LOCUS       NM_001392075            3442 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens lysine acetyltransferase 14 (KAT14), transcript
            variant 10, mRNA.
ACCESSION   NM_001392075
VERSION     NM_001392075.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3442)
  AUTHORS   Gong,Y., Liu,M., Zhang,Q., Li,J., Cai,H., Ran,J., Ma,L., Ma,Y. and
            Quan,S.
  TITLE     Lysine acetyltransferase 14 mediates TGF-beta-induced fibrosis in
            ovarian endometrioma via co-operation with serum response factor
  JOURNAL   J Transl Med 22 (1), 561 (2024)
   PUBMED   38867256
  REMARK    GeneRIF: Lysine acetyltransferase 14 mediates TGF-beta-induced
            fibrosis in ovarian endometrioma via co-operation with serum
            response factor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3442)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3442)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3442)
  AUTHORS   Viita,T., Kyheroinen,S., Prajapati,B., Virtanen,J., Frilander,M.J.,
            Varjosalo,M. and Vartiainen,M.K.
  TITLE     Nuclear actin interactome analysis links actin to KAT14 histone
            acetyl transferase and mRNA splicing
  JOURNAL   J Cell Sci 132 (8) (2019)
   PUBMED   30890647
  REMARK    GeneRIF: Actin binds directly to the hATAC subunit KAT14, and
            modulates its histone acetyl transferase activity in vitro and in
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3442)
  AUTHORS   Krebs,A.R., Karmodiya,K., Lindahl-Allen,M., Struhl,K. and Tora,L.
  TITLE     SAGA and ATAC histone acetyl transferase complexes regulate
            distinct sets of genes and ATAC defines a class of p300-independent
            enhancers
  JOURNAL   Mol Cell 44 (3), 410-423 (2011)
   PUBMED   22055187
REFERENCE   6  (bases 1 to 3442)
  AUTHORS   Orpinell,M., Fournier,M., Riss,A., Nagy,Z., Krebs,A.R., Frontini,M.
            and Tora,L.
  TITLE     The ATAC acetyl transferase complex controls mitotic progression by
            targeting non-histone substrates
  JOURNAL   EMBO J 29 (14), 2381-2394 (2010)
   PUBMED   20562830
REFERENCE   7  (bases 1 to 3442)
  AUTHORS   Nagy,Z., Riss,A., Fujiyama,S., Krebs,A., Orpinell,M., Jansen,P.,
            Cohen,A., Stunnenberg,H.G., Kato,S. and Tora,L.
  TITLE     The metazoan ATAC and SAGA coactivator HAT complexes regulate
            different sets of inducible target genes
  JOURNAL   Cell Mol Life Sci 67 (4), 611-628 (2010)
   PUBMED   19936620
REFERENCE   8  (bases 1 to 3442)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   9  (bases 1 to 3442)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
REFERENCE   10 (bases 1 to 3442)
  AUTHORS   Weiskirchen,R. and Gressner,A.M.
  TITLE     The cysteine- and glycine-rich LIM domain protein CRP2 specifically
            interacts with a novel human protein (CRP2BP)
  JOURNAL   Biochem Biophys Res Commun 274 (3), 655-663 (2000)
   PUBMED   10924333
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL050321.11 and KF459584.1.
            
            Summary: CSRP2 is a protein containing two LIM domains, which are
            double zinc finger motifs found in proteins of diverse function.
