LOCUS       NM_005886               2618 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens katanin regulatory subunit B1 (KATNB1), mRNA.
ACCESSION   NM_005886
VERSION     NM_005886.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2618)
  AUTHORS   Guerreiro,A., De Sousa,F., Liaudet,N., Ivanova,D., Eskat,A. and
            Meraldi,P.
  TITLE     WDR62 localizes katanin at spindle poles to ensure synchronous
            chromosome segregation
  JOURNAL   J Cell Biol 220 (8) (2021)
   PUBMED   34137788
  REMARK    GeneRIF: WDR62 localizes katanin at spindle poles to ensure
            synchronous chromosome segregation.
REFERENCE   2  (bases 1 to 2618)
  AUTHORS   Peluso,F., Caraffi,S.G., Zuntini,R., Trimarchi,G., Ivanovski,I.,
            Valeri,L., Barbieri,V., Marinelli,M., Pancaldi,A., Melli,N.,
            Cesario,C., Agolini,E., Cellini,E., Radio,F.C., Crisafi,A.,
            Napoli,M., Guerrini,R., Tartaglia,M., Novelli,A., Gargano,G.,
            Zuffardi,O. and Garavelli,L.
  TITLE     Whole Exome Sequencing Is the Minimal Technological Approach in
            Probands Born to Consanguineous Couples
  JOURNAL   Genes (Basel) 12 (7), 962 (2021)
   PUBMED   34202629
  REMARK    GeneRIF: Whole Exome Sequencing Is the Minimal Technological
            Approach in Probands Born to Consanguineous Couples.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2618)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2618)
  AUTHORS   Chen,Q., Lin,F., Lin,E., Huang,Q. and Wu,G.
  TITLE     Katanin P60 and P80 in papillary thyroid carcinoma patients:
            Indicators for exacerbated tumor features and worse disease-free
            survival
  JOURNAL   J Clin Lab Anal 34 (12), e23502 (2020)
   PUBMED   33274499
  REMARK    GeneRIF: Katanin P60 and P80 in papillary thyroid carcinoma
            patients: Indicators for exacerbated tumor features and worse
            disease-free survival.
REFERENCE   5  (bases 1 to 2618)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2618)
  AUTHORS   McNally,F.J. and Thomas,S.
  TITLE     Katanin is responsible for the M-phase microtubule-severing
            activity in Xenopus eggs
  JOURNAL   Mol Biol Cell 9 (7), 1847-1861 (1998)
   PUBMED   9658175
REFERENCE   7  (bases 1 to 2618)
  AUTHORS   Hartman,J.J., Mahr,J., McNally,K., Okawa,K., Iwamatsu,A.,
            Thomas,S., Cheesman,S., Heuser,J., Vale,R.D. and McNally,F.J.
  TITLE     Katanin, a microtubule-severing protein, is a novel AAA ATPase that
            targets to the centrosome using a WD40-containing subunit
  JOURNAL   Cell 93 (2), 277-287 (1998)
   PUBMED   9568719
REFERENCE   8  (bases 1 to 2618)
  AUTHORS   McNally,F.J., Okawa,K., Iwamatsu,A. and Vale,R.D.
  TITLE     Katanin, the microtubule-severing ATPase, is concentrated at
            centrosomes
  JOURNAL   J Cell Sci 109 (Pt 3), 561-567 (1996)
   PUBMED   8907702
REFERENCE   9  (bases 1 to 2618)
  AUTHORS   McNally,F.J. and Vale,R.D.
  TITLE     Identification of katanin, an ATPase that severs and disassembles
            stable microtubules
  JOURNAL   Cell 75 (3), 419-429 (1993)
   PUBMED   8221885
REFERENCE   10 (bases 1 to 2618)
  AUTHORS   Cowan,N.J., Dobner,P.R., Fuchs,E.V. and Cleveland,D.W.
  TITLE     Expression of human alpha-tubulin genes: interspecies conservation
            of 3' untranslated regions
  JOURNAL   Mol Cell Biol 3 (10), 1738-1745 (1983)
   PUBMED   6646120
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU501165.1, BC001353.2 and
            AF052432.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005886.2.
