LOCUS       NM_015202               6599 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens katanin interacting protein (KATNIP), mRNA.
ACCESSION   NM_015202 XM_044632
VERSION     NM_015202.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6599)
  AUTHORS   Turner,J.S., McCabe,E.A., Kuang,K.W., Gailey,C.D., Brautigan,D.L.,
            Limerick,A., Wang,E.X. and Fu,Z.
  TITLE     The Scaffold Protein KATNIP Enhances CILK1 Control of Primary Cilia
  JOURNAL   Mol Cell Biol 43 (9), 472-480 (2023)
   PUBMED   37665596
  REMARK    GeneRIF: The Scaffold Protein KATNIP Enhances CILK1 Control of
            Primary Cilia.
REFERENCE   2  (bases 1 to 6599)
  AUTHORS   Niceta,M., Dentici,M.L., Ciolfi,A., Marini,R., Barresi,S.,
            Lepri,F.R., Novelli,A., Bertini,E., Cappa,M., Digilio,M.C.,
            Dallapiccola,B. and Tartaglia,M.
  TITLE     Co-occurrence of mutations in KIF7 and KIAA0556 in Joubert syndrome
            with ocular coloboma, pituitary malformation and growth hormone
            deficiency: a case report and literature review
  JOURNAL   BMC Pediatr 20 (1), 120 (2020)
   PUBMED   32164589
  REMARK    GeneRIF: Co-occurrence of mutations in KIF7 and KIAA0556 in Joubert
            syndrome with ocular coloboma, pituitary malformation and growth
            hormone deficiency: a case report and literature review.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6599)
  AUTHORS   Fujita,A., Higashijima,T., Shirozu,H., Masuda,H., Sonoda,M.,
            Tohyama,J., Kato,M., Nakashima,M., Tsurusaki,Y., Mitsuhashi,S.,
            Mizuguchi,T., Takata,A., Miyatake,S., Miyake,N., Fukuda,M.,
            Kameyama,S., Saitsu,H. and Matsumoto,N.
  TITLE     Pathogenic variants of DYNC2H1, KIAA0556, and PTPN11 associated
            with hypothalamic hamartoma
  JOURNAL   Neurology 93 (3), e237-e251 (2019)
   PUBMED   31197031
  REMARK    GeneRIF: Pathogenic germline variants of KIAA0556 associated with
            hypothalamic hamartoma were found.
REFERENCE   4  (bases 1 to 6599)
  AUTHORS   Cauley,E.S., Hamed,A., Mohamed,I.N., Elseed,M., Martinez,S.,
            Yahia,A., Abozar,F., Abubakr,R., Koko,M., Elsayed,L., Piao,X.,
            Salih,M.A. and Manzini,M.C.
  TITLE     Overlap of polymicrogyria, hydrocephalus, and Joubert syndrome in a
            family with novel truncating mutations in ADGRG1/GPR56 and KIAA0556
  JOURNAL   Neurogenetics 20 (2), 91-98 (2019)
   PUBMED   30982090
  REMARK    GeneRIF: homozygous truncating mutations in both ADGRG1/GPR56 and
            KIAA0556 are found in brothers displaying an overlap of
            polymicrogyria, hydrocephalus, and Joubert syndrome
REFERENCE   5  (bases 1 to 6599)
  AUTHORS   Roosing,S., Rosti,R.O., Rosti,B., de Vrieze,E., Silhavy,J.L., van
            Wijk,E., Wakeling,E. and Gleeson,J.G.
  TITLE     Identification of a homozygous nonsense mutation in KIAA0556 in a
            consanguineous family displaying Joubert syndrome
  JOURNAL   Hum Genet 135 (8), 919-921 (2016)
   PUBMED   27245168
  REMARK    GeneRIF: Whole exome sequencing in a multiplex consanguineous
            family from India revealed a KIAA0556 homozygous single base pair
            deletion mutation (c.4420del; p.Met1474Cysfs*11). Knockdown of the
            gene in zebrafish resulted in a ciliopathy phenotype, rescued by
            co-injection of wildtype cDNA
REFERENCE   6  (bases 1 to 6599)
  AUTHORS   Sanders,A.A., de Vrieze,E., Alazami,A.M., Alzahrani,F.,
            Malarkey,E.B., Sorusch,N., Tebbe,L., Kuhns,S., van Dam,T.J.,
            Alhashem,A., Tabarki,B., Lu,Q., Lambacher,N.J., Kennedy,J.E.,
            Bowie,R.V., Hetterschijt,L., van Beersum,S., van Reeuwijk,J.,
            Boldt,K., Kremer,H., Kesterson,R.A., Monies,D., Abouelhoda,M.,
            Roepman,R., Huynen,M.H., Ueffing,M., Russell,R.B., Wolfrum,U.,
            Yoder,B.K., van Wijk,E., Alkuraya,F.S. and Blacque,O.E.