            CSRP2 and some related proteins are thought to act as protein
            adapters, bridging two or more proteins to form a larger protein
            complex. The protein encoded by this gene binds to one of the LIM
            domains of CSRP2 and contains an acetyltransferase domain. Although
            the encoded protein has been detected in the cytoplasm, it is
            predominantly a nuclear protein. Alternatively spliced transcript
            variants have been described. [provided by RefSeq, Jun 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14038192.1829962.1,
                                    SRR14038196.3314774.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2151358, SAMN03465414 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AL050321.11        3203-3269
            68-779              AL050321.11        8258-8969
            780-898             AL050321.11        11283-11401
            899-1020            AL050321.11        16871-16992
            1021-1202           AL050321.11        25134-25315
            1203-1619           AL050321.11        27873-28289
            1620-2188           AL050321.11        28427-28995
            2189-2325           AL050321.11        47760-47896
            2326-2501           AL050321.11        49173-49348
            2502-2692           AL050321.11        50652-50842
            2693-2926           KF459584.1         1-234               c
            2927-3442           AL050321.11        53570-54085
FEATURES             Location/Qualifiers
     source          1..3442
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..3442
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="lysine acetyltransferase 14"
                     /db_xref="GeneID:57325"
                     /db_xref="HGNC:HGNC:15904"
                     /db_xref="MIM:617501"
     exon            1..67
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            68..779
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     CDS             521..2866
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="isoform 2 is encoded by transcript variant 10; CRP2
                     binding protein; ATAC component 2 homolog; CRP2 binding
                     partner; cysteine-rich protein 2-binding protein;
                     CSRP2-binding protein; ADA2A-containing complex subunit 2"
                     /codon_start=1
                     /product="cysteine-rich protein 2-binding protein isoform
                     2"
                     /protein_id="NP_001379004.1"
                     /db_xref="CCDS:CCDS93011.1"
                     /db_xref="GeneID:57325"
                     /db_xref="HGNC:HGNC:15904"
                     /db_xref="MIM:617501"
                     /translation="MDSSIHLSSLISRHDDEATRTSTSEGLEEGEVEGETLLIVESED
                     QASVDLSHDQSGDSLNSDEGDVSWMEEQLSYFCDKCQKWIPASQLREQLSYLKGDNFF
                     RFTCSDCSADGKEQYERLKLTWQQVVMLAMYNLSLEGSGRQGYFRWKEDICAFIEKHW
                     TFLLGNRKKTSTWWSTVAGCLSVGSPMYFRSGAQEFGEPGWWKLVHNKPPTMKPEGEK
                     LSASTLKIKASKPTLDPIITVEGLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQKE
                     AAGFLDRSTSSTPVKFISRGRRPDVILEKGEVIDFSSLSSSDRTPLTSPSPSPSLDFS
                     APGTPASHSATPSLLSEADLIPDVMPPQALFHDDDEMEGDGVIDPGMEYVPPPAGSVA
                     SGPVVGVRKKVRGPEQIKQEVESEEEKPDRMDIDSEDTDSNTSLQTRAREKRKPQLEK
                     DTKPKEPRYTPVSIYEEKLLLKRLEACPGAVAMTPEARRLKRKLIVRQAKRDRGLPLF
                     DLDQVVNAALLLVDGIYGAKEGGISRLPAGQATYRTTCQDFRILDRYQTSLPSRKGFR
                     HQTTKFLYRLVGSEDMAVDQSIVSPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLHR
                     SDPHWTPEPDAPLDYCYVRPNHIPTINSMCQEFFWPGIDLSECLQYPDFSVVVLYKKV
                     IIAFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTLHVSASNP
                     AMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR"
     exon            780..898
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1020
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1202
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1619
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..2188
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2325
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2501
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2692
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..3442
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3420..3425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="hexamer: AATAAA"
