LOCUS       NM_000217               7985 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily A member 1
            (KCNA1), mRNA.
ACCESSION   NM_000217 XM_001133050
VERSION     NM_000217.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7985)
  AUTHORS   Sun,W.B., Fu,J.X., Chen,Y.L., Li,H.F., Wu,Z.Y. and Chen,D.F.
  TITLE     Both gain- and loss-of-function variants of KCNA1 are associated
            with paroxysmal kinesigenic dyskinesia
  JOURNAL   J Genet Genomics 51 (8), 801-810 (2024)
   PUBMED   38570113
  REMARK    GeneRIF: Both gain- and loss-of-function variants of KCNA1 are
            associated with paroxysmal kinesigenic dyskinesia.
REFERENCE   2  (bases 1 to 7985)
  AUTHORS   Tian,Y., Korn,P., Tripathi,P., Komnig,D., Wiemuth,D., Nikouee,A.,
            Classen,A., Bolm,C., Falkenburger,B.H., Luscher,B. and Grunder,S.
  TITLE     The mono-ADP-ribosyltransferase ARTD10 regulates the voltage-gated
            K+ channel Kv1.1 through protein kinase C delta
  JOURNAL   BMC Biol 18 (1), 143 (2020)
   PUBMED   33059680
  REMARK    GeneRIF: The mono-ADP-ribosyltransferase ARTD10 regulates the
            voltage-gated K(+) channel Kv1.1 through protein kinase C delta.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7985)
  AUTHORS   Zhao,J., Petitjean,D., Haddad,G.A., Batulan,Z. and Blunck,R.
  TITLE     A Common Kinetic Property of Mutations Linked to Episodic Ataxia
            Type 1 Studied in the Shaker Kv Channel
  JOURNAL   Int J Mol Sci 21 (20), 7602 (2020)
   PUBMED   33066705
  REMARK    GeneRIF: A Common Kinetic Property of Mutations Linked to Episodic
            Ataxia Type 1 Studied in the Shaker Kv Channel.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7985)
  AUTHORS   Uhan,S., Zidar,N., Tomazic,A. and Hauptman,N.
  TITLE     Hypermethylated promoters of genes UNC5D and KCNA1 as potential
            novel diagnostic biomarkers in colorectal cancer
  JOURNAL   Epigenomics 12 (19), 1677-1688 (2020)
   PUBMED   33078631
  REMARK    GeneRIF: Hypermethylated promoters of genes UNC5D and KCNA1 as
            potential novel diagnostic biomarkers in colorectal cancer.
REFERENCE   5  (bases 1 to 7985)
  AUTHORS   Kim,E., Niethammer,M., Rothschild,A., Jan,Y.N. and Sheng,M.
  TITLE     Clustering of Shaker-type K+ channels by interaction with a family
            of membrane-associated guanylate kinases
  JOURNAL   Nature 378 (6552), 85-88 (1995)
   PUBMED   7477295
REFERENCE   6  (bases 1 to 7985)
  AUTHORS   Browne,D.L., Gancher,S.T., Nutt,J.G., Brunt,E.R., Smith,E.A.,
            Kramer,P. and Litt,M.
  TITLE     Episodic ataxia/myokymia syndrome is associated with point
            mutations in the human potassium channel gene, KCNA1
  JOURNAL   Nat Genet 8 (2), 136-140 (1994)
   PUBMED   7842011
REFERENCE   7  (bases 1 to 7985)
  AUTHORS   Hasan,S.M. and D'Adamo,M.C.
  TITLE     Episodic Ataxia Type 1
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301785
REFERENCE   8  (bases 1 to 7985)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
REFERENCE   9  (bases 1 to 7985)
  AUTHORS   Curran,M.E., Landes,G.M. and Keating,M.T.
  TITLE     Molecular cloning, characterization, and genomic localization of a
            human potassium channel gene
  JOURNAL   Genomics 12 (4), 729-737 (1992)
   PUBMED   1349297
REFERENCE   10 (bases 1 to 7985)
  AUTHORS   Freeman,S.N., Conley,E.C., Brennand,J.C., Russell,N.J. and
            Brammar,W.J.
  TITLE     Cloning and characterization of a cDNA encoding a human brain
            potassium channel
  JOURNAL   Biochem Soc Trans 18 (5), 891-892 (1990)
   PUBMED   2128063
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA336089.1, DA236475.1 and
            AC006063.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 22, 2018 this sequence version replaced NM_000217.2.
