LOCUS       NM_152903               5234 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens kelch repeat and BTB domain containing 6 (KBTBD6),
            mRNA.
ACCESSION   NM_152903
VERSION     NM_152903.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5234)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   2  (bases 1 to 5234)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5234)
  AUTHORS   Mena,E.L., Kjolby,R.A.S., Saxton,R.A., Werner,A., Lew,B.G.,
            Boyle,J.M., Harland,R. and Rape,M.
  TITLE     Dimerization quality control ensures neuronal development and
            survival
  JOURNAL   Science 362 (6411) (2018)
   PUBMED   30190310
REFERENCE   4  (bases 1 to 5234)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 5234)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   6  (bases 1 to 5234)
  AUTHORS   Genau,H.M., Huber,J., Baschieri,F., Akutsu,M., Dotsch,V.,
            Farhan,H., Rogov,V. and Behrends,C.
  TITLE     CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP
            proteins to spatially restrict TIAM1-RAC1 signaling
  JOURNAL   Mol Cell 57 (6), 995-1010 (2015)
   PUBMED   25684205
  REMARK    GeneRIF: KBTBD6 and KBTBD7 specifically bind to GABARAP
            proteins.KBTBD6 and KBTBD7 form a heterodimeric CRL3 complex.
REFERENCE   7  (bases 1 to 5234)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
REFERENCE   8  (bases 1 to 5234)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL354696.11.
            
            On May 17, 2019 this sequence version replaced NM_152903.4.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660803.32402.1, SRR1803612.9018.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379485.2/ ENSP00000368799.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5234              AL354696.11        8366-13599          c
FEATURES             Location/Qualifiers
     source          1..5234
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.11"
     gene            1..5234
                     /gene="KBTBD6"
                     /note="kelch repeat and BTB domain containing 6"
                     /db_xref="GeneID:89890"
                     /db_xref="HGNC:HGNC:25340"
                     /db_xref="MIM:617738"
     exon            1..5234
                     /gene="KBTBD6"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..2316
                     /gene="KBTBD6"
                     /note="kelch repeat and BTB (POZ) domain containing 6"
                     /codon_start=1
                     /product="kelch repeat and BTB domain-containing protein
                     6"
                     /protein_id="NP_690867.3"
                     /db_xref="CCDS:CCDS9376.1"
                     /db_xref="GeneID:89890"
                     /db_xref="HGNC:HGNC:25340"
                     /db_xref="MIM:617738"
                     /translation="MQSREDAPRSRRLASPRGGKRPKKIHKPTVSAFFTGPEELKDTA
                     HSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTG
                     GMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREAC
                     ASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLT
                     LAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQD
                     YLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENP
                     PQRLGMCAKEMVIFFGHPRDPFLCCDPYSGDLYKVPSPLTCLAHTRTVTTLAVCISPD
                     HDIYLAAQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVK
                     LKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALNSKRMFCYDPSHNMWLKCV
