LOCUS       NM_006766               9153 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens lysine acetyltransferase 6A (KAT6A), transcript
            variant 1, mRNA.
ACCESSION   NM_006766
VERSION     NM_006766.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9153)
  AUTHORS   Olbromski,M., Mrozowska,M., Smolarz,B., Romanowicz,H., Rusak,A. and
            Piotrowska,A.
  TITLE     ERalpha status of invasive ductal breast carcinoma as a result of
            regulatory interactions between lysine deacetylases KAT6A and KAT6B
  JOURNAL   Sci Rep 14 (1), 26935 (2024)
   PUBMED   39505971
  REMARK    GeneRIF: ERalpha status of invasive ductal breast carcinoma as a
            result of regulatory interactions between lysine deacetylases KAT6A
            and KAT6B.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9153)
  AUTHORS   Tan,K., Wang,J., Su,X., Zheng,Y. and Li,W.
  TITLE     KAT6A/YAP/TEAD4 pathway modulates osteoclastogenesis by regulating
            the RANKL/OPG ratio on the compression side during orthodontic
            tooth movement
  JOURNAL   Prog Orthod 25 (1), 29 (2024)
   PUBMED   39129034
  REMARK    GeneRIF: KAT6A/YAP/TEAD4 pathway modulates osteoclastogenesis by
            regulating the RANKL/OPG ratio on the compression side during
            orthodontic tooth movement.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9153)
  AUTHORS   Tham,E., Lindstrand,A., Santani,A., Malmgren,H., Nesbitt,A.,
            Dubbs,H.A., Zackai,E.H., Parker,M.J., Millan,F., Rosenbaum,K.,
            Wilson,G.N. and Nordgren,A.
  TITLE     Dominant mutations in KAT6A cause intellectual disability with
            recognizable syndromic features
  JOURNAL   Am J Hum Genet 96 (3), 507-513 (2015)
   PUBMED   25728777
  REMARK    GeneRIF: Heterozygous truncating mutations in KAT6A, as well as
            deletions of the same locus, cause a syndrome characterized by
            intellectual disability, craniosynostosis, cardiac defects, feeding
            difficulties, and distinct facial features.
REFERENCE   4  (bases 1 to 9153)
  AUTHORS   Dreveny,I., Deeves,S.E., Fulton,J., Yue,B., Messmer,M.,
            Bhattacharya,A., Collins,H.M. and Heery,D.M.
  TITLE     The double PHD finger domain of MOZ/MYST3 induces alpha-helical
            structure of the histone H3 tail to facilitate acetylation and
            methylation sampling and modification
  JOURNAL   Nucleic Acids Res 42 (2), 822-835 (2014)
   PUBMED   24150941
  REMARK    GeneRIF: The double PHD finger domain of MOZ/MYST3 induces
            alpha-helical structure of the histone H3 tail to facilitate
            acetylation and methylation sampling and modification.
REFERENCE   5  (bases 1 to 9153)
  AUTHORS   Ali,M., Yan,K., Lalonde,M.E., Degerny,C., Rothbart,S.B.,
            Strahl,B.D., Cote,J., Yang,X.J. and Kutateladze,T.G.
  TITLE     Tandem PHD fingers of MORF/MOZ acetyltransferases display
            selectivity for acetylated histone H3 and are required for the
            association with chromatin
  JOURNAL   J Mol Biol 424 (5), 328-338 (2012)
   PUBMED   23063713
  REMARK    GeneRIF: These data suggest that the tandem of plant homeodomain
            1/2 fingers play a role in MOZ and MORF histone acetyltransferase
            association with histon H3 regions enriched in acetylated marks.
REFERENCE   6  (bases 1 to 9153)
  AUTHORS   Qiu,Y., Liu,L., Zhao,C., Han,C., Li,F., Zhang,J., Wang,Y., Li,G.,
            Mei,Y., Wu,M., Wu,J. and Shi,Y.