            
            Summary: This gene encodes a voltage-gated delayed potassium
            channel that is phylogenetically related to the Drosophila Shaker
            channel. The encoded protein has six putative transmembrane
            segments (S1-S6), and the loop between S5 and S6 forms the pore and
            contains the conserved selectivity filter motif (GYGD). The
            functional channel is a homotetramer. The N-terminus of the channel
            is associated with beta subunits that can modify the inactivation
            properties of the channel as well as affect expression levels. The
            C-terminus of the channel is complexed to a PDZ domain protein that
            is responsible for channel targeting. Mutations in this gene have
            been associated with myokymia with periodic ataxia (AEMK).
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.830717.1,
                                           SRR1803621.9971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382545.5/ ENSP00000371985.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA336089.1         1-2
            3-577               DA236475.1         1-575
            578-7985            AC006063.1         49354-56761         c
FEATURES             Location/Qualifiers
     source          1..7985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.32"
     gene            1..7985
                     /gene="KCNA1"
                     /gene_synonym="AEMK; EA1; HBK1; HUK1; KV1.1; MBK1; MK1;
                     RBK1"
                     /note="potassium voltage-gated channel subfamily A member
                     1"
                     /db_xref="GeneID:3736"
                     /db_xref="HGNC:HGNC:6218"
                     /db_xref="MIM:176260"
     exon            1..568
                     /gene="KCNA1"
                     /gene_synonym="AEMK; EA1; HBK1; HUK1; KV1.1; MBK1; MK1;
                     RBK1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..7985
                     /gene="KCNA1"
                     /gene_synonym="AEMK; EA1; HBK1; HUK1; KV1.1; MBK1; MK1;
                     RBK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1108..2595
                     /gene="KCNA1"
                     /gene_synonym="AEMK; EA1; HBK1; HUK1; KV1.1; MBK1; MK1;
                     RBK1"
                     /note="voltage-gated potassium channel subunit Kv1.1;
                     voltage-gated K(+) channel HuKI; voltage-gated potassium
                     channel HBK1; potassium voltage-gated channel,
                     shaker-related subfamily, member 1 (episodic ataxia with
                     myokymia); potassium channel, voltage gated shaker related
                     subfamily A, member 1"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily A
                     member 1"
                     /protein_id="NP_000208.2"
                     /db_xref="CCDS:CCDS8535.1"
                     /db_xref="GeneID:3736"
                     /db_xref="HGNC:HGNC:6218"
                     /db_xref="MIM:176260"
                     /translation="MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINIS
                     GLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL
                     RRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYP
                     ESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFT
                     DPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQ
                     EGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLF
