LOCUS       NM_012330               8314 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens lysine acetyltransferase 6B (KAT6B), transcript
            variant 1, mRNA.
ACCESSION   NM_012330
VERSION     NM_012330.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8314)
  AUTHORS   Olbromski,M., Mrozowska,M., Smolarz,B., Romanowicz,H., Rusak,A. and
            Piotrowska,A.
  TITLE     ERalpha status of invasive ductal breast carcinoma as a result of
            regulatory interactions between lysine deacetylases KAT6A and KAT6B
  JOURNAL   Sci Rep 14 (1), 26935 (2024)
   PUBMED   39505971
  REMARK    GeneRIF: ERalpha status of invasive ductal breast carcinoma as a
            result of regulatory interactions between lysine deacetylases KAT6A
            and KAT6B.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8314)
  AUTHORS   Klaniewska,M., Bolanowska-Tyszko,A., Latos-Bielenska,A.,
            Jezela-Stanek,A., Szczaluba,K., Krajewska-Walasek,M., Ciara,E.,
            Pelc,M., Jurkiewicz,D., Stawinski,P., Zubkiewicz-Kucharska,A.,
            Rydzanicz,M., Ploski,R. and Smigiel,R.
  TITLE     Clinical heterogeneity of polish patients with KAT6B-related
            disorder
  JOURNAL   Mol Genet Genomic Med 11 (12), e2265 (2023)
   PUBMED   37658610
  REMARK    GeneRIF: Clinical heterogeneity of polish patients with
            KAT6B-related disorder.
REFERENCE   3  (bases 1 to 8314)
  AUTHORS   Miller,S.A., Solari,A.P., Alberto,G., Benitez Medina,A.C., Garcia
            Ayre,B.M., Parisini,D., Claps,A. and Taboas,M.
  TITLE     Novel variant in the KAT6B gene associated with Say Barber
            Biesecker Young Simpson
  JOURNAL   Clin Dysmorphol 32 (4), 175-179 (2023)
   PUBMED   37646730
  REMARK    GeneRIF: Novel variant in the KAT6B gene associated with Say Barber
            Biesecker Young Simpson.
REFERENCE   4  (bases 1 to 8314)
  AUTHORS   Sun,X., Luo,X., Lin,L., Wang,S., Wang,C., Yuan,F., Lan,X., Yan,J.
            and Chen,Y.
  TITLE     Clinical features and underlying mechanisms of KAT6B disease in a
            Chinese boy
  JOURNAL   Mol Genet Genomic Med 11 (9), e2202 (2023)
   PUBMED   37288707
  REMARK    GeneRIF: Clinical features and underlying mechanisms of KAT6B
            disease in a Chinese boy.
REFERENCE   5  (bases 1 to 8314)
  AUTHORS   Becht,D.C., Klein,B.J., Kanai,A., Jang,S.M., Cox,K.L., Zhou,B.R.,
            Phanor,S.K., Zhang,Y., Chen,R.W., Ebmeier,C.C., Lachance,C.,
            Galloy,M., Fradet-Turcotte,A., Bulyk,M.L., Bai,Y., Poirier,M.G.,
            Cote,J., Yokoyama,A. and Kutateladze,T.G.
  TITLE     MORF and MOZ acetyltransferases target unmethylated CpG islands
            through the winged helix domain
  JOURNAL   Nat Commun 14 (1), 697 (2023)
   PUBMED   36754959
  REMARK    GeneRIF: MORF and MOZ acetyltransferases target unmethylated CpG
            islands through the winged helix domain.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8314)
  AUTHORS   Liu,C., Lu,J., Tan,J., Li,L. and Huang,B.
  TITLE     Human interleukin-5 expression is synergistically regulated by
            histone acetyltransferase CBP/p300 and transcription factors C/EBP,
            NF-AT and AP-1
  JOURNAL   Cytokine 27 (4-5), 93-100 (2004)
   PUBMED   15271374
  REMARK    GeneRIF: role in regulating interleukin-5 expression
REFERENCE   7  (bases 1 to 8314)
  AUTHORS   Pelletier,N., Champagne,N., Stifani,S. and Yang,X.J.