            
            Summary: Microtubules, polymers of alpha and beta tubulin subunits,
            form the mitotic spindle of a dividing cell and help to organize
            membranous organelles during interphase. Katanin is a heterodimer
            that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa
            accessory protein (p80 subunit B 1). The p60 subunit acts to sever
            and disassemble microtubules, while the p80 subunit targets the
            enzyme to the centrosome. Katanin is a member of the AAA family of
            ATPases. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.921620.1,
                                           SRR1803612.485.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379661.8/ ENSP00000368982.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-392               BU501165.1         23-414
            393-1077            BC001353.2         64-748
            1078-2618           AF052432.1         766-2306
FEATURES             Location/Qualifiers
     source          1..2618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..2618
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /note="katanin regulatory subunit B1"
                     /db_xref="GeneID:10300"
                     /db_xref="HGNC:HGNC:6217"
                     /db_xref="MIM:602703"
     exon            1..86
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            87..392
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..2320
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /note="katanin (80 kDa); katanin p80 (WD repeat
                     containing) subunit B 1; katanin p80 (WD40-containing)
                     subunit B 1; katanin p80 WD40-containing subunit B1; p80
                     katanin; katanin p80 subunit B1"
                     /codon_start=1
                     /product="katanin p80 WD40 repeat-containing subunit B1"
                     /protein_id="NP_005877.2"
                     /db_xref="CCDS:CCDS10788.1"
                     /db_xref="GeneID:10300"
                     /db_xref="HGNC:HGNC:6217"
                     /db_xref="MIM:602703"
                     /translation="MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCR
                     VNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLM
                     GHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGK
                     WLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL
                     EKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVA
                     DLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVARDPVQDHRPLAQPLPNPSAPLR
                     RIYERPSTTCSKPQRVKQNSESERRSPSSEDDRDERESRAEIQNAEDYNEIFQPKNSI
                     SRTPPRRSEPFPAPPEDDAATAKEAAKPSPAMDVQFPVPNLEVLPRPPVVASTPAPKA
                     EPAIIPATRNEPIGLKASDFLPAVKIPQQAELVDEDAMSQIRKGHDTMCVVLTSRHKN
                     LDTVRAVWTMGDIKTSVDSAVAINDLSVVVDLLNIVNQKASLWKLDLCTTVLPQIEKL
                     LQSKYESYVQTGCTSLKLILQRFLPLITDMLAAPPSVGVDISREERLHKCRLCYKQLK
                     SISGLVKSKSGLSGRHGSTFRELHLLMASLD"
     exon            393..523
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            524..641
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            642..742
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            743..784
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            785..868
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            869..984
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1056
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1207
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1398
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1529
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1580
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1648
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1768
