LOCUS       NM_152519               4782 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens KAT8 regulatory NSL complex subunit 1 like (KANSL1L),
            transcript variant 1, mRNA.
ACCESSION   NM_152519
VERSION     NM_152519.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4782)
  AUTHORS   Smith,E.R., Cayrou,C., Huang,R., Lane,W.S., Cote,J. and
            Lucchesi,J.C.
  TITLE     A human protein complex homologous to the Drosophila MSL complex is
            responsible for the majority of histone H4 acetylation at lysine 16
  JOURNAL   Mol Cell Biol 25 (21), 9175-9188 (2005)
   PUBMED   16227571
  REMARK    Erratum:[Mol Cell Biol. 2006 Jan;26(1):387]
REFERENCE   2  (bases 1 to 4782)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006994.4, DR002867.1, BC032837.1, AK074441.1, AL133053.1,
            CA393360.1, BQ948513.1, AI289109.1 and BU568066.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152519.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.132720.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281772.14/ ENSP00000281772.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC006994.4         116431-116469       c
            40-88               DR002867.1         1-49
            89-103              AC006994.4         116367-116381       c
            104-2211            BC032837.1         35-2142
            2212-2831           AK074441.1         943-1562
            2832-3860           AL133053.1         785-1813
            3861-4029           CA393360.1         479-647
            4030-4390           BQ948513.1         105-465             c
            4391-4779           AI289109.1         5-393               c
            4780-4782           BU568066.1         677-679
FEATURES             Location/Qualifiers
     source          1..4782
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4782
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /note="KAT8 regulatory NSL complex subunit 1 like"
                     /db_xref="GeneID:151050"
                     /db_xref="HGNC:HGNC:26310"
                     /db_xref="MIM:613833"
     exon            1..261
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /inference="alignment:Splign:2.1.0"
     exon            262..1378
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..3254
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     male-specific lethal 1 homolog; KAT8 regulatory NSL
                     complex subunit 1-like protein; KIAA1267-like"
                     /codon_start=1
                     /product="KAT8 regulatory NSL complex subunit 1-like
                     protein isoform 1"
                     /protein_id="NP_689732.2"
                     /db_xref="CCDS:CCDS33370.1"
                     /db_xref="GeneID:151050"
                     /db_xref="HGNC:HGNC:26310"
                     /db_xref="MIM:613833"
                     /translation="MTPALREATAKGISFSSLPSTMESDKMLYMESPRTVDEKLKGDT
                     FSQMLGFPTPEPTLNTNFVNLKHFGSPQSSKHYQTVFLMRSNSTLNKHNENYKQKKLG
                     EPSCNKLKNILYNGSNIQLSKICLSHSEEFIKKEPLSDTTSQCMKDVQIILDSNITKD
                     TNVDKVQLQNCKWYQENALLDKVTDAEIKKGLLHCTQKKIVPGHSNVPVSSSAAEKEE
                     EVHARLLHCVSKQKILLSQARRTQKHLQMLLAKHVVKHYGQQMKLSMKHQLPKMKTFH
                     EPTTILGNSLPKCTEIKPEVNTLTAENKLWDDAKNGFARCTAAEIQRFAFSATGLLSH
                     VEEGLDSDATDSSSDDDLDEYTLRKNVAVNCSTEWKWLVDRARVGSRWTWLQAQISDL
                     ECKIQQLTDIHRQIRASKGIVVLEECQLPKDILKKQMQFADQAASLNILGNPQVPQEC
                     QDPVPEQDFEMSPSSPTLLLRNIEKQSAQLTEIINSLIAPLNLSPTSSPLSSKSCSHK
                     CLANGIYRSASENLDELSSSSSWLLNQKHSKKKRKDRTRLKSSSLTFMSTSARTRPLQ
                     SFHKRKLYRLSPTFYWTPQTLPSKETAFLNTTQMPCLQSASTWSSYEHNSESYLLREH
                     VSELDSSFHSVLSLPSDVPLHFHFETLLKKTEIKGNLAENKFVDEYIISPSPVHSTLN
                     QWRNGYSPICKPQIRSESSAQLLQGRKKRHLSETALGERTKLEESDFQHTESGSHSNF