  TITLE     KIAA0556 is a novel ciliary basal body component mutated in Joubert
            syndrome
  JOURNAL   Genome Biol 16, 293 (2015)
   PUBMED   26714646
  REMARK    GeneRIF: KIAA0556 mutation identified in patients with Joubert
            syndrome.  KIAA0556 binds to microtubules, p60/p80 katanins and
            genetically interacts with ARL13B.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6599)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   8  (bases 1 to 6599)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   9  (bases 1 to 6599)
  AUTHORS   Parisi,M. and Glass,I.
  TITLE     Joubert Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025275.4, AC002551.1,
            AC016597.4, AC092330.2 and AC008732.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_015202.4.
            
            Summary: This gene encodes a novel, evolutionarily conserved,
            ciliary protein. In human hTERT-RPE1 cells, the protein is found at
            the base of cilia, decorating the ciliary axoneme, and enriched at
            the ciliary tip. The protein binds to microtubules in vitro and
            regulates their stability when it is overexpressed. A null mutation
            in this gene has been associated with Joubert syndrome, a recessive
            disorder that is characterized by a distinctive mid-hindbrain and
            cerebellar malformation and is also often associated with wider
            ciliopathy symptoms. Consistently, in a serum-starvation
            ciliogenesis assay, human fibroblast cells derived from patients
            with the mutation display a reduced number of ciliated cells with
            abnormally long cilia. [provided by RefSeq, Feb 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150276.1, AB011128.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261588.10/ ENSP00000261588.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC025275.4         18034-18067         c
            35-90               AC002551.1         27441-27496
            91-167              AC002551.1         71965-72041
            168-337             AC002551.1         82201-82370
            338-435             AC002551.1         84605-84702
            436-567             AC002551.1         102144-102275
            568-835             AC016597.4         80910-81177         c
            836-967             AC016597.4         77376-77507         c
            968-1140            AC016597.4         60406-60578         c
            1141-1206           AC016597.4         59307-59372         c
            1207-1313           AC016597.4         57211-57317         c
            1314-1416           AC016597.4         54908-55010         c
            1417-1632           AC016597.4         49986-50201         c
            1633-1770           AC016597.4         37211-37348         c
            1771-2650           AC016597.4         17986-18865         c
            2651-3373           AC016597.4         8600-9322           c
            3374-3579           AC016597.4         6982-7187           c
            3580-3658           AC016597.4         4655-4733           c
            3659-3836           AC092330.2         36574-36751
            3837-4002           AC092330.2         41470-41635
            4003-4160           AC092330.2         45022-45179
            4161-4225           AC092330.2         46749-46813
            4226-4336           AC092330.2         48260-48370