  TITLE     MOZ and MORF histone acetyltransferases interact with the
            Runt-domain transcription factor Runx2
  JOURNAL   Oncogene 21 (17), 2729-2740 (2002)
   PUBMED   11965546
REFERENCE   8  (bases 1 to 8314)
  AUTHORS   Panagopoulos,I., Fioretos,T., Isaksson,M., Samuelsson,U.,
            Billstrom,R., Strombeck,B., Mitelman,F. and Johansson,B.
  TITLE     Fusion of the MORF and CBP genes in acute myeloid leukemia with the
            t(10;16)(q22;p13)
  JOURNAL   Hum Mol Genet 10 (4), 395-404 (2001)
   PUBMED   11157802
REFERENCE   9  (bases 1 to 8314)
  AUTHORS   Champagne,N., Bertos,N.R., Pelletier,N., Wang,A.H., Vezmar,M.,
            Yang,Y., Heng,H.H. and Yang,X.J.
  TITLE     Identification of a human histone acetyltransferase related to
            monocytic leukemia zinc finger protein
  JOURNAL   J Biol Chem 274 (40), 28528-28536 (1999)
   PUBMED   10497217
REFERENCE   10 (bases 1 to 8314)
  AUTHORS   Lemire,G., Campeau,P.M. and Lee,B.H.
  TITLE     KAT6B Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   23236640
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA488537.1, BC014143.2,
            BC150618.1, AF217500.1 and AC018511.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_012330.3.
            
            Summary: The protein encoded by this gene is a histone
            acetyltransferase and component of the MOZ/MORF protein complex. In
            addition to its acetyltransferase activity, the encoded protein has
            transcriptional activation activity in its N-terminal end and
            transcriptional repression activity in its C-terminal end. This
            protein is necessary for RUNX2-dependent transcriptional activation
            and could be involved in brain development. Mutations have been
            found in patients with genitopatellar syndrome. A translocation of
            this gene and the CREBBP gene results in acute myeloid leukemias.
            Three transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1, 8, and
            9 all encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF217500.1, BC150618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287239.10/ ENSP00000287239.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA488537.1         188-208
            22-1473             BC014143.2         1-1452
            1474-7291           BC150618.1         1421-7238
            7292-8312           AF217500.1         7263-8283
            8313-8314           AC018511.5         119021-119022
FEATURES             Location/Qualifiers
     source          1..8314
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..8314
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /note="lysine acetyltransferase 6B"
                     /db_xref="GeneID:23522"
                     /db_xref="HGNC:HGNC:17582"
                     /db_xref="MIM:605880"
     exon            1..186
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            187..256
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            257..1135
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     CDS             515..6736
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /EC_number="2.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 1; MYST
