LOCUS       NM_001392076            3704 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens lysine acetyltransferase 14 (KAT14), transcript
            variant 11, mRNA.
ACCESSION   NM_001392076
VERSION     NM_001392076.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3704)
  AUTHORS   Gong,Y., Liu,M., Zhang,Q., Li,J., Cai,H., Ran,J., Ma,L., Ma,Y. and
            Quan,S.
  TITLE     Lysine acetyltransferase 14 mediates TGF-beta-induced fibrosis in
            ovarian endometrioma via co-operation with serum response factor
  JOURNAL   J Transl Med 22 (1), 561 (2024)
   PUBMED   38867256
  REMARK    GeneRIF: Lysine acetyltransferase 14 mediates TGF-beta-induced
            fibrosis in ovarian endometrioma via co-operation with serum
            response factor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3704)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3704)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3704)
  AUTHORS   Viita,T., Kyheroinen,S., Prajapati,B., Virtanen,J., Frilander,M.J.,
            Varjosalo,M. and Vartiainen,M.K.
  TITLE     Nuclear actin interactome analysis links actin to KAT14 histone
            acetyl transferase and mRNA splicing
  JOURNAL   J Cell Sci 132 (8) (2019)
   PUBMED   30890647
  REMARK    GeneRIF: Actin binds directly to the hATAC subunit KAT14, and
            modulates its histone acetyl transferase activity in vitro and in
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3704)
  AUTHORS   Krebs,A.R., Karmodiya,K., Lindahl-Allen,M., Struhl,K. and Tora,L.
  TITLE     SAGA and ATAC histone acetyl transferase complexes regulate
            distinct sets of genes and ATAC defines a class of p300-independent
            enhancers
  JOURNAL   Mol Cell 44 (3), 410-423 (2011)
   PUBMED   22055187
REFERENCE   6  (bases 1 to 3704)
  AUTHORS   Orpinell,M., Fournier,M., Riss,A., Nagy,Z., Krebs,A.R., Frontini,M.
            and Tora,L.
  TITLE     The ATAC acetyl transferase complex controls mitotic progression by
            targeting non-histone substrates
  JOURNAL   EMBO J 29 (14), 2381-2394 (2010)
   PUBMED   20562830
REFERENCE   7  (bases 1 to 3704)
  AUTHORS   Nagy,Z., Riss,A., Fujiyama,S., Krebs,A., Orpinell,M., Jansen,P.,
            Cohen,A., Stunnenberg,H.G., Kato,S. and Tora,L.
  TITLE     The metazoan ATAC and SAGA coactivator HAT complexes regulate
            different sets of inducible target genes
  JOURNAL   Cell Mol Life Sci 67 (4), 611-628 (2010)
   PUBMED   19936620
REFERENCE   8  (bases 1 to 3704)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   9  (bases 1 to 3704)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
REFERENCE   10 (bases 1 to 3704)
  AUTHORS   Weiskirchen,R. and Gressner,A.M.
  TITLE     The cysteine- and glycine-rich LIM domain protein CRP2 specifically
            interacts with a novel human protein (CRP2BP)
  JOURNAL   Biochem Biophys Res Commun 274 (3), 655-663 (2000)
   PUBMED   10924333
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL050321.11 and KF459584.1.
            
            Summary: CSRP2 is a protein containing two LIM domains, which are
            double zinc finger motifs found in proteins of diverse function.
