LOCUS       NM_020122               7500 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens potassium channel modulatory factor 1 (KCMF1), mRNA.
ACCESSION   NM_020122 XM_942130
VERSION     NM_020122.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7500)
  AUTHORS   Haakonsen,D.L., Heider,M., Ingersoll,A.J., Vodehnal,K., Witus,S.R.,
            Uenaka,T., Wernig,M. and Rape,M.
  TITLE     Stress response silencing by an E3 ligase mutated in
            neurodegeneration
  JOURNAL   Nature 626 (8000), 874-880 (2024)
   PUBMED   38297121
REFERENCE   2  (bases 1 to 7500)
  AUTHORS   Varland,S., Silva,R.D., Kjosas,I., Faustino,A., Bogaert,A.,
            Billmann,M., Boukhatmi,H., Kellen,B., Costanzo,M., Drazic,A.,
            Osberg,C., Chan,K., Zhang,X., Tong,A.H.Y., Andreazza,S., Lee,J.J.,
            Nedyalkova,L., Usaj,M., Whitworth,A.J., Andrews,B.J., Moffat,J.,
            Myers,C.L., Gevaert,K., Boone,C., Martinho,R.G. and Arnesen,T.
  TITLE     N-terminal acetylation shields proteins from degradation and
            promotes age-dependent motility and longevity
  JOURNAL   Nat Commun 14 (1), 6774 (2023)
   PUBMED   37891180
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7500)
  AUTHORS   Singh,A., Choudhury,S.D., Singh,P., Singh,V.V., Singh,S.N. and
            Sharma,A.
  TITLE     KCMF1 regulates autophagy and ion channels' function in renal cell
            carcinoma: a future therapeutic target
  JOURNAL   J Cancer Res Clin Oncol 149 (9), 5617-5626 (2023)
   PUBMED   36515749
  REMARK    GeneRIF: KCMF1 regulates autophagy and ion channels' function in
            renal cell carcinoma: a future therapeutic target.
REFERENCE   4  (bases 1 to 7500)
  AUTHORS   Wang,W., Liu,J. and Pan,E.
  TITLE     CircHIPK3 contributes to human villous trophoblast growth,
            migration and invasion via modulating the pathway of miR-346/KCMF1
  JOURNAL   Placenta 118, 46-54 (2022)
   PUBMED   35032791
  REMARK    GeneRIF: CircHIPK3 contributes to human villous trophoblast growth,
            migration and invasion via modulating the pathway of miR-346/KCMF1.
REFERENCE   5  (bases 1 to 7500)
  AUTHORS   Heo,A.J., Kim,S.B., Ji,C.H., Han,D., Lee,S.J., Lee,S.H., Lee,M.J.,
            Lee,J.S., Ciechanover,A., Kim,B.Y. and Kwon,Y.T.
  TITLE     The N-terminal cysteine is a dual sensor of oxygen and oxidative
            stress
  JOURNAL   Proc Natl Acad Sci U S A 118 (50) (2021)
   PUBMED   34893540
REFERENCE   6  (bases 1 to 7500)
  AUTHORS   Hong,J.H., Kaustov,L., Coyaud,E., Srikumar,T., Wan,J.,
            Arrowsmith,C. and Raught,B.
  TITLE     KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4
            (ubiquitin N-recognin domain-containing E3 ligase 4) and
            lysosome-mediated degradation
  JOURNAL   Mol Cell Proteomics 14 (3), 674-685 (2015)
   PUBMED   25582440
  REMARK    GeneRIF: Results showed KCMF1 C-terminus binds directly to RAD6,
            whereas N-terminal domains interact with UBR4 and point mutations
            found in X-linked intellectual disability (XLID) patients
            specifically lose the interaction with KCMF1 and UBR4.
REFERENCE   7  (bases 1 to 7500)
  AUTHORS   Luo,R., Shao,X., Xu,P., Liu,Y., Wang,Y., Zhao,Y., Liu,M., Ji,L.,
            Li,Y.X., Chang,C., Qiao,J., Peng,C. and Wang,Y.L.
  TITLE     MicroRNA-210 contributes to preeclampsia by downregulating
            potassium channel modulatory factor 1
  JOURNAL   Hypertension 64 (4), 839-845 (2014)
   PUBMED   24980667
  REMARK    GeneRIF: Data indicate that expressions of miR-210 and potassium
            channel modulatory factor 1 (KCMF1) exhibited an inverse
            correlation in placentas from patients with severe preeclampsia.
REFERENCE   8  (bases 1 to 7500)
  AUTHORS   Kreppel,M., Aryee,D.N., Schaefer,K.L., Amann,G., Kofler,R.,
            Poremba,C. and Kovar,H.
