LOCUS       NM_032116               7618 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens katanin catalytic subunit A1 like 1 (KATNAL1),
            transcript variant 1, mRNA.
ACCESSION   NM_032116
VERSION     NM_032116.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7618)
  AUTHORS   Cervan-Martin,M., Bossini-Castillo,L., Guzman-Jimenez,A.,
            Rivera-Egea,R., Garrido,N., Lujan,S., Romeu,G., Santos-Ribeiro,S.,
            Castilla,J.A., Gonzalvo,M.D.C., Clavero,A., Maldonado,V.,
            Vicente,F.J., Burgos,M., Jimenez,R., Gonzalez-Munoz,S.,
            Sanchez-Curbelo,J., Lopez-Rodrigo,O., Pereira-Caetano,I.,
            Marques,P.I., Carvalho,F., Barros,A., Bassas,L., Seixas,S.,
            Goncalves,J., Larriba,S., Lopes,A.M., Palomino-Morales,R.J. and
            Carmona,F.D.
  CONSRTM   IVIRMA Group; Lisbon Clinical Group
  TITLE     Common genetic variation in KATNAL1 non-coding regions is involved
            in the susceptibility to severe phenotypes of male infertility
  JOURNAL   Andrology 10 (7), 1339-1350 (2022)
   PUBMED   35752927
  REMARK    GeneRIF: Common genetic variation in KATNAL1 non-coding regions is
            involved in the susceptibility to severe phenotypes of male
            infertility.
REFERENCE   2  (bases 1 to 7618)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 7618)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7618)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7618)
  AUTHORS   Jiang,K., Rezabkova,L., Hua,S., Liu,Q., Capitani,G.,
            Altelaar,A.F.M., Heck,A.J.R., Kammerer,R.A., Steinmetz,M.O. and
            Akhmanova,A.
  TITLE     Microtubule minus-end regulation at spindle poles by an
            ASPM-katanin complex
  JOURNAL   Nat Cell Biol 19 (5), 480-492 (2017)
   PUBMED   28436967
  REMARK    Erratum:[Nat Cell Biol. 2017 Jun 29;19(7):873. doi:
            10.1038/ncb3557.. PMID: 28659643]
REFERENCE   6  (bases 1 to 7618)
  AUTHORS   Sonbuchner,T.M., Rath,U. and Sharp,D.J.
  TITLE     KL1 is a novel microtubule severing enzyme that regulates mitotic
            spindle architecture
  JOURNAL   Cell Cycle 9 (12), 2403-2411 (2010)
   PUBMED   20519956
  REMARK    GeneRIF: KL1-mediated microtubule severing is utilized to generate
            microtubule seeds within the poles and loss of this activity alters
            the normal balance of motor-generated forces that determine spindle
            length.
REFERENCE   7  (bases 1 to 7618)
  AUTHORS   Rigden,D.J., Liu,H., Hayes,S.D., Urbe,S. and Clague,M.J.
  TITLE     Ab initio protein modelling reveals novel human MIT domains
  JOURNAL   FEBS Lett 583 (5), 872-878 (2009)
   PUBMED   19302785
REFERENCE   8  (bases 1 to 7618)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   9  (bases 1 to 7618)
  AUTHORS   Millar,J.K., Christie,S. and Porteous,D.J.
  TITLE     Yeast two-hybrid screens implicate DISC1 in brain development and
            function
  JOURNAL   Biochem Biophys Res Commun 311 (4), 1019-1025 (2003)
   PUBMED   14623284
REFERENCE   10 (bases 1 to 7618)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356750.16, DR006891.1 and BC000612.2.