  TITLE     Combinatorial readout of unmodified H3R2 and acetylated H3K14 by
            the tandem PHD finger of MOZ reveals a regulatory mechanism for
            HOXA9 transcription
  JOURNAL   Genes Dev 26 (12), 1376-1391 (2012)
   PUBMED   22713874
  REMARK    GeneRIF: PHD12 facilitates the localization of MOZ onto the
            promoter locus of the HOXA9 gene, thereby promoting the H3
            acetylation around the promoter region.
REFERENCE   7  (bases 1 to 9153)
  AUTHORS   Qin,S., Jin,L., Zhang,J., Liu,L., Ji,P., Wu,M., Wu,J. and Shi,Y.
  TITLE     Recognition of unmodified histone H3 by the first PHD finger of
            bromodomain-PHD finger protein 2 provides insights into the
            regulation of histone acetyltransferases monocytic leukemic
            zinc-finger protein (MOZ) and MOZ-related factor (MORF)
  JOURNAL   J Biol Chem 286 (42), 36944-36955 (2011)
   PUBMED   21880731
  REMARK    GeneRIF: Recognition of unmodified histone H3 by the first PHD
            finger of bromodomain-PHD finger protein 2 provides insights into
            the regulation of histone acetyltransferases monocytic leukemic
            zinc-finger protein (MOZ) and MOZ-related factor (MORF).
REFERENCE   8  (bases 1 to 9153)
  AUTHORS   Champagne,N., Pelletier,N. and Yang,X.J.
  TITLE     The monocytic leukemia zinc finger protein MOZ is a histone
            acetyltransferase
  JOURNAL   Oncogene 20 (3), 404-409 (2001)
   PUBMED   11313971
REFERENCE   9  (bases 1 to 9153)
  AUTHORS   Borrow,J., Stanton,V.P. Jr., Andresen,J.M., Becher,R., Behm,F.G.,
            Chaganti,R.S., Civin,C.I., Disteche,C., Dube,I., Frischauf,A.M.,
            Horsman,D., Mitelman,F., Volinia,S., Watmore,A.E. and Housman,D.E.
  TITLE     The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses
            a putative acetyltransferase to the CREB-binding protein
  JOURNAL   Nat Genet 14 (1), 33-41 (1996)
   PUBMED   8782817
REFERENCE   10 (bases 1 to 9153)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA442995.1, BC142659.1,
            U47742.1, AA310750.1, CB216817.1, AC090571.5 and AJ420560.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006766.4.
            
            Summary: This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60
            family of histone acetyltransferases. The protein is composed of a
            nuclear localization domain, a double C2H2 zinc finger domain that
            binds to acetylated histone tails, a histone acetyl-transferase
            domain, a glutamate/aspartate-rich region, and a serine- and
            methionine-rich transactivation domain. It is part of a complex
            that acetylates lysine-9 residues in histone 3, and in addition, it
            acts as a co-activator for several transcription factors. Allelic
            variants of this gene are associated with an autosomal dominant
            form of cognitive disability. Chromosomal translocations of this
            gene are associated with acute myeloid leukemia. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jul 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: MW032476.1, U47742.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265713.8/ ENSP00000265713.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-571               DA442995.1         2-572
            572-3855            BC142659.1         558-3841
            3856-6596           U47742.1           3837-6577
            6597-6612           AA310750.1         67-82