                     TAVSNVNVLSRIQNSSRNTARRRLRSESSYDIDNIVIPMSLVAPAKLEKLQYKEILTP
                     SWRMVVLQPLDEYNLGKEEIEDLSDEVFSLRHKKYEEREQARWSLWEQSKWHRRNSRA
                     YSKNVEGQDLLLKEYPNNFSSSQQCAAASPPGLPSENQDLCAYGLPSLNQSQETKSLW
                     WERRAFPLKGEDMAALLCQDEKKDQVERSSTAFHGEIFGTSVPENGHHPKKQSDGMEE
                     YKTFGLGLTNVKKNR"
     exon            1379..1520
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1718
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1840
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2045
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2211
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2319
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2445
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2561
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2686
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2741
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2854
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..3023
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..4782
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3835..3840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /note="hexamer: AATAAA"
     polyA_site      3860
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
     regulatory      4661..4666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /note="hexamer: AAGAAA"
     polyA_site      4678
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /note="major polyA site"
     regulatory      4762..4767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /note="hexamer: ATTAAA"
     polyA_site      4782
                     /gene="KANSL1L"
                     /gene_synonym="C2orf67; MSL1v2"
                     /note="major polyA site"
ORIGIN      
        1 agaccgcggc agggttccgt ccccccgagc cgcacggagc tgcgggcagc gggcggactg
       61 ttaaaccgcg gcggcggcgg cggcggcggc ggcggcggcg gcggcggcgg cggccggggc
      121 gggagcgggg cgcgctctgg agacgagtca gcggcgcccc gggtggggga ggcgggcggg
      181 cagctagaga tcacctcagc agcccccacc acggccggac cgaaggtgcg gcggcggagg
      241 ggagccaggg cgccccagca ggtttccaat acttatctac aggaatcgcc atgaccccag
      301 ctctgaggga ggcaacagca aagggtatca gcttttcatc tttgccaagt accatggagt
      361 ctgacaagat gctctacatg gaaagtccca gaactgtaga tgaaaagcta aagggagaca
      421 ccttttctca gatgcttgga tttccaactc ctgaacctac tcttaatact aattttgtga
      481 atttaaaaca ttttggctcc cctcagtctt caaaacatta ccagactgtt tttttaatga
      541 gatctaattc tacattaaat aaacacaatg agaattataa acaaaagaaa ttaggggagc
      601 ccagttgcaa taagctgaaa aacatactgt ataatggcag caacattcag ctcagtaaaa
      661 tctgtctttc tcattctgaa gagttcatca aaaaggagcc tctatcagat accacgagcc
      721 agtgcatgaa agatgtacaa attattctgg attcaaatat aaccaaagac actaatgtag
      781 ataaagtaca actacaaaac tgtaaatggt atcaagagaa tgcacttttg gataaagtta
      841 ctgatgctga gattaaaaag ggtttattgc actgtactca aaagaaaatt gtacctggcc
      901 actcaaatgt gcctgttagt tcttcagctg ctgaaaaaga ggaggaagta catgctcgtt
      961 tacttcattg tgtaagcaaa cagaaaattt tacttagcca ggctagaaga actcagaaac
     1021 atttgcagat gctcctggca aagcatgttg ttaagcacta tggtcagcag atgaaattgt
     1081 ctatgaaaca tcaactcccc aaaatgaaga catttcatga acctaccaca attttgggta
     1141 atagtttacc taaatgcact gaaattaagc cagaagttaa cacattgact gcagagaata
     1201 aattgtggga tgatgcaaaa aatggctttg cacggtgtac agctgcggaa atccaaagat
     1261 ttgcattttc tgctacaggg ctgttgtctc atgttgaaga gggtttggat tccgatgcaa
     1321 ctgatagcag ctctgatgac gatttggatg aatataccct tagaaaaaat gtggcagtta
     1381 actgtagtac tgaatggaag tggcttgtag acagagcacg agttggcagc cgatggactt
     1441 ggcttcaagc tcagatttca gacctagaat gcaaaatcca acaactaaca gacattcaca
     1501 ggcaaattcg tgcctccaag gggatagtgg tcctagaaga atgtcagctt ccaaaagata
     1561 ttttgaaaaa acaaatgcaa tttgcagacc aagcagcttc actaaacatt ctagggaatc
     1621 ctcaggttcc ccaggagtgt caagatcctg taccggaaca agattttgaa atgtcaccaa
