LOCUS       NM_001392074            3749 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens lysine acetyltransferase 14 (KAT14), transcript
            variant 9, mRNA.
ACCESSION   NM_001392074
VERSION     NM_001392074.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3749)
  AUTHORS   Gong,Y., Liu,M., Zhang,Q., Li,J., Cai,H., Ran,J., Ma,L., Ma,Y. and
            Quan,S.
  TITLE     Lysine acetyltransferase 14 mediates TGF-beta-induced fibrosis in
            ovarian endometrioma via co-operation with serum response factor
  JOURNAL   J Transl Med 22 (1), 561 (2024)
   PUBMED   38867256
  REMARK    GeneRIF: Lysine acetyltransferase 14 mediates TGF-beta-induced
            fibrosis in ovarian endometrioma via co-operation with serum
            response factor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3749)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3749)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3749)
  AUTHORS   Viita,T., Kyheroinen,S., Prajapati,B., Virtanen,J., Frilander,M.J.,
            Varjosalo,M. and Vartiainen,M.K.
  TITLE     Nuclear actin interactome analysis links actin to KAT14 histone
            acetyl transferase and mRNA splicing
  JOURNAL   J Cell Sci 132 (8) (2019)
   PUBMED   30890647
  REMARK    GeneRIF: Actin binds directly to the hATAC subunit KAT14, and
            modulates its histone acetyl transferase activity in vitro and in
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3749)
  AUTHORS   Krebs,A.R., Karmodiya,K., Lindahl-Allen,M., Struhl,K. and Tora,L.
  TITLE     SAGA and ATAC histone acetyl transferase complexes regulate
            distinct sets of genes and ATAC defines a class of p300-independent
            enhancers
  JOURNAL   Mol Cell 44 (3), 410-423 (2011)
   PUBMED   22055187
REFERENCE   6  (bases 1 to 3749)
  AUTHORS   Orpinell,M., Fournier,M., Riss,A., Nagy,Z., Krebs,A.R., Frontini,M.
            and Tora,L.
  TITLE     The ATAC acetyl transferase complex controls mitotic progression by
            targeting non-histone substrates
  JOURNAL   EMBO J 29 (14), 2381-2394 (2010)
   PUBMED   20562830
REFERENCE   7  (bases 1 to 3749)
  AUTHORS   Nagy,Z., Riss,A., Fujiyama,S., Krebs,A., Orpinell,M., Jansen,P.,
            Cohen,A., Stunnenberg,H.G., Kato,S. and Tora,L.
  TITLE     The metazoan ATAC and SAGA coactivator HAT complexes regulate
            different sets of inducible target genes
  JOURNAL   Cell Mol Life Sci 67 (4), 611-628 (2010)
   PUBMED   19936620
REFERENCE   8  (bases 1 to 3749)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   9  (bases 1 to 3749)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
REFERENCE   10 (bases 1 to 3749)
  AUTHORS   Weiskirchen,R. and Gressner,A.M.
  TITLE     The cysteine- and glycine-rich LIM domain protein CRP2 specifically
            interacts with a novel human protein (CRP2BP)
  JOURNAL   Biochem Biophys Res Commun 274 (3), 655-663 (2000)
   PUBMED   10924333
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL050321.11 and KF459584.1.
            
            Summary: CSRP2 is a protein containing two LIM domains, which are
            double zinc finger motifs found in proteins of diverse function.
