LOCUS       NM_032138               4736 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens kelch repeat and BTB domain containing 7 (KBTBD7),
            mRNA.
ACCESSION   NM_032138
VERSION     NM_032138.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4736)
  AUTHORS   Li,X., Lin,Z., Xu,S., Zhang,N., Zhou,J. and Liao,B.
  TITLE     Knockdown of KBTBD7 attenuates septic lung injury by inhibiting
            ferroptosis and improving mitochondrial dysfunction
  JOURNAL   Int Immunopharmacol 133, 112129 (2024)
   PUBMED   38652964
  REMARK    GeneRIF: Knockdown of KBTBD7 attenuates septic lung injury by
            inhibiting ferroptosis and improving mitochondrial dysfunction.
REFERENCE   2  (bases 1 to 4736)
  AUTHORS   Zou,Z., Zhang,B., Li,Z., Lei,L., Sun,G., Jiang,X., Guan,J.,
            Zhang,Y., Xu,S. and Li,Q.
  TITLE     KBTBD7 promotes non-small cell lung carcinoma progression by
            enhancing ubiquitin-dependent degradation of PTEN
  JOURNAL   Cancer Med 11 (23), 4544-4554 (2022)
   PUBMED   35499228
  REMARK    GeneRIF: KBTBD7 promotes non-small cell lung carcinoma progression
            by enhancing ubiquitin-dependent degradation of PTEN.
            Erratum:[Cancer Med. 2024 Sep;13(17):e7462. doi:
            10.1002/cam4.7462.. PMID: 39248706]
REFERENCE   3  (bases 1 to 4736)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   4  (bases 1 to 4736)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4736)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4736)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   7  (bases 1 to 4736)
  AUTHORS   Genau,H.M. and Behrends,C.
  TITLE     GABARAP proteins as scaffolds in localized TIAM1-RAC1 signaling
  JOURNAL   Mol Cell Oncol 3 (1), e1027440 (2015)
   PUBMED   27308540
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4736)
  AUTHORS   Genau,H.M., Huber,J., Baschieri,F., Akutsu,M., Dotsch,V.,
            Farhan,H., Rogov,V. and Behrends,C.
  TITLE     CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP
            proteins to spatially restrict TIAM1-RAC1 signaling
  JOURNAL   Mol Cell 57 (6), 995-1010 (2015)
   PUBMED   25684205
  REMARK    GeneRIF: KBTBD6 and KBTBD7 specifically bind to GABARAP
            proteins.KBTBD6 and KBTBD7 form a heterodimeric CRL3 complex.
REFERENCE   9  (bases 1 to 4736)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
REFERENCE   10 (bases 1 to 4736)
  AUTHORS   Hu,J., Yuan,W., Tang,M., Wang,Y., Fan,X., Mo,X., Li,Y., Ying,Z.,
            Wan,Y., Ocorr,K., Bodmer,R., Deng,Y. and Wu,X.
  TITLE     KBTBD7, a novel human BTB-kelch protein, activates transcriptional
            activities of SRE and AP-1
  JOURNAL   BMB Rep 43 (1), 17-22 (2010)
   PUBMED   20132730
  REMARK    GeneRIF: KBTBD7 proteins may act as a new transcriptional activator
            in mitogen-activated protein kinase (MAPK) signaling.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354696.11, BC022033.2,
            AI631319.1, BU070208.1, BF436101.1, HY094395.1 and BU069965.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_032138.6.
            
            Summary: The protein encoded by this gene is a transcriptional
            activator, having been shown to increase the transcription of
            activator protein-1 and serum response element. The encoded protein
            can also form a complex with KBTBD6 and CUL3, which regulates the
            ubiquitylation and degradation of TIAM1, which is a regulator of
            RAC1. [provided by RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK091344.1, FJ150424.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379483.4/ ENSP00000368797.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL354696.11        75364-75366         c
            4-2995              BC022033.2         1-2992
            2996-3172           AI631319.1         1-177               c
            3173-3561           BU070208.1         115-503
            3562-3990           BF436101.1         1-429               c
            3991-4170           HY094395.1         181-360
            4171-4736           BU069965.1         15-580              c
FEATURES             Location/Qualifiers
