LOCUS       NM_207335               5727 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens kelch repeat and BTB domain containing 12 (KBTBD12),
            transcript variant 1, mRNA.
ACCESSION   NM_207335 XM_005247167
VERSION     NM_207335.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5727)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011311.11.
            
            On Nov 30, 2019 this sequence version replaced NM_207335.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.99248.1,
                                           SRR1803613.159919.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405109.5/ ENSP00000385957.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               AC011311.11        164820-165174       c
            356-1537            AC011311.11        156275-157456       c
            1538-1808           AC011311.11        152372-152642       c
            1809-1959           AC011311.11        150123-150273       c
            1960-2157           AC011311.11        117020-117217       c
            2158-5727           AC011311.11        92740-96309         c
FEATURES             Location/Qualifiers
     source          1..5727
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..5727
                     /gene="KBTBD12"
                     /gene_synonym="KLHDC6"
                     /note="kelch repeat and BTB domain containing 12"
                     /db_xref="GeneID:166348"
                     /db_xref="HGNC:HGNC:25731"
     exon            1..355
                     /gene="KBTBD12"
                     /gene_synonym="KLHDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            356..1537
                     /gene="KBTBD12"
                     /gene_synonym="KLHDC6"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..2339
                     /gene="KBTBD12"
                     /gene_synonym="KLHDC6"
                     /note="kelch domain containing 6; kelch domain-containing
                     protein 6; kelch repeat and BTB (POZ) domain containing
                     12"
                     /codon_start=1
                     /product="kelch repeat and BTB domain-containing protein
                     12"
                     /protein_id="NP_997218.2"
                     /db_xref="CCDS:CCDS33848.2"
                     /db_xref="GeneID:166348"
                     /db_xref="HGNC:HGNC:25731"
                     /translation="MECKIEGKEKYQHSLNLLNKIQNMKELAEMIDVVLTAEGEKFPC
                     HRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQ
                     TVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHF
                     AEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRTVHLVELLK
                     QVRLELVNPSFLRQALRRNTMLLCDADCVDIIQNAFKAIKTPQQHSLNLRYGMETTSL
                     LLCIGNNSSGIRSRHRSYGDASFCYDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTI
                     IVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCTAEFRELYALGSIHNDLYVIGG
                     QMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDL
                     PDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQDKG
                     QVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLYVCGGFHGADRH
                     EVISKEILELDPWENQWNVVAINVLMHDSYDVCLVARMNPRDLIPPPSDLVEEGNEH"
     exon            1538..1808
                     /gene="KBTBD12"
                     /gene_synonym="KLHDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1959
                     /gene="KBTBD12"
                     /gene_synonym="KLHDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2157
                     /gene="KBTBD12"
                     /gene_synonym="KLHDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..5727
                     /gene="KBTBD12"