            4337-4476           AC092330.2         50106-50245
            4477-4578           AC092330.2         52089-52190
            4579-4739           AC008732.9         180202-180362       c
            4740-4828           AC008732.9         180003-180091       c
            4829-6599           AC008732.9         177628-179398       c
FEATURES             Location/Qualifiers
     source          1..6599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.1"
     gene            1..6599
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /note="katanin interacting protein"
                     /db_xref="GeneID:23247"
                     /db_xref="HGNC:HGNC:29068"
                     /db_xref="MIM:616650"
     exon            1..34
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..4884
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /codon_start=1
                     /product="katanin-interacting protein"
                     /protein_id="NP_056017.4"
                     /db_xref="CCDS:CCDS32415.1"
                     /db_xref="GeneID:23247"
                     /db_xref="HGNC:HGNC:29068"
                     /db_xref="MIM:616650"
                     /translation="MDGQTLRKAERSWSCSREKKEGYAKDMVTDFDEKHDEYLILLQQ
                     RNRILKHLKSKDPVQLRLEHLEQGFSVYVNGANSELKSSPRKAIHSDFSRSASHTEGT
                     HDYGRRTLFREAEEALRRSSRTAPSKVQRRGWHQKSVQIRTEAGPRLHIEPPVDYSDD
                     FELCGDVTLQANNTSEDRPQELRRSLELSVNLQRKQKDCSSDEYDSIEEDILSEPEPE
                     DPALVGHPRHDRPPSSGDWTQKDVHGEQETEGRSSPGPDTLVVLEFNPASKSHKRERN
                     LSAKRKDNAEVFVPTKPEPNLTPQAPAVFPDQERMCSRPGSRRERPLSATRKTLCEAE
                     YPEEDASAVLQAIQVENAALQRALLSRKAEQPASPLQDAEGPPAKPWTSLLEEKEETL
                     ELLPITTATTTQEPAGAAGGARAINQAMDRIGLLGSRQQQKLLKVLQAVESDSAHLGR
                     VVSPTKEQVSDTEDKQRMRADEIKDAIYVTMEILSNWGNSWWVGLTEVEFFDLNDTKL
                     YVSPHDVDIRNTATPGELGRLVNRNLAGKKDSSPWTCPFHPPLQLFFVIRNTRQLGDF
                     HLAKIKVRNYWTADGDLDIGAKNVKLYVNRNLIFNGKLDKGDREAPADHSILVDQKNE
                     KSEQLEEAMNAHSEESKGTHEMAGASGDKELGLGCSPPAETLADAKLSSQGNVSGKRK
                     NSTNCRKDSLSQLEEYLRLSAVPTSMGDMPSAPATSPPVKCPPVHEEPSLIQQLENLM
                     GRKICEPPGKTPSWLQPSPTGKDRKQGGRKPKPLWLSPEKPLAWKGRLPSDDVIGEGP
                     GETEARDKGLRHEPGWGTSRSVNTKERPQRATTKVHSDDSDIFNQPPNRERPASGRRG
                     SRKDAGSSSHGDDQPASREDTWSSRTPSRSRWRSEQEHTLHESWSSLSAFDRSHRGRI
                     SNTELPGDILDELLQQKSSRHSDLPPSKKGEQPGLSRGQDGYSGETDAGGDFKIPVLP
                     YGQRLVIDIKSTWGDRHYVGLNGIEIFSSKGEPVQISNIKADPPDINILPAYGKDPRV
                     VTNLIDGVNRTQDDMHVWLAPFTRGRSHSITIDFTHPCHVALIRIWNYNKSRIHSFRG
                     VKDITMLLDTQCIFEGEIAKASGTLAGAPEHFGDTILFTTDDDILEAIFYSDEMFDLD
                     VGSLDSLQDEEAMRRPSTADGEGDERPFTQAGLGADERIPELELPSSSPVPQVTTPEP
                     GIYHGICLQLNFTASWGDLHYLGLTGLEVVGKEGQALPIHLHQISASPRDLNELPEYS
                     DDSRALDKLIDGTNITMEDEHMWLIPFSPGLDHVVTIRLDRAESIAGLRFWNYNKSPE
                     DTYRGAKIVHVSLDGLCVSPPEGFLIRKGPGNCHFDFAQEILFVDYLRAQLLPQPARR
                     LDMRSLECASMDYEAPLMPCGFIFQFQLLTSWGDPYYIGLTGLELYDERGEKIPLSEN
                     NIAAFPDSVNSLEGVGGDVRTPDKLIDQVNDTSDGRHMWLAPILPGLVNRVYVIFDLP
                     TTVSMIKLWNYAKTPHRGVKEFGLLVDDLLVYNGILAMVSHLVGGILPTCEPTVPYHT
                     ILFTEDRDIRHQEKHTTISNQAEDQDVQMMNENQIITNAKRKQSVVDPALRPKTCISE
                     KETRRRRC"
     exon            35..90
