LOCUS       NM_001384192            3567 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens lysine acetyltransferase 14 (KAT14), transcript
            variant 3, mRNA.
ACCESSION   NM_001384192
VERSION     NM_001384192.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3567)
  AUTHORS   Gong,Y., Liu,M., Zhang,Q., Li,J., Cai,H., Ran,J., Ma,L., Ma,Y. and
            Quan,S.
  TITLE     Lysine acetyltransferase 14 mediates TGF-beta-induced fibrosis in
            ovarian endometrioma via co-operation with serum response factor
  JOURNAL   J Transl Med 22 (1), 561 (2024)
   PUBMED   38867256
  REMARK    GeneRIF: Lysine acetyltransferase 14 mediates TGF-beta-induced
            fibrosis in ovarian endometrioma via co-operation with serum
            response factor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3567)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3567)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3567)
  AUTHORS   Viita,T., Kyheroinen,S., Prajapati,B., Virtanen,J., Frilander,M.J.,
            Varjosalo,M. and Vartiainen,M.K.
  TITLE     Nuclear actin interactome analysis links actin to KAT14 histone
            acetyl transferase and mRNA splicing
  JOURNAL   J Cell Sci 132 (8) (2019)
   PUBMED   30890647
  REMARK    GeneRIF: Actin binds directly to the hATAC subunit KAT14, and
            modulates its histone acetyl transferase activity in vitro and in
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3567)
  AUTHORS   Krebs,A.R., Karmodiya,K., Lindahl-Allen,M., Struhl,K. and Tora,L.
  TITLE     SAGA and ATAC histone acetyl transferase complexes regulate
            distinct sets of genes and ATAC defines a class of p300-independent
            enhancers
  JOURNAL   Mol Cell 44 (3), 410-423 (2011)
   PUBMED   22055187
REFERENCE   6  (bases 1 to 3567)
  AUTHORS   Orpinell,M., Fournier,M., Riss,A., Nagy,Z., Krebs,A.R., Frontini,M.
            and Tora,L.
  TITLE     The ATAC acetyl transferase complex controls mitotic progression by
            targeting non-histone substrates
  JOURNAL   EMBO J 29 (14), 2381-2394 (2010)
   PUBMED   20562830
REFERENCE   7  (bases 1 to 3567)
  AUTHORS   Nagy,Z., Riss,A., Fujiyama,S., Krebs,A., Orpinell,M., Jansen,P.,
            Cohen,A., Stunnenberg,H.G., Kato,S. and Tora,L.
  TITLE     The metazoan ATAC and SAGA coactivator HAT complexes regulate
            different sets of inducible target genes
  JOURNAL   Cell Mol Life Sci 67 (4), 611-628 (2010)
   PUBMED   19936620
REFERENCE   8  (bases 1 to 3567)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   9  (bases 1 to 3567)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
REFERENCE   10 (bases 1 to 3567)
  AUTHORS   Weiskirchen,R. and Gressner,A.M.
  TITLE     The cysteine- and glycine-rich LIM domain protein CRP2 specifically
            interacts with a novel human protein (CRP2BP)
  JOURNAL   Biochem Biophys Res Commun 274 (3), 655-663 (2000)
   PUBMED   10924333
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL050321.11 and KF459584.1.
            
            On Feb 3, 2021 this sequence version replaced NM_001384192.2.
            
            Summary: CSRP2 is a protein containing two LIM domains, which are
            double zinc finger motifs found in proteins of diverse function.
