LOCUS       NM_001392078            3482 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens lysine acetyltransferase 14 (KAT14), transcript
            variant 13, mRNA.
ACCESSION   NM_001392078
VERSION     NM_001392078.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3482)
  AUTHORS   Gong,Y., Liu,M., Zhang,Q., Li,J., Cai,H., Ran,J., Ma,L., Ma,Y. and
            Quan,S.
  TITLE     Lysine acetyltransferase 14 mediates TGF-beta-induced fibrosis in
            ovarian endometrioma via co-operation with serum response factor
  JOURNAL   J Transl Med 22 (1), 561 (2024)
   PUBMED   38867256
  REMARK    GeneRIF: Lysine acetyltransferase 14 mediates TGF-beta-induced
            fibrosis in ovarian endometrioma via co-operation with serum
            response factor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3482)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3482)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3482)
  AUTHORS   Viita,T., Kyheroinen,S., Prajapati,B., Virtanen,J., Frilander,M.J.,
            Varjosalo,M. and Vartiainen,M.K.
  TITLE     Nuclear actin interactome analysis links actin to KAT14 histone
            acetyl transferase and mRNA splicing
  JOURNAL   J Cell Sci 132 (8) (2019)
   PUBMED   30890647
  REMARK    GeneRIF: Actin binds directly to the hATAC subunit KAT14, and
            modulates its histone acetyl transferase activity in vitro and in
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3482)
  AUTHORS   Krebs,A.R., Karmodiya,K., Lindahl-Allen,M., Struhl,K. and Tora,L.
  TITLE     SAGA and ATAC histone acetyl transferase complexes regulate
            distinct sets of genes and ATAC defines a class of p300-independent
            enhancers
  JOURNAL   Mol Cell 44 (3), 410-423 (2011)
   PUBMED   22055187
REFERENCE   6  (bases 1 to 3482)
  AUTHORS   Orpinell,M., Fournier,M., Riss,A., Nagy,Z., Krebs,A.R., Frontini,M.
            and Tora,L.
  TITLE     The ATAC acetyl transferase complex controls mitotic progression by
            targeting non-histone substrates
  JOURNAL   EMBO J 29 (14), 2381-2394 (2010)
   PUBMED   20562830
REFERENCE   7  (bases 1 to 3482)
  AUTHORS   Nagy,Z., Riss,A., Fujiyama,S., Krebs,A., Orpinell,M., Jansen,P.,
            Cohen,A., Stunnenberg,H.G., Kato,S. and Tora,L.
  TITLE     The metazoan ATAC and SAGA coactivator HAT complexes regulate
            different sets of inducible target genes
  JOURNAL   Cell Mol Life Sci 67 (4), 611-628 (2010)
   PUBMED   19936620
REFERENCE   8  (bases 1 to 3482)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   9  (bases 1 to 3482)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
REFERENCE   10 (bases 1 to 3482)
  AUTHORS   Weiskirchen,R. and Gressner,A.M.
  TITLE     The cysteine- and glycine-rich LIM domain protein CRP2 specifically
            interacts with a novel human protein (CRP2BP)
  JOURNAL   Biochem Biophys Res Commun 274 (3), 655-663 (2000)
   PUBMED   10924333
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL050321.11 and KF459584.1.
            
            Summary: CSRP2 is a protein containing two LIM domains, which are
            double zinc finger motifs found in proteins of diverse function.