            
            On Nov 23, 2018 this sequence version replaced NM_032116.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.216669.1,
                                           SRR1660805.133479.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380615.8/ ENSP00000369989.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AL356750.16        109010-109073       c
            65-116              DR006891.1         36-87
            117-1781            BC000612.2         13-1677
            1782-7618           AL356750.16        4152-9988           c
FEATURES             Location/Qualifiers
     source          1..7618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.3"
     gene            1..7618
                     /gene="KATNAL1"
                     /note="katanin catalytic subunit A1 like 1"
                     /db_xref="GeneID:84056"
                     /db_xref="HGNC:HGNC:28361"
                     /db_xref="MIM:614764"
     exon            1..221
                     /gene="KATNAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            222..397
                     /gene="KATNAL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1708
                     /gene="KATNAL1"
                     /EC_number="5.6.1.1"
                     /note="p60 katanin-like 1; katanin p60 subunit A like 1;
                     katanin catalytic subunit A like 1"
                     /codon_start=1
                     /product="katanin p60 ATPase-containing subunit A-like 1"
                     /protein_id="NP_115492.1"
                     /db_xref="CCDS:CCDS31956.1"
                     /db_xref="GeneID:84056"
                     /db_xref="HGNC:HGNC:28361"
                     /db_xref="MIM:614764"
                     /translation="MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVR
                     DPAIKGKWQQVRQELLEEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPP
                     VPAEHRAPPQIRRPNREVRPLRKEMAGVGARGPVGRAHPISKSEKPSTSRDKDYRARG
                     RDDKGRKNMQDGASDGEMPKFDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKK
                     LLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSST
                     LTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLI
                     QMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKI
                     NLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSPEEIRALSKE
                     ELQMPVTKGDFELALKKIAKSVSAADLEKYEKWMVEFGSA"
     exon            398..558
                     /gene="KATNAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..727
                     /gene="KATNAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..855
                     /gene="KATNAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..961
                     /gene="KATNAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1120
                     /gene="KATNAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1247
                     /gene="KATNAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1382
                     /gene="KATNAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1509
                     /gene="KATNAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..7618
