LOCUS       NM_181712               5499 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens KN motif and ankyrin repeat domains 4 (KANK4),
            transcript variant 1, mRNA.
ACCESSION   NM_181712 XM_371256
VERSION     NM_181712.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5499)
  AUTHORS   Oishi,M., Shinjo,K., Takanari,K., Muraoka,A., Suzuki,M.M.,
            Kanbe,M., Higuchi,S., Ebisawa,K., Hashikawa,K., Kamei,Y. and
            Kondo,Y.
  TITLE     Exclusive expression of KANK4 promotes myofibroblast mobility in
            keloid tissues
  JOURNAL   Sci Rep 14 (1), 8725 (2024)
   PUBMED   38622256
  REMARK    GeneRIF: Exclusive expression of KANK4 promotes myofibroblast
            mobility in keloid tissues.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5499)
  AUTHORS   Mei,X., Xiong,J., Liu,J., Huang,A., Zhu,D., Huang,Y. and Wang,H.
  TITLE     DHCR7 promotes lymph node metastasis in cervical cancer through
            cholesterol reprogramming-mediated activation of the KANK4/PI3K/AKT
            axis and VEGF-C secretion
  JOURNAL   Cancer Lett 584, 216609 (2024)
   PUBMED   38211648
  REMARK    GeneRIF: DHCR7 promotes lymph node metastasis in cervical cancer
            through cholesterol reprogramming-mediated activation of the
            KANK4/PI3K/AKT axis and VEGF-C secretion.
REFERENCE   3  (bases 1 to 5499)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5499)
  AUTHORS   Haydont,V., Neiveyans,V., Zucchi,H., Fortunel,N.O. and
            Asselineau,D.
  TITLE     Genome-wide profiling of adult human papillary and reticular
            fibroblasts identifies ACAN, Col XI alpha1, and PSG1 as general
            biomarkers of dermis ageing, and KANK4 as an exemplary effector of
            papillary fibroblast ageing, related to contractility
  JOURNAL   Mech Ageing Dev 177, 157-181 (2019)
   PUBMED   29913199
  REMARK    GeneRIF: biomarkers suitable for the assessment of chronological
            ageing were identified, and extrapolated to the context of
            photo-damaged skin. In particular, KANK4, ACAN, Col XI alpha1, and
            PSG1, were expressed at an increased level in both
            chronologically-aged and photo-damaged skin.
REFERENCE   5  (bases 1 to 5499)
  AUTHORS   Gee,H.Y., Zhang,F., Ashraf,S., Kohl,S., Sadowski,C.E.,
            Vega-Warner,V., Zhou,W., Lovric,S., Fang,H., Nettleton,M.,
            Zhu,J.Y., Hoefele,J., Weber,L.T., Podracka,L., Boor,A.,
            Fehrenbach,H., Innis,J.W., Washburn,J., Levy,S., Lifton,R.P.,
            Otto,E.A., Han,Z. and Hildebrandt,F.
  TITLE     KANK deficiency leads to podocyte dysfunction and nephrotic
            syndrome
  JOURNAL   J Clin Invest 125 (6), 2375-2384 (2015)
   PUBMED   25961457
  REMARK    GeneRIF: identified recessive mutations in kidney ankyrin
            repeat-containing protein 1 (KANK1), KANK2, and KANK4 in
            individuals with nephrotic syndrome.
REFERENCE   6  (bases 1 to 5499)
  AUTHORS   Kakinuma,N., Zhu,Y., Wang,Y., Roy,B.C. and Kiyama,R.
  TITLE     Kank proteins: structure, functions and diseases
  JOURNAL   Cell Mol Life Sci 66 (16), 2651-2659 (2009)
   PUBMED   19554261
  REMARK    Review article
REFERENCE   7  (bases 1 to 5499)
  AUTHORS   Zhu,Y., Kakinuma,N., Wang,Y. and Kiyama,R.
  TITLE     Kank proteins: a new family of ankyrin-repeat domain-containing
            proteins
  JOURNAL   Biochim Biophys Acta 1780 (2), 128-133 (2008)
   PUBMED   17996375
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139343.9, BC060866.1 and AL162739.24.