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            91..167
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            168..337
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            338..435
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            436..567
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            568..835
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            836..967
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1140
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1206
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1313
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1416
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1632
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1770
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..2650
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..3373
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3579
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            3580..3658
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3836
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..4002
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            4003..4160
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            4161..4225
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            4226..4336
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            4337..4476
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            4477..4578
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            4579..4739
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            4740..4828
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     exon            4829..6599
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6569..6574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /note="hexamer: AATAAA"
     polyA_site      6599
                     /gene="KATNIP"
                     /gene_synonym="JBTS26; KIAA0556"
                     /note="major polyA site"
ORIGIN      
        1 gagctcccgg aaccgccgcc tctagggatg gacggtcaga ctctgcgaaa ggccgagaga
       61 agctggtcct gctcacgaga gaaaaaggag ggttacgcta aggacatggt gacagacttt
      121 gatgagaaac atgatgagta tttaatattg cttcagcaga ggaaccggat attaaagcat
      181 ttgaaaagca aggaccccgt gcaattgagg ctggagcact tggagcaagg tttctctgtc
      241 tatgtcaacg gtgccaattc ggagctgaaa tcatcaccgc ggaaagctat tcactctgac
      301 ttctccagaa gtgcctccca cacggagggg acacacgatt atggacgaag aactctgttt
      361 cgagaagctg aagaagcctt aagacgcagt tcacggacag cccccagtaa agtccagcgc
      421 cgaggatggc accagaaatc tgtgcagatc agaacagaag ctggcccacg gctccacatc
      481 gaacctcctg tggactattc tgatgatttt gagctgtgtg gggatgtgac tctccaggca
      541 aacaacactt ctgaggatcg tccgcaggag ctgagaagaa gcctggaact tagtgtaaat
      601 ctacaaagga aacaaaagga ttgttccagc gatgagtatg actctattga ggaagacata
      661 ctctctgagc ctgagccaga ggacccggca ctggtgggcc atcccagaca tgaccgccct
      721 ccttccagtg gcgactggac tcagaaagat gttcacgggg aacaggagac agaaggacgc
      781 tcttctccag gcccagacac cctcgtggtg ctggaattta acccagcttc caaaagtcat
      841 aaaagggaaa ggaatttgtc tgcaaagcgg aaggacaatg ctgaggtttt cgttcccacc
      901 aaacctgagc caaacctgac tccccaagct cctgctgtat tcccagacca ggagaggatg
      961 tgctccagac ctggaagccg gcgagagaga cccctgtctg caacccgcaa aactctttgc
     1021 gaggctgagt acccagagga agatgcctct gctgtgctcc aagccatcca ggtggagaac