                     /gene="KATNAL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7592..7597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KATNAL1"
                     /note="hexamer: AATAAA"
     polyA_site      7618
                     /gene="KATNAL1"
                     /note="major polyA site"
ORIGIN      
        1 agtcccaagc tccgccccag agcggactca cagcccccgc gctccctccc gcgctgcgcc
       61 caccgcgcgg ccgcggctgc catggcaaca ctacgccgcc gccgcctttt cacgcacgtc
      121 gcgagctaac ggactcggcg gcggcggcgg cggcggcctg cgccccaccc gcaccccatc
      181 tggaccgcat cgctgaatgt gcccggacct gcgccttctg ggtctctgaa agaagatgaa
      241 tttggctgag atttgtgata atgcaaagaa aggaagagaa tatgcccttc ttggaaatta
      301 cgactcatca atggtatatt accagggggt gatgcagcag attcagagac attgccagtc
      361 agtcagagat ccagctatca aaggcaaatg gcaacaggtt cggcaggaat tattggagga
      421 atatgaacaa gttaaaagta ttgtcagcac tttagaaagt tttaaaattg acaagcctcc
      481 agatttccct gtgtcctgtc aagatgaacc atttagagat cctgctgttt ggccaccccc
      541 tgttcctgca gaacacagag ctccacctca gatcaggcgt cccaatcgag aagtaagacc
      601 tctgaggaaa gaaatggcag gagtaggagc ccggggacct gtaggccgag cacatcctat
      661 atcaaagagt gaaaagcctt ctacaagtag ggacaaggac tatagagcaa gagggagaga
      721 tgacaaggga aggaagaata tgcaagatgg tgcaagtgat ggtgaaatgc caaaatttga
      781 tggtgctggt tatgataagg atctggtgga agcccttgaa agagacattg tatccaggaa
      841 tcctagcatt cattgggatg acatagcaga tctggaagaa gctaagaagt tgctaaggga
      901 agctgttgtt cttccaatgt ggatgcctga ctttttcaaa gggattagaa ggccatggaa
      961 gggtgtactg atggttggac ccccaggcac tggtaaaact atgctagcta aagctgttgc
     1021 cactgaatgt ggtacaacat tcttcaacgt ttcgtcttct acactgacat ctaaatacag
     1081 aggtgaatct gagaagttag ttcgtctgtt gtttgagatg gctagatttt atgcccctac
     1141 cacgatcttc attgatgaga tagattctat ctgcagtcga agaggaacct ctgatgaaca
     1201 tgaggcaagt cgcagggtca agtctgaact gctcattcag atggatggag ttggaggagc
     1261 tttagaaaat gatgatcctt ccaaaatggt tatggtattg gctgctacta atttcccgtg
     1321 ggacattgat gaagctttgc gaagaaggtt agaaaaaagg atatatatac ctctcccaac
     1381 agcaaaagga agagctgagc ttctgaagat caaccttcgt gaggtcgaat tagatcctga
     1441 tattcaactg gaagatatag ccgagaagat tgagggctat tctggtgctg acatcactaa
     1501 tgtttgcagg gatgcctctt taatggcaat gagacggcgt atcaatggct taagtccaga
     1561 agaaatccgt gcactttcta aagaggaact tcagatgcct gttaccaaag gagactttga
     1621 attggcccta aagaaaattg ctaagtctgt ctctgctgca gacttggaga agtatgaaaa
     1681 atggatggtt gaatttggat ctgcttgaat ttctgtcagc tctttaattt ctggtatttt
     1741 tgttgataaa atacgaagaa attcctgcaa tttttaaaaa acaagtttgg aatttttttc
     1801 agtggagtgg ttttcgctta aaggaaaaaa aaatctaaaa ctgcgaagaa tactaaatgt
     1861 agttgagaaa taattgatgg cgagagtttg ctagtctccc tccccggctt tgtgctggta
     1921 ttccacgtat tcctgcatta atattgcaca cccaaaccag tctatcaggg aggctgaagc
     1981 aagggcgcag tgtgatattt taggaataca gaagatttag aaatacccct atttctcatt
     2041 tgcagttttt ttttccaatt ctgtgctctg tcaacatgag ggacctatct atgtatgttg
     2101 acttttaaca tcaaaattgg atttgtgtca aacattcatt gttaagagaa gaatgacagt
     2161 atattttgga ggaaataatg aatttactaa ttaaaccttt agaatttatg acttactgtt
     2221 agagtctgtc atatggttag aatttttact tccgctaccc ctgccatttc ttctgctagc
     2281 tacttcataa tatcttgagc tttactgagg aatattctca cgctctgtgg tatttgaatc
     2341 attttgccag gtcatttctc tgtctttagt attttttgct ggtgcttctt acatttaata