                     histone acetyltransferase (monocytic leukemia) 4;
                     MOZ-related factor; monocytic leukemia zinc finger
                     protein-related factor; histone acetyltransferase MYST4;
                     MYST-4; histone acetyltransferase MORF; histone
                     acetyltransferase MOZ2; MOZ, YBF2/SAS3, SAS2 and TIP60
                     protein 4; histone acetyltransferase KAT6B; K(lysine)
                     acetyltransferase 6B"
                     /codon_start=1
                     /product="histone acetyltransferase KAT6B isoform 1"
                     /protein_id="NP_036462.2"
                     /db_xref="CCDS:CCDS7345.1"
                     /db_xref="GeneID:23522"
                     /db_xref="HGNC:HGNC:17582"
                     /db_xref="MIM:605880"
                     /translation="MVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDK
                     KTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGTFPKSAKGSRGSCNDL
                     RNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAV
                     NNGRLLKDGPQYRVNYGSLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSF
                     CLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCIECKTCSACR
                     VQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQI
                     KRRYAKPIGRPKNKLKQRLLSVTSDEGSMNAFTGRGSPGRGQKTKVCTTPSSGHAASG
                     KDSSSRLAVTDPTRPGATTKITTTSTYISASTLKVNKKTKGLIDGLTKFFTPSPDGRR
                     SRGEIIDFSKHYRPRKKVSQKQSCTSHVLATGTTQKLKPPPSSLPPPTPISGQSPSSQ
                     KSSTATSSPSPQSSSSQCSVPSLSSLTTNSQLKALFDGLSHIYTTQGQSRKKGHPSYA
                     PPKRMRRKTELSSTAKSKAHFFGKRDIRSRFISHSSSSSWGMARGSIFKAIAHFKRTT
                     FLKKHRMLGRLKYKVTPQMGTPSPGKGSLTDGRIKPDQDDDTEIKINIKQESADVNVI
                     GNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYPQ
                     EYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSK
                     IYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVS
                     CIMIMPQHQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYL
                     YHHHERHISIKAISRATGMCPHDIATTLQHLHMIDKRDGRFVIIRREKLILSHMEKLK
                     TCSRANELDPDSLRWTPILISNAAVSEEEREAEKEAERLMEQASCWEKEEQEILSTRA
                     NSRQSPAKVQSKNKYLHSPESRPVTGERGQLLELSKESSEEEEEEEDEEEEEEEEEEE
                     EDEEEEEEEEEEEEEENIQSSPPRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTT
                     ETISETTEVLNEPFDNSDEERPMPQLEPTCEIEVEEDGRKPVLRKAFQHQPGKKRQTE
                     EEEGKDNHCFKNADPCRNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQN
                     KERKTGFKLNLYTPPETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLP
                     QEENRREETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNV
                     EKDPDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMES
                     AEVEKEELPRESFKEVLENQETFLDLNVQPGHSNPEVLMDCGVDLTASCNSEPKELAG
                     DPEAVPESDEEPPPGEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQAVQSLTQES
                     SEQDDTFQDCAETQEACRSLQNYTRADQSPQIATTLDDCQQSDHSSPVSSVHSHPGQS
