LOCUS       NM_007044               1898 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens katanin catalytic subunit A1 (KATNA1), transcript
            variant 1, mRNA.
ACCESSION   NM_007044
VERSION     NM_007044.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1898)
  AUTHORS   Li,S., Liang,Y., Zou,J., Cai,Z., Yang,H., Yang,J., Zhang,Y.,
            Lin,H., Zhang,G. and Tan,M.
  TITLE     SUMOylation of microtubule-cleaving enzyme KATNA1 promotes
            microtubule severing and neurite outgrowth
  JOURNAL   J Biol Chem 298 (9), 102292 (2022)
   PUBMED   35868557
  REMARK    GeneRIF: SUMOylation of microtubule-cleaving enzyme KATNA1 promotes
            microtubule severing and neurite outgrowth.
REFERENCE   2  (bases 1 to 1898)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1898)
  AUTHORS   Cupido,T., Jones,N.H., Grasso,M.J., Pisa,R. and Kapoor,T.M.
  TITLE     A chemical genetics approach to examine the functions of AAA
            proteins
  JOURNAL   Nat Struct Mol Biol 28 (4), 388-397 (2021)
   PUBMED   33782614
  REMARK    GeneRIF: A chemical genetics approach to examine the functions of
            AAA proteins.
REFERENCE   4  (bases 1 to 1898)
  AUTHORS   Chen,Q., Lin,F., Lin,E., Huang,Q. and Wu,G.
  TITLE     Katanin P60 and P80 in papillary thyroid carcinoma patients:
            Indicators for exacerbated tumor features and worse disease-free
            survival
  JOURNAL   J Clin Lab Anal 34 (12), e23502 (2020)
   PUBMED   33274499
  REMARK    GeneRIF: Katanin P60 and P80 in papillary thyroid carcinoma
            patients: Indicators for exacerbated tumor features and worse
            disease-free survival.
REFERENCE   5  (bases 1 to 1898)
  AUTHORS   Wang,L., Tantai,J. and Zhu,X.
  TITLE     Katanin P60: a potential biomarker for lymph node metastasis and
            prognosis for non-small cell lung cancer
  JOURNAL   World J Surg Oncol 18 (1), 157 (2020)
   PUBMED   32631334
  REMARK    GeneRIF: Katanin P60: a potential biomarker for lymph node
            metastasis and prognosis for non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1898)
  AUTHORS   Ahmad,F.J., Yu,W., McNally,F.J. and Baas,P.W.
  TITLE     An essential role for katanin in severing microtubules in the
            neuron
  JOURNAL   J Cell Biol 145 (2), 305-315 (1999)
   PUBMED   10209026
REFERENCE   7  (bases 1 to 1898)
  AUTHORS   McNally,F.J. and Thomas,S.
  TITLE     Katanin is responsible for the M-phase microtubule-severing
            activity in Xenopus eggs
  JOURNAL   Mol Biol Cell 9 (7), 1847-1861 (1998)
   PUBMED   9658175
REFERENCE   8  (bases 1 to 1898)
  AUTHORS   Hartman,J.J., Mahr,J., McNally,K., Okawa,K., Iwamatsu,A.,
            Thomas,S., Cheesman,S., Heuser,J., Vale,R.D. and McNally,F.J.
  TITLE     Katanin, a microtubule-severing protein, is a novel AAA ATPase that
            targets to the centrosome using a WD40-containing subunit
  JOURNAL   Cell 93 (2), 277-287 (1998)
   PUBMED   9568719
REFERENCE   9  (bases 1 to 1898)
  AUTHORS   McNally,F.J., Okawa,K., Iwamatsu,A. and Vale,R.D.
  TITLE     Katanin, the microtubule-severing ATPase, is concentrated at
            centrosomes
  JOURNAL   J Cell Sci 109 (Pt 3), 561-567 (1996)
   PUBMED   8907702
REFERENCE   10 (bases 1 to 1898)
  AUTHORS   McNally,F.J. and Vale,R.D.
  TITLE     Identification of katanin, an ATPase that severs and disassembles
            stable microtubules
  JOURNAL   Cell 75 (3), 419-429 (1993)
   PUBMED   8221885
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292090.1, CA426364.1 and
            BC050428.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007044.3.