                     IGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLC
                     AIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMS
                     KSEYMEIEEDMNNSIAHYRQVNIRTANCTTANQNCVNKSKLLTDV"
     regulatory      7952..7957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNA1"
                     /gene_synonym="AEMK; EA1; HBK1; HUK1; KV1.1; MBK1; MK1;
                     RBK1"
                     /note="hexamer: ATTAAA"
     polyA_site      7985
                     /gene="KCNA1"
                     /gene_synonym="AEMK; EA1; HBK1; HUK1; KV1.1; MBK1; MK1;
                     RBK1"
                     /note="major polyA site"
ORIGIN      
        1 agaaatggac cgagcggacc cgccgccgca cgcaccctgc tccactccaa gctcctaagg
       61 gctcctggcg cgccgcgtag ccttggcgag gtccgcgctg gggtgcggag agcgaaggga
      121 actggagagc catgtagatc caggctctcg cccgcccgcc tccttcggga tcgaatcaag
      181 ggctcccata gtgttaggag ggggcgagag tgctgtttat cgtcatttgc ctcggagctt
      241 cgagagaggg tggtattttg cttttccgcc ccgcatcctc cggaactccc tgcaccggag
      301 agaggacggc gtctccaggt tgctggcaac cggtgagaat gggggtaggg aaggaacatt
      361 ttcgccgtag ctgctccgta aagcgattgt ccaactgaga ggggcgtcgg acgagtggac
      421 cagggcggcg agtttgcccg gcgcgtctcg gatgctgctg cggcggccgc cgcggctccc
      481 gccagggcac tgcaaagacg acctgccgca ttcccactcg ggctctccgc tgactcagca
      541 ccgcccctgc gccaagccag ccggccagcg tgcatcgatc gccctggtgg gagcttagaa
      601 ggcggcaggc gaagaggggt aggagggggg agagccgagg agaagcagag agggtggcag
      661 gcgtggggat ctgccgagcc ggcactgcac cgggtcctag gaaggctctc ggaggggagg
      721 ggaggccagg gcgacccccg aagcaatggc ccagtccgct agaacggcac tgcgttaagg
      781 cacctgggat caggaagaaa tatctaaaca acaacaacag aaaaccaaca aacccccaaa
      841 cccaaaccca accctctgca aaaagctgca cccggcccgc aggcgagggg gattccaaac
      901 tgagtgaaag gcagggtgga ggggaaggca gcgagaggca aagtcgcaga tctcccgacc
      961 tgctcgtgtt gaagcacctc cccctgggcg tgagggagac gcgcgctccg gtgggggggc
     1021 cgcttgggtc ccccccaccc ctggtccctg gctgcttccc accccgggct ctctcctggc
     1081 ctcccacccc cgcgcccggc ttccaccatg acggtgatgt ctggggagaa cgtggacgag
     1141 gcttcggccg ccccgggcca cccccaggat ggcagctacc cccggcaggc cgaccacgac
     1201 gaccacgagt gctgcgagcg cgtggtgatc aacatctccg ggctgcgctt cgagacgcag
     1261 ctcaagaccc tggcgcagtt ccccaacacg ctgctgggca accctaagaa acgcatgcgc
     1321 tacttcgacc ccctgaggaa cgagtacttc ttcgaccgca accggcccag cttcgacgcc
     1381 atcctctact actaccagtc cggcggccgc ctgcggaggc cggtcaacgt gcccctggac
     1441 atgttctccg aggagatcaa gttttacgag ttgggcgagg aggccatgga gaagttccgg
     1501 gaggacgagg gcttcatcaa ggaggaggag cgccctctgc ccgagaagga gtaccagcgc
     1561 caggtgtggc tgctcttcga gtaccccgag agctcggggc ccgccagggt catcgccatc
     1621 gtctccgtca tggtcatcct catctccatc gtcatctttt gcctggagac gctccccgag
     1681 ctgaaggatg acaaggactt cacgggcacc gtccaccgca tcgacaacac cacggtcatc
     1741 tacaattcca acatcttcac agaccccttc ttcatcgtgg aaacgctgtg tatcatctgg
     1801 ttctccttcg agctggtggt gcgcttcttc gcctgcccca gcaagacgga cttcttcaaa
     1861 aacatcatga acttcataga cattgtggcc atcattcctt atttcatcac gctgggcacc
     1921 gagatagctg agcaggaagg aaaccagaag ggcgagcagg ccacctccct ggccatcctc
     1981 agggtcatcc gcttggtaag ggtttttaga atcttcaagc tctcccgcca ctctaagggc
     2041 ctccagatcc tgggccagac cctcaaagct agtatgagag agctagggct gctcatcttt
     2101 ttcctcttca tcggggtcat cctgttttct agtgcagtgt actttgccga ggcggaagaa
     2161 gctgagtcgc acttctccag tatccccgat gctttctggt gggcggtggt gtccatgacc
     2221 actgtaggat acggtgacat gtaccctgtg acaattggag gcaagatcgt gggctccttg
     2281 tgtgccatcg ctggtgtgct aacaattgcc ctgcccgtac ctgtcattgt gtccaatttc