     1681 gcagccctac tttacttctt cgaaacatcg aaaaacagag tgcacagttg actgagatca
     1741 tcaacagttt gattgcccct ctcaacttgt ccccaacttc atcacccctc tcttccaaat
     1801 cctgtagcca taaatgtctg gctaatggca tttacaggag tgcatcagag aatttagatg
     1861 agctgtcttc ctccagtagc tggttactta accagaagca cagtaagaaa aagagaaaag
     1921 acaggacaag actgaaatct tcatccttga ctttcatgag tacatcagcc cgaacaaggc
     1981 cacttcagag tttccacaaa cgaaaactgt acagattgag ccctactttt tattggactc
     2041 cacagacttt gccttcaaaa gaaacagcat ttttaaacac tacacaaatg ccttgcctgc
     2101 aatcagcttc aacttggagt agctatgaac acaattcgga gtcttaccta ttaagagaac
     2161 atgtatcaga gttagattcc tctttccatt ctgttctatc attgccatca gatgtgcctc
     2221 ttcattttca ctttgaaaca ctgttaaaaa agactgaaat aaaaggcaat cttgctgaaa
     2281 ataaatttgt agatgaatat atcatatctc catcacctgt acatagtact ctgaatcaat
     2341 ggagaaatgg atattcacct atatgtaagc ctcaaataag gtcagaatct tctgcacaac
     2401 tgttacaggg aagaaagaaa agacatttga gtgaaacagc attaggagaa agaactaaac
     2461 ttgaagaatc tgattttcaa cacacagaat caggatccca tagcaatttt actgctgttt
     2521 ccaatgtcaa cgttttatca agaatccaga attcatcacg aaatactgca cgacggagat
     2581 tgagaagtga gagctcttat gacatagata acattgtgat tcccatgtca ttagtagccc
     2641 cagctaaatt agagaaactc caatataagg aaatacttac tccaagctgg aggatggttg
     2701 ttcttcagcc tttggatgaa tataatttag gcaaagaaga gatagaagat ctttctgatg
     2761 aagtcttctc cctaaggcac aaaaaatatg aagagagaga gcaagccagg tggtcactat
     2821 gggagcaaag caagtggcac agaagaaaca gcagagctta cagtaaaaat gttgaaggac
     2881 aggacttgct tttgaaagaa taccctaata acttcagtag cagtcagcaa tgtgctgctg
     2941 caagtcctcc tgggcttcct tcagagaacc aggatctgtg tgcatatggc ttaccttctt
     3001 taaatcaaag tcaagaaacc aagtctttgt ggtgggaacg acgggctttt ccactgaagg
     3061 gtgaagacat ggcagcctta ttatgtcaag atgaaaaaaa ggatcaggtt gaaaggtcaa
     3121 gcacagcttt ccatggtgaa atcttcggta ccagtgtacc agagaatggc caccatccaa
     3181 aaaagcagtc agatggaatg gaagaataca aaacctttgg tctaggactt actaatgtta
     3241 aaaaaaatag gtgacaggga acaggttaag aaaactatgt aaatgtagga aagatgggag
     3301 gaaataaagc cctgttctgg atcccccatc ccctccagaa taagagcatg ttctgcatgt
     3361 attaatcttt tatgctgttt atgaaacagg caagataagt ctgtttttcc ttctggaacc
     3421 ataagggtaa ccagattttc atctacagac aagtggtagt catttgtgtt tatcatgcaa
     3481 cttacttaca aacaccaaga tattaattgc tgcaacttga tgtcaaatca cattactggg
     3541 taatttttaa gactatgtac ccacaccata catacataca tatatatata cacatacata
     3601 caaacctgtg tgccaagtga cagctatttt tttatataca tggtaattca ttaaaattgc
     3661 cttagtaata tattagaata tacaaatatg tgtgtataaa ataaacatac acacacacac
     3721 acacccctat gtagttttta aaacactggc aatgacccac tccccttgga aatgcatgta
     3781 tgaactaccc tatgaaatgt aagctgcaga atagataaaa cacaggtttc cactaataaa
     3841 agacatctga acgtcctgaa tatagagaca gaagtttttt gttgttgttg ttgttgtttt
     3901 aacatgttta accaacagaa gttatttaca gaaattcata tatccaggca acacaaaact
     3961 cctttattca aaatcactgc tatctttggg actaaacaca ggctactttc tgtttactcc
     4021 taacaaaata aagcaagcaa atttgagtca aatattggtg cactttaata ctatcacatc
     4081 tttgaaaact caatttgagt tttaccaatt aatgtgtctc atgaagagaa gacaccagtt
     4141 ttaaaatgag ccacaaacag taaagcccta tcagtataaa atttgaaaaa aaaaaaaaag
     4201 atgattgtat ttctagatta gcaagaaatt agttaattct ggctgatttc tatttctagc
     4261 taatttggtc attctttgcc atagcttact ctattcaaat aaacatatat tcttgcttgc
     4321 atcctagatt ggaaattaaa atttttcaaa gaacaaagct tcaatattgg atactgaaga
     4381 gtatacatga aagaaaattc cttttgaagc tattaaacca tttttttcct atgtgaaagt
     4441 tgaggacaat ttatataact cactttttgt catgtaaaaa aggttactca agttgtacta
     4501 cccacataac tgaaaatatt ggccatttgg ccttatctgt gagatttgac actaagtttt
     4561 tgttagagat tggaaattat actagtcctt ttaaggggta aaaaattcaa ttcaatactg
     4621 acaaactttt gcttgtagtt ttactgtaca tttattttta aagaaaaaga aaacaaaagc
     4681 cagacaaacc caagttgtcc aggcaaataa actcaaatct ttgtcacgtc tgatattata
     4741 atcttctatg taagtttttt aattaaagtt atttctatat gc
//
