LOCUS       NM_003884               4410 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens lysine acetyltransferase 2B (KAT2B), mRNA.
ACCESSION   NM_003884 XM_001130666
VERSION     NM_003884.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4410)
  AUTHORS   Lee,S.Y., Lee,S.H., Choi,N.H., Kim,J.Y., Kweon,J.H., Miller,K.M.
            and Kim,J.J.
  TITLE     PCAF promotes R-loop resolution via histone acetylation
  JOURNAL   Nucleic Acids Res 52 (15), 8643-8660 (2024)
   PUBMED   38936834
  REMARK    GeneRIF: PCAF promotes R-loop resolution via histone acetylation.
REFERENCE   2  (bases 1 to 4410)
  AUTHORS   Ma,W., Zhang,J., Chen,W., Liu,N. and Wu,T.
  TITLE     The histone lysine acetyltransferase KAT2B inhibits
            cholangiocarcinoma growth: evidence for interaction with SP1 to
            regulate NF2-YAP signaling
  JOURNAL   J Exp Clin Cancer Res 43 (1), 117 (2024)
   PUBMED   38641672
  REMARK    GeneRIF: The histone lysine acetyltransferase KAT2B inhibits
            cholangiocarcinoma growth: evidence for interaction with SP1 to
            regulate NF2-YAP signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4410)
  AUTHORS   Monte-Serrano,E., Morejon-Garcia,P., Campillo-Marcos,I.,
            Campos-Diaz,A., Navarro-Carrasco,E. and Lazo,P.A.
  TITLE     The pattern of histone H3 epigenetic posttranslational
            modifications is regulated by the VRK1 chromatin kinase
  JOURNAL   Epigenetics Chromatin 16 (1), 18 (2023)
   PUBMED   37179361
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4410)
  AUTHORS   Zhang,J., Hu,Z., Chung,H.H., Tian,Y., Lau,K.W., Ser,Z., Lim,Y.T.,
            Sobota,R.M., Leong,H.F., Chen,B.J., Yeo,C.J., Tan,S.Y.X., Kang,J.,
            Tan,D.E.K., Sou,I.F., McClurg,U.L., Lakshmanan,M., Vaiyapuri,T.S.,
            Raju,A., Wong,E.S.M., Tergaonkar,V., Rajarethinam,R., Pathak,E.,
            Tam,W.L., Tan,E.Y. and Tee,W.W.
  TITLE     Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer
            carcinogenesis
  JOURNAL   Nat Commun 14 (1), 2439 (2023)
   PUBMED   37117180
  REMARK    GeneRIF: Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast
            cancer carcinogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4410)
  AUTHORS   Qiu,L., Liu,X., Xia,H. and Xu,C.
  TITLE     Downregulation of P300/CBP-Associated Factor Protects from Vascular
            Aging via Nrf2 Signal Pathway Activation
  JOURNAL   Int J Mol Sci 23 (20), 12574 (2022)
   PUBMED   36293441
  REMARK    GeneRIF: Downregulation of P300/CBP-Associated Factor Protects from
            Vascular Aging via Nrf2 Signal Pathway Activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4410)
  AUTHORS   Spencer,T.E., Jenster,G., Burcin,M.M., Allis,C.D., Zhou,J.,
            Mizzen,C.A., McKenna,N.J., Onate,S.A., Tsai,S.Y., Tsai,M.J. and
            O'Malley,B.W.
  TITLE     Steroid receptor coactivator-1 is a histone acetyltransferase
  JOURNAL   Nature 389 (6647), 194-198 (1997)
   PUBMED   9296499
REFERENCE   7  (bases 1 to 4410)
  AUTHORS   Chen,H., Lin,R.J., Schiltz,R.L., Chakravarti,D., Nash,A., Nagy,L.,
            Privalsky,M.L., Nakatani,Y. and Evans,R.M.
  TITLE     Nuclear receptor coactivator ACTR is a novel histone
            acetyltransferase and forms a multimeric activation complex with
            P/CAF and CBP/p300
  JOURNAL   Cell 90 (3), 569-580 (1997)
   PUBMED   9267036
REFERENCE   8  (bases 1 to 4410)
  AUTHORS   Ogryzko,V.V., Schiltz,R.L., Russanova,V., Howard,B.H. and
            Nakatani,Y.
