LOCUS       NM_001392071            3436 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens lysine acetyltransferase 14 (KAT14), transcript
            variant 6, mRNA.
ACCESSION   NM_001392071
VERSION     NM_001392071.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3436)
  AUTHORS   Gong,Y., Liu,M., Zhang,Q., Li,J., Cai,H., Ran,J., Ma,L., Ma,Y. and
            Quan,S.
  TITLE     Lysine acetyltransferase 14 mediates TGF-beta-induced fibrosis in
            ovarian endometrioma via co-operation with serum response factor
  JOURNAL   J Transl Med 22 (1), 561 (2024)
   PUBMED   38867256
  REMARK    GeneRIF: Lysine acetyltransferase 14 mediates TGF-beta-induced
            fibrosis in ovarian endometrioma via co-operation with serum
            response factor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3436)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3436)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3436)
  AUTHORS   Viita,T., Kyheroinen,S., Prajapati,B., Virtanen,J., Frilander,M.J.,
            Varjosalo,M. and Vartiainen,M.K.
  TITLE     Nuclear actin interactome analysis links actin to KAT14 histone
            acetyl transferase and mRNA splicing
  JOURNAL   J Cell Sci 132 (8) (2019)
   PUBMED   30890647
  REMARK    GeneRIF: Actin binds directly to the hATAC subunit KAT14, and
            modulates its histone acetyl transferase activity in vitro and in
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3436)
  AUTHORS   Krebs,A.R., Karmodiya,K., Lindahl-Allen,M., Struhl,K. and Tora,L.
  TITLE     SAGA and ATAC histone acetyl transferase complexes regulate
            distinct sets of genes and ATAC defines a class of p300-independent
            enhancers
  JOURNAL   Mol Cell 44 (3), 410-423 (2011)
   PUBMED   22055187
REFERENCE   6  (bases 1 to 3436)
  AUTHORS   Orpinell,M., Fournier,M., Riss,A., Nagy,Z., Krebs,A.R., Frontini,M.
            and Tora,L.
  TITLE     The ATAC acetyl transferase complex controls mitotic progression by
            targeting non-histone substrates
  JOURNAL   EMBO J 29 (14), 2381-2394 (2010)
   PUBMED   20562830
REFERENCE   7  (bases 1 to 3436)
  AUTHORS   Nagy,Z., Riss,A., Fujiyama,S., Krebs,A., Orpinell,M., Jansen,P.,
            Cohen,A., Stunnenberg,H.G., Kato,S. and Tora,L.
  TITLE     The metazoan ATAC and SAGA coactivator HAT complexes regulate
            different sets of inducible target genes
  JOURNAL   Cell Mol Life Sci 67 (4), 611-628 (2010)
   PUBMED   19936620
REFERENCE   8  (bases 1 to 3436)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   9  (bases 1 to 3436)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
REFERENCE   10 (bases 1 to 3436)
  AUTHORS   Weiskirchen,R. and Gressner,A.M.
  TITLE     The cysteine- and glycine-rich LIM domain protein CRP2 specifically
            interacts with a novel human protein (CRP2BP)
  JOURNAL   Biochem Biophys Res Commun 274 (3), 655-663 (2000)
   PUBMED   10924333
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL050321.11 and KF459584.1.
            
            Summary: CSRP2 is a protein containing two LIM domains, which are
            double zinc finger motifs found in proteins of diverse function.