     2341 aactatttct accaccgaga aactgagggg gaagagcagg ctcagttgct ccacgtcagt
     2401 tcccctaact tagcctctga cagtgacctc agtcgccgca gttcctctac tatgagcaag
     2461 tctgagtaca tggagatcga agaggatatg aataatagca tagcccatta tagacaggtc
     2521 aatatcagaa ctgccaattg caccactgct aaccaaaact gcgttaataa gagcaagcta
     2581 ctgaccgatg tttaaaaaac aaaggcaagc aaacaaaaaa gccccactta gcagctcaaa
     2641 agacttaaaa aacaaaacag aaaacctagt gactcatgtc acgctttgta gatactttac
     2701 taagtagact tggaatgctc tatttaactg tcaatgcgtt gttgcattga ggattttggg
     2761 ggtggtgaac cagaagcttt caagatccat gacaaaataa actattttcc ttttattaaa
     2821 aaatgggaaa agagagagta ttttctaaaa ctggcttaaa aagattcagt ccacgaacta
     2881 gtctaggtaa aataataatc atatgcttcc ccaaactgaa acatttttaa tgctttggtt
     2941 tctttaactt ttttaaaaac tcagaacaag atgatcactt agaaatatga aattgaaatt
     3001 cgcatgggac tccagtaaaa catctttgca aactgcgtag cacattgaag acagtgcatc
     3061 agatgtatta tatgtaacat gatagaccag ccaaaatgga caatgaatag atatttttat
     3121 ttcgatcaac tgaactgcat attacaaggt gaaaaaagaa aactccgatt acttaagact
     3181 ggttcacaaa gcaccttata aattggatac tggtcctgat ctgtagggat ttccccctgg
     3241 gcccattctc tttctaatcc agattattct ctaagaaaaa gttaactgaa ttaaattaat
     3301 tgattcttct gcagtgccgc taaatggtct caactgcaga tgagccaaat acaggtcttt
     3361 tctcaccagg cctgcactcc gacccctggc tttcagaact ggatgtaaaa ccttagcctc
     3421 cttattgcaa gagagcacaa atgaagttaa atgtaagcat gtttgaatct gatacaattt
     3481 attttataat cgcatgctga gaagttaacc cagacaatag gggataagct taagttgaaa
     3541 tcgattcttc taaaaataga tcctttttca tttgcattca ccaaaagtgc actcctccat
     3601 ttattaacta ttttattagt aaataaagta ctgtatttaa gtgcatatgt tagtcagatg
     3661 ggaacaataa ctttttggag ctcaaagcat gttctcttat tcagcattat ggcctatttg
     3721 actaagatgt accttgaatt aattaatgca tgatttcagt aataaaaatt ttaaaagtaa
     3781 taaaaattac aagtctgtgg ggtgaaaggc ccaatagaaa ttatgggggg tgggggtggg
     3841 ggcactcagt caattttcct gcctttgctc agggaaatac caggtttttg tgcaggtata
     3901 ggcggagaga ggaccaatat gcccatccct taaagggaag ccatgtgaaa aactcaataa
     3961 gtcatcaaag tacatatagc aacacctaag aacaagtatt ctttctagct gaagacaaac
     4021 acaagcaaca caaacaagca aacaaacaaa caaacaaaaa ggtgcaatac tgcatgtttt
     4081 ttggtgcatt cttaggatgt aaatgaaaat gtttctctat tatatgcatc cgaagcagag
     4141 ctgatttttt tttctttgca gtcattcttt gaagtctgta gagacttcag ccctcccctt
     4201 gaggctccct gaagaaacta aaccaattga tttaatagtt gcttagtgcc tttatcctgt
     4261 acccacagtg aactgtagaa agtgcctcct taacacagct gagaagttag gtagcaaaag
     4321 tggggaaggg ttggggcaca gaccttttgc tttttctttt tccattctcg ctctctcatt
     4381 tcaccactgt gagaagacca caccacccta aaccctggag aggagagacc caggagggtg
     4441 ctgtctctct ggccatctac tagcattggt ccctttgaca gcctgacgct ggatgtgaac
     4501 tgagacccat ctttgaactg gacatgaact gtgaacttgt tttttcctct ctccaccaaa
     4561 gccaagataa actttttggg aatttgtttc ctatcgaggg ccactttgga cacacaaggc
     4621 ttcctcaggt ccagtgtagt gctcctggca cctttcctta tttttttctc tgtcggtaac
     4681 agcactttgc aaatctctct gacggtccag tcttttcagg cattgttgtg gatgtgggaa
     4741 cactcagttc ataataacct ttcctaggcc ttccctcctg gtctacccct ttcagatatt
     4801 tcctgatgcc cctatgatct tcccacctgg cagtcacttc acaggttgaa catctaactt
     4861 ctgctgcccc cccgttaccc agcccagaga atggtgggga ccctgttcct ggctgaaaga
     4921 gagccacgga acacaggcct ctggagctcg gcagctgccc accggtggag aggtactcac
     4981 agcctttcaa aggaccctga ggtggggaat cttcattctg cacttagcat gtggctgcct
     5041 gttacctgac attctggccc agcttcttct gaaaatctgt cctgcttctc ccaccccttt
     5101 cccccatcct gtcctagaac tagcagtgag gcaatcaccc tagaaactcg agttacaccc