            6613-7885           U47742.1           6595-7867
            7886-7901           CB216817.1         222-237
            7902-7920           AC090571.5         136963-136981
            7921-8301           CB216817.1         258-638
            8302-9153           AJ420560.1         471-1322
FEATURES             Location/Qualifiers
     source          1..9153
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.21"
     gene            1..9153
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /note="lysine acetyltransferase 6A"
                     /db_xref="GeneID:7994"
                     /db_xref="HGNC:HGNC:13013"
                     /db_xref="MIM:601408"
     exon            1..87
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     exon            88..1012
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..6427
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /EC_number="2.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 1; MYST
                     histone acetyltransferase (monocytic leukemia) 3; zinc
                     finger protein 220; monocytic leukemia zinc finger
                     protein; runt-related transcription factor binding protein
                     2; histone acetyltransferase MYST3; MOZ, YBF2/SAS3, SAS2
                     and TIP60 protein 3; histone acetyltransferase KAT6A;
                     K(lysine) acetyltransferase 6A"
                     /codon_start=1
                     /product="histone acetyltransferase KAT6A isoform 1"
                     /protein_id="NP_006757.2"
                     /db_xref="CCDS:CCDS6124.1"
                     /db_xref="GeneID:7994"
                     /db_xref="HGNC:HGNC:13013"
                     /db_xref="MIM:601408"
                     /translation="MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDR
                     KTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWNKL
                     IKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRL
                     LKDGPLYRLNTKATNVDGKESCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQ
                     NREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNAD
                     NMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNP
                     IGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITLSSQSASSSSEEGYLERIDGLDF
                     CRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
                     DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRC
                     PSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPP
                     ANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVK
                     GCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKP
                     LSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGICPQDITSTLHHLRMLDFR
                     SDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGE
                     NEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSL
                     PANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYT
                     ESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRR
                     YSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHN
                     SSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRL
                     SSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPL
                     KKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKI
                     QESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPE
                     TETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDED
                     DGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQP
                     SHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEES
                     SEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSV
                     RSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSD
                     LGSIESTTENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMA
                     SMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQP
                     APQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGST
                     GNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSV
                     SLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHT
                     QRLQGQMPVKGHISIRSKSAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMG
                     VNLMPTPAYNVNSMNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMM
                     GSQAYTQQPMQPNPHGNMMYTGPSHHSYMNAAGVPKQSLNGPYMRR"
     exon            1013..1121
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1237
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1319
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1455
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1775
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1894
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2010
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2152
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2314
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2408
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2640
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2848
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..3451
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3764
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..9153
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9128..9133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /note="hexamer: AATAAA"
     polyA_site      9153
                     /gene="KAT6A"
                     /gene_synonym="ARTHS; MOZ; MRD32; MYST-3; MYST3; RUNXBP2;
                     ZC2HC6A; ZNF220"
                     /note="major polyA site"
ORIGIN      
        1 actgtctcca agatggcggc cgtgtcagtt tggggcatct ccgcggtccg gcccggggcc
       61 ccgggatctc ggctgtcctt cctcccggca taagatgcac atttttctgc tctggagccg
      121 ggaatgaaat attcttgagt tcttacaact ttatgacgag acccatgtgt ggtgctattg
      181 agaaattcat tgggaagttg gaagacattt caatcaacag gttgttttgg tttctatagt
      241 acaattgggg tggcattctg ttttgtgaaa ggaggaagga cttaggccag aaaactcata
      301 tgctatggtt aactggttcc cagcctccga gaatcttgtt ttccatggtg taaaacttac
      361 tcagcatcag gataagggat aacgactcta tggatataca gaatccttca ccatggtaaa
      421 actcgcaaac ccgctttata ctgagtggat tttggaggcc atcaaaaaag tgaaaaagca
      481 gaaacagcgt ccttcagaag aaaggatatg caatgctgtg tcttcatccc atggcttgga
      541 tcgtaaaact gttttagaac aattggagtt gagtgttaaa gatggaacaa ttttaaaagt
      601 ctcaaataaa ggactcaatt cctataaaga tcctgataat cctgggcgaa tagcacttcc
      661 taagcctcgg aaccatggaa aattggataa taaacaaaat gtggattgga ataaactgat
      721 aaagcgggca gttgagggct tggcagagtc tggtggctca actttgaaaa gcattgaacg
      781 ttttttgaaa ggtcagaagg atgtgtctgc attattcgga ggcagtgctg cctctggctt
      841 tcaccagcag ttacgattgg ctatcaaacg tgccattggc cacggcagac tccttaaaga