                     VRSVNSPSVPALENSYAQISPDQSAISVPSLQNMETSPMMDVPSVSDHSQQVVDSGFS
                     DLGSIESTTENYENPSSYDSTMGGSICGNGSSQNSCSYSNLTSSSLTQSSCAVTQQMS
                     NISGSCSMLQQTSISSPPTCSVKSPQGCVVERPPSSSQQLAQCSMAANFTPPMQLAEI
                     PETSNANIGLYERMGQSDFGAGHYPQPSATFSLAKLQQLTNTLIDHSLPYSHSAAVTS
                     YANSASLSTPLSNTGLVQLSQSPHSVPGGPQAQATMTPPPNLTPPPMNLPPPLLQRNM
                     AASNIGISHSQRLQTQIASKGHISMRTKSASLSPAAATHQSQIYGRSQTVAMQGPART
                     LTMQRGMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMSQPMMNSGYHSNHGYMNQT
                     PQYPMQMQMGMMGTQPYAQQPMQTPPHGNMMYTAPGHHGYMNTGMSKQSLNGSYMRR"
     exon            1136..1244
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1360
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1442
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1575
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..2507
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2629
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2745
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2887
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3049
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3143
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3375
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3535
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            3536..3886
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            3887..4178
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            4179..8314
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7959..7964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /note="hexamer: AATAAA"
     polyA_site      7983
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /note="major polyA site"
     regulatory      8077..8082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /note="hexamer: AATAAA"
     polyA_site      8101
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
     regulatory      8201..8206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /note="hexamer: AATAAA"
     polyA_site      8221
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
     regulatory      8292..8297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /note="hexamer: AATAAA"
     polyA_site      8314
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
ORIGIN      
        1 agtgtcatgt cggattcatg tcaacgacaa caacaggggg acacaaaatg gcggcggctt
       61 agctcctacc cctggcggcg gcggcagcgg tggcggaggc gacggcacct cctccaggcg
      121 gcagccgcag tttctcaggc agcggcagcg cccccggcag gcgcggtggc ggtggcgcgc
      181 agccagattt gcctgaagac ctggataatc tccatttttg tcatggactg ttaaaacgtt
      241 tgaagttcca attctggtct tgatttccca gttaaagatg ttcttcaccc gaatgcagtc
      301 tttcctgttg gtaaaataag acaaccatca acattgcctg tttgtctgct tttgaatctc
      361 ttaaggatgg atgtttgtaa gatgttgctt aatacagtct ggaatactct gtccatttgt
      421 tgaattgtaa atgactttca aatgtgcaag ttctgttaaa tacaaagaga acctctatgg
      481 gtaacttttg tgttgaagaa gtcatttgtc aaccatggta aaacttgcaa acccacttta
      541 tacagagtgg attcttgaag ctatacagaa aataaaaaag caaaagcaaa ggccctctga
      601 agagagaatc tgccatgcgg tcagtacttc ccatgggttg gataagaaga cagtctctga
