LOCUS       NM_182710               2080 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens lysine acetyltransferase 5 (KAT5), transcript variant
            1, mRNA.
ACCESSION   NM_182710
VERSION     NM_182710.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2080)
  AUTHORS   Wang,Y., Li,M., Chen,Y., Jiang,Y., Zhang,Z., Yan,Z., Liu,X. and
            Wu,C.
  TITLE     SPIN1 facilitates chemoresistance and HR repair by promoting Tip60
            binding to H3K9me3
  JOURNAL   EMBO Rep 25 (9), 3970-3989 (2024)
   PUBMED   39090319
  REMARK    GeneRIF: SPIN1 facilitates chemoresistance and HR repair by
            promoting Tip60 binding to H3K9me3.
REFERENCE   2  (bases 1 to 2080)
  AUTHORS   Sun,M., Yang,B., Xin,G., Wang,Y., Luo,J., Jiang,Q. and Zhang,C.
  TITLE     TIP60 acetylation of Bub1 regulates centromeric H2AT120
            phosphorylation for faithful chromosome segregation
  JOURNAL   Sci China Life Sci 67 (9), 1957-1969 (2024)
   PUBMED   38763998
  REMARK    GeneRIF: TIP60 acetylation of Bub1 regulates centromeric H2AT120
            phosphorylation for faithful chromosome segregation.
REFERENCE   3  (bases 1 to 2080)
  AUTHORS   Chen,H., Li,Y., Li,H., Chen,X., Fu,H., Mao,D., Chen,W., Lan,L.,
            Wang,C., Hu,K., Li,J., Zhu,C., Evans,I., Cheung,E., Lu,D., He,Y.,
            Behrens,A., Yin,D. and Zhang,C.
  TITLE     NBS1 lactylation is required for efficient DNA repair and
            chemotherapy resistance
  JOURNAL   Nature 631 (8021), 663-669 (2024)
   PUBMED   38961290
REFERENCE   4  (bases 1 to 2080)
  AUTHORS   Xuan,F., Xuan,H., Huang,M., He,W., Xu,H., Shi,X. and Wen,H.
  TITLE     The Tudor-knot Domain of KAT5 Regulates Nucleosomal Substrate
            Acetylation
  JOURNAL   J Mol Biol 436 (7), 168414 (2024)
   PUBMED   38141874
  REMARK    GeneRIF: The Tudor-knot Domain of KAT5 Regulates Nucleosomal
            Substrate Acetylation.
REFERENCE   5  (bases 1 to 2080)
  AUTHORS   Shibahara,D., Akanuma,N., Kobayashi,I.S., Heo,E., Ando,M.,
            Fujii,M., Jiang,F., Prin,P.N., Pan,G., Wong,K.K., Costa,D.B.,
            Bararia,D., Tenen,D.G., Watanabe,H. and Kobayashi,S.S.
  TITLE     TIP60 is required for tumorigenesis in non-small cell lung cancer
  JOURNAL   Cancer Sci 114 (6), 2400-2413 (2023)
   PUBMED   36916958
  REMARK    GeneRIF: TIP60 is required for tumorigenesis in non-small cell lung
            cancer.
REFERENCE   6  (bases 1 to 2080)
  AUTHORS   Brady,M.E., Ozanne,D.M., Gaughan,L., Waite,I., Cook,S., Neal,D.E.
            and Robson,C.N.
  TITLE     Tip60 is a nuclear hormone receptor coactivator
  JOURNAL   J Biol Chem 274 (25), 17599-17604 (1999)
   PUBMED   10364196
REFERENCE   7  (bases 1 to 2080)
  AUTHORS   Dechend,R., Hirano,F., Lehmann,K., Heissmeyer,V., Ansieau,S.,
            Wulczyn,F.G., Scheidereit,C. and Leutz,A.