      901 tggacctctt tatcggctca acactaaagc aaccaacgtg gatgggaaag agagttgtga
      961 gtctctttcc tgtttacctc cagtgtccct tcttccacat gaaaaggata agccggttgc
     1021 tgaaccaatc cccatctgta gtttctgtct tggtacaaaa gaacaaaacc gagaaaagaa
     1081 gccagaggaa ctcatctcct gtgccgactg tggcaacagt ggccatccat cctgtttaaa
     1141 gttttcccct gaactaacgg ttcgagtgaa ggccttacgg tggcagtgca tcgagtgtaa
     1201 aacatgcagc tcctgtcgag atcaaggcaa aaatgcggat aacatgctct tttgtgattc
     1261 atgtgaccga ggttttcaca tggagtgttg tgatccgcca ctcacccgta tgccaaaagg
     1321 catgtggata tgtcaaatat gtcgacctag gaaaaaagga cgaaaacttc tacaaaagaa
     1381 ggcagcacag ataaaacggc gctatactaa tccaatagga cgtccaaaaa acaggttaaa
     1441 gaaacaaaac acggtatcaa aaggtccctt cagcaaagtt cgaactggcc ctggaagggg
     1501 taggaaacga aaaatcactc tttccagcca atcagcatca tcatcatcag aagaaggata
     1561 tttagagcgg atagatggct tggacttctg cagagatagc aatgtctcct tgaagttcaa
     1621 caagaaaacc aaagggctca ttgatggcct taccaaattt tttacccctt cccctgatgg
     1681 gcggaaagct cggggggaag tggtggacta ctctgagcaa tatcgaatca gaaagagggg
     1741 caacaggaaa tcaagcactt cagattggcc cacagacaat caggatggct gggatggcaa
     1801 acaagaaaat gaggagcgac tttttgggag ccaggaaatc atgactgaga aagatatgga
     1861 attatttcgt gatatccaag aacaagcact gcagaaagtt ggagtgactg gtccccctga
     1921 tccacaagtc cgctgtccct ctgtcattga gtttgggaag tatgaaattc acacctggta
     1981 ctcctcccca tatcctcaag aatactcaag gctgcccaaa ttgtatcttt gtgaattttg
     2041 tctaaaatat atgaaaagta gaactattct gcagcagcac atgaagaaat gtggttggtt
     2101 ccatcctcct gccaatgaga tttacagaaa gaataatatt tctgtctttg aggttgatgg
     2161 gaatgtgagt accatttatt gtcaaaacct gtgtcttttg gcaaagttgt ttcttgacca
     2221 caaaaccctc tattacgatg tggagccatt tcttttttat gtactaacac agaatgatgt
     2281 caagggctgc caccttgttg gctacttttc taaggaaaag cactgccaac agaagtacaa
     2341 tgtttcctgt ataatgattc ttcctcaata ccagcgtaag ggctatggca ggtttctcat
     2401 cgatttcagt tatttgttat caaagcgtga aggccaagca gggtctccag agaaaccgtt
     2461 atctgatctg ggtcgtcttt cctacatggc atattggaaa agtgtaatat tggagtgcct
     2521 ttatcaccaa aatgacaagc agatcagcat taagaagtta agcaagttga ctggaatctg
     2581 ccctcaagac atcacttcca cactccacca cctacgaatg ctggacttcc gtagtgacca
     2641 atttgtgatt atccgccggg aaaaacttat ccaggatcac atggcaaagc ttcagctgaa
     2701 tttgcgacct gtagatgtag atccagaatg tttgcgctgg actccagtca tagtgtccaa
     2761 ctctgtggtc tcagaggagg aagaagagga ggctgaggaa ggagaaaacg aagagccaca
     2821 gtgccaggaa agagaattag agatcagtgt gggaaagtct gtgtctcatg agaacaaaga
     2881 acaagattct tattcagtag aaagtgaaaa gaaaccagaa gttatggctc cagtcagttc
     2941 tacacgtttg agcaaacaag tccttcctca tgatagtctt cctgcaaata gccagccatc
     3001 tcggaggggc cgctggggga ggaagaacag aaaaacccag gaacgttttg gtgataaaga
     3061 ttctaaactg ctcttggaag agacgtcttc agctcctcag gaacaatatg gagaatgtgg
     3121 ggagaaatca gaagccaccc aggaacaata cactgaaagt gaagaacagc tggtggcttc
     3181 tgaggagcag ccaagccagg acgggaaacc tgaccttccc aagagaagac tcagtgaggg
     3241 ggttgagccc tggcgaggac agctcaagaa aagccctgag gctctgaagt gcagattaac
     3301 agaaggaagt gagaggctgc cccgtcgcta cagtgagggt gacagggctg tcctcagggg
     3361 cttcagtgag agcagcgagg aggaggagga gccggaaagc cctcggtcaa gctcgccacc
     3421 aattctcaca aagcccacgc tgaagcgaaa gaaaccattt ctccaccgaa ggaggagagt
     3481 ccgaaagcgc aaacaccaca atagcagtgt agtcacagaa actatttctg agaccactga
     3541 agtgttagat gaaccttttg aagattctga ctccgagagg ccaatgccaa gattagaacc
     3601 cacgtttgag atcgatgaag aagaggagga agaggatgaa aatgaacttt tccctagaga