     1081 gcagccctgc agagggcgct cctcagcaga aaggccgagc agccagccag cccactgcag
     1141 gatgcagaag gaccaccagc aaaaccatgg accagtctgc tggaggagaa ggaagagacc
     1201 cttgagctgc ttcccatcac cacggcgact actactcagg agccggccgg ggcagcagga
     1261 ggagccaggg ccatcaacca ggccatggac agaattgggc ttctgggaag cagacaacag
     1321 cagaagcttc tgaaagtcct ccaggccgtc gaaagtgact ctgcccatct cggcagggtg
     1381 gtttcaccaa ccaaggagca agtatcagac acagaggaca aacagagaat gagggcagac
     1441 gagatcaaag atgccatcta cgtgaccatg gagatcctgt ccaactgggg caactcgtgg
     1501 tgggtgggtc tcacagaagt cgagttcttt gacttgaatg acacaaagct ttatgtgtcg
     1561 ccccacgatg tggatatccg gaacacagcc acgcctgggg agctgggccg cctcgtcaac
     1621 aggaacttag ctggcaagaa agactcctcc ccgtggacct gccccttcca cccaccactc
     1681 cagctgtttt ttgttattcg aaacacaaga cagctggggg acttccatct ggccaagatc
     1741 aaggttcgga attactggac agctgatggc gatcttgaca ttggtgccaa gaacgtgaag
     1801 ctttacgtca acagaaacct catcttcaat ggcaagttag acaaaggaga tagggaggcc
     1861 ccagctgacc acagcatcct ggttgaccag aagaacgaga agagcgagca actagaggag
     1921 gccatgaacg ctcactcgga agaaagcaaa ggcacccatg agatggctgg tgccagcggg
     1981 gacaaggagc ttggtctcgg ttgctcaccg ccagctgaaa cattagcgga tgcaaagctt
     2041 tcttcacaag gaaatgtgtc tggcaaaaga aagaattcta ctaattgcag gaaagacagt
     2101 ttgtcccagt tagaggaata tttgagactg tcggcagtcc ccacttcgat gggtgacatg
     2161 cccagtgctc ctgccacttc cccacctgtg aagtgccctc ctgtccatga ggagccctct
     2221 ctcatccaac aactggaaaa cctcatgggc agaaaaatct gtgagccacc cgggaaaacc
     2281 ccatcctggt tacaaccttc tcccaccggc aaggacagga agcagggagg caggaagcca
     2341 aaacccctct ggcttagtcc cgagaagccc ctggcctgga agggcaggct cccatcagac
     2401 gatgtcatcg gtgagggtcc tggagagacc gaggccaggg ataaaggcct acggcatgag
     2461 ccagggtggg ggaccagccg gagtgtcaac accaaggaga gaccccagag ggcaaccacc
     2521 aaagtccaca gtgatgactc agacatcttt aaccagcccc ccaacagaga gcgccctgct
     2581 agtgggagga ggggctcaag gaaggatgct ggcagcagta gtcatgggga cgaccagcca
     2641 gccagcagag aagacacctg gtcttccagg acgccgtcac ggtcaaggtg gcgcagtgag
     2701 caggagcaca cacttcacga gtcatggagc tccctcagtg ccttcgaccg ctcccaccgg
     2761 ggacgcatct ccaacacgga gctcccgggg gacatcctgg atgagctcct gcagcaaaag
     2821 agcagccggc acagcgactt gcccccctcc aagaaggggg agcagccagg gctgtcgaga
     2881 gggcaggatg gctactctgg agagacagac gctgggggtg actttaaaat ccccgtcttg
     2941 ccttatggac agcgcttggt cattgacatc aagtctacct ggggggacag acactatgtc
     3001 ggcctcaacg gaatagaaat attcagttcc aagggtgaac cggtgcagat ttcaaacata
     3061 aaagcagacc ctcccgatat caatatttta ccagcctatg ggaaagaccc ccgcgtggtc
     3121 accaacctca tcgacggggt gaacaggacc caggatgaca tgcatgtctg gctggccccc
     3181 ttcacgcggg gcagatccca ctccatcacc attgacttca cgcacccttg ccacgttgcc
     3241 ctgatcagaa tttggaacta caataaatct cggatacatt ccttccgagg cgtgaaggac
     3301 atcacaatgc tgttagacac ccagtgcatc tttgaaggag aaatcgccaa ggcctctgga
     3361 accctggcgg gagccccaga gcactttgga gacacgatct tattcacaac cgatgatgac
     3421 attctcgagg ccatattcta ttctgatgag atgtttgacc tggatgtggg gagcctggac
     3481 agcctgcagg atgaagaggc aatgaggagg cccagcacgg ccgacggcga gggggatgag
     3541 cggcccttca cccaggctgg cttgggggct gatgaacgga tcccggagct agagctccca
     3601 tccagttccc ctgtccccca agtcaccacg ccagagccag gcatctacca cggaatctgc
     3661 cttcagctga atttcactgc ctcctgggga gacttgcact acctggggct cactggcctg
     3721 gaagtggtgg gcaaggaggg ccaggcgctg cccatccacc tgcaccagat ctctgcttcc
     3781 cccagagact taaatgagct ccccgagtac tctgacgact cccgggccct ggacaagtta
