LOCUS       NM_014867               6911 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens kelch repeat and BTB domain containing 11 (KBTBD11),
            mRNA.
ACCESSION   NM_014867 XM_376736
VERSION     NM_014867.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6911)
  AUTHORS   Gong,J., Tian,J., Lou,J., Wang,X., Ke,J., Li,J., Yang,Y., Gong,Y.,
            Zhu,Y., Zou,D., Peng,X., Yang,N., Mei,S., Zhong,R., Chang,J. and
            Miao,X.
  TITLE     A polymorphic MYC response element in KBTBD11 influences colorectal
            cancer risk, especially in interaction with an MYC-regulated SNP
            rs6983267
  JOURNAL   Ann Oncol 29 (3), 632-639 (2018)
   PUBMED   29267898
  REMARK    GeneRIF: Our study highlighted the high colorectal cancer risk of
            people carrying MYC rs6983267 G and KBTBD11 rs11777210 C alleles
REFERENCE   2  (bases 1 to 6911)
  AUTHORS   Cornelis,M.C., Fornage,M., Foy,M., Xun,P., Gladyshev,V.N.,
            Morris,S., Chasman,D.I., Hu,F.B., Rimm,E.B., Kraft,P., Jordan,J.M.,
            Mozaffarian,D. and He,K.
  TITLE     Genome-wide association study of selenium concentrations
  JOURNAL   Hum Mol Genet 24 (5), 1469-1477 (2015)
   PUBMED   25343990
REFERENCE   3  (bases 1 to 6911)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 6911)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   5  (bases 1 to 6911)
  AUTHORS   Verhoeven,K., De Jonghe,P., Van de Putte,T., Nelis,E., Zwijsen,A.,
            Verpoorten,N., De Vriendt,E., Jacobs,A., Van Gerwen,V., Francis,A.,
            Ceuterick,C., Huylebroeck,D. and Timmerman,V.
  TITLE     Slowed conduction and thin myelination of peripheral nerves
            associated with mutant rho Guanine-nucleotide exchange factor 10
  JOURNAL   Am J Hum Genet 73 (4), 926-932 (2003)
   PUBMED   14508709
REFERENCE   6  (bases 1 to 6911)
  AUTHORS   Ranta,S., Lehesjoki,A.E., de Fatima Bonaldo,M., Knowles,J.A.,
            Hirvasniemi,A., Ross,B., de Jong,P.J., Soares,M.B., de la
            Chapelle,A. and Gilliam,T.C.
  TITLE     High-resolution mapping and transcript identification at the
            progressive epilepsy with mental retardation locus on chromosome 8p
  JOURNAL   Genome Res 7 (9), 887-896 (1997)
   PUBMED   9314494
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC019257.3 and AB018254.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014867.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB018254.1, ERR3218371.83971.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320248.4/ ENSP00000321544.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC019257.3         43347-43547         c
            202-696             AB018254.1         1-495
            697-6911            AC019257.3         10288-16502         c
FEATURES             Location/Qualifiers
     source          1..6911
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.3"
     gene            1..6911
                     /gene="KBTBD11"
                     /gene_synonym="KLHDC7C"
                     /note="kelch repeat and BTB domain containing 11"
                     /db_xref="GeneID:9920"
                     /db_xref="HGNC:HGNC:29104"
                     /db_xref="MIM:618794"
     exon            1..259
                     /gene="KBTBD11"
                     /gene_synonym="KLHDC7C"
                     /inference="alignment:Splign:2.1.0"
     exon            260..6911
                     /gene="KBTBD11"
                     /gene_synonym="KLHDC7C"
                     /inference="alignment:Splign:2.1.0"
