LOCUS       NM_001115016            5156 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens KAT8 regulatory NSL complex subunit 3 (KANSL3),
            transcript variant 1, mRNA.
ACCESSION   NM_001115016
VERSION     NM_001115016.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5156)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5156)
  AUTHORS   Wu,D., Zhao,L., Feng,Z., Yu,C., Ding,J., Wang,L., Wang,F., Liu,D.,
            Zhu,H., Xing,F., Conaway,J.W., Conaway,R.C., Cai,Y. and Jin,J.
  TITLE     O-Linked N-acetylglucosamine transferase 1 regulates global histone
            H4 acetylation via stabilization of the nonspecific lethal protein
            NSL3
  JOURNAL   J Biol Chem 292 (24), 10014-10025 (2017)
   PUBMED   28450392
  REMARK    GeneRIF: Data suggest that O-GlcNAc transferase 1 (OGT1)
            specifically binds to, O-GlcNAcylates, and stabilizes nonspecific
            lethal protein3 (NSL3); stabilization of NSL3 by OGT1 up-regulates
            global acetylation levels of histone 4 at Lys-5, Lys-8, and Lys-16.
REFERENCE   3  (bases 1 to 5156)
  AUTHORS   Chatterjee,A., Seyfferth,J., Lucci,J., Gilsbach,R., Preissl,S.,
            Bottinger,L., Martensson,C.U., Panhale,A., Stehle,T., Kretz,O.,
            Sahyoun,A.H., Avilov,S., Eimer,S., Hein,L., Pfanner,N., Becker,T.
            and Akhtar,A.
  TITLE     MOF Acetyl Transferase Regulates Transcription and Respiration in
            Mitochondria
  JOURNAL   Cell 167 (3), 722-738 (2016)
   PUBMED   27768893
REFERENCE   4  (bases 1 to 5156)
  AUTHORS   Meunier,S., Shvedunova,M., Van Nguyen,N., Avila,L., Vernos,I. and
            Akhtar,A.
  TITLE     An epigenetic regulator emerges as microtubule minus-end binding
            and stabilizing factor in mitosis
  JOURNAL   Nat Commun 6, 7889 (2015)
   PUBMED   26243146
  REMARK    GeneRIF: microtubule minus-end-binding protein, essential for
            spindle assembly and chromosome segregation
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5156)
  AUTHORS   Chelmicki,T., Dundar,F., Turley,M.J., Khanam,T., Aktas,T.,
            Ramirez,F., Gendrel,A.V., Wright,P.R., Videm,P., Backofen,R.,
            Heard,E., Manke,T. and Akhtar,A.
  TITLE     MOF-associated complexes ensure stem cell identity and Xist
            repression
  JOURNAL   Elife 3, e02024 (2014)
   PUBMED   24842875
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5156)
  AUTHORS   Zhao,X., Su,J., Wang,F., Liu,D., Ding,J., Yang,Y., Conaway,J.W.,
            Conaway,R.C., Cao,L., Wu,D., Wu,M., Cai,Y. and Jin,J.
  TITLE     Crosstalk between NSL histone acetyltransferase and MLL/SET
            complexes: NSL complex functions in promoting histone H3K4
            di-methylation activity by MLL/SET complexes
  JOURNAL   PLoS Genet 9 (11), e1003940 (2013)
   PUBMED   24244196
REFERENCE   7  (bases 1 to 5156)
  AUTHORS   Cai,Y., Jin,J., Swanson,S.K., Cole,M.D., Choi,S.H., Florens,L.,
            Washburn,M.P., Conaway,J.W. and Conaway,R.C.
  TITLE     Subunit composition and substrate specificity of a MOF-containing
            histone acetyltransferase distinct from the male-specific lethal
            (MSL) complex
  JOURNAL   J Biol Chem 285 (7), 4268-4272 (2010)
   PUBMED   20018852
REFERENCE   8  (bases 1 to 5156)
  AUTHORS   Rea,S., Xouri,G. and Akhtar,A.
  TITLE     Males absent on the first (MOF): from flies to humans
  JOURNAL   Oncogene 26 (37), 5385-5394 (2007)
   PUBMED   17694080
  REMARK    Review article
REFERENCE   9  (bases 1 to 5156)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 5156)
  AUTHORS   Mendjan,S., Taipale,M., Kind,J., Holz,H., Gebhardt,P., Schelder,M.,
            Vermeulen,M., Buscaino,A., Duncan,K., Mueller,J., Wilm,M.,
            Stunnenberg,H.G., Saumweber,H. and Akhtar,A.