  TITLE     Suppression of KCMF1 by constitutive high CD99 expression is
            involved in the migratory ability of Ewing's sarcoma cells
  JOURNAL   Oncogene 25 (19), 2795-2800 (2006)
   PUBMED   16314831
  REMARK    GeneRIF: Suppression of KCMF1 by constitutive high CD99 expression
            levels contribute to the malignant properties of Ewing's sarcoma by
            promoting growth and migration of tumor cells
REFERENCE   9  (bases 1 to 7500)
  AUTHORS   Jang,J.H.
  TITLE     FIGC, a novel FGF-induced ubiquitin-protein ligase in gastric
            cancers
  JOURNAL   FEBS Lett 578 (1-2), 21-25 (2004)
   PUBMED   15581609
  REMARK    GeneRIF: Data indicate that FIGC upregulation in response to basic
            fibroblast growth factor in gastric cancer might be implicated in
            carcinogenesis through dysregulation of growth modulator.
REFERENCE   10 (bases 1 to 7500)
  AUTHORS   Li,Z., Stuart,R.O., Eraly,S.A., Gittes,G., Beier,D.R. and
            Nigam,S.K.
  TITLE     Debt91, a putative zinc finger protein differentially expressed
            during epithelial morphogenesis
  JOURNAL   Biochem Biophys Res Commun 306 (3), 623-628 (2003)
   PUBMED   12810064
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT004343.1, AK023403.1, AC078974.4 and AW466865.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020122.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.182792.1,
                                           SRR1803615.119853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409785.9/ ENSP00000386738.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-575               CT004343.1         54-628
            576-2353            AK023403.1         308-2085
            2354-7492           AC078974.4         6696-11834
            7493-7500           AW466865.1         3-10                c
FEATURES             Location/Qualifiers
     source          1..7500
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..7500
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
                     /note="potassium channel modulatory factor 1"
                     /db_xref="GeneID:56888"
                     /db_xref="HGNC:HGNC:20589"
                     /db_xref="MIM:614719"
     exon            1..307
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1437
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
                     /EC_number="2.3.2.27"
                     /note="FGF-induced ubiquitin-protein ligase in gastric
                     cancers; differentially expressed in branching
                     tubulogenesis 91; zinc finger, ZZ domain containing 1;
                     FGF-induced in gastric cancer; ZZ-type zinc
                     finger-containing protein 1; RING-type E3 ubiquitin
                     transferase KCMF1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase KCMF1"
                     /protein_id="NP_064507.3"
                     /db_xref="CCDS:CCDS46350.1"
                     /db_xref="GeneID:56888"
                     /db_xref="HGNC:HGNC:20589"
                     /db_xref="MIM:614719"
                     /translation="MSRHEGVSCDACLKGNFRGRRYKCLICYDYDLCASCYESGATTT
                     RHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQEHVTSEHA
                     ETSTEVICPICAALPGGDPNHVTDDFAAHLTLEHRAPRDLDESSGVRHVRRMFHPGRG
                     LGGPRARRSNMHFTSSSTGGLSSSQSSYSPSNREAMDPIAELLSQLSGVRRSAGGQLN
                     SSGPSASQLQQLQMQLQLERQHAQAARQQLETARNATRRTNTSSVTTTITQSTATTNI
                     ANTESSQQTLQNSQFLLTRLNDPKMSETERQSMESERADRSLFVQELLLSTLVREESS