     3661 atacttccgt cgtttgtctt cgcaggatgt actcaggtgt cagtcctctt ctaagaggaa
     3721 gtctaaagat gaagaagaag atgaagagtc agatgatgct gatgacactc ctatcttaaa
     3781 gccagtatct cttttgcgaa aacgtgatgt gaagaattct cctcttgagc cagatacatc
     3841 cacacctttg aaaaagaaaa agggatggcc caaaggcaag agccgcaaac caatccactg
     3901 gaagaaaaga cctggtcgaa aaccaggatt taagttgagt cgggaaatca tgccagtttc
     3961 tactcaagca tgcgtcattg agcccatcgt ttccattcct aaagctggac gtaaacccaa
     4021 gatccaggag agtgaagaaa ctgttgagcc aaaagaagac atgcccctac ccgaggagag
     4081 gaaggaggag gaggagatgc aagcagaggc agaagaggct gaagagggtg aggaagagga
     4141 tgcagccagc agtgaagtcc cagcagcctc tccagcagac agcagcaata gtcctgagac
     4201 cgaaaccaag gagcctgagg tggaggagga agaagagaag ccccgtgtct cagaggagca
     4261 gaggcagtca gaggaggagc agcaggaatt agaggagcca gagccagagg aggaggaaga
     4321 tgcagctgca gagactgccc agaatgacga ccacgacgct gatgatgagg atgatggcca
     4381 cctggagtcc acaaagaaaa aggagctaga ggaacagccc acgagggaag atgtcaagga
     4441 ggagcctggt gttcaagagt cttttttaga tgctaatatg cagaagagta gggaaaagat
     4501 aaaggataaa gaggaaaccg agctggattc cgaagaggag cagccttccc atgacacgtc
     4561 cgtggtgtca gagcagatgg ctgggtctga ggacgaccac gaagaagact cccacactaa
     4621 ggaagagtta atcgaattaa aagaggagga agagattcct catagtgagc tggatctgga
     4681 aactgtacag gcagtgcagt ctttgactca agaagaaagc agtgagcatg agggcgccta
     4741 ccaggactgt gaggaaactc ttgcggcgtg tcagaccctg cagagttaca cccaggctga
     4801 cgaggaccct cagatgtcca tggttgaaga ctgtcatgcg tcagaacata atagccctat
     4861 ctcctccgtt cagtctcacc ccagccagtc agtccgttcg gtcagcagtc ccaacgtgcc
     4921 tgcccttgag agtggctaca cccagatcag cccagaacaa ggatccctgt ccgcaccctc
     4981 tatgcagaac atggagacca gccccatgat ggatgtgcct tccgtatcag accactctca
     5041 gcaggtggtg gacagcggct tcagtgacct gggcagcatt gagagcacca ctgaaaacta
     5101 tgagaaccca agcagttacg actccacgat gggcggcagc atctgtggga acagctcttc
     5161 ccagagcagc tgctcctacg gtgggctgtc gtcctccagc agcctcaccc agagcagctg
     5221 tgtggtcact cagcagatgg ccagcatggg cagcagctgc agcatgatgc agcagagcag
     5281 cgtccagcct gctgccaact gcagcatcaa gtcacctcag agctgcgtgg tggagaggcc
     5341 tcccagtaac cagcagcagc agccgccacc accgcctcca cagcagccac agccgccgcc
     5401 gccacaacca caaccagcac cacagcctcc accaccccag cagcagccgc aacagcagcc
     5461 gcagcctcag ccccagcagc ctccaccccc accccctccc cagcagcagc ccccgctgtc
     5521 acagtgtagt atgaataaca gtttcacccc agctcctatg atcatggaga taccagaatc
     5581 tggaagcact gggaacataa gtatctatga gaggattcca ggggattttg gtgccggcag
     5641 ctactctcaa ccatcagcca ccttcagcct agccaagctg cagcagctga ccaacaccat
     5701 tatggaccct catgccatgc cttatagcca ttctcctgct gtgacttcct atgcaaccag
     5761 tgtttctctg tccaatacag gactggctca gctggctcca tctcatccct tagctgggac
     5821 tcctcaagca caagccacca tgacgccacc cccaaacttg gcatccacta ccatgaacct
     5881 cacatctcct ctgcttcagt gcaacatgtc tgccaccaac attggcattc ctcacacgca
     5941 gagattgcaa gggcaaatgc cagtgaaggg gcacatttcc atccgctcca agtctgcgcc
     6001 actgccctct gcggctgctc accagcagca gctgtatggc cgtagcccat cggcagttgc
     6061 catgcaggct ggccctcgcg cactggctgt tcagcgtggc atgaacatgg gggttaatct
     6121 gatgcctact cccgcctata atgtcaattc catgaatatg aacaccttga atgccatgaa
     6181 cagctatcga atgacacagc ccatgatgaa cagcagttac catagtaacc ctgcctacat
     6241 gaaccagaca gcacagtatc ctatgcagat gcagatggga atgatgggga gccaggccta
     6301 tacccagcag cctatgcagc ctaaccctca tgggaacatg atgtacacag gcccctccca
     6361 tcacagctac atgaacgctg ctggcgtgcc caagcagtca ctcaacggac cttacatgag
