LOCUS       NM_001370143            7189 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens lysine acetyltransferase 6B (KAT6B), transcript
            variant 15, mRNA.
ACCESSION   NM_001370143
VERSION     NM_001370143.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7189)
  AUTHORS   Olbromski,M., Mrozowska,M., Smolarz,B., Romanowicz,H., Rusak,A. and
            Piotrowska,A.
  TITLE     ERalpha status of invasive ductal breast carcinoma as a result of
            regulatory interactions between lysine deacetylases KAT6A and KAT6B
  JOURNAL   Sci Rep 14 (1), 26935 (2024)
   PUBMED   39505971
  REMARK    GeneRIF: ERalpha status of invasive ductal breast carcinoma as a
            result of regulatory interactions between lysine deacetylases KAT6A
            and KAT6B.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7189)
  AUTHORS   Klaniewska,M., Bolanowska-Tyszko,A., Latos-Bielenska,A.,
            Jezela-Stanek,A., Szczaluba,K., Krajewska-Walasek,M., Ciara,E.,
            Pelc,M., Jurkiewicz,D., Stawinski,P., Zubkiewicz-Kucharska,A.,
            Rydzanicz,M., Ploski,R. and Smigiel,R.
  TITLE     Clinical heterogeneity of polish patients with KAT6B-related
            disorder
  JOURNAL   Mol Genet Genomic Med 11 (12), e2265 (2023)
   PUBMED   37658610
  REMARK    GeneRIF: Clinical heterogeneity of polish patients with
            KAT6B-related disorder.
REFERENCE   3  (bases 1 to 7189)
  AUTHORS   Miller,S.A., Solari,A.P., Alberto,G., Benitez Medina,A.C., Garcia
            Ayre,B.M., Parisini,D., Claps,A. and Taboas,M.
  TITLE     Novel variant in the KAT6B gene associated with Say Barber
            Biesecker Young Simpson
  JOURNAL   Clin Dysmorphol 32 (4), 175-179 (2023)
   PUBMED   37646730
  REMARK    GeneRIF: Novel variant in the KAT6B gene associated with Say Barber
            Biesecker Young Simpson.
REFERENCE   4  (bases 1 to 7189)
  AUTHORS   Sun,X., Luo,X., Lin,L., Wang,S., Wang,C., Yuan,F., Lan,X., Yan,J.
            and Chen,Y.
  TITLE     Clinical features and underlying mechanisms of KAT6B disease in a
            Chinese boy
  JOURNAL   Mol Genet Genomic Med 11 (9), e2202 (2023)
   PUBMED   37288707
  REMARK    GeneRIF: Clinical features and underlying mechanisms of KAT6B
            disease in a Chinese boy.
REFERENCE   5  (bases 1 to 7189)
  AUTHORS   Becht,D.C., Klein,B.J., Kanai,A., Jang,S.M., Cox,K.L., Zhou,B.R.,
            Phanor,S.K., Zhang,Y., Chen,R.W., Ebmeier,C.C., Lachance,C.,
            Galloy,M., Fradet-Turcotte,A., Bulyk,M.L., Bai,Y., Poirier,M.G.,
            Cote,J., Yokoyama,A. and Kutateladze,T.G.
  TITLE     MORF and MOZ acetyltransferases target unmethylated CpG islands
            through the winged helix domain
  JOURNAL   Nat Commun 14 (1), 697 (2023)
   PUBMED   36754959
  REMARK    GeneRIF: MORF and MOZ acetyltransferases target unmethylated CpG
            islands through the winged helix domain.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7189)
  AUTHORS   Liu,C., Lu,J., Tan,J., Li,L. and Huang,B.
  TITLE     Human interleukin-5 expression is synergistically regulated by
            histone acetyltransferase CBP/p300 and transcription factors C/EBP,
            NF-AT and AP-1
  JOURNAL   Cytokine 27 (4-5), 93-100 (2004)
   PUBMED   15271374
  REMARK    GeneRIF: role in regulating interleukin-5 expression
REFERENCE   7  (bases 1 to 7189)
  AUTHORS   Pelletier,N., Champagne,N., Stifani,S. and Yang,X.J.