                     SSDEDDRGEMADFGAMGCVDIMPLDVALENLNLKESNKGNEPPPPPL"
     exon            308..475
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..615
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..717
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..892
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1175
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..7500
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1771..1776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
                     /note="hexamer: AATAAA"
     polyA_site      1800
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
                     /note="major polyA site"
     regulatory      3250..3255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
                     /note="hexamer: AATAAA"
     polyA_site      3272
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
     regulatory      3711..3716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
                     /note="hexamer: AATATA"
     polyA_site      3731
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
     regulatory      7481..7486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
                     /note="hexamer: AATAAA"
     polyA_site      7500
                     /gene="KCMF1"
                     /gene_synonym="DEBT91; FIGC; PCMF; ZZZ1"
ORIGIN      
        1 aggcccgaga gtgaccggag tcacggcggg cgccggcgga gctgcggcgt cggacccgcc
       61 tcctggagga gctcagcccc gaccaggccc ggccccattc ccgccccgcg ccgcctcccc
      121 gccgccgccg ccgccgccgc cgcgggagcg ctcccctgcc caccccgccc ccgcggccga
      181 gcccgggagt cgagtgggag tcggccggcc ggcgcgggca gcgccgggac cccgcggggg
      241 acactgcagc cggagcccgg gaggggccgc gccgccaccg tctgaactag gatgtcccga
      301 catgaaggtg tcagctgtga tgcatgttta aaaggaaatt ttcgaggtcg cagatataag
      361 tgtttaattt gctacgatta cgatctttgt gcatcttgtt atgaaagtgg tgcaacaaca
      421 acaaggcata caactgacca cccaatgcag tgcatattaa caagggtaga ttttgattta
      481 tactatggtg gggaagcttt ctctgtagag cagccacagt cttttacttg tccctattgt
      541 ggaaaaatgg gctatacgga gacatctctt caagaacatg ttacttctga acatgcagaa
      601 acatcaacag aagtgatttg tccaatatgt gcagcgttac ctggaggcga tcctaatcat
      661 gtcacggatg actttgcagc tcatcttaca cttgaacaca gagcccctag agatttagat
      721 gaatcgagtg gtgttcgaca tgtacgtaga atgtttcacc ctggccgggg attaggaggt
      781 cctcgtgctc gtagatcaaa catgcacttt actagcagtt ctactggtgg actttcttct
      841 tctcagagtt catattctcc aagcaatagg gaagccatgg atcctatagc tgagctttta
      901 tctcagttat caggagtgag acgttctgca ggaggacagc ttaattcctc tggcccttcc
      961 gcttctcagt tacaacaact gcagatgcag ctgcagctag aacggcagca tgcccaggca
     1021 gcacggcaac aactggagac cgcacgcaac gcaacccggc gtactaacac aagcagtgtc
     1081 accactacaa tcacacaatc cacagcaaca accaacatag ctaatacaga aagcagtcag
     1141 cagactctac agaattccca gtttctttta acaaggttga atgatcctaa aatgtctgaa
     1201 acggagcgcc agtccatgga aagcgagcgt gcagaccgca gcctgtttgt ccaagagctc
     1261 cttctgtcca ctttagtgcg tgaagagagc tcatcctcag atgaggatga tcggggggag
     1321 atggcagatt ttggtgctat gggctgtgta gatattatgc ctttagatgt tgctttagaa
     1381 aacctaaatt taaaagagag taataaagga aatgagcctc caccacctcc tctttgatga
     1441 catcccaatt cgcagacaat gtcctctgtg ctgtatttgc caatgaaagt ggacaacaac
     1501 tatcttgggt ttgtttggtg attgtaattt caggtctgtc actcttgtta cattgtgtac
     1561 attcaaaagg aagagagaaa atatatatga taatcatttc cacttaacta atttttactt
     1621 ctagcaggta aatgtaggta gcagtgcagg ggtgatctct gcttcctgta ccttgacatg
     1681 caaaaggctc tcctaatact ccacattcaa actgaagagg aaaattgaaa tctctaatga
     1741 agctgctgtg tgtatttatg aatattaatg aataaaaact gcttggatgg tttaccttaa
