LOCUS       NM_005549               1959 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily A member 10
            (KCNA10), mRNA.
ACCESSION   NM_005549
VERSION     NM_005549.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1959)
  AUTHORS   Kumari,R., Tiwari,S., Atlani,M., Anirudhan,A., Goel,S.K. and
            Kumar,A.
  TITLE     Association of Single Nucleotide Polymorphisms in KCNA10 and
            SLC13A3 Genes with the Susceptibility to Chronic Kidney Disease of
            Unknown Etiology in Central Indian Patients
  JOURNAL   Biochem Genet 61 (4), 1548-1566 (2023)
   PUBMED   36696070
  REMARK    GeneRIF: Association of Single Nucleotide Polymorphisms in KCNA10
            and SLC13A3 Genes with the Susceptibility to Chronic Kidney Disease
            of Unknown Etiology in Central Indian Patients.
REFERENCE   2  (bases 1 to 1959)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1959)
  AUTHORS   Naranjo,D., Moldenhauer,H., Pincuntureo,M. and Diaz-Franulic,I.
  TITLE     Pore size matters for potassium channel conductance
  JOURNAL   J Gen Physiol 148 (4), 277-291 (2016)
   PUBMED   27619418
  REMARK    Review article
REFERENCE   4  (bases 1 to 1959)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 1959)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1959)
  AUTHORS   Yao,X., Tian,S., Chan,H.Y., Biemesderfer,D. and Desir,G.V.
  TITLE     Expression of KCNA10, a voltage-gated K channel, in glomerular
            endothelium and at the apical membrane of the renal proximal tubule
  JOURNAL   J Am Soc Nephrol 13 (12), 2831-2839 (2002)
   PUBMED   12444201
  REMARK    GeneRIF: KCNA10 in human proximal tubular cells, glomerular and
            vascular endothelial cells, and also in vascular smooth muscle
            cells.
REFERENCE   7  (bases 1 to 1959)
  AUTHORS   Tian,S., Liu,W., Wu,Y., Rafi,H., Segal,A.S. and Desir,G.V.
  TITLE     Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a
            novel beta-subunit
  JOURNAL   Am J Physiol Renal Physiol 283 (1), F142-F149 (2002)
   PUBMED   12060596
REFERENCE   8  (bases 1 to 1959)
  AUTHORS   Lang,R., Lee,G., Liu,W., Tian,S., Rafi,H., Orias,M., Segal,A.S. and
            Desir,G.V.
  TITLE     KCNA10: a novel ion channel functionally related to both
            voltage-gated potassium and CNG cation channels
  JOURNAL   Am J Physiol Renal Physiol 278 (6), F1013-F1021 (2000)
   PUBMED   10836990
REFERENCE   9  (bases 1 to 1959)
  AUTHORS   Orias,M., Bray-Ward,P., Curran,M.E., Keating,M.T. and Desir,G.V.
  TITLE     Genomic localization of the human gene for KCNA10, a cGMP-activated
            K channel
  JOURNAL   Genomics 42 (1), 33-37 (1997)
   PUBMED   9177773
REFERENCE   10 (bases 1 to 1959)
  AUTHORS   Landes,G.M., Curran,M.E. and Keating,M.T.
  TITLE     Molecular characterization and refined genomic localization of
            three human potassium ion channel genes
  JOURNAL   Cytogenet Cell Genet 70 (3-4), 280-284 (1995)
   PUBMED   7789190
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358215.16.
            
            On Dec 31, 2002 this sequence version replaced NM_005549.1.
            
            Summary: Potassium channels represent the most complex class of
            voltage-gated ion channels from both functional and structural
            standpoints. Their diverse functions include regulating
            neurotransmitter release, heart rate, insulin secretion, neuronal
            excitability, epithelial electrolyte transport, smooth muscle
            contraction, and cell volume. Four sequence-related potassium
            channel genes - shaker, shaw, shab, and shal - have been identified
            in Drosophila, and each has been shown to have human homolog(s).
            This gene encodes a member of the potassium channel, voltage-gated,
            shaker-related subfamily. This member contains six
            membrane-spanning domains with a shaker-type repeat in the fourth
            segment. It is specifically regulated by cGMP and postulated to
            mediate the effects of substances that increase intracellular cGMP.
