LOCUS       NM_007067               9514 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens lysine acetyltransferase 7 (KAT7), transcript variant
            1, mRNA.
ACCESSION   NM_007067
VERSION     NM_007067.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9514)
  AUTHORS   Rondeau,V., Berman,J.M., Ling,T., O'Brien,C., Culp-Hill,R.,
            Reisz,J.A., Wunderlich,M., Chueh,Y., Jimenez-Camacho,K.E.,
            Sexton,C., Carter,K.M., Stillwell,C., St-Germain,J., Yendi,D.,
            Gupta,A., Shi,M., Bourdine,A., Paralkar,V.R., Jahangiri,S.,
            Hope,K.J., Tikhonova,A.N., Arruda,A., Minden,M.D., Raught,B.,
            D'Alessandro,A. and Jones,C.L.
  TITLE     Spermidine metabolism regulates leukemia stem and progenitor cell
            function through KAT7 expression in patient-derived mouse models
  JOURNAL   Sci Transl Med 16 (766), eadn1285 (2024)
   PUBMED   39321266
  REMARK    GeneRIF: Spermidine metabolism regulates leukemia stem and
            progenitor cell function through KAT7 expression in patient-derived
            mouse models.
REFERENCE   2  (bases 1 to 9514)
  AUTHORS   Yuan,Q., Wu,Y., Xue,C., Zhao,D., Wang,H. and Shen,Y.
  TITLE     KAT7 serves as an oncogenic gene and regulates CCL3 expression via
            STAT1 signaling in osteosarcoma
  JOURNAL   Biochem Biophys Res Commun 722, 150156 (2024)
   PUBMED   38797155
  REMARK    GeneRIF: KAT7 serves as an oncogenic gene and regulates CCL3
            expression via STAT1 signaling in osteosarcoma.
REFERENCE   3  (bases 1 to 9514)
  AUTHORS   Zhang,C., Shan,Y., Lin,H., Zhang,Y., Xing,Q., Zhu,J., Zhou,T.,
            Lin,A., Chen,Q., Wang,J. and Pan,G.
  TITLE     HBO1 determines SMAD action in pluripotency and mesendoderm
            specification
  JOURNAL   Nucleic Acids Res 52 (9), 4935-4949 (2024)
   PUBMED   38421638
  REMARK    GeneRIF: HBO1 determines SMAD action in pluripotency and
            mesendoderm specification.
REFERENCE   4  (bases 1 to 9514)
  AUTHORS   Zhang,X., Zhang,X., Chen,L., Zhao,J., Raj,A., Wang,Y., Li,S.,
            Zhang,C., Yang,J. and Sun,D.
  TITLE     Adipose Mesenchymal Stem Cell-derived Exosomes Enhanced Glycolysis
            through the SIX1/HBO1 Pathway against Oxygen and Glucose
            Deprivation Injury in Human Umbilical Vein Endothelial Cells
  JOURNAL   Curr Stem Cell Res Ther 19 (8), 1153-1163 (2024)
   PUBMED   37779410
  REMARK    GeneRIF: Adipose Mesenchymal Stem Cell-derived Exosomes Enhanced
            Glycolysis through the SIX1/HBO1 Pathway against Oxygen and Glucose
            Deprivation Injury in Human Umbilical Vein Endothelial Cells.
REFERENCE   5  (bases 1 to 9514)
  AUTHORS   Wang,H., Qiu,Y., Zhang,H., Chang,N., Hu,Y., Chen,J., Hu,R.,
            Liao,P., Li,Z., Yang,Y., Cen,Q., Ding,X., Li,M., Xie,X. and Li,Y.
  TITLE     Histone acetylation by HBO1 (KAT7) activates Wnt/beta-catenin
            signaling to promote leukemogenesis in B-cell acute lymphoblastic
            leukemia
  JOURNAL   Cell Death Dis 14 (8), 498 (2023)
   PUBMED   37542030
  REMARK    GeneRIF: Histone acetylation by HBO1 (KAT7) activates
            Wnt/beta-catenin signaling to promote leukemogenesis in B-cell
            acute lymphoblastic leukemia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9514)
  AUTHORS   Cervoni,N., Detich,N., Seo,S.B., Chakravarti,D. and Szyf,M.