            CSRP2 and some related proteins are thought to act as protein
            adapters, bridging two or more proteins to form a larger protein
            complex. The protein encoded by this gene binds to one of the LIM
            domains of CSRP2 and contains an acetyltransferase domain. Although
            the encoded protein has been detected in the cytoplasm, it is
            predominantly a nuclear protein. Alternatively spliced transcript
            variants have been described. [provided by RefSeq, Jun 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.133322.1,
                                           SRR1803612.136115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AL050321.11        3597-3654
            59-770              AL050321.11        8258-8969
            771-889             AL050321.11        11283-11401
            890-1011            AL050321.11        16871-16992
            1012-1193           AL050321.11        25134-25315
            1194-1613           AL050321.11        27870-28289
            1614-2182           AL050321.11        28427-28995
            2183-2319           AL050321.11        47760-47896
            2320-2495           AL050321.11        49173-49348
            2496-2686           AL050321.11        50652-50842
            2687-2920           KF459584.1         1-234               c
            2921-3436           AL050321.11        53570-54085
FEATURES             Location/Qualifiers
     source          1..3436
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..3436
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="lysine acetyltransferase 14"
                     /db_xref="GeneID:57325"
                     /db_xref="HGNC:HGNC:15904"
                     /db_xref="MIM:617501"
     exon            1..58
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            59..770
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     CDS             512..2860
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="isoform 1 is encoded by transcript variant 6; CRP2
                     binding protein; ATAC component 2 homolog; CRP2 binding
                     partner; cysteine-rich protein 2-binding protein;
                     CSRP2-binding protein; ADA2A-containing complex subunit 2"
                     /codon_start=1
                     /product="cysteine-rich protein 2-binding protein isoform
                     1"
                     /protein_id="NP_001379000.1"
                     /db_xref="CCDS:CCDS13133.1"
                     /db_xref="GeneID:57325"
                     /db_xref="HGNC:HGNC:15904"
                     /db_xref="MIM:617501"
                     /translation="MDSSIHLSSLISRHDDEATRTSTSEGLEEGEVEGETLLIVESED
                     QASVDLSHDQSGDSLNSDEGDVSWMEEQLSYFCDKCQKWIPASQLREQLSYLKGDNFF
                     RFTCSDCSADGKEQYERLKLTWQQVVMLAMYNLSLEGSGRQGYFRWKEDICAFIEKHW
                     TFLLGNRKKTSTWWSTVAGCLSVGSPMYFRSGAQEFGEPGWWKLVHNKPPTMKPEGEK
                     LSASTLKIKAASKPTLDPIITVEGLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQK
                     EAAGFLDRSTSSTPVKFISRGRRPDVILEKGEVIDFSSLSSSDRTPLTSPSPSPSLDF
                     SAPGTPASHSATPSLLSEADLIPDVMPPQALFHDDDEMEGDGVIDPGMEYVPPPAGSV
                     ASGPVVGVRKKVRGPEQIKQEVESEEEKPDRMDIDSEDTDSNTSLQTRAREKRKPQLE
                     KDTKPKEPRYTPVSIYEEKLLLKRLEACPGAVAMTPEARRLKRKLIVRQAKRDRGLPL
                     FDLDQVVNAALLLVDGIYGAKEGGISRLPAGQATYRTTCQDFRILDRYQTSLPSRKGF
                     RHQTTKFLYRLVGSEDMAVDQSIVSPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLH
                     RSDPHWTPEPDAPLDYCYVRPNHIPTINSMCQEFFWPGIDLSECLQYPDFSVVVLYKK
                     VIIAFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTLHVSASN
                     PAMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR"
     exon            771..889
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1011
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1193
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1613
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..2182
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2319
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2495
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2686
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..3436
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3414..3419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="hexamer: AATAAA"