     CDS             1168..3039
                     /gene="KBTBD11"
                     /gene_synonym="KLHDC7C"
                     /note="chronic myelogenous leukemia-associated protein;
                     kelch domain-containing protein 7B; kelch repeat and BTB
                     (POZ) domain containing 11"
                     /codon_start=1
                     /product="kelch repeat and BTB domain-containing protein
                     11"
                     /protein_id="NP_055682.1"
                     /db_xref="CCDS:CCDS34795.1"
                     /db_xref="GeneID:9920"
                     /db_xref="HGNC:HGNC:29104"
                     /db_xref="MIM:618794"
                     /translation="MEHAVAPCVLYPGTEPGAAGESESEGAASPAQTPCSLGASLCFS
                     SGEESPPQSLASAAEGAATSPPSSGGPRVVERQWEAGSAGAASPEELASPEERACPEE
                     PAAPSPEPRVWLEDPASPEEPGEPAPVPPGFGAVYGEPDLVLEVSGRRLRAHKAVLAA
                     RSDYFRARASRDVLRVQGVSLTALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLPG
                     AAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLEVLREPAVFGRL
                     SGAERDLLLRRRLRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAA
                     GEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSW
                     SAVRPLRQARSQLRLLALDGHLYAVGGECLLSVERYDPRADRWAPVAPLPRGAFAVAH
                     EATTCHGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLS
                     GSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCVS
                     RAGTWRFQPAREGEAGGDAGQGGGFEALGAPLDVRGVLIPFALSLPEKPPRGEQGAP"
     regulatory      6886..6891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KBTBD11"
                     /gene_synonym="KLHDC7C"
                     /note="hexamer: AATAAA"
     polyA_site      6911
                     /gene="KBTBD11"
                     /gene_synonym="KLHDC7C"
                     /note="major polyA site"
ORIGIN      
        1 gcgccccgcg cgcgcccctc gcagcctgga gccggagcgc tggctccgcg cggcctggag
       61 aggcggagag gcctgtccac cgccccctct gccgcccacg ccccgctgcg ggtcggagga
      121 gcagctcccg ctcgcaggtg ctcggagagg ccgggccgcg gctcccacag gtgccgggaa
      181 gcggccgcgc gcatgcgccg gagcccaccc gcctggctgc gcgtcccggg cccggcggct
      241 gaagaggagc cgcggcgagg aacaagagtg tggtgagagg acgcggaaac acctgatatc
      301 ccagcaaagg aagctgcaga ggaagggtcc tgccccgtga gcgaggacag cctccaggag
      361 cacagcggct tctcctaaca tccccctggc agtgaattac ggatgacccc gtatatgagg
      421 aggtgtggat gccgacacac ggggagagct cctgagacca gcacacagga ccagtgtcct
      481 ccccgtgacc ttgcagttgt gtagccacaa gtgggagcca cagagaagga gagcccataa
      541 ggggactctt ttcaagacac ggtgttaaat caaggctctg aagttggggc cacagccggt
      601 ctcagctttc tgtgttctgg gggcgcggtg atatgacagc atgtgaagtg agtgggtgag
      661 cacggactcc tgagagcgag ggcgcaccca atacctggtt atctggtact gcagagagac
      721 acctagtcag ccagcgttgc aaagagggat agctagtcac tcaggctgca gagagagaca
      781 cctggtcacc caggctgcag aaacaaccgc agtcaactgc agctccagtc attgctggat
      841 gttggctgac gcggtcctgg cgccagctgg agatccattc accaagactt tctgggcaga
      901 tttaaagtgg ctggggttca gaagttcagc aagtcggaca cacccctcct cgctggagag
      961 gagagggcaa aggcgaggcg ggggagcagc gtgtgagatt ccccccttca cacacacaac
     1021 aacaaagcgt ggacacacag aagtgaaatc tgatcgcgtg ccaggaaaag ctgtgaggct
     1081 ggaaaccccg gagtaaggct cgaccttggc cagacctgca ggctgcggaa ccgggggcgc
     1141 gcgggcgcag cgcagcacag cccggccatg gagcacgcgg tggccccctg cgtcctctac
     1201 ccagggactg agcccggggc tgccggggag agcgagagcg agggcgccgc gtccccggcg