  TITLE     The oncoprotein Set/TAF-1beta, an inhibitor of histone
            acetyltransferase, inhibits active demethylation of DNA,
            integrating DNA methylation and transcriptional silencing
  JOURNAL   J Biol Chem 277 (28), 25026-25031 (2002)
   PUBMED   11978794
  REMARK    GeneRIF: inhibition by Set/TAF-1beta inhibits active demethylation
            of DNA, integrating DNA methylation and transcriptional silencing
REFERENCE   7  (bases 1 to 9514)
  AUTHORS   Sharma,D. and Fondell,J.D.
  TITLE     Ordered recruitment of histone acetyltransferases and the
            TRAP/Mediator complex to thyroid hormone-responsive promoters in
            vivo
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7934-7939 (2002)
   PUBMED   12034878
  REMARK    GeneRIF: ordered recruitmenet to thyroid hormone-responsive
            promoters in vivo
REFERENCE   8  (bases 1 to 9514)
  AUTHORS   Burke,T.W., Cook,J.G., Asano,M. and Nevins,J.R.
  TITLE     Replication factors MCM2 and ORC1 interact with the histone
            acetyltransferase HBO1
  JOURNAL   J Biol Chem 276 (18), 15397-15408 (2001)
   PUBMED   11278932
REFERENCE   9  (bases 1 to 9514)
  AUTHORS   Sharma,M., Zarnegar,M., Li,X., Lim,B. and Sun,Z.
  TITLE     Androgen receptor interacts with a novel MYST protein, HBO1
  JOURNAL   J Biol Chem 275 (45), 35200-35208 (2000)
   PUBMED   10930412
REFERENCE   10 (bases 1 to 9514)
  AUTHORS   Iizuka,M. and Stillman,B.
  TITLE     Histone acetyltransferase HBO1 interacts with the ORC1 subunit of
            the human initiator protein
  JOURNAL   J Biol Chem 274 (33), 23027-23034 (1999)
   PUBMED   10438470
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015795.20 and AC027801.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007067.4.
            
            Summary: The protein encoded by this gene is part of the multimeric
            HBO1 complex, which possesses histone H4-specific acetyltransferase
            activity. This activity is required for functional replication
            origins and is involved in transcriptional activation of some
            genes. In both cases, the acetylation of histone H4 helps unfold
            chromatin so that the DNA can be accessed and replicated or
            transcribed. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.89890.1,
                                           SRR1660807.265636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259021.9/ ENSP00000259021.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC015795.20        135213-135381
            170-317             AC015795.20        138418-138565
            318-494             AC015795.20        143282-143458
            495-734             AC015795.20        144851-145090
            735-817             AC015795.20        151895-151977
            818-907             AC015795.20        155651-155740
            908-1006            AC015795.20        158008-158106
            1007-1117           AC015795.20        162335-162445
            1118-1309           AC015795.20        164352-164543
            1310-1399           AC015795.20        167869-167958
            1400-1540           AC015795.20        168182-168322
            1541-1634           AC015795.20        169734-169827