     source          1..4736
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.11"
     gene            1..4736
                     /gene="KBTBD7"
                     /note="kelch repeat and BTB domain containing 7"
                     /db_xref="GeneID:84078"
                     /db_xref="HGNC:HGNC:25266"
                     /db_xref="MIM:617739"
     exon            1..4736
                     /gene="KBTBD7"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..2367
                     /gene="KBTBD7"
                     /note="kelch repeat and BTB (POZ) domain containing 7"
                     /codon_start=1
                     /product="kelch repeat and BTB domain-containing protein
                     7"
                     /protein_id="NP_115514.2"
                     /db_xref="CCDS:CCDS9377.1"
                     /db_xref="GeneID:84078"
                     /db_xref="HGNC:HGNC:25266"
                     /db_xref="MIM:617739"
                     /translation="MQSREDVPRSRRLASPRGGRRPKRISKPSVSAFFTGPEELKDTA
                     HSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTG
                     GMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREAC
                     ASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLT
                     LAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQD
                     YLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENP
                     PQRLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPD
                     HDIYLAAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVK
                     LKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSKRMLCYDPSHNMWLNCA
                     SLKRSDFQEACVFNDEIYCICDIPVMKVYNPARGEWRRISNIPLDSETHNYQIVNHDQ
                     KLLLITSTTPQWKKNRVTVYEYDTREDQWINIGTMLGLLQFDSGFICLCARVYPSCLE
                     PGQSFITEEDDARSESSTEWDLDGFSELDSESGSSSSFSDDEVWVQVAPQRNAQDQQG
                     SL"
     regulatory      3962..3967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KBTBD7"
                     /note="hexamer: TATAAA"
     polyA_site      3982
                     /gene="KBTBD7"
     regulatory      4714..4719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KBTBD7"
                     /note="hexamer: AATAAA"
     polyA_site      4736
                     /gene="KBTBD7"
                     /note="major polyA site"
ORIGIN      
        1 agtagttctc ccgggcgcct agcgggatcg ccagcgcggc agtgggggct tccgcggctg
       61 caagccagcg ggtcctgtga gggcgagcgg aggcggagaa agggcgcggg agtgagagag
      121 ggtgagtcag ccactgtcta tgcaataaag ggaggcctca ccgcgggata gggctgaatt
      181 cagaagtgcg gcccgtgccg cagtctgttc caggacgcgg cttgtcttag cgtcagcgag
      241 ggaaggttga ggaggagcca gagcctggtc ctgcagcctt tctcgccgtc agcgcccgtc
      301 gccatctcca ccatgcagtc ccgggaagac gtcccgcgct ctcgccgcct cgccagtccc
      361 cgtggtggga ggcggcccaa gaggatttcc aagccctcgg tttcggcctt tttcacgggt
      421 ccagaggagt taaaggacac ggcccattct gcagccctgc tggcacagct caagtccttc
      481 tacgacgcgc ggctgctgtg tgatgtgacc atcgaggtgg tgacgcctgg cagcgggcct
      541 ggcacgggtc gcctcttttc ctgcaatcgc aacgtgctag cagctgcgtg tccctacttc
      601 aagagcatgt tcacaggtgg catgtacgag agccagcagg ccagcgtgac catgcacgat
      661 gtggacgccg agtccttcga ggtgttggtc gactactgct acacgggtcg tgtgtctctc
      721 agtgaggcca atgtgcagcg cctgtacgcg gcctccgaca tgctacagct ggaatatgtg
      781 cgggaagcct gtgcctcctt cttagcccga cgtcttgacc tgaccaactg caccgccatc
      841 ctcaagtttg cagacgcctt cgaccatcac aagcttcgat ctcaggccca gtcctacata
      901 gctcacaact tcaagcagct cagccgaatg ggttcaattc gggaggagac tctagcagat
      961 ctaaccctgg cccagctgct ggctgtccta cgcctggata gtctggacat agagagtgag
     1021 cggactgtat gccatgtagc tgtgcagtgg ctggaggctg ctgccaaaga gcggggtccc
     1081 agtgctgcag aagtcttcaa gtgcgtgcgc tggatgcact tcactgaaga agatcaggac
     1141 tacttagaag ggctgctgac caagcccatc gtgaagaagt actgcctgga cgttattgaa
     1201 ggggccctgc agatgcgcta tggtgacctg ttgtacaagt ctctggtgcc agtgccaaac
     1261 agcagcagca gcagtagcag cagcaactct cttgtatctg cagcagaaaa tccaccccag
     1321 agactgggta tgtgtgccaa ggagatggtg atcttctttg gacatcctag agatcccttt
     1381 ctctgctatg acccttactc gggggacatt tacacaatgc catccccttt gaccagcttt