  TITLE     Nuclear pore components are involved in the transcriptional
            regulation of dosage compensation in Drosophila
  JOURNAL   Mol Cell 21 (6), 811-823 (2006)
   PUBMED   16543150
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB275425.1 and BC063792.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001115016.2.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063792.1, SRR14038195.535750.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000431828.6/ ENSP00000396749.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DB275425.1         68-70
            4-5156              BC063792.1         1-5153
FEATURES             Location/Qualifiers
     source          1..5156
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..5156
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /note="KAT8 regulatory NSL complex subunit 3"
                     /db_xref="GeneID:55683"
                     /db_xref="HGNC:HGNC:25473"
                     /db_xref="MIM:617742"
     exon            1..30
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            31..295
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2717
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /note="isoform 1 is encoded by transcript variant 1; serum
                     inhibited-related protein; testis development protein
                     PRTD; NSL complex protein NSL3; non-specific lethal 3
                     homolog"
                     /codon_start=1
                     /product="KAT8 regulatory NSL complex subunit 3 isoform 1"
                     /protein_id="NP_001108488.1"
                     /db_xref="CCDS:CCDS46361.1"
                     /db_xref="GeneID:55683"
                     /db_xref="HGNC:HGNC:25473"
                     /db_xref="MIM:617742"
                     /translation="MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKP
                     WSAHPDASSARPTRMLFVTPRRQHESTIESDVPIDVETVTSTPMPLYDNQKARSVMNE
                     CERHVIFARTDADAPPPPEDWEEHVNRTGWTMAQNKLFNKILKALQSDRLARLANEGA
                     CNEPVLRRVAVDKCARRVRQALASVSWDTKLIQWLHTTLVETLSLPMLAAYLDALQTL
                     KGKIPTLIDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILI
                     ASSGPSSSVFPTSRRHRFWQSQLSCLGKVIPVATHLLNNGSGVGVLQCLEHMIGAVRS
                     KVLEIHSHFPHKPIILIGWNTGALVACHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDP
                     LLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEG
                     LTQSMVDRCIQDEIVDFLTGVLTRAEGHMGSEPRDQDAEKKKKPRDVARRDLAFEVPE
                     RGSRPASPAAKLPASPSGSEDLSSVSSSPTSSPKTKVTTVTSAQKSSQIGSSQLLKRH
                     VQRTEAVLTHKQAQVPISSEPPEEGEKEDLRVQLKRHHPSSPLPGSKTSKRPKIKVSL
                     ISQGDTAGGPCAPSQGSAPEAAGGKPITMTLGQASAGAKELTGLLTTAKSSSSEGGVS
                     ASPVPSVVSSSTAPSALHTLQSRLVATSPGSSLPGATSASSLLQGLSFSLQDISSKTS
                     GLPANPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPT
                     AIHQLLTNGGLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGA
                     APSEESSSQVLPSSSQRLPPAP"
     exon            296..466
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..557
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..743
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..875
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..992
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1094
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1166
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1241
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1399
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1463