            1635-1781           AC027801.10        48412-48558
            1782-1888           AC027801.10        49105-49211
            1889-9514           AC027801.10        49813-57438
FEATURES             Location/Qualifiers
     source          1..9514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..9514
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /note="lysine acetyltransferase 7"
                     /db_xref="GeneID:11143"
                     /db_xref="HGNC:HGNC:17016"
                     /db_xref="MIM:609880"
     exon            1..169
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1990
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /EC_number="2.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 1; MYST
                     histone acetyltransferase 2; histone acetyltransferase
                     MYST2; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; histone
                     acetyltransferase binding to ORC1; histone
                     acetyltransferase KAT7; K(lysine) acetyltransferase 7"
                     /codon_start=1
                     /product="histone acetyltransferase KAT7 isoform 1"
                     /protein_id="NP_008998.1"
                     /db_xref="CCDS:CCDS11554.1"
                     /db_xref="GeneID:11143"
                     /db_xref="HGNC:HGNC:17016"
                     /db_xref="MIM:609880"
                     /translation="MPRRKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTR
                     SSARLSQSSQDSSPVRNLQSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGS
                     ETEQVVDFSDRETKNTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLK
                     DSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSAD
                     ECKVRAQSRDKQIEERMLSHRQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLS
                     KEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGS
                     NMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKH
                     PPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEAD
                     NTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPE
                     RPLSDLGLISYRSYWKEVLLRYLHNFQGKEISIKEISQETAVNPVDIVSTLQALQMLK
                     YWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTPPKGT"
     exon            170..317
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /inference="alignment:Splign:2.1.0"
     exon            318..494
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /inference="alignment:Splign:2.1.0"
     exon            495..734
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /inference="alignment:Splign:2.1.0"
     exon            735..817
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /inference="alignment:Splign:2.1.0"
     exon            818..907
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1006
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1117
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1309
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1399
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1540
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1634
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1781