     3841 attgatggca ccaacatcac catggaggat gagcatatgt ggctgatccc cttctcgccg
     3901 gggctggacc atgtggtcac gatccgcctg gacagggccg aaagcatcgc aggcctgcgc
     3961 ttctggaact acaataaatc tcccgaggac acctatcgcg gggccaagat tgtccacgtc
     4021 tccctggatg gcctgtgcgt ctccccgcca gagggctttc tcatccggaa ggggccaggc
     4081 aactgccact ttgattttgc tcaagaaatc ctcttcgtgg actacctacg ggctcagctg
     4141 ctgccccagc cggccaggag gctggacatg agaagcctgg agtgtgcaag catggactac
     4201 gaggcaccgc tgatgccctg tggcttcatt ttccagtttc agcttctcac cagctggggc
     4261 gacccctact acatcggcct caccggcctg gagctgtatg acgagcgagg agaaaaaatc
     4321 cccttgtcgg aaaacaatat tgcggccttc cccgacagcg tgaactccct ggagggtgtg
     4381 ggcggggacg tccgcacccc agacaagctc atcgaccaag tgaacgacac cagtgatggc
     4441 cggcacatgt ggctggctcc catcctgccg ggcctggtga accgggttta tgtgattttc
     4501 gatctgccta ccaccgtgtc aatgatcaaa ctgtggaatt atgcgaaaac accccatcga
     4561 ggggtgaagg agtttggcct cctggtggac gacctgcttg tgtacaatgg gatcctggcc
     4621 atggtgagcc acctggtggg gggcatcctg cccacatgtg agcccaccgt gccctaccac
     4681 accatcctct tcaccgagga cagggacatc cgccaccagg agaaacacac caccatcagt
     4741 aatcaggccg aggatcaaga tgtccagatg atgaatgaaa accaaatcat taccaacgcg
     4801 aaacggaagc agagcgttgt tgacccagcc ttacgtccca aaacctgcat cagcgagaag
     4861 gagacgagac gacggcgctg ctgactggtg aaggagggag agctggtcct cccactatgg
     4921 tgggctccgt cagcagcccc actcagtgcc tgcgtccctc accctcagtc ccaggagctg
     4981 gaagcgaacc acagtgttga ggggagcccg ctgggaagag gggactcggg aggacagccc
     5041 tggatactac cagagtgaca gatggctgtg gctgcagggc aaagagatcc cctgcagttc
     5101 tgggttggcc acagggagcc caggacaccc gccttcatgc ctctgctgtg agacccagca
     5161 aagcagggcc catgaccact agggcctggg ctgaccctga ctcagaacag gacaatgacg
     5221 gggtggggag gcatcccatc cagcctcaga gggcccagag aatggctgag caggacagtg
     5281 ggagaccaga ccctaccccg caactccagt aagcagggca ctgcccaggg agactgcctt
     5341 cagaaacctg agcttcagcg gccaacaccc cccatcccct gcgcatcctt gtctcatttg
     5401 gggactggtg gagctggctg agaggttggg gtagtttcct ggttacaggg gtccacaaga
     5461 ccctctctca tcccggtata ggggcctctc tcctctcatc gggcctgata agggattggc
     5521 caaggctgtg tgcatcctgc agagggaagg aagtcagctg ggccacccgc catccacctt
     5581 ggcaagagct gggcccactc tggcaggcca gggtatcatc tgcgtgctgc tgccgggcca
     5641 ggaagggtgg gtgggtggcc agcaggctgg cagctccaga ccccagaggg ccagaagaac
     5701 tcaccccagt gccctctgga tgcaggtgtt ggggaacact gaggacaatc ccccatctcc
     5761 cctcaccctt gagcaggccc tccctgcact ctctgccaca tgtccctcct ggtctgatca
     5821 cggctgtgct cactgatgtg gctgctttct gtctctgccc ctgtgccctt ggaggcaggc
     5881 agtgaggtgc tcctttccca ggcccccacc ccttctcccc cttcagccac ttcccagcga
     5941 gttggaaatg tgccttgcac ccccagccga gtgaagccca gaacgcatct atatgcatcg
     6001 atgtaacaag ctcggatcag ggacctaatt ggtttcccag tagtgggtaa tttctcgttg
     6061 caaatattaa tccgttgttt ttctggcgcc cagcccggcc cgccgcagta ctgtactcga
     6121 ggtacgttcc tatgcaaccg agagccccgg caaatacttc atgagcttag cagcctgggc
     6181 tcgagcagct atgcaaacgc gcttttcatt tggagcacgg ggctgatgtg aagataagaa
     6241 ttgtttctcc tggagaaaga tccatcattt ctccagcttc caagcccccg gcacctctgc
     6301 tcagctccca gatgtgacga gcacctcccg ccagggggag tcaggggttg atcaaaccag
     6361 ctcttgtgac ccaaaccagt gccgctgcat taaagggagg cccagctact ccttcccagc
     6421 tgagatgtgg gtacaggtca gatttgtcag ggagatggca ctaacacgac acaagctcac
     6481 tcccagaacc gcagctgatg tttataataa tcgtatgtac tgtgcaattt aggaggggaa
     6541 aaaaaggctg tacaagcttt aactctaaaa taaatttcta tttttttcct cttgcaaaa
//
