LOCUS       NM_024713               2740 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens katanin regulatory subunit B1 like 1 (KATNBL1), mRNA.
ACCESSION   NM_024713
VERSION     NM_024713.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2740)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2740)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2740)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2740)
  AUTHORS   Kovacs,I.A., Luck,K., Spirohn,K., Wang,Y., Pollis,C., Schlabach,S.,
            Bian,W., Kim,D.K., Kishore,N., Hao,T., Calderwood,M.A., Vidal,M.
            and Barabasi,A.L.
  TITLE     Network-based prediction of protein interactions
  JOURNAL   Nat Commun 10 (1), 1240 (2019)
   PUBMED   30886144
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2740)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2740)
  AUTHORS   Cheung,K., Senese,S., Kuang,J., Bui,N., Ongpipattanakul,C.,
            Gholkar,A., Cohn,W., Capri,J., Whitelegge,J.P. and Torres,J.Z.
  TITLE     Proteomic Analysis of the Mammalian Katanin Family of
            Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1
            (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing
  JOURNAL   Mol Cell Proteomics 15 (5), 1658-1669 (2016)
   PUBMED   26929214
  REMARK    GeneRIF: Data indicate that KATNBL1 functions as a regulator of
            Katanin A subunit microtubule-severing activity during mitosis and
            that it likely coordinates with KATNB1 to perform this function.
REFERENCE   7  (bases 1 to 2740)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   8  (bases 1 to 2740)
  AUTHORS   McNally,K.P. and McNally,F.J.
  TITLE     The spindle assembly function of Caenorhabditis elegans katanin
            does not require microtubule-severing activity
  JOURNAL   Mol Biol Cell 22 (9), 1550-1560 (2011)
   PUBMED   21372175
  REMARK    Erratum:[Mol Biol Cell. 2012 Nov;23(22):4472]
REFERENCE   9  (bases 1 to 2740)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 2740)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK311338.1, AL136908.1, BX389537.2, BC026234.1 and BM831547.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024713.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136908.1, SRR1660805.49837.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256544.8/ ENSP00000256544.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AK311338.1         1-74
            75-1146             AL136908.1         1-1072
            1147-1476           BX389537.2         324-653
            1477-2014           BC026234.1         1368-1905
            2015-2201           BM831547.1         436-622
            2202-2740           AL136908.1         2128-2666
FEATURES             Location/Qualifiers
     source          1..2740
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..2740
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /note="katanin regulatory subunit B1 like 1"
                     /db_xref="GeneID:79768"
                     /db_xref="HGNC:HGNC:26199"
                     /db_xref="MIM:616235"
     exon            1..146
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            147..277
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1075
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /note="katanin p80 subunit B-like 1"
                     /codon_start=1
                     /product="KATNB1-like protein 1"
                     /protein_id="NP_078989.1"
                     /db_xref="CCDS:CCDS10034.1"
                     /db_xref="GeneID:79768"
                     /db_xref="HGNC:HGNC:26199"
                     /db_xref="MIM:616235"
                     /translation="MASETHNVKKRNFCNKIEDHFIDLPRKKISNFTNKNMKEVKKSP
                     KQLAAYINRTVGQTVKSPDKLRKVIYRRKKVHHPFPNPCYRKKQSPGSGGCDMANKEN
                     ELACAGHLPEKLHHDSRTYLVNSSDSGSSQTESPSSKYSGFFSEVSQDHETMAQVLFS
                     RNMRLNVALTFWRKRSISELVAYLLRIEDLGVVVDCLPVLTNCLQEEKQYISLGCCVD
                     LLPLVKSLLKSKFEEYVIVGLNWLQAVIKRWWSELSSKTEIINDGNIQILKQQLSGLW
                     EQENHLTLVPGYTGNIAKDVDAYLLQLH"
     exon            278..318
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            319..598
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            599..717
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            718..768