  TITLE     The Bcl-3 oncoprotein acts as a bridging factor between
            NF-kappaB/Rel and nuclear co-regulators
  JOURNAL   Oncogene 18 (22), 3316-3323 (1999)
   PUBMED   10362352
REFERENCE   8  (bases 1 to 2080)
  AUTHORS   Kimura,A. and Horikoshi,M.
  TITLE     Tip60 acetylates six lysines of a specific class in core histones
            in vitro
  JOURNAL   Genes Cells 3 (12), 789-800 (1998)
   PUBMED   10096020
REFERENCE   9  (bases 1 to 2080)
  AUTHORS   Yamamoto,T. and Horikoshi,M.
  TITLE     Novel substrate specificity of the histone acetyltransferase
            activity of HIV-1-Tat interactive protein Tip60
  JOURNAL   J Biol Chem 272 (49), 30595-30598 (1997)
   PUBMED   9388189
REFERENCE   10 (bases 1 to 2080)
  AUTHORS   Kamine,J., Elangovan,B., Subramanian,T., Coleman,D. and
            Chinnadurai,G.
  TITLE     Identification of a cellular protein that specifically interacts
            with the essential cysteine region of the HIV-1 Tat transactivator
  JOURNAL   Virology 216 (2), 357-366 (1996)
   PUBMED   8607265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB103287.1, BC013211.1 and
            BU737532.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_182710.2.
            
            Summary: The protein encoded by this gene belongs to the MYST
            family of histone acetyl transferases (HATs) and was originally
            isolated as an HIV-1 TAT-interactive protein. HATs play important
            roles in regulating chromatin remodeling, transcription and other
            nuclear processes by acetylating histone and nonhistone proteins.
            This protein is a histone acetylase that has a role in DNA repair
            and apoptosis and is thought to play an important role in signal
            transduction. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.827992.1,
                                           SRR3476690.787374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341318.9/ ENSP00000340330.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DB103287.1         218-249
            33-2064             BC013211.1         1-2032
            2065-2080           BU737532.1         18-33               c
FEATURES             Location/Qualifiers
     source          1..2080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..2080
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /note="lysine acetyltransferase 5"
                     /db_xref="GeneID:10524"
                     /db_xref="HGNC:HGNC:5275"
                     /db_xref="MIM:601409"
     exon            1..194
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1657
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /EC_number="2.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 1; cPLA2
                     interacting protein; HIV-1 Tat interactive protein, 60kDa;
                     K-acetyltransferase 5; Tat interacting protein, 60kDa;
                     histone acetyltransferase KAT5; cPLA(2)-interacting
                     protein; 60 kDa Tat-interactive protein; histone
                     acetyltransferase HTATIP; K(lysine) acetyltransferase 5;
                     protein acetyltransferase KAT5; protein
                     crotonyltransferase KAT5; protein
                     2-hydroxyisobutyryltransferase KAT5; protein
                     lactyltransferase KAT5"
                     /codon_start=1
                     /product="histone acetyltransferase KAT5 isoform 1"
                     /protein_id="NP_874369.1"
                     /db_xref="CCDS:CCDS8110.1"
                     /db_xref="GeneID:10524"
                     /db_xref="HGNC:HGNC:5275"
                     /db_xref="MIM:601409"
                     /translation="MAEVVSPVPGAGRREPGEVGRARGPPVADPGVALSPQGEIIEGC
                     RLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQ
                     FPKKEAKTPTKNGLPGSRPGSPEREVPASAQASGKTLPIPVQITLRFNLPKEREAIPG
                     GEPDQPLSSSSCLQPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGAARRAVAAQPG
                     RKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLK
                     PWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISF
                     FEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEK
                     ESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSY
                     WSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILT
                     LSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW"
     exon            195..263
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            264..400
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            401..556
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            557..631
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            632..706
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            707..955
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1045
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1186
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1280
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1440
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1522
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..2080
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2059..2064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /note="hexamer: AATAAA"
     polyA_site      2080
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; NEDFASB;
                     PLIP; TIP; TIP60; ZC2HC5"
                     /note="major polyA site"
ORIGIN      
        1 agtggaggga gggaagatgg cggaggtggt gagtccggtg cccggggcgg ggcggaggga
       61 gccaggggag gtgggtagag cccgaggccc cccagtagcc gaccctggcg tcgcgctgtc
      121 tccccagggg gagataatcg agggctgccg cctacccgtg ctgcggcgga accaggacaa
      181 cgaagatgag tggcccctgg ccgagatcct gagcgtgaag gacatcagtg gccggaagct
      241 tttctacgtc cattacattg acttcaacaa acgtctggat gaatgggtga cgcatgagcg
      301 gctggaccta aagaagatcc agttccccaa gaaagaggcc aagaccccca ctaagaacgg
      361 acttcctggg tcccgtcctg gctctccaga gagagaggtg ccggcctcgg cgcaggccag
      421 cgggaagacc ttgccaatcc cggtccagat cacactccgc ttcaacctgc ccaaggagcg
      481 ggaggccatt cccggtggcg agcctgacca gccgctctcc tccagctcct gcctgcagcc
      541 caaccaccgc tcaacgaaac ggaaggtgga ggtggtttca ccagcaactc cagtgcccag
      601 cgagacagcc ccggcctcgg tttttcccca gaatggagcc gcccgtaggg cagtggcagc
      661 ccagccagga cggaagcgaa aatcgaattg tttgggcact gatgaggact cccaggacag
      721 ctctgatgga ataccgtcag caccacgcat gactggcagc ctggtgtctg atcgaagcca
      781 cgacgacatc gtcacccgga tgaagaacat tgagtgcatt gagctgggcc ggcaccgcct
      841 caagccgtgg tacttctccc cgtacccaca ggaactcacc acattgcctg tcctctacct
      901 gtgcgagttc tgcctcaagt acggccgtag tctcaagtgt cttcagcgtc atttgaccaa
      961 gtgtgaccta cgacatcctc caggcaatga gatttaccgc aagggcacca tctccttctt
     1021 tgagattgat ggacgtaaga acaagagtta ttcccagaac ctgtgtcttt tggccaagtg
     1081 tttccttgac cataagacac tgtactatga cacagaccct ttcctcttct acgtcatgac
     1141 agagtatgac tgtaagggct tccacatcgt gggctacttc tccaaggaga aagaatcaac
     1201 ggaagactac aatgtggcct gcatcctaac cctgcctccc taccagcgcc ggggctacgg
     1261 caagctgctg atcgagttca gctatgaact ctccaaagtg gaagggaaaa cagggacccc
     1321 tgagaagccc ctctcagacc ttggcctcct atcctatcga agctactggt cccagaccat
     1381 cctggagatc ctgatggggc tgaagtcgga gagcggggag aggccacaga tcaccatcaa
     1441 tgagattagt gaaatcacca gcatcaagaa ggaggatgtc atctccactc tgcagtacct
     1501 caatctcatc aactactaca agggccagta catcctcaca ctgtcagagg acatcgtgga
     1561 tggccatgag cgggccatgc tcaagcggct cctgcggatc gactccaagt gtctgcactt
     1621 cactcccaag gactggagca agagggggaa gtggtgacca gacactgccc actgcagtgc
     1681 caagacggca gcaggactgg ggctgatagc ccaccccgcc cccactgcag ctcccacaaa
     1741 gcactctaag ggagatgggg ctgaggacag ctcaaaaagg agaggacagg cctggcaggg
     1801 gcccactggt gcccagcacc aaggcgagct ccgggctcag accaactcca aggtcagctg
     1861 gccacaggcc caggcctcct ctgaagcagg gaccagaggg agccaggcag ctgtgtacag
     1921 tgagaaggga tccggatggg ggagctctgt acagagggct ggtgattgta aaaatttctt
     1981 ttgtaaagta gaagttgggg gtggggtggg tgctggctgc aaaaatttct ggcttctctt
     2041 acccctattg cccccggcaa taaattgttt ctatatgcca
//
