A., Ashley,E.A., Gunnarsson,C.
            and Pantazis,A.
  TITLE     Two epilepsy-associated variants in KCNA2 (KV 1.2) at position H310
            oppositely affect channel functional expression
  JOURNAL   J Physiol 601 (23), 5367-5389 (2023)
   PUBMED   37883018
  REMARK    GeneRIF: Two epilepsy-associated variants in KCNA2 (KV 1.2) at
            position H310 oppositely affect channel functional expression.
REFERENCE   4  (residues 1 to 499)
  AUTHORS   Nilsson,M., Lindstrom,S.H., Kaneko,M., Wang,K., Minguez-Vinas,T.,
            Angelini,M., Steccanella,F., Holder,D., Ottolia,M., Olcese,R. and
            Pantazis,A.
  TITLE     An epilepsy-associated KV1.2 charge-transfer-center mutation
            impairs KV1.2 and KV1.4 trafficking
  JOURNAL   Proc Natl Acad Sci U S A 119 (17), e2113675119 (2022)
   PUBMED   35439054
  REMARK    GeneRIF: An epilepsy-associated KV1.2 charge-transfer-center
            mutation impairs KV1.2 and KV1.4 trafficking.
REFERENCE   5  (residues 1 to 499)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (residues 1 to 499)
  AUTHORS   Nakahira,K., Shi,G., Rhodes,K.J. and Trimmer,J.S.
  TITLE     Selective interaction of voltage-gated K+ channel beta-subunits
            with alpha-subunits
  JOURNAL   J Biol Chem 271 (12), 7084-7089 (1996)
   PUBMED   8636142
REFERENCE   7  (residues 1 to 499)
  AUTHORS   Kim,E., Niethammer,M., Rothschild,A., Jan,Y.N. and Sheng,M.
  TITLE     Clustering of Shaker-type K+ channels by interaction with a family
            of membrane-associated guanylate kinases
  JOURNAL   Nature 378 (6552), 85-88 (1995)
   PUBMED   7477295
REFERENCE   8  (residues 1 to 499)
  AUTHORS   Ramaswami,M., Tanouy,M. and Mathew,M.K.
  TITLE     Facile formation of heteromultimeric potassium channels by
            expression of cloned human cDNAs
  JOURNAL   Indian J Biochem Biophys 31 (4), 254-260 (1994)
   PUBMED   8002006
REFERENCE   9  (residues 1 to 499)
  AUTHORS   Klocke,R., Roberds,S.L., Tamkun,M.M., Gronemeier,M., Augustin,A.,
            Albrecht,B., Pongs,O. and Jockusch,H.
  TITLE     Chromosomal mapping in the mouse of eight K(+)-channel genes
            representing the four Shaker-like subfamilies Shaker, Shab, Shaw,
            and Shal
  JOURNAL   Genomics 18 (3), 568-574 (1993)
   PUBMED   7905852
REFERENCE   10 (residues 1 to 499)
  AUTHORS   Grissmer,S., Dethlefs,B., Wasmuth,J.J., Goldin,A.L., Gutman,G.A.,
            Cahalan,M.D. and Chandy,K.G.
  TITLE     Expression and chromosomal localization of a lymphocyte K+ channel
            gene
  JOURNAL   Proc Natl Acad Sci U S A 87 (23), 9411-9415 (1990)
   PUBMED   2251283
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL365361.12, AK290061.1,
            BC043564.1 and BM682747.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Potassium channels represent the most complex class of
            voltage-gated ion channels from both functional and structural
            standpoints. Their diverse functions include regulating
            neurotransmitter release, heart rate, insulin secretion, neuronal
            excitability, epithelial electrolyte transport, smooth muscle
            contraction, and cell volume. Four sequence-related potassium
            channel genes - shaker, shaw, shab, and shal - have been identified
            in Drosophila, and each has been shown to have human homolog(s).
            This gene encodes a member of the potassium channel, voltage-gated,
            shaker-related subfamily. This member contains six
            membrane-spanning domains with a shaker-type repeat in the fourth
            segment. It belongs to the delayed rectifier class, members of
            which allow nerve cells to efficiently repolarize following an
            action potential. The coding region of this gene is intronless, and
            the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290061.1, DA341137.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316361.10/ ENSP00000314520.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     Protein         1..499
                     /product="potassium voltage-gated channel subfamily A
                     member 2 isoform a"
                     /note="voltage-gated potassium channel protein Kv1.2;
                     potassium voltage-gated channel, shaker-related subfamily,
                     member 2; voltage-gated K(+) channel HuKIV; voltage-gated
                     potassium channel HBK5; voltage-gated potassium channel
                     subunit Kv1.2; potassium channel, voltage gated shaker
                     related subfamily A, member 2"
                     /calculated_mol_wt=56586
     Region          1..125
                     /region_name="Tetramerization domain.
