LOCUS       NM_201628               6049 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens kazrin, periplakin interacting protein (KAZN),
            transcript variant E, mRNA.
ACCESSION   NM_201628
VERSION     NM_201628.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6049)
  AUTHORS   Zhu,S., Bao,H., Zhang,M.C., Liu,H., Wang,Y., Lin,C., Zhao,X. and
            Liu,S.L.
  TITLE     KAZN as a diagnostic marker in ovarian cancer: a comprehensive
            analysis based on microarray, mRNA-sequencing, and methylation data
  JOURNAL   BMC Cancer 22 (1), 662 (2022)
   PUBMED   35710397
  REMARK    GeneRIF: KAZN as a diagnostic marker in ovarian cancer: a
            comprehensive analysis based on microarray, mRNA-sequencing, and
            methylation data.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6049)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6049)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6049)
  AUTHORS   Low,S.K., Chung,S., Takahashi,A., Zembutsu,H., Mushiroda,T.,
            Kubo,M. and Nakamura,Y.
  TITLE     Genome-wide association study of chemotherapeutic agent-induced
            severe neutropenia/leucopenia for patients in Biobank Japan
  JOURNAL   Cancer Sci 104 (8), 1074-1082 (2013)
   PUBMED   23648065
REFERENCE   5  (bases 1 to 6049)
  AUTHORS   Kim,D.K., Cho,M.H., Hersh,C.P., Lomas,D.A., Miller,B.E., Kong,X.,
            Bakke,P., Gulsvik,A., Agusti,A., Wouters,E., Celli,B., Coxson,H.,
            Vestbo,J., MacNee,W., Yates,J.C., Rennard,S., Litonjua,A., Qiu,W.,
            Beaty,T.H., Crapo,J.D., Riley,J.H., Tal-Singer,R. and
            Silverman,E.K.
  CONSRTM   ECLIPSE, ICGN, and COPDGene Investigators
  TITLE     Genome-wide association analysis of blood biomarkers in chronic
            obstructive pulmonary disease
  JOURNAL   Am J Respir Crit Care Med 186 (12), 1238-1247 (2012)
   PUBMED   23144326
REFERENCE   6  (bases 1 to 6049)
  AUTHORS   Wang,Q., Liu,M., Li,X., Chen,L. and Tang,H.
  TITLE     Kazrin F is involved in apoptosis and interacts with BAX and ARC
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 41 (9), 763-772 (2009)
   PUBMED   19727525
  REMARK    GeneRIF: These results suggested that Kazrin F might play an
            important role in regulating cellular apoptosis by interacting with
            ARC and Bax.
REFERENCE   7  (bases 1 to 6049)
  AUTHORS   Sevilla,L.M., Nachat,R., Groot,K.R. and Watt,F.M.
  TITLE     Kazrin regulates keratinocyte cytoskeletal networks, intercellular
            junctions and differentiation
  JOURNAL   J Cell Sci 121 (Pt 21), 3561-3569 (2008)
   PUBMED   18840647
  REMARK    GeneRIF: kazrin is a dual regulator of intercellular adhesion and
            differentiation in keratinocytes and regulates these processes by
            Rho-dependent and -independent mechanisms
REFERENCE   8  (bases 1 to 6049)
  AUTHORS   Uhl,G.R., Liu,Q.R., Drgon,T., Johnson,C., Walther,D., Rose,J.E.,
            David,S.P., Niaura,R. and Lerman,C.
  TITLE     Molecular genetics of successful smoking cessation: convergent
            genome-wide association study results
  JOURNAL   Arch Gen Psychiatry 65 (6), 683-693 (2008)
   PUBMED   18519826
  REMARK    GeneRIF: Clinical trial and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   9  (bases 1 to 6049)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   10 (bases 1 to 6049)
  AUTHORS   Groot,K.R., Sevilla,L.M., Nishi,K., DiColandrea,T. and Watt,F.M.
  TITLE     Kazrin, a novel periplakin-interacting protein associated with
            desmosomes and the keratinocyte plasma membrane
  JOURNAL   J Cell Biol 166 (5), 653-659 (2004)
   PUBMED   15337775
  REMARK    GeneRIF: Kazrin colocalizes with periplakin and desmoplakin at
            desmosomes and with periplakin at the interdesmosomal plasma
            membrane, but its subcellular distribution is independent of
            periplakin [kazrin]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL034395.6, BI916330.1,
            AY505119.1, DR003677.1, DN831635.1, DA317442.1, AL035405.13 and
            BX648256.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_201628.2.