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1888
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..9514
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3562..3567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /note="hexamer: AATAAA"
     polyA_site      3584
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /note="major polyA site"
     regulatory      7278..7283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /note="hexamer: AATAAA"
     polyA_site      7295
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
     regulatory      7739..7744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /note="hexamer: TATAAA"
     polyA_site      7762
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
     regulatory      9496..9501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
                     /note="hexamer: AATAAA"
     polyA_site      9514
                     /gene="KAT7"
                     /gene_synonym="HBO1; HBOA; MYST2; ZC2HC7"
ORIGIN      
        1 gcagaacgct ccagacgctg agaggcagga ggcactaggg atcgtccgca ggattgggac
       61 tgatacagag gccgccacgg agcccgccgg agccaccgtt cctgctgctg ccgccgctgc
      121 ccgaatcgga accgtcgggc cgcagccgcc ggcaatgccg cgaaggaaga ggaatgcagg
      181 cagtagttca gatggaaccg aagattccga tttttctaca gatctcgagc acacagacag
      241 ttcagaaagt gatggcacat cccgacgatc tgctcgagtc acccgctcct cagccaggct
      301 aagccagagt tctcaagatt ccagtcctgt tcgaaatctg cagtcttttg gcactgagga
      361 gcctgcttac tctaccagaa gagtgacccg tagtcagcag cagcctaccc cagtgacacc
      421 gaaaaaatac cctcttcggc agactcgttc atctggttca gaaactgagc aagtggttga
      481 tttttcagat agagaaacta aaaatacagc tgatcatgat gagtcaccgc ctcgaactcc
      541 aactggaaat gcgccttctt ctgagtctga catagacatc tccagcccca atgtatctca
      601 cgatgagagc attgccaagg acatgtccct gaaggactca ggcagtgatc tctctcatcg
      661 ccccaagcgc cgtcgcttcc atgaaagcta caacttcaat atgaagtgtc ctacaccagg
      721 ctgtaactct ctaggacacc ttacaggaaa acatgagaga catttctcca tctcaggatg
      781 cccactgtat cataacctct cagctgacga atgcaaggtg agagcacaga gccgggataa
      841 gcagatagaa gaaaggatgc tgtctcacag gcaagatgac aacaacaggc atgcaaccag
      901 gcaccaggca ccaacggaga gacagcttcg atataaggaa aaagtggctg aactcaggaa
      961 gaaaagaaat tctggactga gcaaagaaca gaaagagaaa tatatggaac acagacagac
     1021 ctatgggaac acacgggaac ctcttttaga aaacctgaca agcgagtatg acttggatct
     1081 tttccgaaga gcacaagccc gggcttcaga ggatttggag aagttaaggc tgcaaggcca
     1141 aatcacagag ggaagcaaca tgattaaaac aattgctttt ggccgctatg agcttgatac
     1201 ctggtatcat tctccatatc ctgaagaata tgcacggctg ggacgtctct atatgtgtga
     1261 attctgttta aaatatatga agagccaaac gatactccgc cggcacatgg ccaaatgtgt
     1321 gtggaaacac ccacctggtg atgagatata tcgcaaaggt tcaatctctg tgtttgaagt
     1381 ggatggcaag aaaaacaaga tctactgcca aaacctgtgc ctgttggcca aactttttct
     1441 ggaccacaag acattatatt atgatgtgga gcccttcctg ttctatgtta tgacagaggc
     1501 ggacaacact ggctgtcacc tgattggata tttttctaag gaaaagaatt cattcctcaa
     1561 ctacaacgtc tcctgtatcc ttactatgcc tcagtacatg agacagggct atggcaagat
     1621 gcttattgat ttcagttatt tgctttccaa agtcgaagaa aaagttggct ccccagaacg
     1681 tccactctca gatctggggc ttataagcta tcgcagttac tggaaagaag tacttctccg
     1741 ctacctgcat aattttcaag gcaaagagat ttctatcaaa gaaatcagtc aggagacggc