     polyA_site      3436
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="major polyA site"
ORIGIN      
        1 agaagggacg tctgtgggag aggggtcagc acggtatcca gaccccgccc ggggtgagag
       61 gcttcgtgac ggagttatca gagacattga gaggcaaatt cggaaaaaag aaaacattcg
      121 tcttttggga gaacagatta ttttgactga gcaacttgaa gcagaaagag agaagatgtt
      181 attggcaaaa ggatctcaaa aatcatgact tgaatgtgaa atatctgttg gacagacaac
      241 acgagtttgt gtgtgtgtgt tgatggagag tagcttagta gtatcttcat cttttttttt
      301 ggtcactgtc cttttaaact tgatcaaata aaggacagtg ggtcatataa gttactgctt
      361 tcagggtccc ttatatctga ataaaggagt gtgggcagac actttttgga agagtctgtc
      421 tgggtgatcc tggtagaagc cccattaggg tcactgtcca gtgcttaggg ttgttactga
      481 gaagcactgc cgagcttgtg agaaggaagg gatggatagt agcatccacc tgagtagtct
      541 gatcagtcgg catgatgacg aagccacgag aacatcgacc tcagaaggac tggaggaagg
      601 tgaagtggag ggagagacgc tcctgatcgt cgaatccgag gatcaggcat cagtggactt
      661 atcgcacgac cagagtgggg attccctcaa cagtgatgaa ggagacgtgt cttggatgga
      721 ggagcagctg tcctacttct gtgacaagtg ccaaaaatgg ataccagcca gtcagctgag
      781 ggaacagctc agttacctta agggtgataa tttttttagg tttacttgtt cggattgctc
      841 agcagatggc aaggagcagt atgaaaggct gaagctgaca tggcagcaag tcgtcatgtt
      901 ggcaatgtac aacttgtctc tggaaggaag tggacgtcaa ggttatttca ggtggaaaga
      961 agatatctgt gcttttattg agaaacattg gactttttta ctagggaata ggaaaaagac
     1021 gtctacctgg tggagcaccg tggcaggttg cctcagcgtg ggaagtccca tgtacttccg
     1081 ttcaggtgct caggaatttg gagagccagg atggtggaaa cttgttcata acaagccccc
     1141 aacgatgaaa cctgaaggag agaagttgtc tgcctctact ttgaaaataa aagcagcctc
     1201 aaaaccaact ttagatccca tcattactgt tgagggactt agaaaacgag caagtcggaa
     1261 tcctgtggaa tctgccatgg aattaaaaga gaaaaggtct cgaactcagg aagcaaaaga
     1321 cattagaaga gcccagaagg aggccgctgg ctttcttgac aggagcacat cttctacccc
     1381 tgtaaaattc ataagccgag gccgcaggcc agatgtgatt ctggaaaaag gcgaagtgat
     1441 tgacttttcc tccttgagct cctctgaccg caccccgctg acaagcccat ctccttctcc
     1501 ttctctggat ttctctgccc ctggtacacc tgcctctcat tctgccacac ctagcttgct
     1561 ttcagaagca gatctgattc cagatgtgat gcccccacaa gccttgtttc atgatgacga
     1621 tgagatggaa ggcgatggag tcatagaccc agggatggag tacgtcccac cccctgctgg
     1681 gtcagtagct tctgggccag tggttggggt cagaaagaag gtcagaggcc ctgaacagat
     1741 aaagcaggag gtagagagtg aggaggaaaa acccgacagg atggatattg acagtgaaga
     1801 cacagattca aacacatctt tgcaaacaag ggctagagaa aagaggaagc ctcagctgga
     1861 gaaggacaca aagccgaaag agcccaggta tactcccgtg agcatctacg aggaaaagct
     1921 gctgctcaag aggctggaag cttgtcccgg tgctgttgcc atgactccgg aagctcggag
     1981 actgaaacgc aaactgattg tcagacaagc gaaaagggat aggggattac cactttttga
     2041 cttggatcaa gttgttaatg ctgctctttt gttagttgac gggatttatg gagccaaaga
     2101 aggaggaatt tccagacttc cagctggaca agccacgtac agaaccacct gtcaggactt
     2161 cagaatcctt gaccgatacc agacttcctt gccgtccagg aagggatttc gacaccagac
     2221 caccaagttt ttgtatcgct tggtaggatc agaagatatg gctgtggacc agagtattgt
     2281 cagcccttat acctctcgga tcttgaaacc ttatatcagg cgtgattatg aaacaaagcc
     2341 acccaaactg cagctcctgt cacagattcg ttcccacctg cacaggagcg accctcactg
     2401 gacgccggag cccgacgcac ctctcgatta ctgttatgtg cggccaaatc acatcccaac
     2461 gatcaactcc atgtgtcagg agtttttttg gcctggcatt gacctgtctg agtgtctgca
     2521 gtacccagac ttcagtgttg ttgttcttta taaaaaagtc atcattgcct ttggcttcat
     2581 ggttcctgat gtgaaataca atgaagctta catttcattt ctgttcgtcc accctgaatg
     2641 gagaagagca gggattgcaa ctttcatgat ctatcatctg attcagacct gcatgggcaa
     2701 ggacgtaacc cttcacgtct cagcaagcaa ccccgctatg ctactgtacc agaagtttgg
     2761 attcaagact gaagaatatg tattagattt ctatgataaa tattacccat tggagagtac
     2821 agagtgtaaa cacgcattct ttctgaggct ccggcgctga tgcgaataca gctcacagag
     2881 aaacgcatgt gctattggag aacaggtctt tgtggagatc taaaggcagt gattgatttc
     2941 acagggagct ctaatctctg tgattacatg gtccttcaaa ctcccaacca aagtgagaaa
     3001 agcggcatgc agtgaaatga gcagtgagca gccctttagc aaaatcgccc tccagtcctt
     3061 cctggagatg ccttcagcca gcatcccaga ctccacagtt atttatgaat gatgtcgtga
     3121 ttctccctcc acctgacagt ttgtaagagt gaaagagcat ctaacctgat gctcttggag
     3181 agagataacc tgtctgtcat aacttaaagg atgagaaaat gtggtgtagc tattaaagat
     3241 tcatgcagtc ccaaaaggca ctgtcctggg atgatgagag attataaggt gatttcataa
     3301 aaggaatcca accctgtgcc cggccattga tgtgttgtca ttgaatccag gaggatttct
     3361 agggcactga agttttgttg tttcttttgc tgactttggt tacagtcaga aaaaataaac
     3421 tagatgtttg tgtcta
//