                     SLKRNDFQEACVFNEEIYCICDIPVMKVYNPVRAEWRQMNNIPLVSETNNYRIIKHGQ
                     KLLLITSRTPQWKKNRVTVYEYDIRGDQWINIGTTLGLLQFDSNFFCLSARVYPSCLE
                     PGQSFLTEEEEIPSESSTEWDLGGFSEPDSESGSSSSLSDDDFWVRVAPQ"
     regulatory      5216..5221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KBTBD6"
                     /note="hexamer: AATAAA"
     polyA_site      5234
                     /gene="KBTBD6"
                     /note="major polyA site"
ORIGIN      
        1 agcattgtcg cccacgctgc agtagcggct tctgcggctc caagccagcg ggtcctgtga
       61 aggcgagcag acgcggagaa aggacgcggg agtgagagag ggtgagtcag ccactgtcta
      121 aacgataacg ggaggcggtt ctgcggggta gggttgaatt cagtaaatgg gctcgtgctg
      181 ctgtctcttc ggagacgctg ctatcttagc gtcagcgagg gaaggttgag gaggagccag
      241 agccgggtcc tgcagcgttt ctcgccatca gcgcccgtcg ccatctccac catgcagtcc
      301 cgggaagacg ccccgcgctc tcgccgccta gccagtcccc gtggtgggaa gcggcccaag
      361 aagattcaca aacccacagt ttcggccttt ttcacgggtc cagaggaatt aaaggacacg
      421 gcccattctg cagccctgct ggcacagctc aagtccttct acgatgcgcg gctgctgtgt
      481 gatgtgacca tcgaggtggt gacgcctggc agcgggcctg gcacgggtcg cctgttcccc
      541 tgcaaccgca atgtgctggc cgcggcatgt ccctacttca agagcatgtt cacaggtggc
      601 atgtacgaga gccagcaggc cagcgtgacc atgcacgatg tggacgccga gtccttcgag
      661 gtgttggtcg actactgcta cacgggtcgt gtgtctctca gtgaggccaa cgtggagcgc
      721 ctgtacgcgg cctccgacat gctacagctg gaatatgtgc gggaagcctg tgcctccttc
      781 ttagcccgac gtcttgacct gaccaactgc accgccatcc tcaagtttgc agatgccttt
      841 ggccatcgca agctgcgatc ccaggcccag tcctatatag ctcagaactt caagcaactc
      901 agccacatgg gttcaattcg ggaggagact ctagcagatc tgaccctggc ccagctgctg
      961 gctgtcctgc gcttggatag tctggacgtg gagagtgagc agacagtgtg ccatgtggca
     1021 gtgcagtggc tggaggctgc tcccaaagag cggggtccca gtgctgcaga agtcttcaag
     1081 tgcgtgcgct ggatgcactt cactgaagaa gatcaggact acttagaagg gctgctgacc
     1141 aagcccatcg tgaagaagta ctgcctggac gttattgaag gggccctgca gatgcgctat
     1201 ggtgacctgt tgtacaagtc tctggtgcca gtgccaaaca gcagcagcag cagtagcagc
     1261 agcaactctc ttgtatctgc agcagaaaat ccaccccaga gactgggtat gtgtgccaag
     1321 gagatggtga tcttctttgg acaccccaga gatccctttc tctgctgtga tccatactcg
     1381 ggggaccttt acaaagtgcc gtcacctttg acctgtctgg ctcacactag gactgtcacc
     1441 actttagctg tctgtatctc tcctgaccat gacatctatc tagctgctca gcccaggaca
     1501 gacctctggg tgtataaacc agctcagaat agttggcagc aacttgcaga tcgcttgctg
     1561 tgtcgtgagg gcatggatgt ggcatatctc aatggctata tctacatttt gggggggcga
     1621 gaccctatta ctggagttaa gttgaaggaa gtggaatgct acaatgttaa gagaaaccag
     1681 tgggcattgg tggctccact gccccattct tttttatcct ttgacctaat ggtaattcga
     1741 gactatctct atgctctcaa cagtaagcgc atgttctgtt atgatcctag ccacaatatg
     1801 tggctgaagt gcgtttctct gaagcgcaat gactttcagg aagcctgcgt cttcaatgag
     1861 gagatctatt gtatctgtga tatcccagtc atgaaggtct acaacccagt tagggcagaa
     1921 tggaggcaaa tgaataatat tcccttggtc tcagagacca acaactacag aattatcaag
     1981 catggccaaa aattgttgct catcacctct cgcaccccac agtggaaaaa gaaccgggtg
     2041 actgtgtatg aatatgatat taggggagac caatggatta atataggtac cacattaggc
     2101 ctcttgcagt ttgattctaa ctttttttgc ctctctgctc gtgtttatcc ttcctgcctt
     2161 gaacctggtc agagtttcct cactgaagaa gaagaaatac caagtgagtc tagcactgaa
     2221 tgggacttag gtggattcag tgagccagac tctgagtcag gaagttcaag ttctctttct
     2281 gatgatgatt tttgggtgcg tgtagcgcct cagtgaaatg cacaggatca acagggtttg
     2341 ttgtaactag attgaaacac taagttgttt ttactgtttt ggaaaatatc ttaaatatcc