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1664
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1821
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..2013
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2098
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2229
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2339
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2562
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2696
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..5156
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5137..5142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /note="hexamer: ATTAAA"
     polyA_site      5156
                     /gene="KANSL3"
                     /gene_synonym="KIAA1310; NSL3; Rcd1"
                     /note="major polyA site"
ORIGIN      
        1 gtggccgagc gcgcggccgt aagaccgcgg gtgactagca tgcagatacc catgctctga
       61 ctttctgccc ctccactgac atggcccacc ggggtgggga gagggacttc cagacttcag
      121 ctcgacgcat gggcacctcg ctgctcttcc agctttcagt gcatgaacgg gagctggacc
      181 tggtttttct ggatcatagc tatgccaagc cttggagtgc ccacccagat gccagtagtg
      241 cccgccccac ccgcatgctc tttgtcactc cccggcggca gcacgaaagt accattgaat
      301 cagacgtccc aatagatgtg gagacggtca catcaacgcc tatgccactc tatgacaatc
      361 agaaggcacg cagcgtgatg aatgagtgtg aacggcatgt catctttgcc aggactgatg
      421 cagatgcccc tcctccacca gaggactggg aggagcatgt caacaggact ggctggacaa
      481 tggcccagaa caagctattc aacaagatcc tcaaagccct gcagtctgac cggcttgccc
      541 gcttggccaa cgaaggggct tgtaatgagc cagtgctgcg ccgtgttgct gtggacaagt
      601 gtgcaaggag agtgcggcag gctctggcaa gtgtgagctg ggataccaag ctgatccagt
      661 ggctgcacac cacccttgtg gagaccttga gtctgcccat gctggcagcc tacctggatg
      721 ctttgcagac gctgaagggg aagatcccaa ccttgattga ccggatgctt gtgtcatcca
      781 acacaaagac tggggctgca ggagctgagg ccttgtctct cctactgaag aggccctggg
      841 accctgctgt gggtgtgctt tctcataaca aaccaagcaa actccctggc tctccgctga
      901 ttctcatcgc ctcctctggt ccctccagct ctgtgtttcc cacttcacgc cgccaccgct
      961 tctggcaatc tcagctgtcc tgcttgggca aggtcatccc tgtagccacc catctgctga
     1021 acaatggcag tggggtagga gttctacagt gtctcgagca tatgattggg gcagtgagaa
     1081 gcaaagtgct ggagattcac agccatttcc cacacaaacc cattatcttg attggctgga
     1141 acacaggagc tttggtggcc tgtcatgtgt cagtaatgga gtatgtcact gcagttgtct
     1201 gccttgggtt tcctctgctt actgtggatg gccccagagg ggatgtagat gatcccctct
     1261 tggatatgaa gactccagtc ctctttgtca ttggtcagaa ttcccttcaa tgtcaccctg
     1321 aagccatgga ggacttccgg gagaagattc gagctgagaa cagcttggtg gtggttgggg
     1381 gagctgatga caatctcaga ataagcaaag caaagaagaa atcagaaggg ttgactcaga
     1441 gcatggtgga cagatgtatt caggatgaga ttgtggactt tctgactgga gtgctcactc
     1501 gtgctgaggg tcacatgggc tctgaacctc gggatcagga tgctgagaag aagaagaagc
     1561 cccgcgatgt ggcccgcaga gacttggcct ttgaagtccc tgagcggggc agtcgacctg
     1621 cctccccagc tgccaagctg cccgcctcac cctcaggctc agaggatctc tccagtgtgt
     1681 ccagcagccc cacctccagt cccaagacca aagtgaccac agtgacctct gcccagaagt
     1741 ccagtcagat tggaagttct cagctgctga agagacatgt gcagcggaca gaagctgtgc
     1801 tgacccacaa acaagctcaa gttcccattt catcagaacc accagaggaa ggagagaaag
     1861 aggatcttag ggttcagctg aagcgacacc atccctcgag tccccttcct ggcagtaaga
     1921 cctccaaacg accgaagatc aaggtgtccc ttatctccca aggggacaca gctggagggc
     1981 cttgtgctcc ttcccaagga agtgctccag aagctgcagg tgggaagccc atcaccatga
     2041 cactggggca ggcttcagca ggggccaagg agctcacagg acttctcacc acagccaagt
     2101 ccagttcttc tgaaggtgga gtctcagcca gcccagtccc ttcagtggtc tccagcagca
     2161 ctgcacccag tgccttgcac acactgcaga gccgcctggt ggccacatct cctggcagct
     2221 ccctcccagg ggccacatca gccagcagcc tcctccaagg cctcagcttc agcttgcagg