            
            Summary: This gene encodes a protein that plays a role in desmosome
            assembly, cell adhesion, cytoskeletal organization, and epidermal
            differentiation. This protein co-localizes with desmoplakin and the
            cytolinker protein periplakin. In general, this protein localizes
            to the nucleus, desmosomes, cell membrane, and cortical actin-based
            structures. Some isoforms of this protein also associate with
            microtubules. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms. Additional splice variants
            have been described but their biological validity has not been
            verified. [provided by RefSeq, Aug 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2142680,
                              SAMEA2145245 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376030.7/ ENSP00000365198.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AL034395.6         92193-92224         c
            33-688              BI916330.1         1-656
            689-1316            AY505119.1         585-1212
            1317-1893           DR003677.1         8-584
            1894-2428           DN831635.1         144-678
            2429-2567           DA317442.1         415-553
            2568-5997           AL035405.13        91579-95008         c
            5998-6049           BX648256.1         5545-5596
FEATURES             Location/Qualifiers
     source          1..6049
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..6049
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /note="kazrin, periplakin interacting protein"
                     /db_xref="GeneID:23254"
                     /db_xref="HGNC:HGNC:29173"
                     /db_xref="MIM:618301"
     exon            1..539
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..2641
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /note="isoform E is encoded by transcript variant E"
                     /codon_start=1
                     /product="kazrin isoform E"
                     /protein_id="NP_963922.2"
                     /db_xref="CCDS:CCDS152.2"
                     /db_xref="GeneID:23254"
                     /db_xref="HGNC:HGNC:29173"
                     /db_xref="MIM:618301"
                     /translation="MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGG
                     GPGPGPGAAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKD
                     LEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQ
                     QLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDH
                     ATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVV
                     QADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTP
                     SDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVF
                     ARGKQRKSLDPGLFDDSDSQCSPTRQSLSLSEGEEQMDRLQQVELVRTTPMSHWKAGT
                     VQAWLEVVMAMPMYVKACTENVKSGKVLLSLSDEDLQLGLGVCSSLHRRKLRLAIEDY
                     RDAEAGRSLSKAAELDHHWVAKAWLNDIGLSQYSQAFQNHLVDGRMLNSLMKRDLEKH
                     LNVSKKFHQVSILLGIELLYQVNFSREALQERRARCETQNIDPVVWTNQRVLKWVRDI
                     DLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGIPSGKHILRRHLAEEMSAVFHPA
                     NSTGIREAERFGTPPGRASSVTRAGKEENSSGLKYKAGRLPLGKIGRGFSSKDPDFHD
                     DYGSLQNEDCGDDDPQSRLEQCRLEGYNSLEVTNV"
     exon            540..731
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            732..868
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1039
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1229
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1360
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1411
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1535
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1741
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1860
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2092
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2194