     1261 cagacaccct gcagtctcgg cgcgtccctg tgcttcagct ccggggaaga gtccccgccg
     1321 cagtccctcg cctcagcggc ggaaggcgcg gccacctccc cgccctccag cggtggcccg
     1381 cgggtggtgg agcggcagtg ggaggccggc agcgcgggcg ccgcgtcccc ggaggagctc
     1441 gcgtcccctg aggagcgcgc gtgcccggaa gagcccgcgg cgccgtcccc cgaaccgcgc
     1501 gtttggcttg aggaccccgc gtcccccgag gagcccgggg agcccgcgcc cgtacccccg
     1561 gggttcgggg cggtgtacgg ggagccggac ctggtgctgg aggtgtcggg gcgccggctg
     1621 cgcgcgcaca aggcggtgct ggcggcgcgc agcgactact tccgcgcgcg cgcgtcgcgg
     1681 gacgtgctgc gggtgcaggg agtgagcctg acggcgctgc ggctgctcct cgccgacgcc
     1741 tacagcgggc gcatggcggg cgtgcggccc gacaacgtgg ccgaggtggt ggccggcgcg
     1801 cgccgcctgc agctgcccgg cgccgcgcag cgcgccaccg acgccgtggg gccgcagctg
     1861 agcctggcca actgctacga ggtcctgagc gcggccaagc ggcagcggct gaacgagctg
     1921 cgcgacgccg cctactgctt catgagcgac cactatctgg aggtgctgcg cgagcccgcc
     1981 gtgttcggcc gcctgtcggg cgcagagcgg gacctgctgc tgcgccgccg cctgcgcgcc
     2041 ggccgcgccc acctcttggc cgcggcgctc gggccggcgg gggagcgcgc gggcagccgg
     2101 cctcagagcc cctcggggga cgcggacgcg cgcggggacg cggccgtcta ctgcttccac
     2161 gcggcggccg gagagtggcg cgagctgacg cggctgcccg agggcgcgcc ggcgcggggc
     2221 tgcggcctgt gcgtcctcta caactacctc ttcgtggcgg gcggcgtggc gcccgcgggc
     2281 cccgacggcc gcgcgcgccc gtccgaccag gtcttctgct acaacccggc cacggacagc
     2341 tggagcgccg tgaggcccct gcgccaggcg cgctcgcagc tgcggctgct ggccctggac
     2401 ggtcacctct acgccgtggg cggcgagtgc ctgctcagcg tggagcgcta cgacccgcgc
     2461 gccgaccgct gggcccccgt ggcgccgctg ccccggggcg ccttcgccgt ggcgcatgag
     2521 gccaccacct gccacggcga gatctacgtg tccgggggct ccctcttcta tcgcctgctc
     2581 aagtatgacc cgcggcgcga cgagtggcag gagtgcccgt gcagcagcag ccgcgagcgc
     2641 tcggccgaca tggtggctct cgacggcttc atctaccgct tcgatctgag cggcagccgc
     2701 ggcgaggcgc aggcggcggg gccgagcggg gtcagcgtgt cccgatacca ctgcctggcc
     2761 aagcagtgga gcccgtgcgt cgcgcccctg cgcctccccg gcggccccac gggcctgcag
     2821 cccttccgct gcgccgccct ggacggcgcc atctactgcg tgagccgcgc gggcacctgg
     2881 cgcttccagc ctgcccggga aggcgaggcc ggcggcgacg caggccaggg cggcggcttc
     2941 gaggcgctgg gcgccccctt ggacgtccgg ggtgtgctca tcccgttcgc tctcagcctg
     3001 cctgagaagc cgccccgagg ggagcagggc gccccgtagg ccggcggggt cggcgggcgt
     3061 ctccctcggc aggggtttgc ggggcccagg tccctttggg cccgcggagg aggacgtggt
     3121 ggggagtcgg ggccgctggc cacgctggtg gtttggacac ttcgaaggag ccccgaggac
     3181 gctctcaggg ccgctttcgc tttgctttcc ttttgcttgt ctttgcttct gggggtggat
     3241 gccttgagac ccaggaggtg tgcggatggg tcccttgaca gacaggacac agagaaggct
     3301 gtgggatcca aagggtcagc ctcagggtac agtgggggtt cctgaggcag cctgcagccg
     3361 gccccggggt gtcccgaacc ccgcagagca ccgaggctgt gcgcaggagc ctgggaccct
     3421 caagtaggtc gccgcgaact atcgggggaa gcacgcagag agggtcacgc cttttatttt
     3481 tggcttgaga tttaaaatta taactgataa gtaaagctct ttctgattta gttgaaaatt
     3541 tcgtaccatg tgctcgcttt ggttggctca actccaaaaa gagtaattta ataagcatta
     3601 aaggtaaaat ctttgattac cagtaaggtt tcttgttcaa tatgcattgg aagtatttcc
     3661 ttccccacac cattgctact caaactcaca tgcctagagc agctccgtct cactgttgga
     3721 ccgagggggc tttcatattt tcagttgaaa ggatgttaac tgatgtagcg atgatttacc
     3781 attatttaaa ttttaagtct tcagtggcta aatgtgacca aacagcacat cataagtagg
     3841 aaaaacttac cagggtgctt gtctatctaa aaagcaatct ttgatagtcc actctgtatg
     3901 cccagccgct ttcataatct ggaacgagat aaaatattcc taaaaagcgg ggaaaatcat
     3961 tttgctttga cagttctata aaaaaaagtg taggcacatt ttaaacccac tgtatatgat
     4021 gttttcaatg tggatcgtgt agttctgatg agggagatta atttttacaa tcagtattct