  TITLE     The transcriptional coactivators p300 and CBP are histone
            acetyltransferases
  JOURNAL   Cell 87 (5), 953-959 (1996)
   PUBMED   8945521
REFERENCE   9  (bases 1 to 4410)
  AUTHORS   Yang,X.J., Ogryzko,V.V., Nishikawa,J., Howard,B.H. and Nakatani,Y.
  TITLE     A p300/CBP-associated factor that competes with the adenoviral
            oncoprotein E1A
  JOURNAL   Nature 382 (6589), 319-324 (1996)
   PUBMED   8684459
REFERENCE   10 (bases 1 to 4410)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099057.3.
            
            On Nov 23, 2018 this sequence version replaced NM_003884.4.
            
            Summary: CBP and p300 are large nuclear proteins that bind to many
            sequence-specific factors involved in cell growth and/or
            differentiation, including c-jun and the adenoviral oncoprotein
            E1A. The protein encoded by this gene associates with p300/CBP. It
            has in vitro and in vivo binding activity with CBP and p300, and
            competes with E1A for binding sites in p300/CBP. It has histone
            acetyl transferase activity with core histones and nucleosome core
            particles, indicating that this protein plays a direct role in
            transcriptional regulation. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060823.1, SRR1803611.10333.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263754.5/ ENSP00000263754.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               AC099057.3         17529-17863
            336-462             AC099057.3         49416-49542
            463-608             AC099057.3         72346-72491
            609-701             AC099057.3         76945-77037
            702-883             AC099057.3         78370-78551
            884-1075            AC099057.3         88679-88870
            1076-1182           AC099057.3         91965-92071
            1183-1308           AC099057.3         96681-96806
            1309-1445           AC099057.3         99751-99887
            1446-1654           AC099057.3         102988-103196
            1655-1781           AC099057.3         104506-104632
            1782-1892           AC099057.3         114025-114135
            1893-2036           AC099057.3         117304-117447
            2037-2151           AC099057.3         123399-123513
            2152-2188           AC099057.3         125046-125082
            2189-2252           AC099057.3         125326-125389
            2253-2337           AC099057.3         125486-125570
            2338-4410           AC099057.3         129415-131487
FEATURES             Location/Qualifiers
     source          1..4410
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.3"
     gene            1..4410
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /note="lysine acetyltransferase 2B"
                     /db_xref="GeneID:8850"
                     /db_xref="HGNC:HGNC:8638"
                     /db_xref="MIM:602303"
     exon            1..335
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2531
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /EC_number="2.3.1.57"
                     /EC_number="2.3.1.48"
                     /note="CREBBP-associated factor; K(lysine)
                     acetyltransferase 2B; p300/CBP-associated factor; histone
                     acetylase PCAF; histone acetyltransferase PCAF; spermidine
                     acetyltransferase KAT2B"
                     /codon_start=1
                     /product="histone acetyltransferase KAT2B"
                     /protein_id="NP_003875.3"
                     /db_xref="CCDS:CCDS2634.1"
                     /db_xref="GeneID:8850"
                     /db_xref="HGNC:HGNC:8638"
                     /db_xref="MIM:602303"
                     /translation="MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAA
                     AAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKA
                     EESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNR
                     LLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEK
                     PSIEQGVNNFVQYKFSHLPAKERQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDIS
                     GYKENYTRWLCYCNVPQFCDSLPRYETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKL
                     PLEKRTLILTHFPKFLSMLEEEVYSQNSPIWDQDFLSASSRTSQLGIQTVINPPPVAG
                     TISYNSTSSSLEQPNAGSSSPACKASSGLEANPGEKRKMTDSHVLEEAKKPRVMGDIP
                     MELINEVMSTITDPAAMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPN
                     KKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQ
                     GFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHDILNFLTYADEYAIGYFKKQGFSK
                     EIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQIR
                     KVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPRDPDQLYSTLKSILQQVK
                     SHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTN
                     CKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK"
     exon            336..462
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            463..608
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            609..701
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            702..883
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1075
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1182
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1308
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1445
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1654
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1781
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1892
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2036
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2151
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2188
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2252
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2337
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..4410
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4357..4362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /note="hexamer: AATATA"
     regulatory      4388..4393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /note="hexamer: ATTATA"
     polyA_site      4407
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
     polyA_site      4410
                     /gene="KAT2B"
                     /gene_synonym="CAF; P/CAF; PCAF"
                     /note="major polyA site"
ORIGIN      
        1 actcggcgcc tcctgccgtg ctccggggcg gcatgtccga ggctggcggg gccgggccgg
       61 gcggctgcgg ggcaggagcc ggggcagggg ccgggcccgg ggcgctgccc ccgcagcctg
      121 cggcgcttcc gcccgcgccc ccgcagggct ccccctgcgc cgctgccgcc gggggctcgg
      181 gcgcctgcgg tccggcgacg gcagtggctg cagcgggcac ggccgaagga ccgggaggcg
      241 gtggctcggc ccgaatcgcc gtgaagaaag cgcaactacg ctccgctccg cgggccaaga
      301 aactggagaa actcggagtg tactccgcct gcaaggccga ggagtcttgt aaatgtaatg
      361 gctggaaaaa ccctaacccc tcacccactc cccccagagc cgacctgcag caaataattg
      421 tcagtctaac agaatcctgt cggagttgta gccatgccct agctgctcat gtttcccacc
      481 tggagaatgt gtcagaggaa gaaatgaaca gactcctggg aatagtattg gatgtggaat
      541 atctctttac ctgtgtccac aaggaagaag atgcagatac caaacaagtt tatttctatc
      601 tatttaagct cttgagaaag tctattttac aaagaggaaa acctgtggtt gaaggctctt
      661 tggaaaagaa acccccattt gaaaaaccta gcattgaaca gggtgtgaat aactttgtgc
      721 agtacaaatt tagtcacctg ccagcaaaag aaaggcaaac aatagttgag ttggcaaaaa
      781 tgttcctaaa ccgcatcaac tattggcatc tggaggcacc atctcaacga agactgcgat
      841 ctcccaatga tgatatttct ggatacaaag agaactacac aaggtggctg tgttactgca
      901 acgtgccaca gttctgcgac agtctacctc ggtacgaaac cacacaggtg tttgggagaa
      961 cattgcttcg ctcggtcttc actgttatga ggcgacaact cctggaacaa gcaagacagg
     1021 aaaaagataa actgcctctt gaaaaacgaa ctctaatcct cactcatttc ccaaaatttc
     1081 tgtccatgct agaagaagaa gtatatagtc aaaactctcc catctgggat caggattttc
     1141 tctcagcctc ttccagaacc agccagctag gcatccaaac agttatcaat ccacctcctg