            CSRP2 and some related proteins are thought to act as protein
            adapters, bridging two or more proteins to form a larger protein
            complex. The protein encoded by this gene binds to one of the LIM
            domains of CSRP2 and contains an acetyltransferase domain. Although
            the encoded protein has been detected in the cytoplasm, it is
            predominantly a nuclear protein. Alternatively spliced transcript
            variants have been described. [provided by RefSeq, Jun 2011].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. This variant contains a uORF with the complete coding
            region for the PET117 protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.18280.1,
                                           SRR11853564.17130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AL050321.11        3913-4101
            190-901             AL050321.11        8258-8969
            902-1020            AL050321.11        11283-11401
            1021-1142           AL050321.11        16871-16992
            1143-1324           AL050321.11        25134-25315
            1325-1744           AL050321.11        27870-28289
            1745-2313           AL050321.11        28427-28995
            2314-2450           AL050321.11        47760-47896
            2451-2626           AL050321.11        49173-49348
            2627-2817           AL050321.11        50652-50842
            2818-3051           KF459584.1         1-234               c
            3052-3567           AL050321.11        53570-54085
FEATURES             Location/Qualifiers
     source          1..3567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..3567
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="lysine acetyltransferase 14"
                     /db_xref="GeneID:57325"
                     /db_xref="HGNC:HGNC:15904"
                     /db_xref="MIM:617501"
     exon            1..189
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            190..901
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     CDS             643..2991
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="isoform 1 is encoded by transcript variant 3; CRP2
                     binding protein; ATAC component 2 homolog; CRP2 binding
                     partner; cysteine-rich protein 2-binding protein;
                     CSRP2-binding protein; ADA2A-containing complex subunit 2"
                     /codon_start=1
                     /product="cysteine-rich protein 2-binding protein isoform
                     1"
                     /protein_id="NP_001371121.2"
                     /db_xref="CCDS:CCDS13133.1"
                     /db_xref="GeneID:57325"
                     /db_xref="HGNC:HGNC:15904"
                     /db_xref="MIM:617501"
                     /translation="MDSSIHLSSLISRHDDEATRTSTSEGLEEGEVEGETLLIVESED
                     QASVDLSHDQSGDSLNSDEGDVSWMEEQLSYFCDKCQKWIPASQLREQLSYLKGDNFF
                     RFTCSDCSADGKEQYERLKLTWQQVVMLAMYNLSLEGSGRQGYFRWKEDICAFIEKHW
                     TFLLGNRKKTSTWWSTVAGCLSVGSPMYFRSGAQEFGEPGWWKLVHNKPPTMKPEGEK
                     LSASTLKIKAASKPTLDPIITVEGLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQK
                     EAAGFLDRSTSSTPVKFISRGRRPDVILEKGEVIDFSSLSSSDRTPLTSPSPSPSLDF
                     SAPGTPASHSATPSLLSEADLIPDVMPPQALFHDDDEMEGDGVIDPGMEYVPPPAGSV
                     ASGPVVGVRKKVRGPEQIKQEVESEEEKPDRMDIDSEDTDSNTSLQTRAREKRKPQLE
                     KDTKPKEPRYTPVSIYEEKLLLKRLEACPGAVAMTPEARRLKRKLIVRQAKRDRGLPL
                     FDLDQVVNAALLLVDGIYGAKEGGISRLPAGQATYRTTCQDFRILDRYQTSLPSRKGF
                     RHQTTKFLYRLVGSEDMAVDQSIVSPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLH
                     RSDPHWTPEPDAPLDYCYVRPNHIPTINSMCQEFFWPGIDLSECLQYPDFSVVVLYKK
                     VIIAFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTLHVSASN
                     PAMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR"
     exon            902..1020
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1142
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1324
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1744
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..2313
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2450
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2626
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2817
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..3567
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3545..3550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="hexamer: AATAAA"
     polyA_site      3567
                     /gene="KAT14"