  TITLE     MOZ and MORF histone acetyltransferases interact with the
            Runt-domain transcription factor Runx2
  JOURNAL   Oncogene 21 (17), 2729-2740 (2002)
   PUBMED   11965546
REFERENCE   8  (bases 1 to 7189)
  AUTHORS   Panagopoulos,I., Fioretos,T., Isaksson,M., Samuelsson,U.,
            Billstrom,R., Strombeck,B., Mitelman,F. and Johansson,B.
  TITLE     Fusion of the MORF and CBP genes in acute myeloid leukemia with the
            t(10;16)(q22;p13)
  JOURNAL   Hum Mol Genet 10 (4), 395-404 (2001)
   PUBMED   11157802
REFERENCE   9  (bases 1 to 7189)
  AUTHORS   Champagne,N., Bertos,N.R., Pelletier,N., Wang,A.H., Vezmar,M.,
            Yang,Y., Heng,H.H. and Yang,X.J.
  TITLE     Identification of a human histone acetyltransferase related to
            monocytic leukemia zinc finger protein
  JOURNAL   J Biol Chem 274 (40), 28528-28536 (1999)
   PUBMED   10497217
REFERENCE   10 (bases 1 to 7189)
  AUTHORS   Lemire,G., Campeau,P.M. and Lee,B.H.
  TITLE     KAT6B Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   23236640
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC063962.11 and AC018511.5.
            
            Summary: The protein encoded by this gene is a histone
            acetyltransferase and component of the MOZ/MORF protein complex. In
            addition to its acetyltransferase activity, the encoded protein has
            transcriptional activation activity in its N-terminal end and
            transcriptional repression activity in its C-terminal end. This
            protein is necessary for RUNX2-dependent transcriptional activation
            and could be involved in brain development. Mutations have been
            found in patients with genitopatellar syndrome. A translocation of
            this gene and the CREBBP gene results in acute myeloid leukemias.
            Three transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (15), as well as variant 16,
            encodes isoform 8.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.222480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC063962.11        159919-160114       c
            197-1075            AC063962.11        142115-142993       c
            1076-1184           AC063962.11        25515-25623         c
            1185-1300           AC063962.11        15818-15933         c
            1301-1382           AC063962.11        15492-15573         c
            1383-1504           AC063962.11        8156-8277           c
            1505-1620           AC063962.11        6254-6369           c
            1621-1762           AC063962.11        3665-3806           c
            1763-1924           AC063962.11        352-513             c
            1925-2018           AC018511.5         75417-75510
            2019-2250           AC018511.5         106980-107211
            2251-2410           AC018511.5         107524-107683
            2411-2761           AC018511.5         108279-108629
            2762-3053           AC018511.5         111356-111647
            3054-7189           AC018511.5         114887-119022
FEATURES             Location/Qualifiers
     source          1..7189
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..7189
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /note="lysine acetyltransferase 6B"
                     /db_xref="GeneID:23522"
                     /db_xref="HGNC:HGNC:17582"
                     /db_xref="MIM:605880"
     exon            1..196
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            197..1075