     2401 tggaaaggtg ggaagaatat tactgcatta gatgtaattc ttcattctag acttccaagt
     2461 ttgttttcac ttttttgtgt gtgcgtgaag gagtctgtgt cacccaggct gtgtagtgca
     2521 gtggttgatc ttggctcact gcaacctctg cctcctagat tcaagcaatt ctcctgtctc
     2581 agcctcccaa gtagctggga ttacaggtgc gcaccaccat gcctggctgt gttttcactt
     2641 ttctttcaac atgttcaacc agatatatag ccattatttt tctcagctcc agcattgttt
     2701 gatttttctt gagtttgatt ttagtatttg agataaatac ttttacattc taaacaagtc
     2761 cactctctgt ggctaacgca aaacaaatga aatctttatt gttttccaaa cagctagttt
     2821 aacaaaacag catcatacat agtgaatgat gttcattgga aaattctaaa atttgtcctt
     2881 gtctaggttg agaactttta cacacactaa gataaagata gaaatctgac atgctcactc
     2941 aattcagcag gaattacaca ttagaaagaa gccagaaaaa taaatggcat atatccaatc
     3001 acaagtaaat gatcctggcg ttagttttta tgattacatg tgtctcatta ggcaatttat
     3061 gctttaatgg tcaagctttt aaaaatttgt atttgataac atcctgaatt ctcagtttcg
     3121 aatagtgcct actggtttaa aactaaaaat aatacagctt tttggacatt taaccaagat
     3181 actaagaagg ttttttttaa aaaaagagat ttgattattt ttccctgcta aaaactgtaa
     3241 atgccttatg ttcttttcag ataacttaag tctgacctaa actccagtat tcatctgatg
     3301 ctgtaaattg cccttctttc tgagacacag attataagat gccagatcat aagacatcat
     3361 gattttattg taattgaatt cttcctaaaa attgagaggt ttccttttat taacttttaa
     3421 aataaagaaa taagtagttt cattacgatt attttgcaaa ctattgccag tcagaaatgc
     3481 actttttttt tccctgaagt tttaggagcc gtcactaaaa cattagtctt gtgattgtta
     3541 aaacttgttt gtaatgggtt ggtgcaaaag taattgtggt ttttccatta ctttcaatgg
     3601 caaaaaccgc aattactttt gcaccagcct aacaatagtt gattagttag accttttctg
     3661 ggttttgtat tgattatctt ggtgtgcatt taattatttt tctgaattct tcatggataa
     3721 tgacatagta attgtgattc ttttaatacc agttaagcag tatttggcaa cttaaacttc
     3781 ctgggagcct aactttacta tgttaagtga gtcaggtgtg ctttttattt cccttgtttc
     3841 tcattttgcc ctgtcagtgg atggtagatg ctttgtatat cttaaatccc ttaaaggatc
     3901 ttaaagacat ccctcaggtg ttctatttaa cttttatttt attttatttt atttatttat
     3961 ttattttgag actgagtctt gctctgtcgc ccaggctgga gtgcagtggc atgatctcgg
     4021 ctcactgcaa cttctgcctc ccaggttcaa gccattctcc tgcctcggcc tcctgagtag
     4081 ctgggattac agttgccgcc acacccggct tatttttttg tatttttagt agaggcagag
     4141 tttcaccatg ttggccaggc tagtctcgaa ctcctgacct cagatgatcc gcccacattg
     4201 gcctcccaaa gtgctgggat tacaggtgtg atccaccgca cctggcccta acttttaata
     4261 tacaacacac acacacacac acacacacac acacacacac acacacacac acacacacac
     4321 actatttcag aagacagtgt gttgccttac ccagaatgag tgctaggatt acaggcgtga
     4381 gacagacaca catacacaca catacacaca cacagagtct ttattgcaga agacagtgtg
     4441 ttgccttata ggcgtgagac acacacacac acacacacac acacacacac acacacagtc
     4501 tttattgcag aagacagtgt gttgccttac cagaatgagt gcttggatta caggcgtgag
     4561 ccactgtgcc cagccctaac ttttaatgta catcacacac acactcacac tcacatacac
     4621 acacacacac acactctgac tgtctttatt gcagaagaca gtgtgttgcc ttacccagaa
     4681 tgagattgaa ttgttttgct tcgttttgtt ttgttattca gtgttgcggt agcagatgca
     4741 ttatcaaagg aaaaatattt ggctccttta attcctctga aaacatgagt attttgagtt
     4801 ctgcagcaca atgactgtag gactaagcta agtctgcttt gcagatatct gatcagatag
     4861 tcccttcatt ctgtagacgt gtattggttg gtccaagaca cagtgagtag gagctctgtg
     4921 gaccaagaca aagctggact agagagtaca gttcaaactt ggcagtttct ctaacgactc