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2361
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2476
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..6049
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6029..6034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /note="hexamer: AATAAA"
     polyA_site      6049
                     /gene="KAZN"
                     /gene_synonym="C1orf196; KAZ"
                     /note="major polyA site"
ORIGIN      
        1 cttcttggag cagctctcgg cgcccgcccg ccggggtctc ggcgatcgct gctcctcctc
       61 ctccttctcc tcctcttttt tctcctccgc ctcctccccc cgccgcctcg ccaccgccgc
      121 ggctagggct ggaggcgccg ctgtcattcc tgtgccggag gaaccggcgc tgccggtgcc
      181 tgggggtcgg ggcgcgggcg aagccgggcc gcggaggaca caacaggtag agccgggggt
      241 gcccggccgc gcgccccccg cgcatcatgc agctctttgt cacctctctc gcccccaggc
      301 caaaatcctg agcatgatgg aagacaataa gcagctcgcg ctccgcatcg atggggcggt
      361 ccagtcggcc agccaggagg tgaccaacct gcgagccgaa ctcacggcca ccaaccggag
      421 actggcggaa ctgagcggcg gcggcggccc cggcccgggc ccgggagccg cggccagcgc
      481 ctcggcggcg ggggactcgg cggcgacgaa catggagaac ccccagcttg gagcgcaagt
      541 gctcctgcgg gaagaagtgt cgcggctcca ggaggaagtt caccttctcc ggcagatgaa
      601 ggagatgttg gcgaaggacc tggaggagtc gcagggcggc aagtcctctg aggtcctctc
      661 ggccaccgag ctcagggtcc agctggccca gaaggagcag gagctagcca gagccaaaga
      721 agccttgcag gccatgaaag ctgatcggaa gcgcttaaag ggcgagaaga cagacctggt
      781 gagccagatg cagcagctgt atgccacact ggagagccgc gaggagcagc tccgagactt
      841 catccgcaac tatgagcagc accgcaagga gagcgaggat gcggtcaaag cgctggccaa
      901 ggagaaggac ctgctggagc gtgagaagtg ggagctgcgg cgccaagcca aggaggccac
      961 agaccacgcc acggcactgc gctcccagct ggacctcaag gacaaccgga tgaaggagct
     1021 ggaggccgag ctggccatgg ccaaacagtc cttagctacg ctgaccaagg acgtccccaa
     1081 gcggcattcc ctcgccatgc cgggcgagac ggtgctcaat ggcaaccagg agtgggtggt
     1141 gcaggcggac ctcccgctga ccgcagccat ccggcagagt caacagactc tctaccactc
     1201 acacccccct caccctgcgg accggcaagc ggtcagggtg agcccctgcc actcccggca
     1261 gccctctgtc atctccgacg catctgccgc cgaaggcgac cggtcgtcca caccgagcga
     1321 catcaactcc cctcgacacc ggacacactc cctctgcaac ggcgacagtc ccggcccagt
     1381 tcagaagaac ctgcacaacc ctattgtaca gtcactagag gatcttgaag accaaaaacg
     1441 gaaaaagaag aaagagaaga tgggattcgg ctccatctcc cgcgtcttcg ccagagggaa
     1501 gcagcggaag tccctcgacc ccggcctctt tgatgactcg gacagccagt gcagccccac
     1561 gcggcagagc ctcagcctgt cggaaggcga ggagcagatg gaccggctgc agcaggtgga
     1621 gctggtgagg accaccccta tgtcccactg gaaggcgggc accgtccagg cctggctgga
     1681 ggtggtgatg gccatgccta tgtacgtcaa ggcctgcacg gagaacgtga agagcgggaa
     1741 ggtgctgctg agcctgagtg acgaggacct gcagctgggc cttggggtgt gcagctccct
     1801 gcaccggcgc aagctgcgcc tggccatcga ggactaccgt gatgccgagg caggccgcag
     1861 cctgtccaaa gctgccgagc tggaccatca ctgggtggcc aaggcctggc tgaatgacat
     1921 tggcctgtcc cagtactccc aggcctttca gaaccacctg gttgatgggc ggatgctgaa
     1981 ttccctgatg aagcgagacc tggagaagca cctgaacgtg tccaagaagt tccaccaggt
     2041 cagcatcctg ctggggatcg agctgctgta ccaagtgaac ttcagcaggg aggccctcca
     2101 ggagcgccgg gcccgctgcg agacgcagaa cattgacccc gtggtgtgga ccaaccagcg
     2161 ggtgctcaag tgggttcgag acatcgacct gaaggagtac gcagacaacc tgaccaacag
     2221 cggcgtccat ggtgctgtgc tggtgctgga gcccacattc aatgccgagg ccatggccac
     2281 tgccctgggc atccccagtg ggaagcacat cctccggaga cacctggcag aggagatgag
     2341 cgccgtcttc cacccagcca actccacagg catccgggag gctgagcgtt ttggaacgcc
     2401 ccctggcagg gcctccagcg tcacgcgggc aggaaaggag gagaacagca gcggtctcaa
     2461 gtacaaggct ggccggctgc ccctggggaa gataggaagg ggcttcagca gcaaagatcc
     2521 cgatttccat gatgactatg gctctcttca aaacgaagat tgcggagacg atgaccccca
     2581 gagcaggctg gaacagtgcc gtctggaagg ctacaacagc ctggaggtca ccaacgtgta
     2641 aggaactggt ggctccacca gacccaacgt gagagaccca ggaaggaaga gaagccagat
     2701 ggccccaggt gtcgttctca ctgtacatag cggccgcagg ctgaggatgt cccttgctcc
     2761 tgggcaaaat cccgatggac tctgcggttt cagctccaca gcgcccagga gagagaagac