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     CDS             455..5611
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /EC_number="2.3.1.48"
                     /note="isoform 8 is encoded by transcript variant 15; MYST
                     histone acetyltransferase (monocytic leukemia) 4;
                     MOZ-related factor; monocytic leukemia zinc finger
                     protein-related factor; histone acetyltransferase MYST4;
                     MYST-4; histone acetyltransferase MORF; histone
                     acetyltransferase MOZ2; MOZ, YBF2/SAS3, SAS2 and TIP60
                     protein 4; histone acetyltransferase KAT6B; K(lysine)
                     acetyltransferase 6B"
                     /codon_start=1
                     /product="histone acetyltransferase KAT6B isoform 8"
                     /protein_id="NP_001357072.1"
                     /db_xref="GeneID:23522"
                     /db_xref="HGNC:HGNC:17582"
                     /db_xref="MIM:605880"
                     /translation="MVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDK
                     KTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGTFPKSAKGSRGSCNDL
                     RNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAV
                     NNGRLLKDGPQYRVNYGSLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSF
                     CLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCIECKTCSACR
                     VQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKDTEIKINIKQESADVNVIGNKDVVT
                     EEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYPQEYARLPK
                     LYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLC
                     LLAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQ
                     HQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLYHHHERH
                     ISIKAISRATGMCPHDIATTLQHLHMIDKRDGRFVIIRREKLILSHMEKLKTCSRANE
                     LDPDSLRWTPILISNAAVSEEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPA
                     KVQSKNKYLHSPESRPVTGERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEE
                     EEEEEEEEENIQSSPPRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETT
                     EVLNEPFDNSDEERPMPQLEPTCEIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDN
                     HCFKNADPCRNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQNKERKTGF
                     KLNLYTPPETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRRE
                     ETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGA
                     KSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEE
                     LPRESFKEVLENQETFLDLNVQPGHSNPEVLMDCGVDLTASCNSEPKELAGDPEAVPE
                     SDEEPPPGEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQAVQSLTQESSEQDDTF
                     QDCAETQEACRSLQNYTRADQSPQIATTLDDCQQSDHSSPVSSVHSHPGQSVRSVNSP
                     SVPALENSYAQISPDQSAISVPSLQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIES
                     TTENYENPSSYDSTMGGSICGNGSSQNSCSYSNLTSSSLTQSSCAVTQQMSNISGSCS
                     MLQQTSISSPPTCSVKSPQGCVVERPPSSSQQLAQCSMAANFTPPMQLAEIPETSNAN
                     IGLYERMGQSDFGAGHYPQPSATFSLAKLQQLTNTLIDHSLPYSHSAAVTSYANSASL
                     STPLSNTGLVQLSQSPHSVPGGPQAQATMTPPPNLTPPPMNLPPPLLQRNMAASNIGI
                     SHSQRLQTQIASKGHISMRTKSASLSPAAATHQSQIYGRSQTVAMQGPARTLTMQRGM
                     NMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMSQPMMNSGYHSNHGYMNQTPQYPMQM
                     QMGMMGTQPYAQQPMQTPPHGNMMYTAPGHHGYMNTGMSKQSLNGSYMRR"