            
            Summary: Microtubules, polymers of alpha and beta tubulin subunits,
            form the mitotic spindle of a dividing cell and help to organize
            membranous organelles during interphase. Katanin is a heterodimer
            that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa
            accessory protein (p80 subunit B 1). The p60 subunit acts to sever
            and disassemble microtubules, while the p80 subunit targets the
            enzyme to the centrosome. This gene encodes the p80 subunit. This
            protein is a member of the AAA family of ATPases. Multiple
            alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.177021.1,
                                           SRR1660807.46546.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367411.7/ ENSP00000356381.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1286              AK292090.1         1-1286
            1287-1287           CA426364.1         533-533             c
            1288-1894           AK292090.1         1288-1894
            1895-1898           BC050428.1         1467-1470
FEATURES             Location/Qualifiers
     source          1..1898
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..1898
                     /gene="KATNA1"
                     /note="katanin catalytic subunit A1"
                     /db_xref="GeneID:11104"
                     /db_xref="HGNC:HGNC:6216"
                     /db_xref="MIM:606696"
     exon            1..246
                     /gene="KATNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            247..421
                     /gene="KATNA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1735
                     /gene="KATNA1"
                     /EC_number="5.6.1.1"
                     /note="isoform 1 is encoded by transcript variant 1; p60
                     katanin; katanin p60 subunit A1; katanin p60 (ATPase
                     containing) subunit A 1"
                     /codon_start=1
                     /product="katanin p60 ATPase-containing subunit A1 isoform
                     1"
                     /protein_id="NP_008975.1"
                     /db_xref="CCDS:CCDS5217.1"
                     /db_xref="GeneID:11104"
                     /db_xref="HGNC:HGNC:6216"
                     /db_xref="MIM:606696"
                     /translation="MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVK
                     DTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPV
                     PVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQ
                     NKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAK
                     KLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSS
                     TLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELL
                     VQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLR
                     ISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSK
                     EEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC"
     exon            422..579
                     /gene="KATNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..760
                     /gene="KATNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..882
                     /gene="KATNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..988
                     /gene="KATNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1147
                     /gene="KATNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1274
                     /gene="KATNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1409
                     /gene="KATNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1536
                     /gene="KATNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1898
                     /gene="KATNA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1871..1876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KATNA1"
                     /note="hexamer: AATAAA"
     polyA_site      1898
                     /gene="KATNA1"
                     /note="major polyA site"
ORIGIN      
        1 agagtcgccg aggtcgtccc cggcaccgga agtgaccctg gcgggtttgt cttcaaattc
       61 tcggcgagca ggagccgcgc cggcaggtgg tgttgacgat tgaactgggc agtactgggg
      121 ccgtgagcgg agagcaaagt gggctggact gggtcaggcc ctccttcctc gctgccggga
      181 tctccactcc gccaatcccc tgtgcctggc gttgggcggt ttcccgagga gcttgggccg
      241 ccgcagctta cagttgaaca tgagtcttct tatgattagt gagaatgtaa aattggctcg
      301 tgaatatgca ttgctgggaa actatgactc tgcgatggtc tattatcagg gagttcttga
      361 ccaaatgaac aagtatctgt actcagtcaa agatacatac ctccagcaga aatggcaaca
      421 ggtttggcag gaaataaatg tggaagctaa acatgttaaa gatatcatga aaacactaga
      481 gagctttaaa ctggacagca ctcccttgaa agcggcacag catgaccttc cagcttctga
      541 gggagaagtc tggtccatgc ctgtacctgt tgaacgaaga ccctcaccag gacctagaaa
      601 acgccaatct tctcagtaca gtgaccctaa atcacatggt aatcgtccaa gtacaactgt
      661 cagagttcac cgttcatctg cacagaatgt tcacaatgac agagggaaag ctgttcgttg
      721 tcgtgaaaag aaagaacaga ataaaggaag agaggaaaag aacaaatcac ctgctgcagt
      781 aacagaacca gagacaaata aatttgatag taccggatat gataaagact tagtagaagc
      841 tttggaaaga gatataattt cccagaatcc caatgttcga tgggatgata tcgctgattt
      901 agtagaagct aaaaagttgc ttaaggaagc cgtagtgtta ccaatgtgga tgcccgaatt
      961 ctttaagggc attaggagac catggaaagg agtactgatg gtcggcccac ctggcacggg
     1021 gaagacgctc cttgctaaag cagtagctac agaatgcaag acaacattct tcaatgtctc
     1081 ttcatcaact ttgacttcca aatacagagg agaatctgag aagcttgttc gtcttctgtt
     1141 tgaaatggct cgattttatt ctccagccac catatttatt gatgagatag actccatctg
     1201 tagtcgccga gggacttctg aagaacatga agcaagcaga agggtgaaag cggagctgct
     1261 ggttcagatg gatggtgttg gaggtacttc tgaaaatgat gacccttcca aaatggttat
     1321 ggttctggca gctactaatt ttccctggga tatagatgag gctttaagac gacgccttga
     1381 gaaacgaatc tatattcctt tgccgtcagc aaaaggcagg gaggagctat tacgaataag
     1441 tctacgtgag ttggaattgg ctgatgatgt tgaccttgca agtatagcag aaaacatgga
     1501 aggttattca ggtgcggaca ttaccaacgt gtgcagggat gcgtccttga tggcaatgag
     1561 aaggcgcatt gaaggtttga ctccagagga aatccgaaat ctttccaaag aagaaatgca
     1621 catgcctaca actatggagg atttcgagat ggctttaaaa aaggtttcta agtcagtgtc
     1681 tgctgcagac attgaaagat acgagaaatg gatatttgag tttggatcat gctaaattct
     1741 cacatgtaaa ctgtgagaaa tgtgccttaa gtgtttgaat attaaatgca gtaattcatt
     1801 gtactgagtg ctatattttt tttaactttc ataatggtaa gattttttta aaaaaaccct
     1861 tatgattctg aataaaggca atatttttaa gctgaaaa
//
