LOCUS       NM_021078               3115 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens lysine acetyltransferase 2A (KAT2A), transcript
            variant 1, mRNA.
ACCESSION   NM_021078
VERSION     NM_021078.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3115)
  AUTHORS   Han,Y., Zhao,H., Li,G., Jia,J., Guo,H., Tan,J., Sun,X., Li,S.,
            Ran,Q., Bai,C., Gu,Y., Li,Z., Guan,H., Gao,S. and Zhou,P.K.
  TITLE     GCN5 mediates DNA-PKcs crotonylation for DNA double-strand break
            repair and determining cancer radiosensitivity
  JOURNAL   Br J Cancer 130 (10), 1621-1634 (2024)
   PUBMED   38575732
  REMARK    GeneRIF: GCN5 mediates DNA-PKcs crotonylation for DNA double-strand
            break repair and determining cancer radiosensitivity.
REFERENCE   2  (bases 1 to 3115)
  AUTHORS   Xu,Z., Wang,X., Yu,P., Zhang,Y., Huang,L., Mao,E. and Han,Y.
  TITLE     Lysine acetyltransferase KAT2A modulates ferroptosis during
            colorectal cancer development
  JOURNAL   Scand J Gastroenterol 59 (4), 437-444 (2024)
   PUBMED   38258976
  REMARK    GeneRIF: Lysine acetyltransferase KAT2A modulates ferroptosis
            during colorectal cancer development.
REFERENCE   3  (bases 1 to 3115)
  AUTHORS   Chen,Y., Wu,J., Zhai,L., Zhang,T., Yin,H., Gao,H., Zhao,F.,
            Wang,Z., Yang,X., Jin,M., Huang,B., Ding,X., Li,R., Yang,J., He,Y.,
            Wang,Q., Wang,W., Kloeber,J.A., Li,Y., Hao,B., Zhang,Y., Wang,J.,
            Tan,M., Li,K., Wang,P., Lou,Z. and Yuan,J.
  TITLE     Metabolic regulation of homologous recombination repair by MRE11
            lactylation
  JOURNAL   Cell 187 (2), 294-311 (2024)
   PUBMED   38128537
REFERENCE   4  (bases 1 to 3115)
  AUTHORS   Militi,S., Nibhani,R., Jalali,M. and Pauklin,S.
  TITLE     RBL2-E2F-GCN5 guide cell fate decisions during tissue specification
            by regulating cell-cycle-dependent fluctuations of
            non-cell-autonomous signaling
  JOURNAL   Cell Rep 42 (9), 113146 (2023)
   PUBMED   37725511
  REMARK    GeneRIF: RBL2-E2F-GCN5 guide cell fate decisions during tissue
            specification by regulating cell-cycle-dependent fluctuations of
            non-cell-autonomous signaling.
REFERENCE   5  (bases 1 to 3115)
  AUTHORS   Li,H., Li,C., Yang,L.Z. and Liu,J.
  TITLE     Integrative analysis of histone acetyltransferase KAT2A in human
            cancer
  JOURNAL   Cancer Biomark 38 (4), 443-463 (2023)
   PUBMED   38007639
  REMARK    GeneRIF: Integrative analysis of histone acetyltransferase KAT2A in
            human cancer.
REFERENCE   6  (bases 1 to 3115)
  AUTHORS   Carter,K.C., Wang,L., Shell,B.K., Zamir,I., Berger,S.L. and
            Moore,P.A.
  TITLE     The human transcriptional adaptor genes TADA2L and GCN5L2
            colocalize to chromosome 17q12-q21 and display a similar tissue
            expression pattern
  JOURNAL   Genomics 40 (3), 497-500 (1997)
   PUBMED   9073520
REFERENCE   7  (bases 1 to 3115)
  AUTHORS   Wang,L., Mizzen,C., Ying,C., Candau,R., Barlev,N., Brownell,J.,
            Allis,C.D. and Berger,S.L.
  TITLE     Histone acetyltransferase activity is conserved between yeast and
            human GCN5 and is required for complementation of growth and
            transcriptional activation
  JOURNAL   Mol Cell Biol 17 (1), 519-527 (1997)
   PUBMED   8972232
REFERENCE   8  (bases 1 to 3115)
  AUTHORS   Yang,X.J., Ogryzko,V.V., Nishikawa,J., Howard,B.H. and Nakatani,Y.
  TITLE     A p300/CBP-associated factor that competes with the adenoviral
            oncoprotein E1A
  JOURNAL   Nature 382 (6589), 319-324 (1996)
   PUBMED   8684459
REFERENCE   9  (bases 1 to 3115)
  AUTHORS   Candau,R., Moore,P.A., Wang,L., Barlev,N., Ying,C.Y., Rosen,C.A.
            and Berger,S.L.