     1801 tgtgaatcct gtggacattg tcagcactct gcaagccctt cagatgctca aatactggaa
     1861 gggaaaacac ctagttttaa agagacagga cctgattgat gagtggatag ccaaagaggc
     1921 caaaaggtcc aactccaata aaaccatgga tcccagctgc ttaaaatgga cccctcccaa
     1981 gggcacttaa agtgacctgt cattccgagc cagcgaaccc cagcagtagg aatccgtacc
     2041 ctagggatct gtctgtcatt tctctgttgc tcttgtgatt ggcaagtaca gtatcctttg
     2101 ggaaggccat ccccctcagg actgtcctgg ctccgacctt tgtgtacact gcagacgctg
     2161 gttctgagga actgttgttt cggcctcagt gaggttgcct ggatgggatc tgtattagac
     2221 ttgagtgcag gtctctcagc actgacccaa ggagttctgt tatggtactg tacctgtcca
     2281 gtcactggtt ctctcctcat gtcctctcgc cccatgaggt tgtgttgtgt cttctaagcg
     2341 tggtactagt gcttgccacc tggtcaccag acctccaaat atggctgcca ccaccaggac
     2401 ctttccagtt actccttata tgtgtgttct atggaggggc agggaaaagg tggcacttgt
     2461 gagtgtgtgt ggattggcag ggggtccatt cactttgggt tccatcttgc tttaaatttc
     2521 ttcattttga ttaagagacc tctttttgat ctgtattggg ctaaccagag ccaaatactt
     2581 ttgaagagtt tcccagggac tagtcatggt aatagcatat aattgatctg aatgagatgg
     2641 agagaagaat gaaggggtgg tggttctggg tttgatttga gttcacctgt gggcagtggg
     2701 cagtgggcag tgtcttggtg aaagggaacg gatactactt tttgcctcac cgtaaagtac
     2761 tcactagtaa atatttcctt ctctctttac tcccactttt tacgtttgca ggtgccaaag
     2821 taatgtccac ttttcccttt catgctgcat attaactggt taattatact gcagaaacct
     2881 tttcacctcc actagtctga tacagtacat ctgtacttcc atataccttg cactgatttt
     2941 gtctgagtgc cctgggagaa gtagaaaatg attgaaagtg acttccgtat ctcagcccat
     3001 gactcagcaa ggcagaatgg ccacccctgc caaagtttgc ttctcttttc aacagtgcct
     3061 caccctccct ctaggattaa agtgcttctg cccttccacg aactcctcct ccatttcctt
     3121 tttgggattt gtcaccatcc ttctattctc tggtcttcta tttttggtgt tgttcaagtg
     3181 aaggaagaga tgttccctct aatttctctc tagcccatta taacctgcta tcttggggca
     3241 acttttgatg tatgacatgt cacccttccc aacttggtct cctccaacat gctgtcttca
     3301 tgtggagccc tcaccacaat ccctgactcc ggtcatttgt gcctttctct tgtcatctct
     3361 gtacactact tatattcact gtgggttggg ggagctaatt ttaagcatgt tcagtggcag
     3421 ctcccctcca gtttcagtgt cactgttaaa atttatcaaa aagcaacttc actaggggtt
     3481 ttcttaaggg ataaaggcct tttacagaag ctaaaccctt ccccacatgt ggtagaatgt
     3541 gctcttctat atctactcct caataaagca tgttctctgc tcaagtctgt ttcatctggg
     3601 ggctctcatt tatatatgaa aatgatgcac acgatctgct actaatagta aatgcacttg
     3661 ggatttgctt tccctagcag taaactgttg agggatgtgg tttgtggcta tggaatgttt
     3721 ttccctgtga tacaggctgt ctgtaaagat caagggagtg ctcactctga acttctctag
     3781 atggtggcac aaatttgatc tgcctcactt tggttccagc taatcagtat acgtagcaat
     3841 gattagtcag tattacccat tctttcacta agtgccattt tccactgatt ttaggggcaa
     3901 aggaaccaat aggaaattag gatatatggg ggtacagttg atgcctgtag gagatgggaa
     3961 cagacattcc ttctcatctc caagctcatt caccagtatt gagcagtgtc acctctaatt
     4021 attgactctc tcgcaggttg aaattattct ttttgaaaat agctgcattt tcatgtaaga
     4081 tatacccagc acaggaaaag ggtggctgag cactaacctc cgtatggtgg aaaggaggag
     4141 gctgggaatt gtatgtgctg gaatggtttc actcactgtg accagtagtg gtgagaaccc
     4201 atacagttga agttttttgc acagtcctga tcccaggtct ccactcgctt tgccatccca
     4261 ctttactccc taaaaataaa aggatttatt atctcattta aacccccaca ggtgtggaaa
     4321 cagagtttca cttgccttgg caactttgca tgagactatc ccatttcatt ccgttttttt