     2401 tttttgttcc taaaggagag gaaaagttga ttaacttctg gtttggttta gaaaaagtaa
     2461 tgtttgaaat acgaaggtaa tttaatgtta caaattttaa cactcaaatc aaccttttaa
     2521 taattttctg tgctaagggt ccagtattta tttgattatt tagtatgttt atgtttcatg
     2581 acactaattt agtcttttga tacattttac attctgttta ctgccacaag cactgtggca
     2641 ataacttttg aattttaatt tttataatag aaaaatgatt aggaattgct agatagtgtt
     2701 ttgaaagcat atctttttct tcagaacaat gtagacttcc aaaatggtta acctaagggg
     2761 tctttacaaa atgtgttata agttaaacat aatttgggaa gttttacttt tgttttcttc
     2821 tatgaagaaa aaaatgcagg ctgggcgcgg tggctcacgc ctgtaatcct agcactttgg
     2881 gaggccgagg caggtggatc acctgaggtc agttcaagac cagcctggcc aacatggtga
     2941 aaccccgtct ctactaaaaa tacaaaaatt agctgggcgt ggtggcatgc gcctgtaatc
     3001 ccagctaccc aggaggctga ggcaggagaa ttgctgaaac ccgggagtca gaggctgcag
     3061 agagccgaga ctgggccact gcactccagc ctggatgaca gagtgagact ccgtctcaaa
     3121 aaaaaaaaaa aaaaaaaaag gaaaaaaaaa aaagaaaaaa aaccatatgt gtattagggt
     3181 gactgagtgg tgacttcatt tataataata cagagaatag ctataagctc attgacagta
     3241 aaaacaacaa accaggattc tactgtttga aaagaagttt cgttttaatt ttggaattta
     3301 gaatgtgtat ttgcaaagtc accaattttc atctaaaagg ttatattcta gttgtgtcac
     3361 caaatcatca aaaaacctta aaaaagaagt aacttgcttt gtaggtttgt attgttgatc
     3421 taaacctgat acatgcttca tttaatcagg aataatcctt ttttttctgc tggacatgta
     3481 taaatttcac tggattgtat aaatttttat ctattgcctt aaacatttac atgattctca
     3541 atatgtttta gctgtacagt tttggtgttc atcttagagg attcttcagc agaagtgata
     3601 tttctttact gttttgtgag gtaatactga ttttgaaaat atatataagc taaaaacagt
     3661 atttcgttga tatcagtagt cattgtgtta actataaagt caagtgccag caaagaactt
     3721 taaaactgta aagctgtgta tagaactgtt ttgtgtagca tggaaatatt ctgtcagctt
     3781 tttaaagtca ctaaatgttc ttgattatca gcttgaaggt atttttgtat tacaagttga
     3841 cagttgctgg gtgtagtggc tcatgcctgt aatcctagca actcggggct gaggtgggag
     3901 gattgcttca gcccaggagt ttgagaccag cctgggcaac atagcaaaac cccatctcta
     3961 caaaaataaa aaatatgtct gggcatggtg gcccaagtct gagtcccagt tacttgggag
     4021 gatcacttga atgtaggatc acttgagtct aggagttcgg ggctgcagct atcatctgca
     4081 gctataatca tagctcactg cagctatgat catgtctcag cactccagct ttggcaacag
     4141 aacgagatcc catctcttag aaaaacaaag ttgatagtta aagaacataa gtggatgatg
     4201 gcatttgagg ccactagtga aagtatgttt tctctaaaat atttctctaa tagtgatata
     4261 aatggctatt ttattatgat gtttgtatgt gttttgtatt tctctgtaaa ccatgctcca
     4321 gtctttgttt ttctgttacc ataatgtaag agaaggtcct ggaacagaga ctaaatccca
     4381 cgaaactgac attgttaaac acactaaaac agaagtactt acctcttgaa gatttaatat
     4441 ataatggttg acatgataca tgtacatgat gaatgaccag atgcttatgg tctacatttt
     4501 cctttatcct gttagtatta ccttccttaa tctttgttca ttaacatgct aattcctctt
     4561 cagtgtttat tttctagtga cagaatgcta acatttctta caccctggca gaagggagag
     4621 aaatgtgttt tggggtgggt aactaaattt ttgagtgaaa tatcataaga tgagaatgga
     4681 aagagggaga cacaaagagt tataacaaaa aaacaatggt ttttttagcc atttgactgg
     4741 ctctttaaat agtctacaag acattcacgt ttaacatcac ttttagtgaa ataaaatgtg
     4801 ccatactagt atgtgcttca aaagggcaaa tgtgctttag tgccctaagg ctaaattttg
     4861 gtcatttgac atcagagatg ttgtaagtat tgcacttaat acgcacctat ttctcaatag
     4921 tgttattttt tggctagcat tttctttacc actatcttgt tgatagcttt ttgttctcta
     4981 aggttgaaac atgacagtgc ttatctcaaa cagattaccc atctgcagaa ctaaggaaag
     5041 caatttatgt atgaaagaaa ttcttgaatt cgtcattctc aacctttgaa ttaaagctta
     5101 gactaaatag taatatatcg tgggaaggat tttggttttg tgatatttct gtgaattaag
     5161 gaatagatgt taaccattat tttgtagaaa agtgatttgt atgtggttaa ttataaataa
     5221 aactggtacc agaa
//