            CSRP2 and some related proteins are thought to act as protein
            adapters, bridging two or more proteins to form a larger protein
            complex. The protein encoded by this gene binds to one of the LIM
            domains of CSRP2 and contains an acetyltransferase domain. Although
            the encoded protein has been detected in the cytoplasm, it is
            predominantly a nuclear protein. Alternatively spliced transcript
            variants have been described. [provided by RefSeq, Jun 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.3896381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AL050321.11        3597-3703
            108-819             AL050321.11        8258-8969
            820-938             AL050321.11        11283-11401
            939-1060            AL050321.11        16871-16992
            1061-1242           AL050321.11        25134-25315
            1243-1659           AL050321.11        27873-28289
            1660-2228           AL050321.11        28427-28995
            2229-2365           AL050321.11        47760-47896
            2366-2541           AL050321.11        49173-49348
            2542-2732           AL050321.11        50652-50842
            2733-2966           KF459584.1         1-234               c
            2967-3482           AL050321.11        53570-54085
FEATURES             Location/Qualifiers
     source          1..3482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..3482
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="lysine acetyltransferase 14"
                     /db_xref="GeneID:57325"
                     /db_xref="HGNC:HGNC:15904"
                     /db_xref="MIM:617501"
     exon            1..107
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            108..819
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     CDS             561..2906
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="isoform 2 is encoded by transcript variant 13; CRP2
                     binding protein; ATAC component 2 homolog; CRP2 binding
                     partner; cysteine-rich protein 2-binding protein;
                     CSRP2-binding protein; ADA2A-containing complex subunit 2"
                     /codon_start=1
                     /product="cysteine-rich protein 2-binding protein isoform
                     2"
                     /protein_id="NP_001379007.1"
                     /db_xref="CCDS:CCDS93011.1"
                     /db_xref="GeneID:57325"
                     /db_xref="HGNC:HGNC:15904"
                     /db_xref="MIM:617501"
                     /translation="MDSSIHLSSLISRHDDEATRTSTSEGLEEGEVEGETLLIVESED
                     QASVDLSHDQSGDSLNSDEGDVSWMEEQLSYFCDKCQKWIPASQLREQLSYLKGDNFF
                     RFTCSDCSADGKEQYERLKLTWQQVVMLAMYNLSLEGSGRQGYFRWKEDICAFIEKHW
                     TFLLGNRKKTSTWWSTVAGCLSVGSPMYFRSGAQEFGEPGWWKLVHNKPPTMKPEGEK
                     LSASTLKIKASKPTLDPIITVEGLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQKE
                     AAGFLDRSTSSTPVKFISRGRRPDVILEKGEVIDFSSLSSSDRTPLTSPSPSPSLDFS
                     APGTPASHSATPSLLSEADLIPDVMPPQALFHDDDEMEGDGVIDPGMEYVPPPAGSVA
                     SGPVVGVRKKVRGPEQIKQEVESEEEKPDRMDIDSEDTDSNTSLQTRAREKRKPQLEK
                     DTKPKEPRYTPVSIYEEKLLLKRLEACPGAVAMTPEARRLKRKLIVRQAKRDRGLPLF
                     DLDQVVNAALLLVDGIYGAKEGGISRLPAGQATYRTTCQDFRILDRYQTSLPSRKGFR
                     HQTTKFLYRLVGSEDMAVDQSIVSPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLHR
                     SDPHWTPEPDAPLDYCYVRPNHIPTINSMCQEFFWPGIDLSECLQYPDFSVVVLYKKV
                     IIAFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTLHVSASNP
                     AMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR"
     exon            820..938
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1060
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1242
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1659
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..2228
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2365
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2541
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2732
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..3482
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3460..3465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="hexamer: AATAAA"
     polyA_site      3482