     4381 ttttttgagt cagagtctgg ctctgttgcc caggttggag tgcagtggcg cagttttggc
     4441 tcacaacctc tgcctcccgg gttcaagtga ttcttctgtc tcagccttcc gaatagctgg
     4501 gattacaggt gcctgtcacc atgcccagct aatttttgta tttttagtag agacagggtt
     4561 tcgtcatgtt ggtcaggctg atctcgaact cctgacctca ggtgatccgc ccaccttggc
     4621 ctcccaaagt gctgggatta caggcgtgag ccactgcacc cgacctattt tttttttttt
     4681 tttttttttt ttttttaaaa aaagacagtc tcactctatc atccagtccg gaatgcagtg
     4741 gcatgatctc agctcactgc aatgtctgcc tcctggattc cagtgattct cctgcctcag
     4801 cctctcaagt agctgggatt acaggtgcag gccacctggc taatttttgt atgtttagta
     4861 gagacagggt tttgccatgt tggccaggcc agtctcaaac tcttgacctc aagtgatcac
     4921 ccgcctcatc ctcccaaagt gctgggatta cagccgtgag cctctgcacc cagcttttaa
     4981 ctccctctta tctgcataac agaagcttag ctgcttaagc tcctttatta gaagagcaaa
     5041 agtctgaaat tattcctgaa acctgctcaa tggaagtacc tactctattg gttgcttccc
     5101 atatggttgt cactgtacct tcatactgcc tcatttgacc ctcatattag ccctgtacag
     5161 tagatgggta cactggtttg ccaaaggaga cctggaatcc aaggtggaag taagcagcaa
     5221 agccagaaac ttcaattctg gtctgtctac cttgatagcc tgcaccctcc cctctaccgt
     5281 tttcttccac tatttttgat tccttaatga tgaatcatcc tctcccttct agttggattt
     5341 gtttctaatg gcttccatta caaggataat aatgaaactg gtgaaaactt tcaggcaaaa
     5401 ggattttctt tttatatttt ttcttattat tttttaatta ttaaccaaat taactcatta
     5461 cagtaaaaag gactgatttt taagccagct gtgatagctc tgtaatagtc tgtaatctca
     5521 gcactttggg aggccaaggc gggcagatcg cttgagtcca ggaattcgag actagcctgg
     5581 gcagcatggt gaaaccccag ctctacaaaa aatagaaaaa tcagacgtgg gcacatgcct
     5641 gtagtctcag ctacttggga ggctgaggca cgagaatcgc ctgaacctgg gaggcagaag
     5701 ttgcaatgag ctgagatgat gccactgcac tccagcctgg gtgacagagt gagaccctgt
     5761 ctcaaaaaca aaaaacagaa ttgattgatg ttagttggct ttagaagcag caagtttagg
     5821 gggctacaga gctaaaccag gaagcaaaag atgtgcctca ttctggcatt gtttctgatt
     5881 taggaataaa ctgttcagta agcactgtcc ctttacttcc atggttttct tcattcctca
     5941 ccacagcaca gtaaggtgga tattatagtc ttcttctaga tgaaaaattg aggctcatag
     6001 tggtcttgct gctgtgtcat agcaatagaa tgagagagcc ttgcttccct gagtccaaat
     6061 cccatacttt tggcattgtt atgaggtctg gtcacctgat gcttccatgc tattttccca
     6121 tttcttatct ggggataatg agtcatatta agtaattttt ttttttgaga cggagtttcg
     6181 ttctgtcacc caggctggag tgcagtggtg cgatcttggc tcactgcaag ctctgcctcc
     6241 cgggttcatg ccattcttct gcttcagtct cccgagtagc tgggactaca ggtgcccacc
     6301 accacgccca gctaattttt tgtattttta gtagaatgag gtttcaccgt gttagccagg
     6361 atgatctcga tctcctgacc tcgtgatcca ctcgcctcag cctcccaaag tgctgggatt
     6421 acaggcgtga gccattgcac ccagccattt tttttttttt taagacgacg tctcactctg
     6481 tcacctatgc tggagtgcag tggcgtgatc taggctcatt gcaacctctg cctcccaggt
     6541 tcaagcgatt ttcctgcctc agcctcccaa gtagctggga ttacaggtgc ccaccacctc
     6601 gcctggctaa tttttgtatt tttagtagag atgaggtttt gccctgttgg ctaggttggt
     6661 cttgaactcc tgacctcagg tgatccactc acctcagcct cccaaagtgc tgggattaca
     6721 ggcaggagcc actgcgccca gccaagtaac ttttaacagt gtggtataac ctttaaatga
     6781 caaggtgatg cttttgactt gtcctcaact ttgatttgta ctgatttgtc cctatagttc
     6841 tgggtggggt gggtcaaaac aaagtctcga gctgtaccag gatcaagcag cacagctcag
     6901 ccatgatcct tttaccactt ttttcttctg tccttgagac tctaattaaa gcactggatt