     exon            1076..1184
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1300
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1382
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1504
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1620
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1762
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1924
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2018
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2250
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2410
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2761
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..3053
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..7189
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6834..6839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /note="hexamer: AATAAA"
     polyA_site      6858
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /note="major polyA site"
     regulatory      6952..6957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /note="hexamer: AATAAA"
     polyA_site      6976
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
     regulatory      7076..7081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /note="hexamer: AATAAA"
     polyA_site      7096
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
     regulatory      7167..7172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
                     /note="hexamer: AATAAA"
     polyA_site      7189
                     /gene="KAT6B"
                     /gene_synonym="GTPTS; MORF; MOZ2; MYST4; qkf; querkopf;
                     ZC2HC6B"
ORIGIN      
        1 gcgctgcagc ccggagccga ggaggaggag gcggaggagg agaaggaggc ggcggcggtg
       61 ggtcccgggc ggggggagcg cggcgctgcg gacccgggcg gctggcaaag gacgaggcgg
      121 aggctgagga aggcagcggg gagacccagg ctgcagcaac aaagggcagc gagcgattgg
      181 ccgggctgca ggcgaggtct tgatttccca gttaaagatg ttcttcaccc gaatgcagtc
      241 tttcctgttg gtaaaataag acaaccatca acattgcctg tttgtctgct tttgaatctc
      301 ttaaggatgg atgtttgtaa gatgttgctt aatacagtct ggaatactct gtccatttgt
      361 tgaattgtaa atgactttca aatgtgcaag ttctgttaaa tacaaagaga acctctatgg
      421 gtaacttttg tgttgaagaa gtcatttgtc aaccatggta aaacttgcaa acccacttta
      481 tacagagtgg attcttgaag ctatacagaa aataaaaaag caaaagcaaa ggccctctga
      541 agagagaatc tgccatgcgg tcagtacttc ccatgggttg gataagaaga cagtctctga
      601 acagctggaa ctcagtgttc aggatggctc agttctcaaa gtcaccaaca aaggccttgc
      661 ctcctataag gacccagaca accctgggcg cttttcatca gttaaaccag gcacttttcc
      721 taagtcagcc aaggggtcta gaggatcatg taatgatctc cgcaatgtgg attggaataa
      781 acttttaagg agagcaattg aaggacttga ggagccgaat ggctcctccc tgaagaacat
      841 agagaagtat ctcagaagtc aaagtgatct cacaagcacc accaacaacc cagcctttca
      901 gcagcggctg cgactggggg ccaaacgcgc tgtgaataat gggaggttac tgaaagacgg
      961 accgcagtac agggtcaatt atgggagctt agatggcaaa ggggcacctc agtatcccag
     1021 tgcattccca tcctcgctcc cacctgtcag ccttctaccc catgagaaag accagccccg
     1081 tgctgatccc attccaatat gtagcttctg tttggggact aaagaatcaa atcgtgaaaa
     1141 gaaaccagaa gaactcctct cttgtgcaga ttgtggcagt agtggacacc catcctgttt
     1201 gaaattttgt cctgaattaa caacaaatgt aaaggcctta aggtggcagt gcatcgaatg
     1261 caagacatgc agtgcctgta gagtccaagg cagaaatgct gataatatgc ttttttgtga
     1321 ttcctgtgat agaggatttc atatggaatg ctgtgaccca ccactttcca gaatgccaaa
     1381 agatactgaa ataaaaataa acatcaaaca agaaagtgca gatgtaaatg tgattggaaa
     1441 caaggatgtc gttactgaag aggatttgga tgtttttaag caggcccagg aactttcttg