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="major polyA site"
ORIGIN      
        1 agaagggacg tctgtgggag aggggtcagc acggtatcca gaccccgccc ggggtgaggt
       61 tggtactgaa ctgactgagg ggcatggaac ccccaccctc caccctgagg cttcgtgacg
      121 gagttatcag agacattgag aggcaaattc ggaaaaaaga aaacattcgt cttttgggag
      181 aacagattat tttgactgag caacttgaag cagaaagaga gaagatgtta ttggcaaaag
      241 gatctcaaaa atcatgactt gaatgtgaaa tatctgttgg acagacaaca cgagtttgtg
      301 tgtgtgtgtt gatggagagt agcttagtag tatcttcatc tttttttttg gtcactgtcc
      361 ttttaaactt gatcaaataa aggacagtgg gtcatataag ttactgcttt cagggtccct
      421 tatatctgaa taaaggagtg tgggcagaca ctttttggaa gagtctgtct gggtgatcct
      481 ggtagaagcc ccattagggt cactgtccag tgcttagggt tgttactgag aagcactgcc
      541 gagcttgtga gaaggaaggg atggatagta gcatccacct gagtagtctg atcagtcggc
      601 atgatgacga agccacgaga acatcgacct cagaaggact ggaggaaggt gaagtggagg
      661 gagagacgct cctgatcgtc gaatccgagg atcaggcatc agtggactta tcgcacgacc
      721 agagtgggga ttccctcaac agtgatgaag gagacgtgtc ttggatggag gagcagctgt
      781 cctacttctg tgacaagtgc caaaaatgga taccagccag tcagctgagg gaacagctca
      841 gttaccttaa gggtgataat ttttttaggt ttacttgttc ggattgctca gcagatggca
      901 aggagcagta tgaaaggctg aagctgacat ggcagcaagt cgtcatgttg gcaatgtaca
      961 acttgtctct ggaaggaagt ggacgtcaag gttatttcag gtggaaagaa gatatctgtg
     1021 cttttattga gaaacattgg acttttttac tagggaatag gaaaaagacg tctacctggt
     1081 ggagcaccgt ggcaggttgc ctcagcgtgg gaagtcccat gtacttccgt tcaggtgctc
     1141 aggaatttgg agagccagga tggtggaaac ttgttcataa caagccccca acgatgaaac
     1201 ctgaaggaga gaagttgtct gcctctactt tgaaaataaa agcctcaaaa ccaactttag
     1261 atcccatcat tactgttgag ggacttagaa aacgagcaag tcggaatcct gtggaatctg
     1321 ccatggaatt aaaagagaaa aggtctcgaa ctcaggaagc aaaagacatt agaagagccc
     1381 agaaggaggc cgctggcttt cttgacagga gcacatcttc tacccctgta aaattcataa
     1441 gccgaggccg caggccagat gtgattctgg aaaaaggcga agtgattgac ttttcctcct
     1501 tgagctcctc tgaccgcacc ccgctgacaa gcccatctcc ttctccttct ctggatttct
     1561 ctgcccctgg tacacctgcc tctcattctg ccacacctag cttgctttca gaagcagatc
     1621 tgattccaga tgtgatgccc ccacaagcct tgtttcatga tgacgatgag atggaaggcg
     1681 atggagtcat agacccaggg atggagtacg tcccaccccc tgctgggtca gtagcttctg
     1741 ggccagtggt tggggtcaga aagaaggtca gaggccctga acagataaag caggaggtag
     1801 agagtgagga ggaaaaaccc gacaggatgg atattgacag tgaagacaca gattcaaaca
     1861 catctttgca aacaagggct agagaaaaga ggaagcctca gctggagaag gacacaaagc
     1921 cgaaagagcc caggtatact cccgtgagca tctacgagga aaagctgctg ctcaagaggc
     1981 tggaagcttg tcccggtgct gttgccatga ctccggaagc tcggagactg aaacgcaaac
     2041 tgattgtcag acaagcgaaa agggataggg gattaccact ttttgacttg gatcaagttg
     2101 ttaatgctgc tcttttgtta gttgacggga tttatggagc caaagaagga ggaatttcca
     2161 gacttccagc tggacaagcc acgtacagaa ccacctgtca ggacttcaga atccttgacc
     2221 gataccagac ttccttgccg tccaggaagg gatttcgaca ccagaccacc aagtttttgt
     2281 atcgcttggt aggatcagaa gatatggctg tggaccagag tattgtcagc ccttatacct
     2341 ctcggatctt gaaaccttat atcaggcgtg attatgaaac aaagccaccc aaactgcagc
     2401 tcctgtcaca gattcgttcc cacctgcaca ggagcgaccc tcactggacg ccggagcccg
     2461 acgcacctct cgattactgt tatgtgcggc caaatcacat cccaacgatc aactccatgt
     2521 gtcaggagtt tttttggcct ggcattgacc tgtctgagtg tctgcagtac ccagacttca
     2581 gtgttgttgt tctttataaa aaagtcatca ttgcctttgg cttcatggtt cctgatgtga
     2641 aatacaatga agcttacatt tcatttctgt tcgtccaccc tgaatggaga agagcaggga
     2701 ttgcaacttt catgatctat catctgattc agacctgcat gggcaaggac gtaacccttc
     2761 acgtctcagc aagcaacccc gctatgctac tgtaccagaa gtttggattc aagactgaag
     2821 aatatgtatt agatttctat gataaatatt acccattgga gagtacagag tgtaaacacg
     2881 cattctttct gaggctccgg cgctgatgcg aatacagctc acagagaaac gcatgtgcta
     2941 ttggagaaca ggtctttgtg gagatctaaa ggcagtgatt gatttcacag ggagctctaa
     3001 tctctgtgat tacatggtcc ttcaaactcc caaccaaagt gagaaaagcg gcatgcagtg
     3061 aaatgagcag tgagcagccc tttagcaaaa tcgccctcca gtccttcctg gagatgcctt
     3121 cagccagcat cccagactcc acagttattt atgaatgatg tcgtgattct ccctccacct
     3181 gacagtttgt aagagtgaaa gagcatctaa cctgatgctc ttggagagag ataacctgtc
     3241 tgtcataact taaaggatga gaaaatgtgg tgtagctatt aaagattcat gcagtcccaa
     3301 aaggcactgt cctgggatga tgagagatta taaggtgatt tcataaaagg aatccaaccc
     3361 tgtgcccggc cattgatgtg ttgtcattga atccaggagg atttctaggg cactgaagtt
     3421 ttgttgtttc ttttgctgac tttggttaca gtcagaaaaa ataaactaga tgtttgtgtc
     3481 ta
//