     2821 accagcccac ctgtcttggg tgggccatgg actttcctgt tcagctggag atgggcccag
     2881 aggacctgtc acagtgtccg gccctgcctc catccaggat acacaggctc cacctcagag
     2941 tgaccgtcac tgtggagcag ccaagcagtc cctggagcct taaacggagc tgccaaggtg
     3001 ggaggaggcc cacagttccc taaaacaccc ttccggcggg agcagggggg accccaaccc
     3061 cacaccccag cgcccagtgc attggcagag ccgggtgcag gaagtgctgc ctcttgccga
     3121 gacgtcggac agggcggggg ttggggaact ctcggctaca gcatcttacc cttgactgag
     3181 aacttgggtc ctgacttggc tcactgaatc tctcttggga gaatgcaaaa tccttccacc
     3241 tgaaaagctc tgtgacacat gggggtggac gtattgaaga gctgtttgcc gatccaccca
     3301 ggagtggcta cgctgagtgg ggagccggtg aatgatccgt gcaggagtgg ggcttagcag
     3361 ccacatttct aggagatgca gatatcctat caccagaatg aaagctattg ggacaacagg
     3421 atcggggatg accgacggcc ccatatggtg aatctctggc ctgtggtttg gctttactga
     3481 gattccaaac cccactatct gcactccgtg acagtggtat ggagtgtggc aatgagtttg
     3541 gggtctgggg cagggaaatg cttgacattg ttaacccaac aaacctttgt tgtgatgtcc
     3601 ctgtcacctg aaacataggt gacatagctc accaatgtcc taaccgagac acaaactcca
     3661 cagagcaaaa tcatttggta ttggtgggga gaaccccagc ccttttcttg acctgccact
     3721 gttatgctgt gtggcttctt cccagtggcc tcacctctct gtgcctcgat gtcttcatct
     3781 acgatacttc tggttccctc ccagggacat cgtgaggatt aacacttgct aatatctgta
     3841 acacaatttg taacctctca ggagacaatg ggaagttatg gggtagctaa tttcccattt
     3901 acaacacaga aatgatatag agctagttcg ctccaactct ttaggttgaa gcagtgtgca
     3961 aaaggaagaa aagaaatgtt taatgttcag acctgccaag agcctccaac agggctcaag
     4021 aaacatataa atcccatgag cacagccttg aaaaccagtt tgactcaagc cttcgggcct
     4081 cagttcattg accagatgac agccacgtga tgattaggga aggacggatg cattgcgatt
     4141 ctgcttacac atcgggttat caaagcgagt cacttgttgg aaccatgatg ctcgacctcc
     4201 ttcaaggccg tttgcactgg ggcttgagtt tccaagattc acaacaggtg tcagcctctg
     4261 agaaccctca aagcgtgtgt tcttcaacct ggcaaattgt ttcctctcat gggggaagcc
     4321 gagctctgat gaacttgaga attacacctc tctcatgccg aagaccgtgg tgttccccct
     4381 aatgacataa acgcagcctt tcttgctgtc tgagaccaaa tgtctagttg gtagacaggt
     4441 ggatgtttgg cctcctaagg gcacacttct gatcctgggc cccaggtggt gaatctctgg
     4501 catgtggctt ggctttgttg agactccaaa ttccattatc ttcatgacat tcggcctcat
     4561 ccatagggtc ctgaagctgc agtccacagc tcagaaagga gaggtgagac ctccctccaa
     4621 cctggtgcca caggtctctc ccaagccaca tccagcctgg atgacctggg accccagaaa
     4681 ctgccgtttg ggaggcagca acagcaacgt gcccaggcag gcagttattc ccacagagtg
     4741 agccagaatt gtagcagggc acttgaatgc agagctgatg atttgaaacc aacgttcacc
     4801 caacttgtca gaaatggcac ttacatggtt cgatcttgct ggagacaagt ggacaattgg
     4861 gggtcactgg cagagacagt attgcccaaa atgttcacag caggaggcca gcaggcctga
     4921 ggcaacacgg gcaaccgcga atgcctcttt tggtttaaat tatgccatca caaccctctt
     4981 tcacccatga ggctccccat ccctgacagc caggtgagca tttggagctg gtttctcaac
     5041 atgaggatgg gttggttgtt aaattaacaa cctccacagt atcagattga gtgagctttg
     5101 tctgctggaa aaacctgaaa cgtcaactct gcttcaaggt cggcaagaag aacagaaggc
     5161 ggagacttgg cagagagact caagctgatt gtcacaggct acagaggggc cagctccaga
     5221 acagtgacca gctacatcct gtccaagcag cccgagtgtg gtcttggtcc ctgcagggca
     5281 atgtgggcat ctggacctgg ggacgatgtg gatgcacttc ttggaaagct gttgtagctt
     5341 gtgcctgtgg gtggagaagg cacctgcctg gtagactctc agctttctga cccccaggag
     5401 cctctgcgag gcccctttgt ccttggctga gccggacctt tcttttggaa atctgtctgt
     5461 ctgttggcat cgctgttttc agaccccagg ctgcagagga ggggagaagc cacacaacaa
     5521 tctggaccca ataaagtgga gagaagggcg tctctacaca gcccggccag cgtggagggc
     5581 cccaggacag ggacccaaaa gcttgacgtc actgaacagg gctgggtact ggcagaacag
     5641 gaagatttgg ccagaggtga cctcagtgtt ccctccaggg gcatccaggc ccctctgacc
     5701 tggggagaag aaggcccatg ctcaggccca cctccctctt cccatcagag cccatgcgtc
     5761 ctgggcacca ccacttccac tctgcttttc gaggctccgg agggctcttc ctgctgtgaa
     5821 aggaaaggag aagaaagcct gtgggcaatg gcaacctctg agtctggcat tcttgccaat
     5881 ggctggccag cgaggagaat ctcccgagcc ctgacacaca aaggcatttt gtggctgcag
     5941 aggaaatggg ttggctctga acaaagatgc agtttctagg gccgtggccc caaatcgctt
     6001 ccccgagagt gaattttaac actgtaacaa taaatactac tgcacagca
//