     1501 ggagaaaata gagtgtgaga gtggggtgga agactgtggc cggtaccctt ctgtgattga
     1561 atttggtaaa tatgaaatcc aaacctggta ctcctcgcct tacccacagg aatatgcaag
     1621 attaccaaag ctttacctgt gtgaattctg tcttaaatat atgaaaagta aaaatatttt
     1681 gctaagacac tccaagaagt gtggatggtt tcatcctcca gcaaatgaaa tttaccgaag
     1741 gaaagacctt tcagtatttg aggttgatgg gaatatgagc aaaatttatt gccaaaacct
     1801 ttgcttgtta gccaagctct tcctggacca caaaacgttg tattatgatg tcgagccatt
     1861 ccttttttat gtccttacaa aaaatgatga aaagggctgt catctggttg gatacttctc
     1921 taaggaaaag ctttgccagc agaagtataa tgtctcctgc ataatgatca tgccccagca
     1981 ccaaaggcaa ggatttggac ggtttctcat tgatttcagc tatttgcttt ctagaagaga
     2041 aggccaagca gggtctcctg aaaagcctct ctccgatctg ggccgtctct cctacctggc
     2101 atattggaag agcgtcatct tggagtatct ctaccaccac catgagaggc acatcagcat
     2161 caaggcaatt agcagagcga cgggcatgtg cccacatgac attgccacca ctctgcagca
     2221 cctccacatg atcgacaaga gagatggcag atttgtcatc attagacggg aaaagttgat
     2281 attgagccac atggaaaagc tgaaaacctg ttccagagcc aatgaacttg atccagacag
     2341 tctgaggtgg accccaattt taatttctaa tgctgcagtg tctgaagaag agcgagaagc
     2401 tgagaaagag gctgagcggc taatggaaca agctagctgc tgggagaagg aggaacaaga
     2461 aatcctgtca actagagcta acagtaggca atcacctgca aaagtacaat cgaaaaataa
     2521 atatttgcat tccccggaga gccggccagt cacaggggag cgagggcagc tgctggagct
     2581 gtctaaagag agcagtgaag aagaagagga ggaggaggac gaggaggagg aagaagagga
     2641 ggaagaagag gaagaggatg aagaggagga agaagaggaa gaagaagaag aagaagaaga
     2701 aaatattcaa agctctcccc caagattgac gaaaccacag tcagttgcca taaagagaaa
     2761 gaggcctttt gtactaaaga agaaaagggg tcgtaaacgc aggaggatca acagcagtgt
     2821 aacaacagag accatttcag agacgacaga agtactgaat gagccctttg acaactcaga
     2881 tgaagagagg ccaatgccac agctggagcc tacctgtgag attgaagtgg aggaagatgg
     2941 caggaagcca gtcctgagaa aagcattcca gcatcagcct gggaagaaaa gacaaacaga
     3001 ggaagaggaa ggaaaagaca atcattgctt caagaatgct gacccttgta gaaacaatat
     3061 gaatgatgat tcaagtaact tgaaagaagg cagtaaagac aatcccgaac ctctaaagtg
     3121 caaacaagtg tggccaaaag gaacaaagcg cggtctatct aagtggaggc aaaacaaaga
     3181 gaggaagacc ggatttaaac tgaatttgta caccccgcca gaaacaccca tggagcctga
     3241 cgagcaggta acagtggaag aacagaagga gacttcagaa ggaaaaacca gccccagtcc
     3301 catcaggatt gaggaggagg tcaaggaaac tggggaagcc ctgttgcctc aagaggaaaa
     3361 cagaagggaa gaaacatgtg cccctgtaag tccaaacaca tcaccaggtg aaaaaccaga
     3421 agatgatctc atcaaacctg aggaagagga agaggaggag gaggaggaag aggaagaaga
     3481 ggaagaagag gaaggggaag aagaagaagg aggaggaaat gtagaaaaag atccagatgg
     3541 tgctaaaagc caagaaaaag aggaaccaga aatctccacg gaaaaagaag actctgcacg
     3601 tttggatgat cacgaagagg aggaggaaga ggatgaagag ccatcccaca acgaggacca
     3661 tgatgccgat gacgaggatg acagccacat ggagtctgcc gaagtggaga aggaagagct
     3721 gcccagagaa agcttcaaag aagtactgga aaaccaggag acttttttag accttaatgt
     3781 gcagcctggt cactcgaacc cagaggtctt aatggactgt ggcgtcgacc tgacagcttc
     3841 ttgtaacagt gagcccaagg agcttgctgg ggaccctgaa gctgtacccg aatctgacga
     3901 ggagccaccc ccaggagaac aggcacagaa gcaggaccaa aagaacagca aggaagtcga
     3961 tacagagttc aaagagggaa acccagcaac catggaaatc gactctgaga ctgtccaggc
     4021 cgttcagtct ttgacccagg agagcagcga acaggacgac acctttcagg attgtgccga
     4081 gactcaagag gcctgtagaa gcctacagaa ctacacccgt gcagaccaaa gtccacagat
     4141 tgccaccacg ctcgacgatt gccaacagtc ggaccacagt agcccagttt catccgtcca
     4201 ctcccatcct ggccagtccg tacgttctgt caacagccca agtgtccctg ctctggaaaa
     4261 cagctacgcc caaatcagcc cagatcaaag tgccatctca gtgccatctc tgcagaacat
     4321 ggaaaccagt cccatgatgg atgtcccatc agtttcagat cattcacagc aagtcgtaga