     4081 aagtgtggcc gagtgacagt gggcatagat ttataacaag gaagtgacgt gcttatcacc
     4141 atagatttgc aagtaaactg catgtattta attgtattga attgagttcc aaaataccct
     4201 aatagaatta acacgaggct cactgcattg acagggtatg aggattaaaa acaaatcagt
     4261 tgggtcgttt ctcatttaac attttacttt tcaagtgtgt atacagagga cttactatta
     4321 tgactttgag gatgagatcc atgctcacaa atagaggcga acatttgaac tccgaatcca
     4381 acccattttc ttactgtaag aggaaaagtt actggaacgt aactagttga aatcctgcct
     4441 actttaatat tatttgtttg ttaatccagt aatgggaact gccatctctg tagaaatcag
     4501 tgggtaattg aaaaataggt tatgcttttt aaagagtctg tggttatgag aggtctcagt
     4561 taagtgtgtt tagaagtgat cagcttgaac cttatgcatg actcgggggc tggaatttat
     4621 gatctgggtt acggtatgtt ctggggacgt gtctgcttgc ccatggttac tcatgaactg
     4681 aggggatagc ttggcaactt ggttaatcat cttgggaaag aaaaacagac ttcatatcgc
     4741 ctgacttgat tggcctttta taggagtata ctggagaaat ggttgtagaa acagtattta
     4801 cagcaaaagg aaacaaataa tgttcatttt aagcaatgta ccattcacac tgtcctgcct
     4861 tttcctctag aattttatta atggtagaaa tttttatatg aaatgggacc aggaccaggc
     4921 taatattttc agtccttaaa tatcaaactc atatgctgtt atcactgtga ttttacttgt
     4981 gaaatcattc ctgtaatgtt tattgtttga aaatgaaata ttgaaattag gcttccagag
     5041 taacactgtc cccggaaaag gatatgagaa gtggtggatg ttggatgggg gtggttgcac
     5101 agtcctgtgc ggttcccatg gctttccagc gtttcattta gtgaaggaat gctcacacta
     5161 gatgtagcac agcttcctgt ggggcccggc agcaaagccc caggtgctcc ctgtcacctc
     5221 acaacaaaat gcactaagaa acgtaaagaa taagaggaat taatacccac cattaaagga
     5281 tgtccggcca acctattgtg gaaatttata gaatagtata caccacagtt ctgaatagtg
     5341 atatcacata aaaatacata ctagaggacc tgccacgcca tgagcagtgt ttttgctttt
     5401 tgggggccag tccctggggt gtggagccgc tagggtttgc acccatgaaa cagagaaaag
     5461 ccacaccctc caaggtgtgg ctttcatttt gggactgctg cagggagggc agaggcattg
     5521 ctgagactgc ctggcaacgg ctgatgcccc aggtaggacc ttttccaatt caaagtggtg
     5581 ttctaagtct gcgtccaaca ctgtgtagga aaaaggttgg tgcaaaaata ttcctggtca
     5641 tccacccatt aaaatagtta gatgaggcta ttgccttgat gacagctgtc cacactcctc
     5701 atgaaattaa cccgtatgcc ggggcatttc caaatgtctg actcgtgaaa ttaacccata
     5761 cgcaggggcc tttccaaatg tctgaaaagg cagtggtgtc ttttggggaa aatgttatgc
     5821 atggaagcct gaccttttgc ttagttgaca gcaatccctt ctgtattgcc aatcaaggtt
     5881 catttgagat gcagaggaat gagcttgagc cttcctcctt ttccttccgg ttttattctt
     5941 cctcttggga acatccctcc actccgcact gcttcctgca gctttgtaga gctggatttg
     6001 gaacttcggg atttggtttc tgagtctgtg gaggcaccga cttctgctgt aagaaaatga
     6061 atgttgtgga aattctttgg ctacttaact aaaactcgtg actgtataag tttggctaca
     6121 aataagtaag aaattaatca tctgctctgt ttctgctaat ttctggtgtc acttcagtaa
     6181 ttctggtagc agccgttgaa tctgtcagtc tcttaggtaa cttcctgtaa acgatttgga
     6241 aataggatgt tttcaacgtt cttttgtctt ttgctgaagt caggatagat tcaagacata
     6301 atctcttgta agatctaaat agagcaaatg taaacaaaag tgcatttttg tattcttgtt
     6361 aattttagat gctttcctag cttacaaaaa gttctgtttt tgggttaaaa atcaatcaac
     6421 tttctgatat ttccccttct gcaatgttat tgttcataag aaaacacgag ctgaaaatgg
     6481 aaatctgcag ttgtttcagt tgtcttgaat ttctttcagt ggccacatca tttccacgtt
     6541 ttccacatcc gggaggaagc ctggactgtg cagccttcgg gcacccggca cagacactgt
     6601 gctggcagga gcttcagaca cgccaagtgg atggatttgg attgaacgca tatgaaacag
     6661 gagacgggtt ctcatgtgag atcaaagctc ctccaaagcc tgttcaagct ctaagcgatt
     6721 ctcaaatgtt accatttatt aaaggtaaac tacacctgtt gaaggccaag ttcagggcag
     6781 ctgttgtgat ctgtgtagtt aatgtattta ttaatgcttg acttttaaaa tcctgggcat
     6841 aaatagtgca gagcctcgta tgtttgtcag ttcatgccga gatgaaataa atcacgcaga
     6901 aagtgccagt c
//