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1918
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..1995
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2070
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2187
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2618
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2601..2606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /note="hexamer: ATTAAA"
     polyA_site      2618
                     /gene="KATNB1"
                     /gene_synonym="KAT; LIS6"
                     /note="major polyA site"
ORIGIN      
        1 aagcagcggc caatcaaggc aggggatgga ggcaagtggg ggtcgcgcct ggagcggagc
       61 ctcggcctcc ggagccgcag ctgcagccct gtattgagct gagatggctc gagcctaaca
      121 ttccatgatc caggatcgtg acagatgtgc acaggctgct gctgttgctg ctgtgggtaa
      181 tttggaacca cgaggcaccc cagggccaga agacgaggca ttctgtctgc ctggatgtgt
      241 gggaactctc tgccaacttg attggtggat ctgggggggg atccaccccc accccacgag
      301 gaaagcacag tttattttgt gggtggggct tcaggtgcca gccagctgaa ggatggccac
      361 ccctgtggtc accaagacag cctggaagtt gcaagagatc gtcgcgcatg ccagcaacgt
      421 gtcctcactg gtgctgggca aagcctccgg gcggctgctg gctacaggcg gggatgactg
      481 ccgcgtcaac ctgtggtcca tcaacaagcc caactgcatc atgagcctga cgggccacac
      541 atccccagtg gagagcgtcc gcctcaacac ccccgaggag ctcatcgtgg ccggctctca
      601 gtcgggctcc atccgtgtct gggacctgga agctgccaaa attcttcgca cactcatggg
      661 acacaaagcc aacatctgca gcctggattt ccacccgtac ggcgagtttg tagcctctgg
      721 ttcccaggac acaaacatca agctctggga catcaggagg aaaggctgtg tcttccgata
      781 cagggggcac agccaggccg tgcggtgtct ccggttcagc cccgatggga agtggttggc
      841 gtcggccgca gatgaccaca ccgtgaagct ctgggatctc actgccggca agatgatgtc
      901 tgagttccct ggtcacacgg ggcctgtcaa cgtggtcgag tttcacccca acgagtacct
      961 cctggcctcc ggcagctctg acaggacaat ccgcttctgg gacctggaga agttccaggt
     1021 ggtgagctgc atcgaagggg agcctgggcc cgtcaggagc gtcctcttca acccagacgg
     1081 ctgctgcctg tacagcggct gccaggactc actgcgtgtc tacggctggg aacctgagcg
     1141 gtgctttgat gtggtcctcg tcaactgggg caaggtggcc gacctggcca tctgcaatga
     1201 ccagttgata ggtgtggcct tctcccagag caacgtctcc tcctacgtgg tggatctgac
     1261 gcgtgtcacc aggactggca cggtggcccg ggaccctgtg caggaccacc ggcccctggc
     1321 acagccactg cccaacccca gcgcccccct ccggcgcatc tatgagcggc ccagcacaac
     1381 ctgcagcaag cctcagaggg tgaagcagaa ctcagagagc gagcgccgca gccccagcag
     1441 cgaggatgac cgggacgagc gcgagtcccg cgcggagatc cagaacgccg aggactacaa
     1501 cgagatcttc cagcccaaga acagcatcag tcggacgcca ccccggagaa gtgagccctt
     1561 ccctgcaccc ccagaggacg acgcagccac agcaaaggag gcagcaaagc ccagccctgc
     1621 catggatgtg cagttcccgg tgccaaatct ggaggtcctg ccccggcccc cagtggttgc
     1681 ttccacacct gcacccaagg ctgagcctgc catcatccct gccacccgga acgagcccat
     1741 cgggctgaag gcctccgact tcctgcccgc cgtgaagatc ccccagcagg ccgagctggt
     1801 ggacgaggat gccatgtcac agatccgcaa aggccacgac accatgtgtg tggtgctcac
     1861 cagccgccac aagaacctgg acactgtgcg ggctgtgtgg accatgggcg acatcaagac
     1921 gtcggtggac tccgctgtgg ccatcaacga cctgtcggtg gtggtggacc tcctgaacat
     1981 cgtcaaccag aaagcctccc tgtggaagct ggacctgtgc accaccgtcc tgccacagat
     2041 tgagaagctt ctgcagagca agtatgagag ctacgtccag acgggctgca cctccctgaa
     2101 gctgatcctg cagcggtttc tgcccctcat cacagacatg ctggcggccc caccctctgt
     2161 gggtgtggat atcagcaggg aggagaggct gcataagtgc cggctctgct acaagcagct
     2221 taagagcatc agcggcctgg tcaagagcaa gtcaggcctg agcggccgcc atggcagtac
     2281 cttccgcgag ctgcacctgc tcatggccag tctggactga ggaaagcagt gggcaggggc
     2341 gctcggcagc ccacagggcc tggcctcagc ccccactcct gttccttgtg cacccactgg
     2401 cccatgagcc tctgcctggc ccctgctgct gtcctgtggc cgtcctggag gaggtgatgc
     2461 tggtccctgg ccacctctac agccctgaac tcttgagaca actctctcca gcaatagctg
     2521 cccagctttg cccaactgtt gcttcttggg gcagcgaact gagccctggg gctgctgctg
     2581 taatttataa ggcaaatttt attaaatttg taactatt
//