  TITLE     Identification of human proteins functionally conserved with the
            yeast putative adaptors ADA2 and GCN5
  JOURNAL   Mol Cell Biol 16 (2), 593-602 (1996)
   PUBMED   8552087
REFERENCE   10 (bases 1 to 3115)
  AUTHORS   Berry,R., Stevens,T.J., Walter,N.A., Wilcox,A.S., Rubano,T.,
            Hopkins,J.A., Weber,J., Goold,R., Soares,M.B. and Sikela,J.M.
  TITLE     Gene-based sequence-tagged-sites (STSs) as the basis for a human
            gene map
  JOURNAL   Nat Genet 10 (4), 415-423 (1995)
   PUBMED   7670491
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105024.8, DB497139.1 and BC105977.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021078.2.
            
            Summary: KAT2A, or GCN5, is a histone acetyltransferase (HAT) that
            functions primarily as a transcriptional activator. It also
            functions as a repressor of NF-kappa-B (see MIM 164011) by
            promoting ubiquitination of the NF-kappa-B subunit RELA (MIM
            164014) in a HAT-independent manner (Mao et al., 2009 [PubMed
            19339690]).[supplied by OMIM, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105977.1, SRR11853567.13044.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225916.10/ ENSP00000225916.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC105024.8         143134-143136       c
            4-34                DB497139.1         1-31
            35-3115             BC105977.1         1-3081
FEATURES             Location/Qualifiers
     source          1..3115
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..3115
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /note="lysine acetyltransferase 2A"
                     /db_xref="GeneID:2648"
                     /db_xref="HGNC:HGNC:4201"
                     /db_xref="MIM:602301"
     exon            1..402
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2577
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /EC_number="2.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     General control of amino acid synthesis, yeast,
                     homolog-like 2; GCN5 (general control of amino-acid
                     synthesis, yeast, homolog)-like 2; histone
                     acetyltransferase KAT2A; K(lysine) acetyltransferase 2A;
                     STAF97; hsGCN5; histone acetyltransferase GCN5; general
                     control of amino acid synthesis protein 5-like 2; histone
                     succinyltransferase KAT2A; histone glutaryltransferase
                     KAT2A"
                     /codon_start=1
                     /product="histone acetyltransferase KAT2A isoform 1"
                     /protein_id="NP_066564.2"
                     /db_xref="CCDS:CCDS11417.1"
                     /db_xref="GeneID:2648"
                     /db_xref="HGNC:HGNC:4201"
                     /db_xref="MIM:602301"
                     /translation="MAEPSQAPTPAPAAQPRPLQSPAPAPTPTPAPSPASAPIPTPTP
                     APAPAPAAAPAGSTGTGGPGVGSGGAGSGGDPARPGLSQQQRASQRKAQVRGLPRAKK
                     LEKLGVFSACKANETCKCNGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSH
                     LENVSEDEINRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVE
                     GSLGSPPFEKPNIEQGVLNFVQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQF
                     RQRSQAEDVATYKVNYTRWLCYCHVPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLL
                     EKFRVEKDKLVPEKRTLILTHFPKFLSMLEEEIYGANSPIWESGFTMPPSEGTQLVPR
                     PASVSAAVVPSTPIFSPSMGGGSNSSLSLDSAGAEPMPGEKRTLPENLTLEDAKRLRV
                     MGDIPMELVNEVMLTITDPAAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSL
                     TPKANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTLALIKDGRVIGGICFR
                     MFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHNILYFLTYADEYAIGYFKK
                     QGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKKQKEIIKKLIERK
                     QAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLGKEKGKELKDPDQLYTTLKNL
                     LAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQ
                     RVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK"
     exon            403..526
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            527..672
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            673..762
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            763..944
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1136
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1243
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1354
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1491
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1700