            CSRP2 and some related proteins are thought to act as protein
            adapters, bridging two or more proteins to form a larger protein
            complex. The protein encoded by this gene binds to one of the LIM
            domains of CSRP2 and contains an acetyltransferase domain. Although
            the encoded protein has been detected in the cytoplasm, it is
            predominantly a nuclear protein. Alternatively spliced transcript
            variants have been described. [provided by RefSeq, Jun 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1645722.1,
                                           SRR14038191.1649897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-374               AL050321.11        4121-4494
            375-1086            AL050321.11        8258-8969
            1087-1205           AL050321.11        11283-11401
            1206-1327           AL050321.11        16871-16992
            1328-1509           AL050321.11        25134-25315
            1510-1926           AL050321.11        27873-28289
            1927-2495           AL050321.11        28427-28995
            2496-2632           AL050321.11        47760-47896
            2633-2808           AL050321.11        49173-49348
            2809-2999           AL050321.11        50652-50842
            3000-3233           KF459584.1         1-234               c
            3234-3749           AL050321.11        53570-54085
FEATURES             Location/Qualifiers
     source          1..3749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..3749
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="lysine acetyltransferase 14"
                     /db_xref="GeneID:57325"
                     /db_xref="HGNC:HGNC:15904"
                     /db_xref="MIM:617501"
     exon            1..374
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            375..1086
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     CDS             828..3173
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="isoform 2 is encoded by transcript variant 9; CRP2
                     binding protein; ATAC component 2 homolog; CRP2 binding
                     partner; cysteine-rich protein 2-binding protein;
                     CSRP2-binding protein; ADA2A-containing complex subunit 2"
                     /codon_start=1
                     /product="cysteine-rich protein 2-binding protein isoform
                     2"
                     /protein_id="NP_001379003.1"
                     /db_xref="CCDS:CCDS93011.1"
                     /db_xref="GeneID:57325"
                     /db_xref="HGNC:HGNC:15904"
                     /db_xref="MIM:617501"
                     /translation="MDSSIHLSSLISRHDDEATRTSTSEGLEEGEVEGETLLIVESED
                     QASVDLSHDQSGDSLNSDEGDVSWMEEQLSYFCDKCQKWIPASQLREQLSYLKGDNFF
                     RFTCSDCSADGKEQYERLKLTWQQVVMLAMYNLSLEGSGRQGYFRWKEDICAFIEKHW
                     TFLLGNRKKTSTWWSTVAGCLSVGSPMYFRSGAQEFGEPGWWKLVHNKPPTMKPEGEK
                     LSASTLKIKASKPTLDPIITVEGLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQKE
                     AAGFLDRSTSSTPVKFISRGRRPDVILEKGEVIDFSSLSSSDRTPLTSPSPSPSLDFS
                     APGTPASHSATPSLLSEADLIPDVMPPQALFHDDDEMEGDGVIDPGMEYVPPPAGSVA
                     SGPVVGVRKKVRGPEQIKQEVESEEEKPDRMDIDSEDTDSNTSLQTRAREKRKPQLEK
                     DTKPKEPRYTPVSIYEEKLLLKRLEACPGAVAMTPEARRLKRKLIVRQAKRDRGLPLF
                     DLDQVVNAALLLVDGIYGAKEGGISRLPAGQATYRTTCQDFRILDRYQTSLPSRKGFR
                     HQTTKFLYRLVGSEDMAVDQSIVSPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLHR
                     SDPHWTPEPDAPLDYCYVRPNHIPTINSMCQEFFWPGIDLSECLQYPDFSVVVLYKKV
                     IIAFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTLHVSASNP
                     AMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR"
     exon            1087..1205
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1327
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1509
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1926
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2495
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2632
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2808
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2999
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3749
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3727..3732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="hexamer: AATAAA"
     polyA_site      3749
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="major polyA site"
ORIGIN      
        1 ctcttccggg cccgcgcgcg cggcgtcgac ctggggcctc tcgtggtctc tgcccgctcg