      661 acagctggaa ctcagtgttc aggatggctc agttctcaaa gtcaccaaca aaggccttgc
      721 ctcctataag gacccagaca accctgggcg cttttcatca gttaaaccag gcacttttcc
      781 taagtcagcc aaggggtcta gaggatcatg taatgatctc cgcaatgtgg attggaataa
      841 acttttaagg agagcaattg aaggacttga ggagccgaat ggctcctccc tgaagaacat
      901 agagaagtat ctcagaagtc aaagtgatct cacaagcacc accaacaacc cagcctttca
      961 gcagcggctg cgactggggg ccaaacgcgc tgtgaataat gggaggttac tgaaagacgg
     1021 accgcagtac agggtcaatt atgggagctt agatggcaaa ggggcacctc agtatcccag
     1081 tgcattccca tcctcgctcc cacctgtcag ccttctaccc catgagaaag accagccccg
     1141 tgctgatccc attccaatat gtagcttctg tttggggact aaagaatcaa atcgtgaaaa
     1201 gaaaccagaa gaactcctct cttgtgcaga ttgtggcagt agtggacacc catcctgttt
     1261 gaaattttgt cctgaattaa caacaaatgt aaaggcctta aggtggcagt gcatcgaatg
     1321 caagacatgc agtgcctgta gagtccaagg cagaaatgct gataatatgc ttttttgtga
     1381 ttcctgtgat agaggatttc atatggaatg ctgtgaccca ccactttcca gaatgccaaa
     1441 agggatgtgg atttgccaag tctgcagacc aaagaaaaag ggaagaaaac tacttcatga
     1501 gaaagctgca caaataaaac gacgatatgc aaaacccatt ggacgaccga aaaataaatt
     1561 aaagcaacga ttgttgtctg taaccagtga tgaaggatcc atgaatgcat tcacaggaag
     1621 ggggtcacct ggtaggggtc aaaagactaa agtctgtacc acaccttcat ctggtcatgc
     1681 tgcatctggg aaggactcaa gcagcagatt ggctgttaca gaccccactc ggcctggtgc
     1741 caccaccaaa atcaccacca cctccaccta catttctgcc tctacactta aagttaacaa
     1801 gaaaaccaaa gggctcattg atggccttac taagtttttt acaccatcac ctgatggtcg
     1861 cagatcacga ggtgaaatta tagacttttc aaagcactat cgtccaagga aaaaggtctc
     1921 tcagaaacag tcatgcactt ctcatgtgtt ggctacaggt accacacaaa agctaaaacc
     1981 tccaccttct tcacttccac ccccaacccc catctccggt cagagcccca gttcacaaaa
     2041 gtccagcacg gccacttctt ctccctctcc ccagagttct tccagccagt gcagtgtgcc
     2101 ctccctgagc agccttacca ctaacagcca gctgaaggca ctctttgatg ggctttctca
     2161 tatctatacc actcagggac agtctcgcaa aaagggacac ccgagttatg caccacccaa
     2221 acgtatgcgt cgtaaaactg aattatcttc cacggcaaaa tctaaagccc acttctttgg
     2281 caaaagagat attagaagtc ggtttatttc tcactcctcc tcctctagct gggggatggc
     2341 tagaggaagt atttttaaag caattgctca cttcaagcga acaactttcc ttaaaaagca
     2401 caggatgcta ggcagattaa aatataaagt gacccctcag atggggaccc cctcaccagg
     2461 gaaggggagc ttgacagacg gaaggattaa acctgatcag gatgatgata ctgaaataaa
     2521 aataaacatc aaacaagaaa gtgcagatgt aaatgtgatt ggaaacaagg atgtcgttac
     2581 tgaagaggat ttggatgttt ttaagcaggc ccaggaactt tcttgggaga aaatagagtg
     2641 tgagagtggg gtggaagact gtggccggta cccttctgtg attgaatttg gtaaatatga
     2701 aatccaaacc tggtactcct cgccttaccc acaggaatat gcaagattac caaagcttta
     2761 cctgtgtgaa ttctgtctta aatatatgaa aagtaaaaat attttgctaa gacactccaa
     2821 gaagtgtgga tggtttcatc ctccagcaaa tgaaatttac cgaaggaaag acctttcagt
     2881 atttgaggtt gatgggaata tgagcaaaat ttattgccaa aacctttgct tgttagccaa
     2941 gctcttcctg gaccacaaaa cgttgtatta tgatgtcgag ccattccttt tttatgtcct
     3001 tacaaaaaat gatgaaaagg gctgtcatct ggttggatac ttctctaagg aaaagctttg
     3061 ccagcagaag tataatgtct cctgcataat gatcatgccc cagcaccaaa ggcaaggatt
     3121 tggacggttt ctcattgatt tcagctattt gctttctaga agagaaggcc aagcagggtc
     3181 tcctgaaaag cctctctccg atctgggccg tctctcctac ctggcatatt ggaagagcgt