            CSRP2 and some related proteins are thought to act as protein
            adapters, bridging two or more proteins to form a larger protein
            complex. The protein encoded by this gene binds to one of the LIM
            domains of CSRP2 and contains an acetyltransferase domain. Although
            the encoded protein has been detected in the cytoplasm, it is
            predominantly a nuclear protein. Alternatively spliced transcript
            variants have been described. [provided by RefSeq, Jun 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.28696.1,
                                           SRR18074969.1342072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-329               AL050321.11        4121-4449
            330-1041            AL050321.11        8258-8969
            1042-1160           AL050321.11        11283-11401
            1161-1282           AL050321.11        16871-16992
            1283-1464           AL050321.11        25134-25315
            1465-1881           AL050321.11        27873-28289
            1882-2450           AL050321.11        28427-28995
            2451-2587           AL050321.11        47760-47896
            2588-2763           AL050321.11        49173-49348
            2764-2954           AL050321.11        50652-50842
            2955-3188           KF459584.1         1-234               c
            3189-3704           AL050321.11        53570-54085
FEATURES             Location/Qualifiers
     source          1..3704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..3704
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="lysine acetyltransferase 14"
                     /db_xref="GeneID:57325"
                     /db_xref="HGNC:HGNC:15904"
                     /db_xref="MIM:617501"
     exon            1..329
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            330..1041
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     CDS             783..3128
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="isoform 2 is encoded by transcript variant 11; CRP2
                     binding protein; ATAC component 2 homolog; CRP2 binding
                     partner; cysteine-rich protein 2-binding protein;
                     CSRP2-binding protein; ADA2A-containing complex subunit 2"
                     /codon_start=1
                     /product="cysteine-rich protein 2-binding protein isoform
                     2"
                     /protein_id="NP_001379005.1"
                     /db_xref="CCDS:CCDS93011.1"
                     /db_xref="GeneID:57325"
                     /db_xref="HGNC:HGNC:15904"
                     /db_xref="MIM:617501"
                     /translation="MDSSIHLSSLISRHDDEATRTSTSEGLEEGEVEGETLLIVESED
                     QASVDLSHDQSGDSLNSDEGDVSWMEEQLSYFCDKCQKWIPASQLREQLSYLKGDNFF
                     RFTCSDCSADGKEQYERLKLTWQQVVMLAMYNLSLEGSGRQGYFRWKEDICAFIEKHW
                     TFLLGNRKKTSTWWSTVAGCLSVGSPMYFRSGAQEFGEPGWWKLVHNKPPTMKPEGEK
                     LSASTLKIKASKPTLDPIITVEGLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQKE
                     AAGFLDRSTSSTPVKFISRGRRPDVILEKGEVIDFSSLSSSDRTPLTSPSPSPSLDFS
                     APGTPASHSATPSLLSEADLIPDVMPPQALFHDDDEMEGDGVIDPGMEYVPPPAGSVA
                     SGPVVGVRKKVRGPEQIKQEVESEEEKPDRMDIDSEDTDSNTSLQTRAREKRKPQLEK
                     DTKPKEPRYTPVSIYEEKLLLKRLEACPGAVAMTPEARRLKRKLIVRQAKRDRGLPLF
                     DLDQVVNAALLLVDGIYGAKEGGISRLPAGQATYRTTCQDFRILDRYQTSLPSRKGFR
                     HQTTKFLYRLVGSEDMAVDQSIVSPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLHR
                     SDPHWTPEPDAPLDYCYVRPNHIPTINSMCQEFFWPGIDLSECLQYPDFSVVVLYKKV
                     IIAFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTLHVSASNP
                     AMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR"
     exon            1042..1160
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1282
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1464
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1881
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2450
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2587
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2763
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2954
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3704
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3682..3687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="hexamer: AATAAA"
     polyA_site      3704
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="major polyA site"
ORIGIN      
        1 ctcttccggg cccgcgcgcg cggcgtcgac ctggggcctc tcgtggtctc tgcccgctcg