                     /gene_synonym="KLHDC6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5707..5712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KBTBD12"
                     /gene_synonym="KLHDC6"
                     /note="hexamer: AATAAA"
     polyA_site      5727
                     /gene="KBTBD12"
                     /gene_synonym="KLHDC6"
                     /note="major polyA site"
ORIGIN      
        1 agtagggtac gggacgcgcg cggggagacc ctgtgcagcg acaccggggc tgtagtcgcc
       61 gtctggaacc agcgcgggaa taggtgcgca ggcgcacagt ggctggaggg cagcggcggc
      121 gtggtctcgg gccacttcca agcagagggc agcacctgtc ccctcggagg cgctgccagc
      181 gccctccctc ctcctccgca gggcgcggga cctctattta tatcgcccag ccagcacagg
      241 cccatattgg gcagtggcct cagtcaggcc cgctggccgc cctgccacac ggtagcgtcc
      301 aagccaggtc gtggcccagc gagtggggac gcgccccgaa ccaggcagca ccttcaaatg
      361 tttcctgaca tctttgtagc ttcatgagta atcagacatg caaatagccc ctcaggaatc
      421 aagctacact taaagaagac ttagttggaa actttggaga gtagatcatg gagtgcaaga
      481 ttgagggaaa agaaaaatac caacatagct tgaatttact gaataaaatt cagaacatga
      541 aagaattagc agaaatgatt gatgtggtac tcacagcaga aggagagaaa tttccttgcc
      601 acagactggt cctggctgca tttagccctt atttcaaagc tatgttcacc tgtggactac
      661 ttgaatgtaa tcaaagggaa gtcatacttt atgacatcac agcagaaagt gtgtcggtgt
      721 tattaaatta catgtacaat gcagctttgg agatcaataa tgccaatgta cagactgtag
      781 ctatggctgc ctattttatg cagatggaag aagtcttcag tgtgtgtcaa aaatatatga
      841 tggaccacat ggatgcctcc aactgtttag gtatctatta ttttgcaaag cagattggag
      901 ctgaagattt atctgatcga tcaaagaaat atttatatca gcactttgcc gaggtgagct
      961 tacatgaaga aatactagaa atcgaagtgc accaattttt gacacttatt aaatcagatg
     1021 atcttaacat atccagagaa gagagcattc tggacttagt tctgagatgg gtaaatcata
     1081 acaaagaatt gcgtacagtg catcttgttg agcttttgaa gcaagtcaga ttggaacttg
     1141 taaatccttc ttttttaaga caagccctaa gaaggaacac aatgcttctg tgtgatgcag
     1201 attgtgttga cataattcaa aatgcattca aagccatcaa gacaccccaa cagcactctc
     1261 taaatctgcg ctatggtatg gagactacca gtcttctgct ttgcattggc aacaattctt
     1321 caggaatcag atcaagacat aggagctatg gggatgccag tttttgttat gatcctgtat
     1381 cacggaaaac ctatttcatc tcatctccca agtacggaga gggtttagga actgtgtgta
     1441 ctggtgttgt catggaaaat aatactataa ttgtggctgg agaagcaagt gcctctaaac
     1501 tctctagaca aaagaacaag aatgttgaaa tttataggta tcatgataga ggaaaccagt
     1561 tttgggaaaa gttatgcaca gctgaatttc gagaactcta tgctctgggc agtattcata
     1621 atgaccttta tgttatagga ggacagatga aaattaaaaa ccagtatctt attacaaact
     1681 gtgttgataa gtactctgta gaacgggaca attggaaaag ggtgtctccc cttccactgc
     1741 aattggcatg tcatgctgta gtgacagtga ataataaact ttatgtaatt ggaggctgga
     1801 cccctcagat ggatcttcct gatgaagaac ctgatcgatt aagcaacaaa ctgttgcagt
     1861 atgaccccag ccaagatcaa tggagtgtgc gggcacccat gaagtactct aagtaccgat
     1921 tcagtacagc tgtagtcaac agtgagattt atgttttggg tggcattggc tgtgtaggtc
     1981 aagacaaggg ccaggttcga aaatgccttg acgtggtgga gatctacaac ccagatgggg
     2041 acttttggcg agagggccct cccatgccaa gtcccctcct ctcactccgc accaattcca
     2101 ccaatgcagg ggcagtggat gggaaactct atgtctgcgg gggattccat ggagcagatc
     2161 gccatgaggt tatctccaaa gaaatattgg aactggaccc atgggaaaac cagtggaatg
     2221 ttgtagccat caacgtcctc atgcatgaca gctatgatgt ctgcctagta gccaggatga
     2281 atccccgaga cctcatcccc ccgccttcag atttggtgga agaaggcaat gagcactaag
     2341 gtgaccttgc tggaggacct cctgctgttc tgcaaacaag gccttcagaa cggagagggc
     2401 ccacagcatc tctgtcatgc cagtcatgtg cactgcatgc gtagtggcct gtgtgtgaag
     2461 aagcagtgtg tgctgggcac tgggtgggga gcatggggag tctcccttca gggacttccc
     2521 agcctgatag ggtaaataag acactacaaa gaagaggtga tgacggccac aggaggggca
     2581 cagggccaca ggagagcagc agagggaggg tctcactctg ctggggaccc atgaacagca
     2641 ctgccaagga gcagaccttt tattgggtcc ccaaaaggat gaggaggaag tggtcccatg