     4381 cagtggattt agtgacctgg gcagtatcga gagcacaact gagaactacg aaaacccaag
     4441 cagctacgat tctactatgg gaggcagcat ctgtggaaac ggctcttcac agaacagctg
     4501 ctcctatagc aacctcacct ccagcagtct gacacagagc agctgtgctg tcacccagca
     4561 gatgtccaac atcagcggga gctgcagcat gctgcagcaa accagcatca gctcccctcc
     4621 gacctgcagc gtcaagtctc ctcaaggctg tgtggtggag aggcctccga gcagcagcca
     4681 gcagctggct cagtgcagca tggctgctaa cttcacccca cccatgcagc tggctgaaat
     4741 ccccgagacg agcaacgcca acattggctt atacgagcga atgggtcaga gtgattttgg
     4801 ggctgggcat tacccgcagc cgtcagccac cttcagcctt gccaaactgc agcagttaac
     4861 taatacactt attgatcatt cattgcctta cagccattcc gctgctgtga cttcctatgc
     4921 aaacagtgcc tctttgtcca caccattaag taacacaggg cttgttcaac tttctcagtc
     4981 tccacactcc gtccctgggg gaccccaagc acaagctacc atgaccccac cccccaacct
     5041 gactcctcct ccaatgaatc tgccgccgcc tcttttgcaa cggaacatgg ctgcatcaaa
     5101 tattggcatc tctcacagcc aaagactgca aacccagatt gccagcaagg gccacatctc
     5161 catgagaacc aagtcagcgt ctctgtcacc agccgctgcc acccatcagt cacaaatcta
     5221 tgggcgctcc cagactgtag ccatgcaggg tcctgcacgg actttaacga tgcaaagagg
     5281 catgaacatg agtgtgaacc tgatgccagc gccagcctac aatgtcaact ctgtgaacat
     5341 gaacatgaac actctcaacg ccatgaatgg gtacagcatg tcccagccaa tgatgaacag
     5401 tggctaccac agcaatcatg gctatatgaa tcaaacgccc caatacccta tgcagatgca
     5461 gatgggcatg atgggcaccc agccatatgc ccagcagcca atgcagaccc caccccacgg
     5521 taacatgatg tacacggccc ccggacatca cggctacatg aacacaggca tgtccaaaca
     5581 gtctctcaat ggctcctaca tgagaaggta gacaacgtgg gcagtccaca aaacctacgg
     5641 ggcatcacta ttggattgat ctgcacaaat acctttgaag agtacgattt caaaaccagc
     5701 aattggtgtg aatgcaaaaa catttgttgg caccatttat ttaaaaaaaa aaaaagctgt
     5761 atgcagcaga aagccttata caagttgttt ttcttttttt cctttttctt ttttttggta
     5821 ccttcatttc tgttactttt atataaaatt ctctgcaaag gaaggcctct ctttggacta
     5881 caatttggag gcagccactt gttgtgcctg cttctgttaa acaatgtgga tatcaagccc
     5941 ccccaaatta tctgttttaa tattgaacct agagcttttt ttttcccttc cctgtccact
     6001 ccatgtaaat gcctttagca tttcagttat tgtatatttt gtttaaggtg acacttcagc
     6061 atgccgctaa tgtctttgtt agtgacagtg cattttgtag tactgtacaa gtgttgtgct
     6121 aacagtaagc catttcttaa gttttttgcc ttgattaggg tgccctaatt tgagggtttt
     6181 aaaaaaaact atatttttgt taattataaa actgtaaaga gctataaaag ctattcccat
     6241 ttggttagtc aaaagggttt tattgctaaa tgtttggtgt aaagttgaga cccttttcca
     6301 ttttggtgac agatttcttt ggggaaaaaa ggcagctttc tgttttataa atgcagactt
     6361 ctgtttattg aatgaagcat atctcagtgt ttatctgtca ggttttgaaa catttcatat
     6421 atgtccaaat acttggcagg atttaaaaaa aaatagtgaa tttggtgtaa agttgctatt
     6481 ttatggaaat gcctctaact ttacattttc attccatctg tagatttttc tatctttata
     6541 aaatattgga gttatttttt aaggaaaaat agaaaagtag cttgtgaata gctcaaacta
     6601 agcttacaaa tcgcatgtaa aaaagcaaaa aagttatttg tgtctgttta tattgcttcc
     6661 ttttttgtag cctttgtacc tgtacagggt gacagtaagg gccaagcagg agaggcgtaa
     6721 tccttgtata aaataggatc cagcgacact cttgtattta tctgttctct ttttagtcag
     6781 tcacttcaaa aaaacaaaaa acaaacaaaa aaaagctgta cattttaaca taaaataaat
     6841 tatgatgagc catttttagc ctcttgtgtc ctgtcatatt atgattgata gagaatgacc
     6901 aatggaactg tatcatgtgt cacgcctcag aacacataca cattttggga aaataaatta
     6961 tttagtgtaa attggagtta tgggattttc tgatttgttt tgactttggg ggaggggttg
     7021 gcaataaata agagtaatat ctaataaaac catcacatat accaaatacc tatttaataa
     7081 attaatttat aatggatttt aatgcttttc atgaaagttt attttatgcg agtgcatacc
     7141 ttctgtatgc caatcattgt ctttaaaata aagtgaaatt gtttttttc
//