     1441 gctcacacta agactgtcac ctcctcagct gtctgtgtgt ccccagacca tgacatctat
     1501 ctagctgctc agcccaggaa agacctctgg gtgtataaac cagctcagaa tagttggcag
     1561 caacttgcag atcgcttgct gtgtcgtgag ggcatggatg tggcatatct caatggctac
     1621 atctacattt tggggggacg agaccctatt actggagtta agttgaagga agtggaatgc
     1681 tacagtgttc agagaaacca gtgggcattg gtggctcctg tccctcattc cttctattcc
     1741 tttgaactca tagtggttca gaactatctt tatgctgtca acagtaagcg catgctttgc
     1801 tatgatccta gccacaatat gtggctgaac tgtgcttctc ttaaacgtag tgactttcag
     1861 gaagcatgtg tcttcaatga tgaaatctat tgtatctgtg acatcccagt catgaaggtc
     1921 tacaacccag ctaggggaga atggaggcgg attagtaata ttcctttgga ttcagagacc
     1981 cacaactacc agattgtcaa tcatgaccaa aagttgcttc tcatcacttc tacaacccca
     2041 caatggaaaa agaaccgagt gacagtgtat gagtatgata ctagggaaga tcagtggatt
     2101 aatataggta ccatgttagg ccttttgcag tttgactctg gctttatttg cctttgtgct
     2161 cgtgtttatc cttcctgcct tgaacctggt cagagtttta ttactgagga agatgatgca
     2221 cggagtgagt ctagtactga atgggactta gatggattca gtgagctgga ctctgagtca
     2281 ggaagttcaa gttctttttc agatgatgaa gtctgggtgc aagtagcacc tcagcgaaat
     2341 gcacaggatc agcagggttc tttgtaaata gtattttgag acactaagat gtttctactg
     2401 ctacggaatg tattttaaac acatatcgtt tctttttctt ggaaaaaaag ttgattagga
     2461 ccacagattt ggtttagaaa gggtaatatt ttgaaatact acaaggttta gacagtccat
     2521 gaaatcgacc tgtttaataa tttaccatcc tgaaagtcca gaattaaaat atggaagcaa
     2581 gaactatata attgattagg atgcttggta ggtttttttc attgttcaaa tattcattgc
     2641 acagtggatt gttttgatta gttagtatgc ttttttttta attaattcag tcttctgtta
     2701 atttttaagt tttggttagt gccacaagga atttaacttt ttgatttgta taatagaaaa
     2761 ctgaactagg aattgttagc ggggttttga aggatgtgta ctttccttca aaataaagtg
     2821 gtagattttc aaaattttac actagtcagt tctttatatt ctaagttaaa tgtagtttgt
     2881 aaaattattt tggttttctt ctacaaagga aaaaattgga tttatatata taaggttact
     2941 gcataatgat ttcattttga taatgtgcag aatggcctca taagctcaca gaaagtaaaa
     3001 aaaaaaaaaa aaaaaaagaa aaaatcagga ttccactgtt ttaaaagaaa tctcagtttt
     3061 tattttggaa tataaaatgt gtatttggta tatgtgacca attttctatc ccaaaaaaca
     3121 cccattctta gtaatgtcat gaattaaaca cccttctaaa ccaaaaaaaa aaaaaaaaac
     3181 ggtaacttgc tttttatgtt tgtgttttta atttatgccc aatacatgct ttactgactc
     3241 agaggaacaa ttcctggaca tataattggg taatgcaaat ttttatccac tggtcatgat
     3301 ttgtcttaaa atgtttactt gcctccctaa aatattttgg ctgtgtaggt ttggtgtttg
     3361 tcctagagga ttcttcaaca gaaagtgatt tattctttac tgttttgtga ggtaatatgg
     3421 tttagaacat atgtataagc taaaaacagt attttactca gatcagtagt tatcgtgtct
     3481 atcagctata aaaaaaatca actgccagcc aagaacttta aaactttaag ctgtgtatta
     3541 tagaaccgtt ttgtgtagca ttggaatatt gtccattttg taagtcattg tgaatgttct
     3601 taattatcag cttgaaggta tttttgtatt aaaagttgac attgaagaac ctaagtggat
     3661 gatgggattt ggggccagta gtgaaagtat gtttcctcta aaatatttcc ctaaacagtg
     3721 gtatacatgg ttattttatt atgagatttg tatatgttct gtgtttctct gtgaacaatg
     3781 tttcagtctc tctgtcacca tatgtaaggg gaagtccaca aatatagact acattgcaca
     3841 aaactaaaat tgttaattac aagaaaatat aggtgcttac cttttgaagg tttattaata
     3901 catatggttg tcacaatacg tatatatgat aaatggtgta catatacaga tgtttatggt
     3961 gtataaattt ttctataccc aattagaatt atcttcctga ttctttattc aataacatgc
     4021 taattcctct tctatgttct atagtgacag aatgctaact tttcttatac cctggcagag
     4081 gacagaggag tctggtctag gatggggaac tgaatttttg aacgaaaagg aaagagaaag
     4141 gatgaaaaaa caaacaaaca aaaaaacaca cgataatgtt tcttagtcat tttgattggc
     4201 catttgaaca gtctacaagt ttaacgttat ttccagtgaa gtaggatggc tgacctagca
     4261 atacatgttt cttcaaaagg gtaaacatgc tttagtgacc taaagctaaa ttttgtacat
     4321 ttgacatcag ggatgttata agtactgcac ttaatacaaa gctatttctc aattgtgtta
     4381 tttttgagac aaatttttct tcaccattaa cttcttgttg gtagcttttt gttttgtaaa
     4441 aattgagaga tggcaatgct tatctcaacc agattatcca tctgcagaat taaggtatgc
     4501 aactggtaaa taaaagacaa atgctccagt ttgtctttct caacctttga gttcttaacc
     4561 tttgagttaa aacctagtct aaatagtggg aatgtcttgg tttacagtaa ggttttcttg
     4621 ggaaggatct tggttttgtg atctatttgt gaattaagga gtagatgtta accattattt
     4681 tatagataag tgatttgtac atggttagtt ataaataaaa ctggtactag aaccca
//