     2701 ggtgcagtca atgatgagtt catggaaaca gccaagcaag ggcccagaga cagaaagctc
     2761 gtgcctgtct gcagtatcct ggctgggcca gattgcctgg ggcacagggt ttgtggtcaa
     2821 ggctggaaaa gtaggttgta gctagatgac caacgcctga aagaatgagg agttggacct
     2881 ggtctgtaag ccagggaatt gtctcaaaat cgtgcattaa gggagacttc tctctgtgct
     2941 ctgttccagc ttcagtctta taaacactga ccattctcct tcagaatccc cttctactga
     3001 agcaacgcca cccagcagca gggctagctg tactaccagc ccctaacaac caaggcactc
     3061 aagccagacc acagtggcca agaatcctgc cctgggctga ctctgtccgg gacagggatg
     3121 tggggttctg cagcctggtc cactccgggg ctggcaggga gtgtcctgga gtgggctgac
     3181 ccaggctgcc tttgcccacc tctcagacac atacaaccat ctgcagggta gtcctggctg
     3241 aacaggactc gcccaagcca cccaagccag ggacagagaa ggctctggct gaggacaggg
     3301 gaagaagcat ctcctccagc tgctgccaac cccatggccc ggcctttgca ataaagatgg
     3361 agccacccac ttcagcccac aattgagcat aatcagaaga cagtcactcc caaaatatat
     3421 gttagaaata acatttaaat gacacatggg aagtccgtct atcttacttc ccgtctctaa
     3481 ttctggaagc acagtggatt caatgagggc atcttcatag ctcttcttca gcaacttctc
     3541 caaagagttt cacattgcac aaggctcttt tggaagcagg agtggtcagt aaattcagag
     3601 ggagacaaac cctaagtaga gacagctttc tttggtgctg agctgtgtga ttgtgatgac
     3661 cgctagcctg tgcccctagg ttccagctgc ccaccaggca ggacaggcag gtcttgccaa
     3721 aactggagcc tgttggaaac ctatttctgc caccaaggag agggaccagg agacccagcg
     3781 taggttggcc ccaagtaggc tcaactcggg agggtggggg tcccgccttt ctcttcgcac
     3841 ttgtgcccca agtgcactca cagtacctgg catgtgggtg acctcttggg tggccggcat
     3901 ggggcagtgt ttctcaatca gagggcctgg gccccgagca cgtccaggaa tctgagttaa
     3961 agtgagctta ctctttcccc agtggatgat catgatctgt gcattctttt tcttgctaca
     4021 aagatgttcc tcctagctgc tgtgttggct gtcggcggcc agggttgagg acggcctcca
     4081 cagggcctcc acttccctcc attcctcttc acatagtcac tccacctgct ccacctgctt
     4141 gaaaagtcca gaaagctgcc gcgtctccct ggctcaagga ggccttgttg gcatgtcatg
     4201 gcacatctcc tagatgtttt gggttcaaga tctgggttcc agcccccgct ctgctactta
     4261 gctaaccatg tgaacttggg caagatgacc tttctaaagc ctcatttccc tcatatgcag
     4321 agtgggaagg aaaatattaa tacatacttt atagggttgg tatgaggatt aagtgctgag
     4381 caaagtgcct gtgaaatcct gaaataataa gcatgtttta gctgccatta ttatcatcac
     4441 tgtcattatc attgcagtca gcacttccca aagcaaggtg cccaaaacag actcagtgct
     4501 ttagggaagt ggggcagatg tgcatatggc ttgtgacggt tctttctttt tttttttttt
     4561 tttgagacgg agtctctctc tctcgccagg ctggagtgca gtgcagtggc acgatctcag
     4621 cccactgcaa cctccgcctc ccaggttcaa gtgattctcc tgcctcagcc tcccaagtag
     4681 ctgggattac aggcgcccac caccacaccc agctaatttt tgtattttta gtagagacgg
     4741 ggtttcacca tgttggccag gatggtctca atctcttgac ctcgtgatct gcccgcctcg
     4801 gcctcccaaa gtgctgggat tacaggcatg agcccctgca cctggctgag atggttctta
     4861 atttcccata ccctgttgct tggctcctcc agttggcggc tgagagttaa gcaagggttt
     4921 actcggatct gaggcccccg atgccctcaa tggacacatt caggaccctg tggcagctca
     4981 gcagaggcac ctgagggtca cgctaggtga gaccatcgcc cgcctgtggg aggcaagata
     5041 agtgggtaaa catcattcct gtctaatgcg aggtctgggc agtgtcccag tggaactttc
     5101 cagagagtgc caagggagga ccgagaaggg gcatgacctc tgctggagcc aggagggcag
     5161 tgaccaggag ctggcttagc actgaaggga agcaggcatc aagggcagga tttctcaaac
     5221 ttcttctgag gaatccccga ggtcgaaacc ggtgcttcac agatttcaga tgtctgatct
     5281 tgatttttct ttgattccat acaacagatt gcttgcctgg gttagtgctt attttaagtt
     5341 cttggtgctt cttgtctgac ttctgtattt gcaattaaaa acaacatgac cctccccacc
     5401 tgcagccaga tatcgttaga aattcaactt cgaaatatat tcctatcact cctgttttca
     5461 ctttaataga aggctgttgc agtactgcat gatgggctct tataaaactt ctactatctg
     5521 ctaattctta tctttgtgac aggattgttt gacactgagc aaggaaacac aataaggaag
     5581 taatttggat gctaggctgg cagaagcctg cagctgtcaa ccacagcctg ccccagtgtg
     5641 ttcaacacgg tggcattgtt ctccctgact tcataatgag caaatgtttc acatttgaac
     5701 ttaaggaata aatttttact aataaaa
//