     4981 tgtatagctt ctggcttcta ctactgaaac aagagtttag atcactgatg gagaggcata
     5041 gtaatctgtt tgtgctttgg aaaaatatat aaaagttttt ttcccctatt ttttgcactt
     5101 taaatctgtt ttgaaattag aactgatata catttatttg aataatgtgt aactattatg
     5161 gatctatttt aatgaacaat ttttaccatt tcccaagctg cctgtttatt ataagcatga
     5221 catgtttact ataaaccttt tgcccccata atttcttttt ttaaaggaaa ttaatattag
     5281 taaaataaac acctctttaa tggaagctgc aaccttctag tgatccaagt agacaataga
     5341 tggtggcatc acagacttta tctacacact ttcgggtctg accactacct cccacaatac
     5401 ctagccattt tggaagggga aaacatgcgg tggtctagct gtatagctca gggcttaatt
     5461 tcagcttctg agattgtgat gtcatatttc actctcaaaa cataggctga aagcacgaat
     5521 tactcaaaaa gtaagcaaac caatacctgg tgaatctatg gacagtcata cacatacatc
     5581 aggggaaaat gtgtgtgtac aacccaaatt tacagtatga ttgtcattct ttgactttgt
     5641 tttgtatagc ctgactctgt tgaacatgaa attattagta ctctaggttt tggacagctt
     5701 gagttcattt gaattccttc cttaggaata agtttttata tacactgcta aatgtgtgat
     5761 gagaatcata aaacactaac cagctgaggt agctgtgatt cactttcccc ccaccctaac
     5821 ttgagataaa atgaaggact aggcaagtat ttcatgttgt gtgagtggac ttcggttcct
     5881 tcagtattgt ctaggttatt gagtctttct ttgcctaata gtggattccc actcttaaga
     5941 taacttttat tagtgataaa tcagtttagg gtatattctg tatgacaggc ataaaatgtt
     6001 aagggtgaat gctggccttt tccaagaaaa ggccacctta acttgtatga ggaaaaaatc
     6061 ctaactattc tcttttttgt atcttttttt ccgtaactgt tttgattgta tattttaaag
     6121 aaaccactta atttgtgatg cacgtaatat ttgtgtgaac ctgagaatat gtcacaatag
     6181 gaaaaagcag aaattatact taggggacat gttagggggg taaaaatatt taagcctcga
     6241 atgttttact gtcatctcca ctaactattt ttacagaaaa agctaaaaac tctgttgtaa
     6301 ttattgtaag tttacttatt tatactttta aattaggctt ttcatactta aatttttttg
     6361 acatttgctt ttaatatttg tttcttaatg tggaaattgt gtattttaat aatcaaatta
     6421 ttaggataat agatatattt ttaaacattc acctcattaa caaatagatc tttgaatttt
     6481 tattaggttt tttggctcca gacaactgtt tagctttaat gatatttcta aattcccagt
     6541 gacttattaa taaaaacagg aaaaatattt aggtaatgtc ataaaattta ttttaccttt
     6601 ctcattttct gagaaaataa atgaaaaaaa ccctagatat tgctttatta ccaacagtgt
     6661 gtaggttttt gtacatatgg aaatttgaca caaaaaaata gggaatttgt atagagaagt
     6721 ttccctctta taaaaggact cccatttgat tgttcgaaac tataaaatgc acttttactt
     6781 taccatatct gaaatgacaa aatatcgccc tttggaaaac ctgactcttt gcacgtgtaa
     6841 ttcccagagt ctacctcagt taaccaggct tagttttagg caggaatgaa ttgaattaaa
     6901 ttcagttcat catctatgca gatttgtttc ttttaagcac atccttccct cctgctgttg
     6961 ccctcctccc attaactttt ctttttaatc ttgaaattgt ttaaaatatt ccatctttct
     7021 ttctctagca aagtgtttgt attccaaata aggcctctgt gaaatgtctg aattactttt
     7081 cccgtctttg ttatggtcag cttcattatt tggatgtatt gcattcaaag cagcagttcc
     7141 aaacataaca cacatctatt ttcttagagt tttgtaaata caaactaacc tgatgacatt
     7201 aaaaattgtg gatcctacat gttcctatgt tcattctcta aaaacctgag taactttatg
     7261 aaaacacaca aacctggaaa aacatcacat ttttgtcaca tttttactga caaatgtata
     7321 ttcatatgat ggtacggcag cagggagtgg cccccagtta acatggctgt gagtggacac
     7381 agtgtctcgc aggatcactg catgttatga tggcttgtaa gtgcgttgtt aagacttttg
     7441 tttcagtgtt tgtctcccag tatttgaacc taatttaaag aaaaagacgt ttccaagttg
     7501 tatttattaa atgtgttttt ccttaccttt tgtgctgcta ctttgctaat ctcattagct
     7561 tagctgtgtt tgtgcatagg ttatatttgg taataaattt atagagtgtt ggttgtca
//