     6961 tttaaaaatc acccttgtaa atatgcacac atttgtctat agttgaggaa attgtgccgt
     7021 tgaagtccat tcttggacat ggagttaaga aaccctggtt tgagaaaaag ccccagtgag
     7081 acagcaggaa tccttttacc atacaaccct caactagttt agtgtgctca agctcaaata
     7141 accaatccca tcaagtgaaa agaatggcag cagggagaag gcctggctca ctgaggctct
     7201 cagcattagt ttcctctacc tcttgtgtct cacaggtgca catatgtaca gcatatcaaa
     7261 gtgttgaatg tcatgagaat aaaatatgaa aactactttg ctgaatgata gtatgtgatg
     7321 tgtgctagga cttctagaag ccaccctttg ctttgctgtt cattgggatc atggaatcgg
     7381 acctcagctg gttttgcctc agcactttct ttcacaaaat tatgtgtgac tgcctcctcc
     7441 agactgtttc ctgctgatag gggcagttta atagccttct tcctgtgtgg tatctgcaac
     7501 aaaatcccaa tgaatgtcac caagaaggaa acaaaggatt gcccagcgat gagaaatgtc
     7561 cctggtgcca aaacatcagt ttgcccctaa cctcttgtgc aataccttta agtccaggtc
     7621 atgttgttac catttggggg tttgcggatt tgtttacttg tgcccaagaa tggagaaaat
     7681 aacctgtact attgtacaac tctggctcca tggctcctca caaatgttcc atgtgagata
     7741 taaacatctt tatcctcgac aagtcatgtt cattccaaga aaccagtctt tgttcttaat
     7801 tggacatttg tttctgcaaa cagcttacca tacattcaat tccaaagtta tcagaaacct
     7861 acactcttat ctcacaaatt tagaggtgtg gtagatcatc tccaaagatg gccaccaaca
     7921 gttgctctca tcctctgtgc acgtgctatt tccaataagg tctatttttt tctacagtga
     7981 gggctgaact tgtgacttgt tttgactaat aggatatgga agtgatattt tggcagcttc
     8041 cacttttgct cttgaaaata agctgacacg tttccaaacg agaagcttgg gctaaattac
     8101 tgaatggtga gagacgatgc ataggagaac caaggtgctc tagtcacagc actaaaagcc
     8161 cagacttgtg tctcttgaag gtttcaaccc cgccagactc ccagctgaac gcaccctcat
     8221 gagtggccct tgctggtacc acatgacact aaagacatct agctgagtcc tgttaaccca
     8281 gagaattatg agaatactgt tttaaccaca cgttttggaa tggtttgata catggcaatg
     8341 gagaagtgaa acaaggggac ttcggaaact aaagggctgg aattcagttt gccttgtagg
     8401 ttgattggaa gccagatgtg cctagaggaa ggctaccacc ttgtgcaatt ccaggggaca
     8461 ctgtttatgt tccgtgtaaa tggcagcctc agttcacctc atttggttat ttatcgtgtc
     8521 ttcgctgtca gtcaaattgc ttctgagata actggctggc cttggaattc ttagccacct
     8581 ccttaagcgg atcaggaaaa ctgaagaata tccttctgta tgtatgtatg tatttattga
     8641 ttgatcgatt tatgagacag ggtctccttc tgtcacccag gctggagtgc agtggtacga
     8701 tcacggctca ctgctgcgtc gccttcccag gctccagcta tcctcccacc tcaacctcca
     8761 gagtagttga gaccacaggc gtgcactacc acgcccggct acctttttgt attttcagta
     8821 gagacgaggt ttcgccgtgt tgcccaggct ggttcaagcg gagctcaagc aatcagcctg
     8881 cctcggcctc ccaaagtgtt gggattacag gcatgagccg ctgcgcccaa ccttcttctg
     8941 ctgtcgagat actgctcatc acctgcctgc tccagaattc atgtggcttc tcattgctca
     9001 atggattaag ttcatgttta tcctggcttt caagtctttc cgtaagctga ctcaacctac
     9061 atagctttca tcattccctt acacataacc tcaacgtgca acaggattag tctattattc
     9121 cctttcttgt gtttactgag aaagcctcca cttcaacgtt ccatgaagtg tgttccatta
     9181 aataccaaag tataggcaaa aagttctgtg gtcaaataaa tttggaaaac acagagtgtt
     9241 tccaaagtta gtatcaggcc aggcatggtg ggaggatcac ttgagcccag gagttcgaga
     9301 ccagcctggg caacataggg agacccaatc cctacaaaaa aattagttgg gcatggtggt
     9361 gtgcacccgt agtgccagct actcaggagg ctgaggtagg aggatcacct gagcccagga
     9421 agtcaaggct gtggtcagct gagatcccac cagtgtgctc cagcctgggt gacagagcaa
     9481 gaccctgtct caaaaaataa aaaaataaag ataa
//