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1827
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1938
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2082
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2197
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2234
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2298
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2383
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..3115
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3092..3097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /note="hexamer: AATAAA"
     polyA_site      3115
                     /gene="KAT2A"
                     /gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
                     /note="major polyA site"
ORIGIN      
        1 gctggttgcc catgcggccc tagggctggg agcgcggcgc cgctctccgc tgcgggggag
       61 gccatggcgg aaccttccca ggccccgacc ccggccccgg ctgcgcagcc ccggcccctt
      121 cagtccccag cccctgcccc aactccgact cctgcaccca gcccggcttc agccccgatt
      181 ccgactccca ccccggcacc agcccctgcc ccagctgcag ccccagccgg cagcacaggg
      241 actggggggc ccggggtagg aagtgggggg gccgggagcg ggggggatcc ggctcgacct
      301 ggcctgagcc agcagcagcg cgccagtcag aggaaggcgc aagtccgggg gctgccgcgc
      361 gccaagaagc ttgagaagct aggggtcttc tcggcttgca aggccaatga aacctgtaag
      421 tgtaatggct ggaaaaaccc caagcccccc actgcacccc gcatggatct gcagcagcca
      481 gctgccaacc tgagtgagct gtgccgcagt tgtgagcacc ccttggctga ccacgtatcc
      541 cacttggaga atgtgtcaga ggatgagata aaccgactgc tggggatggt ggtggatgtg
      601 gagaatctct tcatgtctgt tcacaaggaa gaggacacag acaccaagca ggtctatttc
      661 tacctcttca agctactgcg gaaatgcatc ctgcagatga cccggcctgt ggtggagggg
      721 tccctgggca gccctccatt tgagaaacct aatattgagc agggtgtgct gaactttgtg
      781 cagtacaagt ttagtcacct ggctccccgg gagcggcaga cgatgttcga gctctcaaag
      841 atgttcttgc tctgccttaa ctactggaag cttgagacac ctgcccagtt tcggcagagg
      901 tctcaggctg aggacgtggc tacctacaag gtcaattaca ccagatggct ctgttactgc
      961 cacgtgcccc agagctgtga tagcctcccc cgctacgaaa ccactcatgt ctttgggcga
     1021 agccttctcc ggtccatttt caccgttacc cgccggcagc tgctggaaaa gttccgagtg
     1081 gagaaggaca aattggtgcc cgagaagagg accctcatcc tcactcactt ccccaaattc
     1141 ctgtccatgc tggaggagga gatctatggg gcaaactctc caatctggga gtcaggcttc
     1201 accatgccac cctcagaggg gacacagctg gttccccggc cagcttcagt cagtgcagcg
     1261 gttgttccca gcacccccat cttcagcccc agcatgggtg ggggcagcaa cagctccctg
     1321 agtctggatt ctgcaggggc cgagcctatg ccaggcgaga agaggacgct cccagagaac
     1381 ctgaccctgg aggatgccaa gcggctccgt gtgatgggtg acatccccat ggagctggtc
     1441 aatgaggtca tgctgaccat cactgaccct gctgccatgc tggggcctga gacgagcctg
     1501 ctttcggcca atgcggcccg ggatgagaca gcccgcctgg aggagcgccg cggcatcatc
     1561 gagttccatg tcatcggcaa ctcactgacg cccaaggcca accggcgggt gttgctgtgg
     1621 ctcgtggggc tgcagaatgt cttttcccac cagctgccgc gcatgcctaa ggagtatatc
     1681 gcccgcctcg tctttgaccc gaagcacaag actctggcct tgatcaagga tgggcgggtc
     1741 atcggtggca tctgcttccg catgtttccc acccagggct tcacggagat tgtcttctgt
     1801 gctgtcacct cgaatgagca ggtcaagggt tatgggaccc acctgatgaa ccacctgaag
     1861 gagtatcaca tcaagcacaa cattctctac ttcctcacct acgccgacga gtacgccatc
     1921 ggctacttca aaaagcaggg tttctccaag gacatcaagg tgcccaagag ccgctacctg
     1981 ggctacatca aggactacga gggagcgacg ctgatggagt gtgagctgaa tccccgcatc
     2041 ccctacacgg agctgtccca catcatcaag aagcagaaag agatcatcaa gaagctgatt
     2101 gagcgcaaac aggcccagat ccgcaaggtc tacccggggc tcagctgctt caaggagggc
     2161 gtgaggcaga tccctgtgga gagcgttcct ggcattcgag agacaggctg gaagccattg
     2221 gggaaggaga aggggaagga gctgaaggac cccgaccagc tctacacaac cctcaaaaac
     2281 ctgctggccc aaatcaagtc tcaccccagt gcctggccct tcatggagcc tgtgaagaag
     2341 tcggaggccc ctgactacta cgaggtcatc cgcttcccca ttgacctgaa gaccatgact
     2401 gagcggctgc gaagccgcta ctacgtgacc cggaagctct ttgtggccga cctgcagcgg
     2461 gtcatcgcca actgtcgcga gtacaacccc ccggacagcg agtactgccg ctgtgccagc
     2521 gccctggaga agttcttcta cttcaagctc aaggagggag gcctcattga caagtaggcc
     2581 catctttggg ccgcagccct gacctggaat gtctccacct cggattctga tctgatcctt
     2641 agggggtgcc ctggccccac ggacccgact cagcttgaga cactccagcc aagggtcctc
     2701 cggacccgat cctgcagctc tttctggacc ttcaggcacc cccaagcgtg cagctctgtc
     2761 ccagccttca ctgtgtgtga gaggtctcct gggttggggc ccagcccctc tagagtagct
     2821 ggtggccagg gatgaacctt gcccagccgt ggtggccccc aggcctggtc cccaagagct
     2881 ttggaggctt ggattcctgg gcctggccca ggtggctgtt tccctgagga ccagaactgc
     2941 tcattttagc ttgagtgatg gcttcagggg ttggaagttc agcccaaact gaagggggcc
     3001 atgccttgtc cagcactgtt ctgtcagtct cccccagggg tggggggtat ggggaccatt
     3061 cattccctgg cattaatccc ttagagggaa taataaagct ttttatttct ctgtg
//