     5161 attctggcta actcgattaa aagaaagaac atggatatct tattttccta tgtgactttt
     5221 gtgaatctgt gagatgaaca caacacacat cgtggaagat gaggggccaa gaactgcgca
     5281 gcatccgact acagggcatt aaaccctccc atgtgatgtc tccttctcgt ctgaacctta
     5341 actcattctg gcgattcctt tcctacttgc ttaaaaatcc ccaattagga aaaaaatgcc
     5401 aacctcctcc caggcttggg gttatcttga tctttcattt caacgttgag gtctagtgca
     5461 cacagaactt gaaacaccgc actctgtcaa cagcaataat ccactcagta ctgtgggatg
     5521 gatgggttaa tggatgagaa aacggcacca agactgactt tgggtatttg gtatatttac
     5581 cgtggttaca ctctggactg gttgattctt ctgcatgtga tatagaaaaa agtgctgcat
     5641 gcggtgaacc tgtcagtctg ggactggggg tgagttgttg ttatgagttt ggggtggtgt
     5701 gaggaaagtg aatgctgctt agctcatctg tagctcattg caatgaattc agtaagaatg
     5761 gagtacaggg attatctgtg tagcataggc atgcaatgtt tgaccaagct cttaccctcg
     5821 cactgtaatg tgttgaaatg tctttgtaga cctgaaggtg cacttaacaa aactgcctat
     5881 taagggatga ctattttttg gtttacttat tcatatttat tttagcagcc tttttacctt
     5941 ttcttcccct tcctaggcat ggagctgtaa cagctcatgt cctgactatg tgttttctcc
     6001 agaaggagaa gacttctgat gtgctgatag ctataattcc tctcttccag tctattgggg
     6061 ccctagttca atagggtggc aatagaagag ttggtcacac cagggctgtt agccatccca
     6121 gaatctctga agtggttaac tcacctgaag tgatctgaat cagagagacc aaagacattc
     6181 atttcctctg tcctcagatt tctagaagac aaattctagc caggaaaact ttctgttttt
     6241 gcatctccct tttcccattt gtgcccaact ccccttgcac tccctggaga cttgagttct
     6301 gattttcagt tatatcagct cattgggagt gtgttcgtgg gtgagccttg cagaatcaga
     6361 taaaccaata gcaagtcctt ctccaggatt ctggccagtg ggcagtcatt tccctgaaat
     6421 gaattgtagg gcaggtttag attccactat ggtggacgtg aagcacaggt ggtgtcacaa
     6481 tcttgatttg cttgagaatt aaaaaaatac atgtaaatgg taaatgagga atacattttt
     6541 ttaaagtaga aatttggttt agcctataaa aggccttctt cacattgtgt atagttacac
     6601 gtttttcaaa ttaggtacca tctaaaagtc aataaaaata gtttcctagc cctctcattt
     6661 aatataggag acctcaaaac acatgctttt taacaatttt acattttaat tcttagtttg
     6721 gtagattgga ttgaaagaaa ggagaaagaa cattagcaga aggcactttc ccattttctt
     6781 ccaggaatga cttattcctg gggtggtgag aattggtggg tggtaaccat ccatagtata
     6841 aaattgttag aaagaatata aactgccaaa caagcatgtt atcttcaggc ttttccaagc
     6901 aagaatgaag tcttttgatg tttatgttca ttttaagaag acaaacaaac taaaatttta
     6961 agaccagaca caacccaagt tgaattgtga tctcaggagg tgaactctca ttcaccatgt
     7021 ggcatattac tacctgtatt tatatcatgg aatttcaggg tatatgtgaa catgtctagt
     7081 atgactcagg taaaccttta aagaatgtat gttacttacc atttttgtaa agaagcaaac
     7141 aggagctgaa ttgttaacca aaactgttcc attaccttgg gtcactgtgc aaactaattc
     7201 agggtacaga tataaagttt agaagccttg ggattaaatg ccagcctctt tgctcaggca
     7261 aaatgaccct gggctttctt gggaagtcca gcatgtatgt aaggggtgag gccctgctga
     7321 cctcagggct tttcgcttta aggagattaa ccctagtcac agtgattttc atttaggagc
     7381 taactaggag tttactcttt atgacgtgaa acttcaaaga gtatagaaaa cttttgtacc
     7441 acaatcaaag aagaagaaat ggtgtatgga aagaaaacaa aacaaaacaa gaaatctctt
     7501 gtaaaatatt ccaggtcaaa gttgtctcct ctccaaacct tgcagaagca cctttcttct
     7561 cttcagcgca ctgttttggg actgtttatg cagcagatgt aagtagacaa catggactcc
     7621 atgtgacatg cctctaatag taaagataaa gtattactga ggttaaaaat aaaaattgag
     7681 tagtattaat ttaaagtgca ccatcaggac aacaaaccat ttaagctgaa aaaacgctat
     7741 tttatttctt gagtttgcca gttgcttcca ccttgagtta aggacgtgtc tcatcttcac
     7801 ctactgcgca ttctcccttc tctaactgtg taatatgtca ggtcaaggac attgaatgtt
     7861 atgaattgag aacctaattg atgcgcatag ttttcatcta tgcaatttta cttgcttctg
     7921 tcactttacg atctgttcat atttggcatc aattaaagat actttttaag gatcttatca
     7981 aggaa
//