     polyA_site      3442
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="major polyA site"
ORIGIN      
        1 gccaggcgcg gtggctcacg cctgtaatcc tctcgggagg ctgaggcagg agaatcgctt
       61 gaatccgagg cttcgtgacg gagttatcag agacattgag aggcaaattc ggaaaaaaga
      121 aaacattcgt cttttgggag aacagattat tttgactgag caacttgaag cagaaagaga
      181 gaagatgtta ttggcaaaag gatctcaaaa atcatgactt gaatgtgaaa tatctgttgg
      241 acagacaaca cgagtttgtg tgtgtgtgtt gatggagagt agcttagtag tatcttcatc
      301 tttttttttg gtcactgtcc ttttaaactt gatcaaataa aggacagtgg gtcatataag
      361 ttactgcttt cagggtccct tatatctgaa taaaggagtg tgggcagaca ctttttggaa
      421 gagtctgtct gggtgatcct ggtagaagcc ccattagggt cactgtccag tgcttagggt
      481 tgttactgag aagcactgcc gagcttgtga gaaggaaggg atggatagta gcatccacct
      541 gagtagtctg atcagtcggc atgatgacga agccacgaga acatcgacct cagaaggact
      601 ggaggaaggt gaagtggagg gagagacgct cctgatcgtc gaatccgagg atcaggcatc
      661 agtggactta tcgcacgacc agagtgggga ttccctcaac agtgatgaag gagacgtgtc
      721 ttggatggag gagcagctgt cctacttctg tgacaagtgc caaaaatgga taccagccag
      781 tcagctgagg gaacagctca gttaccttaa gggtgataat ttttttaggt ttacttgttc
      841 ggattgctca gcagatggca aggagcagta tgaaaggctg aagctgacat ggcagcaagt
      901 cgtcatgttg gcaatgtaca acttgtctct ggaaggaagt ggacgtcaag gttatttcag
      961 gtggaaagaa gatatctgtg cttttattga gaaacattgg acttttttac tagggaatag
     1021 gaaaaagacg tctacctggt ggagcaccgt ggcaggttgc ctcagcgtgg gaagtcccat
     1081 gtacttccgt tcaggtgctc aggaatttgg agagccagga tggtggaaac ttgttcataa
     1141 caagccccca acgatgaaac ctgaaggaga gaagttgtct gcctctactt tgaaaataaa
     1201 agcctcaaaa ccaactttag atcccatcat tactgttgag ggacttagaa aacgagcaag
     1261 tcggaatcct gtggaatctg ccatggaatt aaaagagaaa aggtctcgaa ctcaggaagc
     1321 aaaagacatt agaagagccc agaaggaggc cgctggcttt cttgacagga gcacatcttc
     1381 tacccctgta aaattcataa gccgaggccg caggccagat gtgattctgg aaaaaggcga
     1441 agtgattgac ttttcctcct tgagctcctc tgaccgcacc ccgctgacaa gcccatctcc
     1501 ttctccttct ctggatttct ctgcccctgg tacacctgcc tctcattctg ccacacctag
     1561 cttgctttca gaagcagatc tgattccaga tgtgatgccc ccacaagcct tgtttcatga
     1621 tgacgatgag atggaaggcg atggagtcat agacccaggg atggagtacg tcccaccccc
     1681 tgctgggtca gtagcttctg ggccagtggt tggggtcaga aagaaggtca gaggccctga
     1741 acagataaag caggaggtag agagtgagga ggaaaaaccc gacaggatgg atattgacag
     1801 tgaagacaca gattcaaaca catctttgca aacaagggct agagaaaaga ggaagcctca
     1861 gctggagaag gacacaaagc cgaaagagcc caggtatact cccgtgagca tctacgagga
     1921 aaagctgctg ctcaagaggc tggaagcttg tcccggtgct gttgccatga ctccggaagc
     1981 tcggagactg aaacgcaaac tgattgtcag acaagcgaaa agggataggg gattaccact
     2041 ttttgacttg gatcaagttg ttaatgctgc tcttttgtta gttgacggga tttatggagc
     2101 caaagaagga ggaatttcca gacttccagc tggacaagcc acgtacagaa ccacctgtca
     2161 ggacttcaga atccttgacc gataccagac ttccttgccg tccaggaagg gatttcgaca
     2221 ccagaccacc aagtttttgt atcgcttggt aggatcagaa gatatggctg tggaccagag
     2281 tattgtcagc ccttatacct ctcggatctt gaaaccttat atcaggcgtg attatgaaac
     2341 aaagccaccc aaactgcagc tcctgtcaca gattcgttcc cacctgcaca ggagcgaccc
     2401 tcactggacg ccggagcccg acgcacctct cgattactgt tatgtgcggc caaatcacat
     2461 cccaacgatc aactccatgt gtcaggagtt tttttggcct ggcattgacc tgtctgagtg
     2521 tctgcagtac ccagacttca gtgttgttgt tctttataaa aaagtcatca ttgcctttgg
     2581 cttcatggtt cctgatgtga aatacaatga agcttacatt tcatttctgt tcgtccaccc
     2641 tgaatggaga agagcaggga ttgcaacttt catgatctat catctgattc agacctgcat
     2701 gggcaaggac gtaacccttc acgtctcagc aagcaacccc gctatgctac tgtaccagaa
     2761 gtttggattc aagactgaag aatatgtatt agatttctat gataaatatt acccattgga
     2821 gagtacagag tgtaaacacg cattctttct gaggctccgg cgctgatgcg aatacagctc
     2881 acagagaaac gcatgtgcta ttggagaaca ggtctttgtg gagatctaaa ggcagtgatt
     2941 gatttcacag ggagctctaa tctctgtgat tacatggtcc ttcaaactcc caaccaaagt
     3001 gagaaaagcg gcatgcagtg aaatgagcag tgagcagccc tttagcaaaa tcgccctcca
     3061 gtccttcctg gagatgcctt cagccagcat cccagactcc acagttattt atgaatgatg
     3121 tcgtgattct ccctccacct gacagtttgt aagagtgaaa gagcatctaa cctgatgctc
     3181 ttggagagag ataacctgtc tgtcataact taaaggatga gaaaatgtgg tgtagctatt
     3241 aaagattcat gcagtcccaa aaggcactgt cctgggatga tgagagatta taaggtgatt
     3301 tcataaaagg aatccaaccc tgtgcccggc cattgatgtg ttgtcattga atccaggagg
     3361 atttctaggg cactgaagtt ttgttgtttc ttttgctgac tttggttaca gtcagaaaaa
     3421 ataaactaga tgtttgtgtc ta
//