     6421 aagatgagca agatgaactt gcaatcaaaa acttaaatat atataaataa aggaaccttt
     6481 tatactgaca aaccagagaa aaatggacct ttttccagtt aaaatattgc tgtagattta
     6541 gaggaatttt tctttggttt attttatttt ttagaaaacc tgatcttctc tttttttggg
     6601 ttcattttgt tctgggtttt ggttttcttc acaatcttga acattttaca gtagaactca
     6661 tctaaaaatg gatttgggga tggggaaaca tgcacaaaat cttttcataa ttaaaaagag
     6721 ccttactttc tttacatacc acatggacag aatttgtgta aaagtgaatt atctttattt
     6781 taaaatgtat gtttcccctc actgtttgca gctcccaatg ttgtcatttt taaatgttat
     6841 atacatctca agggttaacc agaccctttc ctccaaaccc aacctttcat ttcctacttc
     6901 attccagcag gaggcactta ggggagactc ggatggggac atggagaaca acccaagctc
     6961 cttaaactta ttattattgt taatattatt attattatta ttaataaagt gaggcaggaa
     7021 aatgcttctc cttttaaaat cccctccact cctcacacac acacacctct tgaaaccctt
     7081 ccccaagaat gtttctttat agacggactt cattgaaatc tttgttgttc ttgaatcaag
     7141 tgtaatataa tttttttctt cttttttaaa atattcccac tcagcactca gagacacaaa
     7201 aatactgtaa gtctcaatta acagcagaat ctcagagaaa agctgtttgc aatccaaatc
     7261 cagcctttgg aggaatagag atggtcaatt aacaatcaaa aagaggagat taacctcttg
     7321 tttttttacc acctggtgaa tcagccataa cgcacacaca cgccacccag cctcttgttt
     7381 ctagtatgta ctttgaaatg ctaactgagg gtcttgatgc ttgagccttt gactgataaa
     7441 actcaaatag cagtccccag tgatttgcct cttaggttct ttcttaaatt gttggtggat
     7501 gactgtacat tttagtgatt tgaaaaataa ctgacaaacc attgaaacag tttattttat
     7561 gttggaagag atggcgcaga tgtgtgtcag aagggagatc acggtgtgag tttcgtagct
     7621 atttaagtga tacatacctc tagtttttgt atgtcttttg agatcctgag ttcatcccct
     7681 gtgaatcaga gtgcacaagc acctctcctg tgagtggcta atgagaagag ggacagaccg
     7741 accaccagca cagtagggca gatctggaca gcagaatgtt ataacgcaag ttcatgtgtt
     7801 gctcccaact ccattctctt ttctctcgtg caaccagttt gcccattctc ttcctattac
     7861 ttgctccagg gataggtaaa aaaaaaaaaa aaaaaaaaaa aaatatatat atatatatat
     7921 acacacacac acacacacac acacacacat atatatatat atatattcca tcattagaag
     7981 atggaaacta ttataccact tggtatgtgc agtcaaatat ccaaaagggg gaagtactgc
     8041 ttagagaaat atctgtaagc attaaattct ctcctttatt tgtacatttt atatagataa
     8101 atttttaaag tactaattag gcattaactt ttttcaaatg cacaggtttg ttggtttttt
     8161 taatacactt taattgactt tctcaagcgt gctaggtaga aacgcagaat tccacatctt
     8221 cccgctctca gctctgagca tgtgcaaggc tgtgtaggac ccagtttctc tgtatatact
     8281 attccagttc ccagtcatct atgtagaaag tgcactgtgc tgccatcgcc ctacatcttc
     8341 agctgtgtca ttgcttcctg gttggggtgg ggacggggtg ggtcgggagg gaggtatatt
     8401 gggaggaggg tgggtcaagg cagaaggaga agctgttgaa atgagggccg tgaaatcagt
     8461 ttctgttggt ttgcggttgt gtttggtttt gtttgtttct ttataaaaaa ttcaatcggg
     8521 cagctccctt ttccacaagc ctctttgtga ctgtagaact attgtagaaa aaaaaagttc
     8581 ttttctatat tataaaagaa attatccaac acagtaatat tggtacctgt cattttttca
     8641 cttctgttta aaaaaaatgt atttttagca agataacttg ggtaatcttc taaaaaagaa
     8701 atttaaaaac tcactgttag tgactttgat gccttttaaa ataagagctt tttcatttca
     8761 ttccatcttt aaaatttttt atctttgttg tagaatatta aaaactattt taagaaagat
     8821 aaattctctt taaagagatc tctagcgtgt gtgaatagag ctccagatgc ctctaaaagc
     8881 cgcatgtaca aaggaagcca cgtctatcct gtctgtttat atttgctttt cctgttttgt
     8941 aacctctttg tactttgttc atggtgactt gtaagctaag gggaaggggt gcctagatgc
     9001 ctttgtatct ctccatgtca cgcgctcctg ggccagccgg cctcccttcc tctccttgta
     9061 tgtaatacct ttttttcccc tttctagcaa gtactttcaa aagaactctg tacattttaa
     9121 cataaaaaat aaattatgtt gagccatttt gga
//