                     /gene_synonym="ATAC2; CRP2BP; CSRP2BP; dJ717M23.1;
                     PRO1194"
                     /note="major polyA site"
ORIGIN      
        1 gagcctgggc agtacaggcg gcggtgcgca ctctgcggcg gcctctgcgc ctcgggcggg
       61 cgggagagag aggccgcggc cgccagcgtg gggatgtcta ggagctcgaa ggtggtgctg
      121 ggcctctcgg tgctgctgac ggcggccaca gtggccggcg tacatgtgaa gcagcagtgg
      181 gaccagcaga ggcttcgtga cggagttatc agagacattg agaggcaaat tcggaaaaaa
      241 gaaaacattc gtcttttggg agaacagatt attttgactg agcaacttga agcagaaaga
      301 gagaagatgt tattggcaaa aggatctcaa aaatcatgac ttgaatgtga aatatctgtt
      361 ggacagacaa cacgagtttg tgtgtgtgtg ttgatggaga gtagcttagt agtatcttca
      421 tctttttttt tggtcactgt ccttttaaac ttgatcaaat aaaggacagt gggtcatata
      481 agttactgct ttcagggtcc cttatatctg aataaaggag tgtgggcaga cactttttgg
      541 aagagtctgt ctgggtgatc ctggtagaag ccccattagg gtcactgtcc agtgcttagg
      601 gttgttactg agaagcactg ccgagcttgt gagaaggaag ggatggatag tagcatccac
      661 ctgagtagtc tgatcagtcg gcatgatgac gaagccacga gaacatcgac ctcagaagga
      721 ctggaggaag gtgaagtgga gggagagacg ctcctgatcg tcgaatccga ggatcaggca
      781 tcagtggact tatcgcacga ccagagtggg gattccctca acagtgatga aggagacgtg
      841 tcttggatgg aggagcagct gtcctacttc tgtgacaagt gccaaaaatg gataccagcc
      901 agtcagctga gggaacagct cagttacctt aagggtgata atttttttag gtttacttgt
      961 tcggattgct cagcagatgg caaggagcag tatgaaaggc tgaagctgac atggcagcaa
     1021 gtcgtcatgt tggcaatgta caacttgtct ctggaaggaa gtggacgtca aggttatttc
     1081 aggtggaaag aagatatctg tgcttttatt gagaaacatt ggactttttt actagggaat
     1141 aggaaaaaga cgtctacctg gtggagcacc gtggcaggtt gcctcagcgt gggaagtccc
     1201 atgtacttcc gttcaggtgc tcaggaattt ggagagccag gatggtggaa acttgttcat
     1261 aacaagcccc caacgatgaa acctgaagga gagaagttgt ctgcctctac tttgaaaata
     1321 aaagcagcct caaaaccaac tttagatccc atcattactg ttgagggact tagaaaacga
     1381 gcaagtcgga atcctgtgga atctgccatg gaattaaaag agaaaaggtc tcgaactcag
     1441 gaagcaaaag acattagaag agcccagaag gaggccgctg gctttcttga caggagcaca
     1501 tcttctaccc ctgtaaaatt cataagccga ggccgcaggc cagatgtgat tctggaaaaa
     1561 ggcgaagtga ttgacttttc ctccttgagc tcctctgacc gcaccccgct gacaagccca
     1621 tctccttctc cttctctgga tttctctgcc cctggtacac ctgcctctca ttctgccaca
     1681 cctagcttgc tttcagaagc agatctgatt ccagatgtga tgcccccaca agccttgttt
     1741 catgatgacg atgagatgga aggcgatgga gtcatagacc cagggatgga gtacgtccca
     1801 ccccctgctg ggtcagtagc ttctgggcca gtggttgggg tcagaaagaa ggtcagaggc
     1861 cctgaacaga taaagcagga ggtagagagt gaggaggaaa aacccgacag gatggatatt
     1921 gacagtgaag acacagattc aaacacatct ttgcaaacaa gggctagaga aaagaggaag
     1981 cctcagctgg agaaggacac aaagccgaaa gagcccaggt atactcccgt gagcatctac
     2041 gaggaaaagc tgctgctcaa gaggctggaa gcttgtcccg gtgctgttgc catgactccg
     2101 gaagctcgga gactgaaacg caaactgatt gtcagacaag cgaaaaggga taggggatta
     2161 ccactttttg acttggatca agttgttaat gctgctcttt tgttagttga cgggatttat
     2221 ggagccaaag aaggaggaat ttccagactt ccagctggac aagccacgta cagaaccacc
     2281 tgtcaggact tcagaatcct tgaccgatac cagacttcct tgccgtccag gaagggattt
     2341 cgacaccaga ccaccaagtt tttgtatcgc ttggtaggat cagaagatat ggctgtggac
     2401 cagagtattg tcagccctta tacctctcgg atcttgaaac cttatatcag gcgtgattat
     2461 gaaacaaagc cacccaaact gcagctcctg tcacagattc gttcccacct gcacaggagc
     2521 gaccctcact ggacgccgga gcccgacgca cctctcgatt actgttatgt gcggccaaat
     2581 cacatcccaa cgatcaactc catgtgtcag gagttttttt ggcctggcat tgacctgtct
     2641 gagtgtctgc agtacccaga cttcagtgtt gttgttcttt ataaaaaagt catcattgcc
     2701 tttggcttca tggttcctga tgtgaaatac aatgaagctt acatttcatt tctgttcgtc
     2761 caccctgaat ggagaagagc agggattgca actttcatga tctatcatct gattcagacc
     2821 tgcatgggca aggacgtaac ccttcacgtc tcagcaagca accccgctat gctactgtac
     2881 cagaagtttg gattcaagac tgaagaatat gtattagatt tctatgataa atattaccca
     2941 ttggagagta cagagtgtaa acacgcattc tttctgaggc tccggcgctg atgcgaatac
     3001 agctcacaga gaaacgcatg tgctattgga gaacaggtct ttgtggagat ctaaaggcag
     3061 tgattgattt cacagggagc tctaatctct gtgattacat ggtccttcaa actcccaacc
     3121 aaagtgagaa aagcggcatg cagtgaaatg agcagtgagc agccctttag caaaatcgcc
     3181 ctccagtcct tcctggagat gccttcagcc agcatcccag actccacagt tatttatgaa
     3241 tgatgtcgtg attctccctc cacctgacag tttgtaagag tgaaagagca tctaacctga
     3301 tgctcttgga gagagataac ctgtctgtca taacttaaag gatgagaaaa tgtggtgtag
     3361 ctattaaaga ttcatgcagt cccaaaaggc actgtcctgg gatgatgaga gattataagg
     3421 tgatttcata aaaggaatcc aaccctgtgc ccggccattg atgtgttgtc attgaatcca
     3481 ggaggatttc tagggcactg aagttttgtt gtttcttttg ctgactttgg ttacagtcag
     3541 aaaaaataaa ctagatgttt gtgtcta
//