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            769..858
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            859..948
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1042
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..2740
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /note="hexamer: ATTAAA"
     polyA_site      1517
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /note="major polyA site"
     regulatory      1579..1584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /note="hexamer: ATTAAA"
     polyA_site      1603
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /note="major polyA site"
     regulatory      2718..2723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /note="hexamer: AATATA"
     polyA_site      2740
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /note="major polyA site"
ORIGIN      
        1 agctatcccg gcgggccgcg cgcgcggccg cgtttgaatg gccctgagtg ggactcggcc
       61 cagaagccga gggactctct aggctgccgg gcgctggtcg tcagcgccga ggctgggctg
      121 aggcgccgcg gtaccatgag gcgccggtac ttaagagatt atggcatcag aaacccacaa
      181 tgttaaaaaa cggaactttt gtaataagat tgaggatcat ttcattgatc ttcctagaaa
      241 aaagatctct aatttcacta ataagaacat gaaggaggtt aagaaatctc caaaacagtt
      301 ggctgcttac ataaatagaa cagttggaca aactgtgaaa agcccagata aacttcgtaa
      361 agtgatctat cgcagaaaga aagttcatca tccctttcca aatccttgtt acagaaaaaa
      421 acagtcccct ggaagtgggg gctgtgacat ggcaaataaa gaaaatgaac tggcttgtgc
      481 aggccacctg cctgaaaaat tacaccatga tagtcgaaca tatttggtta actccagtga
      541 ttctggttct tcacagacag aaagcccatc atcaaaatat agtgggtttt tttctgaggt
      601 ttctcaggac catgaaacaa tggcccaagt tttgttcagc aggaatatga gattgaatgt
      661 agctttaact ttctggagaa agagaagtat aagtgaactt gtagcttatt tgttgaggat
      721 agaagatctt ggcgttgtgg tagattgcct tcctgtgctc accaattgtt tacaggaaga
      781 aaaacaatat atctcacttg gctgctgtgt tgacttgttg cctctagtaa agtcactact
      841 taaaagcaaa tttgaagaat atgttatagt tggtttaaac tggcttcaag cagtcattaa
      901 aaggtggtgg tcagaactat catccaaaac agaaattata aatgatggaa atattcaaat
      961 tttaaaacaa caattaagtg gattatggga acaggaaaac catcttactt tggttccagg
     1021 atatactggt aatatagcta aggatgtaga tgcttattta ttacagttac attgagagat
     1081 ttcatctact aaagagcatt tggtttttca aaacatccct gaactgtata atttacaaaa
     1141 aaaaaaagtc tcgtctgaga actgtgaact gtggaagaaa tcaaaactat tttttctttt
     1201 aaaaagccac gtaatgaaac cactaatgaa atcccagcaa tctgcttcac attgaagtgg
     1261 aaaaatatcc aaaaggagca gcttcaattt cattgaggtg aaagtgcact atgaagattg
     1321 ttcacctttg ctgcatttgg gagttatatg gttatttggt aacattaaga actactggat
     1381 tttaatgcaa tcctgcataa aaatataatt tatactatgt gaaaaaataa gacaggactt
     1441 accactagga accaccaaga ccaatcatca ttaacttttt taagattgtg ttttattaaa
     1501 aaaaaaaaac acttaaatgt gtgcagctat tttcttatgt tgaaaagact gaaagtttaa
     1561 aacatgaaaa aaatcaatat taaacatttt ttgttcacac tgagatactg tgtatgtaaa
     1621 atgccttaat tattaataag ccaatgtgtt atgataccaa tatctgtttt aaaaaactaa
     1681 aaccaaccat gcttctggca tgataaaatc atggaattaa atcaggggtt tacattcttg
     1741 tagagtgttc ttgaaacact ctctgcacca tttttaaaac ttgagaatag ttttagtatc
     1801 tctgatattt tttgccagaa tcatcatgtc atgtatgaat gtgttatccc tatctaagga
     1861 aaaaggtgaa tatgtttttg tatgaatgtt taactggaaa tgtccatgga cttggctaat
     1921 ttatatttac tttttattgt acatagattt ctaatatttt tcattcctgt atcatttaaa
     1981 cttccttcat ttgagtaaat tcactaaata tttctatttt ttgctttttt aaattctgat
     2041 tttatatgaa ttctaattct ttttcactac atatgtttta aagagttaca tacagtgatt
     2101 tagaatggtt tacagttaat gctgatcttg tattttaaat tccaacactt tgtgtcacta
     2161 cctcctctaa tggttagtat gatatgctag cagactgtat gaggtctttt tttaaaatac
     2221 cacttttagt gtcagtgaac caaattctgg aatgtcttaa cagctctaaa tcttacttgt
     2281 cttgaaaatg attggggttt aataccactg ctggtggttc acacatcatc ccatccttaa
     2341 tatgcctgac aggcatctga gcaaaggttt ttagtaattg aatttctctg cagtagtcct
     2401 tcaagcactt gaatgtaaac ctttagcatt tattcgttta atgactactg atacgaatct
     2461 caagcagatt tcttgctctt aaaagttatg tttcactgag ttctggtttt gtgtagctat
     2521 attttatata gctagatatt cctcacagtg aacatgaatt gtaataattg gttatttcct
     2581 taagtcttta gattataata atttcagatt attgcacgtc tgtgatttga gaggtgagtt
     2641 atttaagagg ccagttttca ggacatggga atttgaattg taaacctgtt atctctgtga
     2701 aacttttaac atgataaaat ataacctttc tttgtgctta
//