     2281 atatcagcag caagacctct ggccttccag caaatccctc cccaggacca gccccacagg
     2341 ccaccagtgt gaagttgccc acccccatgc agagcctggg tgccatcacc acgggcacca
     2401 gcaccattgt ccgtaccatt cctgtggcca ccactctctc ctccttgggt gccactcctg
     2461 gtgggaagcc cacagccatc caccagctgc tgaccaatgg gggcctcgct aagttggcaa
     2521 gcagcctccc tggcctggct cagatctcta accaagcatc aggcttgaag gtccccacca
     2581 ccattactct gacacttcgt ggccagccga gcaggatcac tacactgagc cctatgggct
     2641 caggagcagc cccatccgag gagtcctctt cccaggtgct gccctccagc tcacagcgcc
     2701 tgcctccagc accctgaaga tgctgtgtga tatgtcctcc ttaccaagtt ggtgatggct
     2761 gcctcatggt gggccctgga caggtgtgtg gtcctgctga gctgtccacg tgtcggaaga
     2821 cctgtttaag acagtcattt ttgcctctcc gccaactgtc ttcagagaaa ccattaggtt
     2881 aggtgatacg gtgccagcaa gggaagcacc atcgtccagg atctgcaaat ctggttcctg
     2941 ggaaccccag actcctcagc agatctggct gtacatggat cagaaccact tcttcccccg
     3001 cttaagctgt ggtttgaccc aagggtcagc atataggact gcctgctgca tttaatgaag
     3061 gtgtttcctt ttggaagtct gtgctaccct ctgcgcctag ttgggaggag acatccatct
     3121 ggtctgggat ttcgggagtt agaatggaaa gctctttgct aaagactgga gtcatcctgg
     3181 cctgccaact ggtggttcag agccggacgg gcttgttttg gacatcactg ttgccttcac
     3241 tcagcagcca cgggagagtg ctccccatgc aactccacct tagaaaccac gtcagatact
     3301 gagtagcttg ctgactcctg gaaacttctg gtttttgtta gtatcataat gaaggcaaag
     3361 agaactaggc tgtcatcttt cagcctcttt gacttactct agatgttggg agcagtggtt
     3421 gccaggtgaa acctgggccc tttgtctttt tcaccatgct ttgggcagtt tctgtatcca
     3481 gagagtccgc aggttcagat aagctgaaga agagtaatag aacagcaaag gaagtggctt
     3541 gaaggatgtg ctagtaagcc ctgtggtttg tgcttaggtc tctgctctgc tacccaagga
     3601 actggtggtt cagctggaga taaaaagaag aatttgccaa gtcagagaag aaaccccaac
     3661 cccggaaaat cctctgtctc cagtctctgg aggtgaagca gggacaataa gctaaggtag
     3721 tatcttggcc atcccaggaa acttgtggca ttaggacgat gaaggccatg cttcagtgtt
     3781 ttcgtttcta tttcatgaga ctttttgtct tcctgcttac aagtgggaag atgattgaca
     3841 gtgactctac tatgcagggc tgttggtacc aacctgagcc ctataggtgg cagtccctgg
     3901 agaagtggtc acagaagatg gagctctgat cccctgctta cctcttcaca acacttgtgt
     3961 gcaaagatag ttttagattt ggtttagaag ctatcctcca gaacaggctc ccatacttag
     4021 aatgtttcta gttaaggtaa taaattaggc aacccaagtg tgactccact caagtgtcct
     4081 tttctgtagg caggaagggc ccacaacatg gcttaaaatg tagtccatgg ttctggccca
     4141 cagtacagtg tgtatctata ccaggtcacc tgtgttcaat ctgggagcct tcctggccag
     4201 tctgagtggc agccagaagg gagctcatag tgtctaggag tctcaggcaa ggtaggtcag
     4261 ggtactgtgg gcagggggga tgtgtgtgat aggagagggt accctaaacc ccataccttc
     4321 cctccctgac ctgaaaagct gatctcaaca gggattcaca cagaattagg ctgtgttttt
     4381 gcattagctg gtaggtgact ttctcaaaat tcttaaattc agaaagtatt tagtaaactt
     4441 gaggaaggta tgaaatctgg aggaggcatc caggacccag gggtttgata gctttacagg
     4501 taggatcata ccacaccaaa agagcagtgg acaataagac tatatgagct atatgaagct
     4561 tttaggaatc atttaggaca gacagagccc taaacaaccc attcatgact taagttgttg
     4621 gctcagtgta tgctggggac aaagaaaaac taacaagccg acctgccttt atgataaatt
     4681 ctagtgtgct tacaagggat gacttcctga ggtgtgatct gtccaccttg aagaactcca
     4741 caactgaaga aggggagctg tgagaacgtg gattgttcta caacttgcac agggtaacag
     4801 aggaagtggc tgaggcctag agtcacgttt tccagttccc ttcgcaaact atatttcttg
     4861 gaacgcgaaa ggaagcttta cctatttcat agaagacctg gaatccataa cctcagaagg
     4921 caatattatt gatagaaaat gtggaaggat caggaagttc ttagattctt ggatgacaga
     4981 tgcatgttga tgccctatgg agatgtcctt gtgttttgag gtcactgagg taggaagacc
     5041 tgtctactct tggtttcacc actagaacag tcttgggctg gatgggttat agagctgagc
     5101 ggctgtgatg gttctgtttt tacattaaca aaaacaatta aaaacaccaa aaacaa
//