     1201 tggctgggac aatttcatac aattcaacct catcttccct tgagcagcca aacgcaggga
     1261 gcagcagtcc tgcctgcaaa gcctcttctg gacttgaggc aaacccagga gaaaagagga
     1321 aaatgactga ttctcatgtt ctggaggagg ccaagaaacc ccgagttatg ggggatattc
     1381 cgatggaatt aatcaacgag gttatgtcta ccatcacgga ccctgcagca atgcttggac
     1441 cagagaccaa ttttctgtca gcacactcgg ccagggatga ggcggcaagg ttggaagagc
     1501 gcaggggtgt aattgaattt cacgtggttg gcaattccct caaccagaaa ccaaacaaga
     1561 agatcctgat gtggctggtt ggcctacaga acgttttctc ccaccagctg ccccgaatgc
     1621 caaaagaata catcacacgg ctcgtctttg acccgaaaca caaaaccctt gctttaatta
     1681 aagatggccg tgttattggt ggtatctgtt tccgtatgtt cccatctcaa ggattcacag
     1741 agattgtctt ctgtgctgta acctcaaatg agcaagtcaa gggctatgga acacacctga
     1801 tgaatcattt gaaagaatat cacataaagc atgacatcct gaacttcctc acatatgcag
     1861 atgaatatgc aattggatac tttaagaaac agggtttctc caaagaaatt aaaataccta
     1921 aaaccaaata tgttggctat atcaaggatt atgaaggagc cactttaatg ggatgtgagc
     1981 taaatccacg gatcccgtac acagaatttt ctgtcatcat taaaaagcag aaggagataa
     2041 ttaaaaaact gattgaaaga aaacaggcac aaattcgaaa agtttaccct ggactttcat
     2101 gttttaaaga tggagttcga cagattccta tagaaagcat tcctggaatt agagagacag
     2161 gctggaaacc gagtggaaaa gagaaaagta aagagcccag agaccctgac cagctttaca
     2221 gcacgctcaa gagcatcctc cagcaggtga agagccatca aagcgcttgg cccttcatgg
     2281 aacctgtgaa gagaacagaa gctccaggat attatgaagt tataaggttc cccatggatc
     2341 tgaaaaccat gagtgaacgc ctcaagaata ggtactacgt gtctaagaaa ttattcatgg
     2401 cagacttaca gcgagtcttt accaattgca aagagtacaa cccccctgag agtgaatact
     2461 acaaatgtgc caatatcctg gagaaattct tcttcagtaa aattaaggaa gctggattaa
     2521 ttgacaagtg attttttttc ccctctgctt cttagaaact caccaagcag tgtgcctaaa
     2581 gcaaggtggt ttagtttttt acaaagaatt ggacatgatg tattgaagag acttgtaaat
     2641 gtaataatta gcacttttga aaaaacaaaa aacctccttt tagcttttca gatatgtatt
     2701 taaattgaag tcataggaca tttttatttt atggaataga ttttaatcta tttactacta
     2761 ttaaggtaaa ttttctatgg catgtccatt agctatttca tgatagatga ttaggggttt
     2821 cctcaaaacc tgtgtgtgag gaaattgcac acagtagcaa aatttgggga aatccataac
     2881 attttcagac catgaatgaa tgtttccatt tttttctaat ggaatgtgag agtttacttt
     2941 tattttattc tgaaggactt taaggaaggg atacatgatt ttaaaaaagc ctgtaagagg
     3001 tgaaatatgt gatgtttgaa gtctctttat agacttttta tatatatttt ttaaaacact
     3061 catctagatg aggtgctttg agcagttctg aaaaatgcag ttccaggaaa gcaactgctt
     3121 tggttcctaa ggaagaaatt ctaaataatg caaactttta aaataagcat ctaggttttt
     3181 gataattctg tctacttaca acaaacttgt tagtacataa ccactatttt aataattatt
     3241 ttctctacac aaatgtgtaa tatcatattt gactttgctt atgcaggcca taagttccaa
     3301 aagataattt ccctgcccac aaaggcataa acttgaaaac acatgagatt gaatcaacat
     3361 gctttaatag gaaaagatgt atggtctata tatgtatcaa tctggtgaat cctcgttcta
     3421 ataaaggttc tttttctttt ctatgataca cacagccacg ctgataatat gcaaatgaac
     3481 attttccttt atgtctctcc agataatgtt tattgtctga ggtaaattaa attcccacca
     3541 gggtttgctg tcagtatttt aacacccaca ttagtatatg cgtccagggt cataaccccc
     3601 taaaatccat catgcaacct tattaatctg tcttgggatt ccagtttagt gcttggattt
     3661 atttcctgat tacactacat agaaaagtga gacatctgcc attcccaact ctgggaaaac
     3721 caactaatat acaaccatat aaatgaaggc catcttgatg gtctcaacac taatttttat
     3781 gatgcaaatt tatacactga tttttgtaaa ggacaaagtt ttaaaagcgt atttaacttg
     3841 atgttttcta tcagcataaa taaaatggtc atgaatagtc attaaaaaca gttgccagtg
     3901 ataatctgca tgaaggaaaa agaaccctgc aaatggctat tgagttggaa gtattgtttt
     3961 tgatatgtaa gagatattca gaatgctcac actgaaaatg cctcaacttt ttaaagtgta
     4021 agaaaccacc atgagtggtg tctagatttc taatgaagaa tcatgataca gtttggatta
     4081 agtatcttgg actggtttta aacagtgctt tgtaccggat ctgctgaagc atctgtccag
     4141 ctggtatcct gtgaaagttt gttattttct gagtagacat tcttatagag tattgtcttt
     4201 aaaatcagat tgtctcttct atattgaaag catttttatg ttttctaatt taaaaattaa
     4261 tattttctta tagatattgt gcaataaagc tgaagtagaa tgtgtggttt ttgcaaatgc
     4321 tttaacagct gataaaaatt ttacatttgt aaaattaata tattgtactg gtacaaaata
     4381 gttttaaatt atattttaaa aagcttccaa
//