     1801 ctactgcatg aggttttttg cagcgtgcat gagttttagt gaccttgtta tttaagaagt
     1861 taaatacaag gagtaaaact taaaaaaaaa atacaaagcc caaagctttc ccaaacatta
     1921 ttcaatggtt acacgacgaa gtagcttttg aataatgtct gcctgaatca cctttctttg
     1981 tgtgcctcct acgcacaaag ccagctctgc agtggaatct ggggattata gccgggtgtg
     2041 gcactccgcc ctgtgtgact gtcctgtcgc cctgttagtc atcttgcctg tgtggagctc
     2101 agcctgtctc tttaactcat ctgtagaaga cacaccagta aagctactgt tggaatctgc
     2161 tgcaggggcc tttgtgtgcc ctaaaaacaa atcctgttca tgtttgttta aagtttttac
     2221 tttttgtggt tgtttaaaat tttttcaatt gttaaatatg ttttattcag gtgtagatga
     2281 atttcattta ttgactgttc aacagagtta acctgaatta tgttgtcttt gtttttaaaa
     2341 atctcacatt ctcaatcata ttttgcatta tttatgtatt tgctttgtag tttgctgaga
     2401 cagatcagta tcaggggagc tttgaggatt tgccttccca gatttgtcag tatattacaa
     2461 ccaaattctt aatgctaatt ttagcacctt ttatttattg ggttttttct ggcataaaaa
     2521 gtaaagcctt ttaattgaat catgccacct atatgcctat attattaatc ctatgtgtaa
     2581 aaaaaatgta cagctttttt tgggtttgtt ttggggtttg gaagggccgg gttatttttt
     2641 atttcctgtt tcagtttttg tgcatagact ttcacaatag ctccaaggca gggacagcgg
     2701 gtttgggggt tgggagggca gtttttggaa tgtaaattta ggacttttaa aaaggtgcgc
     2761 acagcttctg ataaatttat aactagactt aacctaatca tgtctcgttc cagttctctt
     2821 ttctctgagc ccttttcaaa gtctcctctc tttctcctgt catccttttc ctttcctgtc
     2881 cgtgtatctc cgtttcttca acatgacaag catacagact tgaacacccc tccggtgttc
     2941 ttccgagaac tgtgaagtcc atgttcatcc aaatgtaacc aaaaaagaag tcaccctaca
     3001 tgtctgaaaa actgttgctt ctcctctgaa acttcaaact ccaacgattt ccaaatacaa
     3061 tagctttgtt ttctttagtt ctgtaatgga taatgtttaa aggaaaactt tacaccaggc
     3121 ttctggttac actagaagtc aagcccatta gggattttca ttttttttca tttggttgtt
     3181 gagaagtttc aaaaatcagt tttcaagctg tggtctttca aacacatctg cacataagtc
     3241 acacatttca ataaagcatt ttcaagactg ttgaccactt gaatttcttt ggtgttagtg
     3301 gattaaccta accattactc tgagatttta tatctctaat ccagtatttt ttttcttttt
     3361 atgctaaaca tgggagatcc tggttttgtg tgaatgcatt attttggatg tgagaaataa
     3421 atgccaatta tatgtacttt cccttttctg cacaaattct gggaaaatgt aaaagccttc
     3481 attttttaac atggttttag ggaacaactg taagtccatt cagagcagtt taatttagat
     3541 gatcactttt aacactgcag aagacctaag gagtcataag attccatctc atgtagaata
     3601 ctgtatatta attatttttt accagatatt ttacaaatac ctcacctcat cctgtatgta
     3661 atcaataatg tattatttta gggtagaacg acacagaata tcaatataaa aatatattca
     3721 agcccttgaa attcttgtgt cctttttctt tagtttctga atgaaaatct tattactgga
     3781 tgtactattg aataaaaatt aattgcaaag actttgatgg agacaaaatc aaaatatacc
     3841 actgtttatt ttggcagcac cttcaaattt ctaaggacca gatcctgaat tttgagaatt
     3901 ttttgtttcg ttgagttttg agtgtctagg atataagttt ataaatgttc tacagtgctt
     3961 gtctttactt cctgtttaga aatcatttaa atctttcccc tcgaggtgct ctggaagaag
     4021 tttaatttca gctctgaaca agtagaaata actgtgcttc cttgtatggc tgcaatcata
     4081 agacagaatt tctgtggttg gctaccgtga aatctttgta tttatattgc attgttttgt
     4141 taaaaaaaaa aaaatccaca gaagtagaac ctaggtttgc tactaacaaa gtagtggatt
     4201 cttataatta ggctcaggta aagtaagaga aaacttctct ccctgtggcc cccagagaaa
     4261 tgaagtagga tagcagatta cactattaga aataatagac gtaacaaaaa aaatccagcc
     4321 cattatcccc accccccatt ttccctctca atattagaaa tttcaataat atgctgacag
     4381 attttcaaag gtcaccaagg cttttgtgtt tttttccggt ctgtgggcca cagttaaaag
     4441 aacgggtaac aggttcagag ttctcttgat acgtccaagc cttagtttcc aggaaaaaag
     4501 ctaggctcct cactgcaaat attaacgctt tatatattta ctccatggat gttggggtaa
     4561 gcacatatat caatagttca tagctctagt taaggacaaa gtgggttggg gggtagaagg