                     /evidence=ECO:0000250|UniProtKB:P63142"
                     /note="propagated from UniProtKB/Swiss-Prot (P16389.2)"
     Region          1..26
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P16389.2)"
     Region          33..159
                     /region_name="BTB_POZ"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain superfamily; cl38908"
                     /db_xref="CDD:453885"
     Site            161..182
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P16389.2)"
     Region          162..420
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Site            207
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16389.2)"
     Site            222..243
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P16389.2)"
     Site            252
                     /site_type="other"
                     /note="Important for normal, slow channel gating.
                     /evidence=ECO:0000250|UniProtKB:P63142; propagated from
                     UniProtKB/Swiss-Prot (P16389.2)"
     Site            255..275
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P16389.2)"
     Site            290..310
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P16389.2)"
     Region          312..325
                     /region_name="S4-S5 linker.
                     /evidence=ECO:0000250|UniProtKB:P63142"
                     /note="propagated from UniProtKB/Swiss-Prot (P16389.2)"
     Site            326..347
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P16389.2)"
     Region          374..379
                     /region_name="Selectivity filter.
                     /evidence=ECO:0000250|UniProtKB:P63142"
                     /note="propagated from UniProtKB/Swiss-Prot (P16389.2)"
     Site            381
                     /site_type="other"
                     /note="Important for binding with the scorpion
                     mesomartoxin, when the scorpion mesomartoxin-rKv1.2/KCNA2
                     interaction is modeled, this residue is close to the
                     'Y-57' residue of the toxin.
                     /evidence=ECO:0000250|UniProtKB:P63142; propagated from
                     UniProtKB/Swiss-Prot (P16389.2)"
     Site            389..417
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P16389.2)"
     Site            429
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P63141; propagated from
                     UniProtKB/Swiss-Prot (P16389.2)"
     Site            434
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P63141; propagated from
                     UniProtKB/Swiss-Prot (P16389.2)"
     Site            440
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P63141; propagated from
                     UniProtKB/Swiss-Prot (P16389.2)"
     Site            441
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q09081; propagated from
                     UniProtKB/Swiss-Prot (P16389.2)"
     Site            449
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q09081; propagated from
                     UniProtKB/Swiss-Prot (P16389.2)"
     Site            458
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P63142; propagated from
                     UniProtKB/Swiss-Prot (P16389.2)"
     Site            468
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P63141; propagated from
                     UniProtKB/Swiss-Prot (P16389.2)"
     Region          497..499
                     /region_name="PDZ-binding.
                     /evidence=ECO:0000250|UniProtKB:P63142"
                     /note="propagated from UniProtKB/Swiss-Prot (P16389.2)"
     CDS             1..499
                     /gene="KCNA2"
                     /gene_synonym="DEE32; EIEE32; HBK5; HK4; HUKIV; KV1.2;
                     MK2; NGK1; RBK2"
                     /coded_by="NM_004974.4:627..2126"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS827.1"
                     /db_xref="GeneID:3737"
                     /db_xref="HGNC:HGNC:6220"
                     /db_xref="MIM:176262"
ORIGIN      
        1 mtvatgdpad eaaalpghpq dtydpeadhe ccervvinis glrfetqlkt laqfpetllg
       61 dpkkrmryfd plrneyffdr nrpsfdaily yyqsggrlrr pvnvpldifs eeirfyelge
      121 eamemfrede gyikeeerpl penefqrqvw llfeypessg pariiaivsv mvilisivsf
      181 cletlpifrd enedmhgsgv tfhtysnsti gyqqstsftd pffivetlci iwfsfeflvr
      241 ffacpskagf ftnimniidi vaiipyfitl gtelaekped aqqgqqamsl ailrvirlvr
      301 vfrifklsrh skglqilgqt lkasmrelgl lifflfigvi lfssavyfae aderesqfps
      361 ipdafwwavv smttvgygdm vpttiggkiv gslcaiagvl tialpvpviv snfnyfyhre
      421 tegeeqaqyl qvtscpkips spdlkksrsa stisksdyme iqegvnnsne dfreenlkta
      481 nctlantnyv nitkmltdv
//