     3241 catcttggag tatctctacc accaccatga gaggcacatc agcatcaagg caattagcag
     3301 agcgacgggc atgtgcccac atgacattgc caccactctg cagcacctcc acatgatcga
     3361 caagagagat ggcagatttg tcatcattag acgggaaaag ttgatattga gccacatgga
     3421 aaagctgaaa acctgttcca gagccaatga acttgatcca gacagtctga ggtggacccc
     3481 aattttaatt tctaatgctg cagtgtctga agaagagcga gaagctgaga aagaggctga
     3541 gcggctaatg gaacaagcta gctgctggga gaaggaggaa caagaaatcc tgtcaactag
     3601 agctaacagt aggcaatcac ctgcaaaagt acaatcgaaa aataaatatt tgcattcccc
     3661 ggagagccgg ccagtcacag gggagcgagg gcagctgctg gagctgtcta aagagagcag
     3721 tgaagaagaa gaggaggagg aggacgagga ggaggaagaa gaggaggaag aagaggaaga
     3781 ggatgaagag gaggaagaag aggaagaaga agaagaagaa gaagaaaata ttcaaagctc
     3841 tcccccaaga ttgacgaaac cacagtcagt tgccataaag agaaagaggc cttttgtact
     3901 aaagaagaaa aggggtcgta aacgcaggag gatcaacagc agtgtaacaa cagagaccat
     3961 ttcagagacg acagaagtac tgaatgagcc ctttgacaac tcagatgaag agaggccaat
     4021 gccacagctg gagcctacct gtgagattga agtggaggaa gatggcagga agccagtcct
     4081 gagaaaagca ttccagcatc agcctgggaa gaaaagacaa acagaggaag aggaaggaaa
     4141 agacaatcat tgcttcaaga atgctgaccc ttgtagaaac aatatgaatg atgattcaag
     4201 taacttgaaa gaaggcagta aagacaatcc cgaacctcta aagtgcaaac aagtgtggcc
     4261 aaaaggaaca aagcgcggtc tatctaagtg gaggcaaaac aaagagagga agaccggatt
     4321 taaactgaat ttgtacaccc cgccagaaac acccatggag cctgacgagc aggtaacagt
     4381 ggaagaacag aaggagactt cagaaggaaa aaccagcccc agtcccatca ggattgagga
     4441 ggaggtcaag gaaactgggg aagccctgtt gcctcaagag gaaaacagaa gggaagaaac
     4501 atgtgcccct gtaagtccaa acacatcacc aggtgaaaaa ccagaagatg atctcatcaa
     4561 acctgaggaa gaggaagagg aggaggagga ggaagaggaa gaagaggaag aagaggaagg
     4621 ggaagaagaa gaaggaggag gaaatgtaga aaaagatcca gatggtgcta aaagccaaga
     4681 aaaagaggaa ccagaaatct ccacggaaaa agaagactct gcacgtttgg atgatcacga
     4741 agaggaggag gaagaggatg aagagccatc ccacaacgag gaccatgatg ccgatgacga
     4801 ggatgacagc cacatggagt ctgccgaagt ggagaaggaa gagctgccca gagaaagctt
     4861 caaagaagta ctggaaaacc aggagacttt tttagacctt aatgtgcagc ctggtcactc
     4921 gaacccagag gtcttaatgg actgtggcgt cgacctgaca gcttcttgta acagtgagcc
     4981 caaggagctt gctggggacc ctgaagctgt acccgaatct gacgaggagc cacccccagg
     5041 agaacaggca cagaagcagg accaaaagaa cagcaaggaa gtcgatacag agttcaaaga
     5101 gggaaaccca gcaaccatgg aaatcgactc tgagactgtc caggccgttc agtctttgac
     5161 ccaggagagc agcgaacagg acgacacctt tcaggattgt gccgagactc aagaggcctg
     5221 tagaagccta cagaactaca cccgtgcaga ccaaagtcca cagattgcca ccacgctcga
     5281 cgattgccaa cagtcggacc acagtagccc agtttcatcc gtccactccc atcctggcca
     5341 gtccgtacgt tctgtcaaca gcccaagtgt ccctgctctg gaaaacagct acgcccaaat
     5401 cagcccagat caaagtgcca tctcagtgcc atctctgcag aacatggaaa ccagtcccat
     5461 gatggatgtc ccatcagttt cagatcattc acagcaagtc gtagacagtg gatttagtga
     5521 cctgggcagt atcgagagca caactgagaa ctacgaaaac ccaagcagct acgattctac
     5581 tatgggaggc agcatctgtg gaaacggctc ttcacagaac agctgctcct atagcaacct
     5641 cacctccagc agtctgacac agagcagctg tgctgtcacc cagcagatgt ccaacatcag
     5701 cgggagctgc agcatgctgc agcaaaccag catcagctcc cctccgacct gcagcgtcaa