       61 gttcctcagc tcctcttcgt gtctttcccc cgcggtggcg cggccctgca ccccacgcgt
      121 ttgcggctgc ggccggcggc cgctctgctg ggctccgggc gctgcagctc ccggcgggcg
      181 tgtgcagccc gcagattcag gacgacccgg ctgcccggct tagcgccttt ggagctccgc
      241 gctgaagggg ccttgctccg cacaggcacg gcacgcaagc ttttggggtg cccagtggct
      301 ctgttttcaa gtcacagccg gcccgcaggg tgcggacctt tccacatctc acttgggccg
      361 ctagaaaata gaagaggctt cgtgacggag ttatcagaga cattgagagg caaattcgga
      421 aaaaagaaaa cattcgtctt ttgggagaac agattatttt gactgagcaa cttgaagcag
      481 aaagagagaa gatgttattg gcaaaaggat ctcaaaaatc atgacttgaa tgtgaaatat
      541 ctgttggaca gacaacacga gtttgtgtgt gtgtgttgat ggagagtagc ttagtagtat
      601 cttcatcttt ttttttggtc actgtccttt taaacttgat caaataaagg acagtgggtc
      661 atataagtta ctgctttcag ggtcccttat atctgaataa aggagtgtgg gcagacactt
      721 tttggaagag tctgtctggg tgatcctggt agaagcccca ttagggtcac tgtccagtgc
      781 ttagggttgt tactgagaag cactgccgag cttgtgagaa ggaagggatg gatagtagca
      841 tccacctgag tagtctgatc agtcggcatg atgacgaagc cacgagaaca tcgacctcag
      901 aaggactgga ggaaggtgaa gtggagggag agacgctcct gatcgtcgaa tccgaggatc
      961 aggcatcagt ggacttatcg cacgaccaga gtggggattc cctcaacagt gatgaaggag
     1021 acgtgtcttg gatggaggag cagctgtcct acttctgtga caagtgccaa aaatggatac
     1081 cagccagtca gctgagggaa cagctcagtt accttaaggg tgataatttt tttaggttta
     1141 cttgttcgga ttgctcagca gatggcaagg agcagtatga aaggctgaag ctgacatggc
     1201 agcaagtcgt catgttggca atgtacaact tgtctctgga aggaagtgga cgtcaaggtt
     1261 atttcaggtg gaaagaagat atctgtgctt ttattgagaa acattggact tttttactag
     1321 ggaataggaa aaagacgtct acctggtgga gcaccgtggc aggttgcctc agcgtgggaa
     1381 gtcccatgta cttccgttca ggtgctcagg aatttggaga gccaggatgg tggaaacttg
     1441 ttcataacaa gcccccaacg atgaaacctg aaggagagaa gttgtctgcc tctactttga
     1501 aaataaaagc ctcaaaacca actttagatc ccatcattac tgttgaggga cttagaaaac
     1561 gagcaagtcg gaatcctgtg gaatctgcca tggaattaaa agagaaaagg tctcgaactc
     1621 aggaagcaaa agacattaga agagcccaga aggaggccgc tggctttctt gacaggagca
     1681 catcttctac ccctgtaaaa ttcataagcc gaggccgcag gccagatgtg attctggaaa
     1741 aaggcgaagt gattgacttt tcctccttga gctcctctga ccgcaccccg ctgacaagcc
     1801 catctccttc tccttctctg gatttctctg cccctggtac acctgcctct cattctgcca
     1861 cacctagctt gctttcagaa gcagatctga ttccagatgt gatgccccca caagccttgt
     1921 ttcatgatga cgatgagatg gaaggcgatg gagtcataga cccagggatg gagtacgtcc
     1981 caccccctgc tgggtcagta gcttctgggc cagtggttgg ggtcagaaag aaggtcagag
     2041 gccctgaaca gataaagcag gaggtagaga gtgaggagga aaaacccgac aggatggata
     2101 ttgacagtga agacacagat tcaaacacat ctttgcaaac aagggctaga gaaaagagga
     2161 agcctcagct ggagaaggac acaaagccga aagagcccag gtatactccc gtgagcatct
     2221 acgaggaaaa gctgctgctc aagaggctgg aagcttgtcc cggtgctgtt gccatgactc
     2281 cggaagctcg gagactgaaa cgcaaactga ttgtcagaca agcgaaaagg gataggggat
     2341 taccactttt tgacttggat caagttgtta atgctgctct tttgttagtt gacgggattt
     2401 atggagccaa agaaggagga atttccagac ttccagctgg acaagccacg tacagaacca
     2461 cctgtcagga cttcagaatc cttgaccgat accagacttc cttgccgtcc aggaagggat
     2521 ttcgacacca gaccaccaag tttttgtatc gcttggtagg atcagaagat atggctgtgg
     2581 accagagtat tgtcagccct tatacctctc ggatcttgaa accttatatc aggcgtgatt
     2641 atgaaacaaa gccacccaaa ctgcagctcc tgtcacagat tcgttcccac ctgcacagga
     2701 gcgaccctca ctggacgccg gagcccgacg cacctctcga ttactgttat gtgcggccaa
     2761 atcacatccc aacgatcaac tccatgtgtc aggagttttt ttggcctggc attgacctgt
     2821 ctgagtgtct gcagtaccca gacttcagtg ttgttgttct ttataaaaaa gtcatcattg
     2881 cctttggctt catggttcct gatgtgaaat acaatgaagc ttacatttca tttctgttcg
     2941 tccaccctga atggagaaga gcagggattg caactttcat gatctatcat ctgattcaga
     3001 cctgcatggg caaggacgta acccttcacg tctcagcaag caaccccgct atgctactgt
     3061 accagaagtt tggattcaag actgaagaat atgtattaga tttctatgat aaatattacc
     3121 cattggagag tacagagtgt aaacacgcat tctttctgag gctccggcgc tgatgcgaat
     3181 acagctcaca gagaaacgca tgtgctattg gagaacaggt ctttgtggag atctaaaggc
     3241 agtgattgat ttcacaggga gctctaatct ctgtgattac atggtccttc aaactcccaa
     3301 ccaaagtgag aaaagcggca tgcagtgaaa tgagcagtga gcagcccttt agcaaaatcg
     3361 ccctccagtc cttcctggag atgccttcag ccagcatccc agactccaca gttatttatg
     3421 aatgatgtcg tgattctccc tccacctgac agtttgtaag agtgaaagag catctaacct
     3481 gatgctcttg gagagagata acctgtctgt cataacttaa aggatgagaa aatgtggtgt
     3541 agctattaaa gattcatgca gtcccaaaag gcactgtcct gggatgatga gagattataa
     3601 ggtgatttca taaaaggaat ccaaccctgt gcccggccat tgatgtgttg tcattgaatc
     3661 caggaggatt tctagggcac tgaagttttg ttgtttcttt tgctgacttt ggttacagtc
     3721 agaaaaaata aactagatgt ttgtgtcta
//