            This gene is intronless, and the gene is clustered with genes KCNA2
            and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369771.4/ ENSP00000358786.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1959              AL358215.16        63616-65574         c
FEATURES             Location/Qualifiers
     source          1..1959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..1959
                     /gene="KCNA10"
                     /gene_synonym="Kcn1; Kv1.8"
                     /note="potassium voltage-gated channel subfamily A member
                     10"
                     /db_xref="GeneID:3744"
                     /db_xref="HGNC:HGNC:6219"
                     /db_xref="MIM:602420"
     exon            1..1959
                     /gene="KCNA10"
                     /gene_synonym="Kcn1; Kv1.8"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..1924
                     /gene="KCNA10"
                     /gene_synonym="Kcn1; Kv1.8"
                     /note="cyclic GMP gated potassium channel; voltage-gated
                     potassium channel subunit Kv1.8; potassium voltage-gated
                     channel, shaker-related subfamily, member 10; potassium
                     channel, voltage gated shaker related subfamily A, member
                     10"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily A
                     member 10"
                     /protein_id="NP_005540.1"
                     /db_xref="CCDS:CCDS826.1"
                     /db_xref="GeneID:3744"
                     /db_xref="HGNC:HGNC:6219"
                     /db_xref="MIM:602420"
                     /translation="MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGS
                     SFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLR
                     TLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPID
                     IFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAV
                     AVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVES
                     TCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQN
                     MSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSA
                     VYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIA
                     LPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEK
                     SRK"
ORIGIN      
        1 acaagatcat gctttttatt attaaggaat gttaacttcc tcttttagta tggcccctct
       61 gccatcacat atggagacca tcctttgctg gggagaatct ccccttcttt gccaggatcc
      121 tttttttgca atttctccta gttattagtt tatgcaaact caggggtaca aaatgatttt
      181 aagggaagca tgctgccaaa ataaccatga cgttccttcc caagctacaa ataagtcatt
      241 gattagccca ttggtgtacc ttacctcaat aaacaagggc cagttgtatt ctgccctgga
      301 tcttgtataa tgaacttctt cttctccata gctcacagca ggcagtgaag gctgaggatc
      361 ttcatgcttc ttccctggct cccctagaat ggatgtgtgt ggctggaaag aaatggaggt
      421 tgcgctggtc aattttgata attcagatga aatccaagaa gagccaggct atgccacaga
      481 cttcgactca accagcccaa aaggccggcc tgggggcagc tccttctcca acgggaagat
      541 cctcatcagc gaaagcacca accatgagac ggccttctcc aagcttccgg gagactatgc
      601 tgacccccca gggcctgagc cagtggtcct aaatgaagga aaccagcggg tgatcatcaa
      661 cattgctggg ctgagatttg agacccagct cagaaccctt agtcagttcc cagagactct
      721 cctgggagac cgggaaaaaa ggatgcagtt ctttgactcc atgagaaatg agtatttctt
      781 tgatcggaac cggcccagtt ttgatggaat cctatattat taccaatctg gtgggaaaat
      841 tcggcgccca gccaatgttc ccattgatat ctttgctgat gaaatctcct tctatgagct
      901 gggtagtgag gccatggacc agttccggga ggatgaaggc ttcatcaaag accctgaaac
      961 actgctaccc accaatgaca tccaccgtca gttctggctc ctctttgagt accctgaaag
     1021 ttccagcgct gcccgtgctg tggccgtggt ctcggtgttg gttgtggtca tctccatcac
     1081 catcttctgc ctggagacac tgccagagtt ccgggaggat agggagctaa aggtggtcag
     1141 agaccccaat ctcaacatga gcaagacagt cctctcccag accatgttca ccgacccttt
     1201 cttcatggtg gagtctacct gcatcgtgtg gttcaccttc gagctggtgc tccggttcgt
     1261 ggtctgcccc agcaagactg acttcttcag gaacatcatg aacatcattg acatcatctc
     1321 cattatcccc tactttgcaa ctctcatcac agagctagtc caggagacag agccgagtgc
     1381 ccaacagaac atgtccctgg ccatcctgag gatcatccgc ctggtgaggg tcttccgcat
     1441 cttcaagctc tcgcgccact ccaaggggct gcagatcctc gggcaaacac tgaaggcgtc
     1501 catgcgggag ttggggttgc tcatcttctt tctcttcatt ggagtcatcc tcttctccag
     1561 tgcagtctac tttgctgagg tggatgagcc agagtcccat ttctctagca ttcctgatgg
     1621 cttctggtgg gcagtggtca ccatgacaac tgtaggctat ggggacatgt gcccgaccac
     1681 cccagggggg aagattgtgg gcactctgtg tgccattgca ggggtcctca ccattgccct
     1741 ccctgtgcct gtcattgtct ccaacttcaa ttacttctac caccgggaga ctgagaatga
     1801 agaaaagcag aacatcccag gagaaattga aagaatcctc aacagtgtag gctcaagaat
     1861 gggcagcaca gactctctta ataagaccaa tggtggctgt tccacagaga agtctaggaa
     1921 atgatcagtc cagggcttct tgggtccatc ctgtctctc
//