     5761 gtctcctcaa ggctgtgtgg tggagaggcc tccgagcagc agccagcagc tggctcagtg
     5821 cagcatggct gctaacttca ccccacccat gcagctggct gaaatccccg agacgagcaa
     5881 cgccaacatt ggcttatacg agcgaatggg tcagagtgat tttggggctg ggcattaccc
     5941 gcagccgtca gccaccttca gccttgccaa actgcagcag ttaactaata cacttattga
     6001 tcattcattg ccttacagcc attccgctgc tgtgacttcc tatgcaaaca gtgcctcttt
     6061 gtccacacca ttaagtaaca cagggcttgt tcaactttct cagtctccac actccgtccc
     6121 tgggggaccc caagcacaag ctaccatgac cccacccccc aacctgactc ctcctccaat
     6181 gaatctgccg ccgcctcttt tgcaacggaa catggctgca tcaaatattg gcatctctca
     6241 cagccaaaga ctgcaaaccc agattgccag caagggccac atctccatga gaaccaagtc
     6301 agcgtctctg tcaccagccg ctgccaccca tcagtcacaa atctatgggc gctcccagac
     6361 tgtagccatg cagggtcctg cacggacttt aacgatgcaa agaggcatga acatgagtgt
     6421 gaacctgatg ccagcgccag cctacaatgt caactctgtg aacatgaaca tgaacactct
     6481 caacgccatg aatgggtaca gcatgtccca gccaatgatg aacagtggct accacagcaa
     6541 tcatggctat atgaatcaaa cgccccaata ccctatgcag atgcagatgg gcatgatggg
     6601 cacccagcca tatgcccagc agccaatgca gaccccaccc cacggtaaca tgatgtacac
     6661 ggcccccgga catcacggct acatgaacac aggcatgtcc aaacagtctc tcaatggctc
     6721 ctacatgaga aggtagacaa cgtgggcagt ccacaaaacc tacggggcat cactattgga
     6781 ttgatctgca caaatacctt tgaagagtac gatttcaaaa ccagcaattg gtgtgaatgc
     6841 aaaaacattt gttggcacca tttatttaaa aaaaaaaaaa gctgtatgca gcagaaagcc
     6901 ttatacaagt tgtttttctt tttttccttt ttcttttttt tggtaccttc atttctgtta
     6961 cttttatata aaattctctg caaaggaagg cctctctttg gactacaatt tggaggcagc
     7021 cacttgttgt gcctgcttct gttaaacaat gtggatatca agccccccca aattatctgt
     7081 tttaatattg aacctagagc tttttttttc ccttccctgt ccactccatg taaatgcctt
     7141 tagcatttca gttattgtat attttgttta aggtgacact tcagcatgcc gctaatgtct
     7201 ttgttagtga cagtgcattt tgtagtactg tacaagtgtt gtgctaacag taagccattt
     7261 cttaagtttt ttgccttgat tagggtgccc taatttgagg gttttaaaaa aaactatatt
     7321 tttgttaatt ataaaactgt aaagagctat aaaagctatt cccatttggt tagtcaaaag
     7381 ggttttattg ctaaatgttt ggtgtaaagt tgagaccctt ttccattttg gtgacagatt
     7441 tctttgggga aaaaaggcag ctttctgttt tataaatgca gacttctgtt tattgaatga
     7501 agcatatctc agtgtttatc tgtcaggttt tgaaacattt catatatgtc caaatacttg
     7561 gcaggattta aaaaaaaata gtgaatttgg tgtaaagttg ctattttatg gaaatgcctc
     7621 taactttaca ttttcattcc atctgtagat ttttctatct ttataaaata ttggagttat
     7681 tttttaagga aaaatagaaa agtagcttgt gaatagctca aactaagctt acaaatcgca
     7741 tgtaaaaaag caaaaaagtt atttgtgtct gtttatattg cttccttttt tgtagccttt
     7801 gtacctgtac agggtgacag taagggccaa gcaggagagg cgtaatcctt gtataaaata
     7861 ggatccagcg acactcttgt atttatctgt tctcttttta gtcagtcact tcaaaaaaac
     7921 aaaaaacaaa caaaaaaaag ctgtacattt taacataaaa taaattatga tgagccattt
     7981 ttagcctctt gtgtcctgtc atattatgat tgatagagaa tgaccaatgg aactgtatca
     8041 tgtgtcacgc ctcagaacac atacacattt tgggaaaata aattatttag tgtaaattgg
     8101 agttatggga ttttctgatt tgttttgact ttgggggagg ggttggcaat aaataagagt
     8161 aatatctaat aaaaccatca catataccaa atacctattt aataaattaa tttataatgg
     8221 attttaatgc ttttcatgaa agtttatttt atgcgagtgc ataccttctg tatgccaatc
     8281 attgtcttta aaataaagtg aaattgtttt tttc
//