     4621 agaatactag agaggttacg gtagcaggtg gctgcagaaa agaatctttt gaatgggatt
     4681 cctgtaacag tgttcagtac caatattaag tctactgtaa gtggggtctg atatggctta
     4741 ctgatacagg catgtgtaaa aaactaagtg tgatggagga atgggtgcta aaagctctta
     4801 acagttttgt agagaagccc tgcagccgtg tttactatat atgacatgcc tgtttcttag
     4861 tttgcatgca cagtttaagg ggcacatgca atattggttt catgtgcagt aaaaattaaa
     4921 acacggctga gcgtggtggc tcacgcctgt aatcccagca ctttgcgagg ccgaggcggg
     4981 tggatcacga ggtcgagttt gagaccattt tggccagcat agtgaaaccc catctctact
     5041 aaaaaataca aaaagttagc tgggcatggt ggcaggcacc tgtaatccca gctactcggg
     5101 aggctgaggc aggagaatcg cttgaacctg ggaggcagag gttgcagtga gctgagatca
     5161 cgccgccatt gcactccagc ccgggcgacg gtgcaagact ctgtctcaaa aaaaaaaaaa
     5221 attaaaacac taggtacgaa attatcccag aattatacgc gaaagttggt gttcatgctg
     5281 gaaaacagtt acggttatct gtgctctttc taaagctcaa ctagacacta aaacagttct
     5341 ctccttgaga ccggaagtgg gatgggggtg ggcaggtgga agggaagagg ctggggagga
     5401 gcctctcatc tcatctcatt tcagcctcaa cagtaattga aaccctatgc ctggcctgga
     5461 gtgggtagag gttagggtta gagtgcagga tggagcagca gtctgcagac tttcaggttg
     5521 tgacgatgtc atgaaattct gtgctattaa acatggctat gtctgagtca gtcattacgg
     5581 tattccaaag ccaaattcaa gtgactgttt ttctgaatag tataaaaatc taattccctg
     5641 tgcttatcgg cttcaactgt gcttacacaa cgtttgtttc taattcgtac tcttgcctct
     5701 tggtttctgt agtttttcaa cccatttctg tcagtgttct ataaatgcat acattcgtta
     5761 tttaaggaac cctgcagcag acctcgaata aaatgtgact tgatgtttgt tgccacttcc
     5821 tcaacttggt tagcaaattc aagttttgaa agacgattcg tctcagagaa gttgatcctg
     5881 aacctccacg tcacatttta gtcggttgct attaggtggg taatgcctaa taacatgggt
     5941 tcctcaaatc acaaaggaga atgctctcaa gtcctcatgt taactttagt aagtcagtta
     6001 actttacagc aactaaagag atcaattaaa aagaaccctt aagtctgact gtcccaggta
     6061 actttacttg ctgtacagat agtgcacaga tatggatgag ggctgcacat ggctgatttg
     6121 aaaacccatg tggggccggg tgtggtggct cacgcctgta atcccagcac tttgggaggc
     6181 caaggcgggt ggatcacgag gttagttcag gaccagcctg gccaagatgg tgaaacccca
     6241 tctctactaa aaatacgaaa attagctggg cttggtggca gatgcctgta attcctgcta
     6301 ctcgggaggc tgaggcagag aattgcttga acccgggagg cggaggttgc agtgagccga
     6361 gattgcgcca ctgcactcca gcctgggcga cacagtgaga ctctcctcaa aacaaaaaaa
     6421 aaagaaagaa aacccatgtg ggccgcatgt gcacagcctg gggctgcttt ccacaggcct
     6481 ggataatgat gtttctcttc aaggaggcct ttactaacca cagggaacct agcatctgac
     6541 tgtgtccttg gcagacagtg catgtagcct gtagaatgtt ggctcctctg tctatagaaa
     6601 ccatcagttc gctgctctct cattcataca tactttttga gttcccagta ggtacgaagc
     6661 tttgtctaaa cattatttac caactgcgat ttttacagac ttcccctgta agaattttct
     6721 aaaagagcct ttctccctta cacaattgaa acgttttcaa aggtcatcaa gccggttgcg
     6781 tttggtcagt cacgtgacca atcagagctg gtgagtgagc tgctccctta aatctaccaa
     6841 attagactga cagcatttgg aatctgcctc acacataaga gatccatatt catttaatag
     6901 tgaagccagc ccagaagcat cctcttctgt aagctggatg gagtcccagc tctctctcct
     6961 tgtatataag gagaccacac cctgtatata aggttttctt gaggtagatg cagcaatatt
     7021 cctggggtaa gattctataa tactcctgta ttggcaagtg gactggacca acagacacag
     7081 gcctcagcca ctgtcgctag ggactgaagg agagttcatg gattcttacc ccctagtcat
     7141 gaaagctatt ctggccagcc ttgaatccat ttaattttgc ccacgagaac ctttcatgac
     7201 aattaacaag acactagttt ccccataaaa gtccattttt aaatatatag tatgctaatt
     7261 agcagtgtct gttgaattgc cctatcggat agcagccacc atgtgtgctg accactcacg
     7321 attcagactt accttggaaa atatcacact gacgatacag tactttagaa taaattgcat
     7381 attgtatcag gctccgagac taatttgtac tgaacccttg atatagatta ccttttataa
     7441 catcaccacc tgtcatgaag cttatctgtt ttctgatttg aataaacttt gtgttgtgca
//