       61 gttcctcagc tcctcttcgt gtctttcccc cgcggtggcg cggccctgca ccccacgcgt
      121 ttgcggctgc ggccggcggc cgctctgctg ggctccgggc gctgcagctc ccggcgggcg
      181 tgtgcagccc gcagattcag gacgacccgg ctgcccggct tagcgccttt ggagctccgc
      241 gctgaagggg ccttgctccg cacaggcacg gcacgcaagc ttttggggtg cccagtggct
      301 ctgttttcaa gtcacagccg gcccgcagga ggcttcgtga cggagttatc agagacattg
      361 agaggcaaat tcggaaaaaa gaaaacattc gtcttttggg agaacagatt attttgactg
      421 agcaacttga agcagaaaga gagaagatgt tattggcaaa aggatctcaa aaatcatgac
      481 ttgaatgtga aatatctgtt ggacagacaa cacgagtttg tgtgtgtgtg ttgatggaga
      541 gtagcttagt agtatcttca tctttttttt tggtcactgt ccttttaaac ttgatcaaat
      601 aaaggacagt gggtcatata agttactgct ttcagggtcc cttatatctg aataaaggag
      661 tgtgggcaga cactttttgg aagagtctgt ctgggtgatc ctggtagaag ccccattagg
      721 gtcactgtcc agtgcttagg gttgttactg agaagcactg ccgagcttgt gagaaggaag
      781 ggatggatag tagcatccac ctgagtagtc tgatcagtcg gcatgatgac gaagccacga
      841 gaacatcgac ctcagaagga ctggaggaag gtgaagtgga gggagagacg ctcctgatcg
      901 tcgaatccga ggatcaggca tcagtggact tatcgcacga ccagagtggg gattccctca
      961 acagtgatga aggagacgtg tcttggatgg aggagcagct gtcctacttc tgtgacaagt
     1021 gccaaaaatg gataccagcc agtcagctga gggaacagct cagttacctt aagggtgata
     1081 atttttttag gtttacttgt tcggattgct cagcagatgg caaggagcag tatgaaaggc
     1141 tgaagctgac atggcagcaa gtcgtcatgt tggcaatgta caacttgtct ctggaaggaa
     1201 gtggacgtca aggttatttc aggtggaaag aagatatctg tgcttttatt gagaaacatt
     1261 ggactttttt actagggaat aggaaaaaga cgtctacctg gtggagcacc gtggcaggtt
     1321 gcctcagcgt gggaagtccc atgtacttcc gttcaggtgc tcaggaattt ggagagccag
     1381 gatggtggaa acttgttcat aacaagcccc caacgatgaa acctgaagga gagaagttgt
     1441 ctgcctctac tttgaaaata aaagcctcaa aaccaacttt agatcccatc attactgttg
     1501 agggacttag aaaacgagca agtcggaatc ctgtggaatc tgccatggaa ttaaaagaga
     1561 aaaggtctcg aactcaggaa gcaaaagaca ttagaagagc ccagaaggag gccgctggct
     1621 ttcttgacag gagcacatct tctacccctg taaaattcat aagccgaggc cgcaggccag
     1681 atgtgattct ggaaaaaggc gaagtgattg acttttcctc cttgagctcc tctgaccgca
     1741 ccccgctgac aagcccatct ccttctcctt ctctggattt ctctgcccct ggtacacctg
     1801 cctctcattc tgccacacct agcttgcttt cagaagcaga tctgattcca gatgtgatgc
     1861 ccccacaagc cttgtttcat gatgacgatg agatggaagg cgatggagtc atagacccag
     1921 ggatggagta cgtcccaccc cctgctgggt cagtagcttc tgggccagtg gttggggtca
     1981 gaaagaaggt cagaggccct gaacagataa agcaggaggt agagagtgag gaggaaaaac
     2041 ccgacaggat ggatattgac agtgaagaca cagattcaaa cacatctttg caaacaaggg
     2101 ctagagaaaa gaggaagcct cagctggaga aggacacaaa gccgaaagag cccaggtata
     2161 ctcccgtgag catctacgag gaaaagctgc tgctcaagag gctggaagct tgtcccggtg
     2221 ctgttgccat gactccggaa gctcggagac tgaaacgcaa actgattgtc agacaagcga
     2281 aaagggatag gggattacca ctttttgact tggatcaagt tgttaatgct gctcttttgt
     2341 tagttgacgg gatttatgga gccaaagaag gaggaatttc cagacttcca gctggacaag
     2401 ccacgtacag aaccacctgt caggacttca gaatccttga ccgataccag acttccttgc
     2461 cgtccaggaa gggatttcga caccagacca ccaagttttt gtatcgcttg gtaggatcag
     2521 aagatatggc tgtggaccag agtattgtca gcccttatac ctctcggatc ttgaaacctt
     2581 atatcaggcg tgattatgaa acaaagccac ccaaactgca gctcctgtca cagattcgtt
     2641 cccacctgca caggagcgac cctcactgga cgccggagcc cgacgcacct ctcgattact
     2701 gttatgtgcg gccaaatcac atcccaacga tcaactccat gtgtcaggag tttttttggc
     2761 ctggcattga cctgtctgag tgtctgcagt acccagactt cagtgttgtt gttctttata
     2821 aaaaagtcat cattgccttt ggcttcatgg ttcctgatgt gaaatacaat gaagcttaca
     2881 tttcatttct gttcgtccac cctgaatgga gaagagcagg gattgcaact ttcatgatct
     2941 atcatctgat tcagacctgc atgggcaagg acgtaaccct tcacgtctca gcaagcaacc
     3001 ccgctatgct actgtaccag aagtttggat tcaagactga agaatatgta ttagatttct
     3061 atgataaata ttacccattg gagagtacag agtgtaaaca cgcattcttt ctgaggctcc
     3121 ggcgctgatg cgaatacagc tcacagagaa acgcatgtgc tattggagaa caggtctttg
     3181 tggagatcta aaggcagtga ttgatttcac agggagctct aatctctgtg attacatggt
     3241 ccttcaaact cccaaccaaa gtgagaaaag cggcatgcag tgaaatgagc agtgagcagc
     3301 cctttagcaa aatcgccctc cagtccttcc tggagatgcc ttcagccagc atcccagact
     3361 ccacagttat ttatgaatga tgtcgtgatt ctccctccac ctgacagttt gtaagagtga
     3421 aagagcatct aacctgatgc tcttggagag agataacctg tctgtcataa cttaaaggat
     3481 gagaaaatgt ggtgtagcta ttaaagattc atgcagtccc aaaaggcact gtcctgggat
     3541 gatgagagat tataaggtga tttcataaaa ggaatccaac cctgtgcccg gccattgatg
     3601 tgttgtcatt gaatccagga ggatttctag ggcactgaag ttttgttgtt tcttttgctg
     3661 actttggtta cagtcagaaa aaataaacta gatgtttgtg tcta
//