            
            On Nov 23, 2018 this sequence version replaced NM_181712.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.138016.1, BC060866.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371153.9/ ENSP00000360195.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL139343.9         68744-68765         c
            23-725              BC060866.1         1-703
            726-2271            AL139343.9         22564-24109         c
            2272-2783           BC060866.1         2250-2761
            2784-2918           AL139343.9         12444-12578         c
            2919-3201           BC060866.1         2897-3179
            3202-3282           AL162739.24        78805-78885         c
            3283-5499           AL162739.24        67498-69714         c
FEATURES             Location/Qualifiers
     source          1..5499
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..5499
                     /gene="KANK4"
                     /gene_synonym="ANKRD38; dJ1078M7.1"
                     /note="KN motif and ankyrin repeat domains 4"
                     /db_xref="GeneID:163782"
                     /db_xref="HGNC:HGNC:27263"
                     /db_xref="MIM:614612"
     exon            1..329
                     /gene="KANK4"
                     /gene_synonym="ANKRD38; dJ1078M7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..415
                     /gene="KANK4"
                     /gene_synonym="ANKRD38; dJ1078M7.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..3387
                     /gene="KANK4"
                     /gene_synonym="ANKRD38; dJ1078M7.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat domain 38; KN motif and ankyrin repeat
                     domain-containing protein 4; kidney ankyrin
                     repeat-containing protein 4; ankyrin repeat
                     domain-containing protein 38"
                     /codon_start=1
                     /product="KN motif and ankyrin repeat domain-containing
                     protein 4 isoform 1"
                     /protein_id="NP_859063.3"
                     /db_xref="CCDS:CCDS620.1"
                     /db_xref="GeneID:163782"
                     /db_xref="HGNC:HGNC:27263"
                     /db_xref="MIM:614612"
                     /translation="MEKTDAKDQSSQGDEEKDPPKSHPYSVETPYGFHLDLDFLKYVD
                     DIEKGNTIKRIPIHRRAKQAKFSTLPRNFSLPDSGARPPAAPPLQNWSPVVPREASLG
                     TQEQNQSPPLGNAPQASTSRSEVSYHRKALLAEATRQLEAAEPEDAELTFGSGRPQLL
                     RASSMPATLLHSRASEEPGLSLGPPAPPALPPLQGEGSVCDGTFEPAEGLAGFHSSSP
                     RASTRIPELVQEGAEPPEGVVKVPNHLPLPGPPFSFQNVLVVLEDKEDEHNAREAEVL
                     FTPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPPPPVEVDMRSIGIRVTEESLGL
                     ARVDPGSISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVA
                     QLEGQFHQENAKDTQGQTDVMVNTDPVHGLLTRESCDKGIEVNLLGSMESESWGHRGE
                     ENGLLWGPDGHKQGNQSPAERVLLPQLSLPQGPEQVLTSSVHSFLSTELRIEEAGTEQ
                     EGGPQGGTRGAGGFLWGSDRKTPPAGREETSSNLPGKEHPGRPPSSPTDATIGQYVKK
                     IQELLQEQWNCLEHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAHPPKEP
                     PASSSSPPVEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSG
                     EDSTPEDLSDSEAEKKCDGPDHKHVKDAHLTCEAGQGIPEGTCHAAQESGPGEEVPHS
                     KAERYKPSEEFLNACRALSQHLPETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVV
                     ASYLHEVQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNK
                     AGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQA
                     LLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALK
                     SPTHMEIAGLLRAHAEQGRSLGL"
     exon            416..2299
                     /gene="KANK4"
                     /gene_synonym="ANKRD38; dJ1078M7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2411
                     /gene="KANK4"
                     /gene_synonym="ANKRD38; dJ1078M7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2630
                     /gene="KANK4"
                     /gene_synonym="ANKRD38; dJ1078M7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2718
                     /gene="KANK4"
                     /gene_synonym="ANKRD38; dJ1078M7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2938
                     /gene="KANK4"
                     /gene_synonym="ANKRD38; dJ1078M7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3081
                     /gene="KANK4"
                     /gene_synonym="ANKRD38; dJ1078M7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3282
                     /gene="KANK4"
                     /gene_synonym="ANKRD38; dJ1078M7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..5499
                     /gene="KANK4"
                     /gene_synonym="ANKRD38; dJ1078M7.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5481..5486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KANK4"
                     /gene_synonym="ANKRD38; dJ1078M7.1"
                     /note="hexamer: ATTAAA"
     polyA_site      5499
                     /gene="KANK4"
                     /gene_synonym="ANKRD38; dJ1078M7.1"
                     /note="major polyA site"
ORIGIN      
        1 cccctagcga aggcggggac tcgggcgctg ttggcagctg gcgacgcggg gcgaagccgc
       61 ggctggcggc gcctggccag tcccgcatcc gccgcggtgg gtgtgcccgc aggggtgcgc
      121 cggggccagg gccgagaccg tcggccagag ggcgcctgga gggtgtgcgc gccgcggacg
      181 accagggtgc gccagccccg gggtgcgcgc ctgggacgcg gacagtgcac ccggaggttg
      241 cgtgcgctcc gaagccgggg tgtgcgccta gctgccccgg ccccgtgcac cgcgggccgc
      301 ctcgcgcagg acttccgcag ctcgccaaga accttcaaca agttttacag actcattgga
      361 tgaagagtgc ctgagacact gagggtcagc gctccaaaga tggagaagac agatgccaaa
      421 gaccagtcct ctcaggggga tgaagagaaa gaccctccga agagccaccc ttattctgtg
      481 gagaccccat atggctttca tttagacctg gacttcctca agtatgtgga tgacatcgag
      541 aagggaaaca ctatcaaaag aattcctatc cacagaaggg ccaagcaggc caaatttagc
      601 actctgcccc gaaacttcag ccttcctgac agtggggctc gcccccctgc agccccgccc
      661 ctccaaaact ggtctcccgt ggtgccaagg gaggcatcac ttgggacaca ggagcaaaac
      721 cagtcaccac cgcttggtaa tgccccccag gcctcaacaa gcaggagtga ggtgagctac
      781 cacaggaagg ctctgttggc agaggccacc agacagttgg aagctgctga gccagaggat
      841 gccgagctca cttttgggag tggacggccc cagctcttga gagcatccag catgcctgcc
      901 acgctgctgc acagcagggc ttctgaggag ccaggcctga gcctggggcc ccctgcccct
      961 cctgccctcc ctccccttca gggtgaaggc agtgtctgtg atggcacctt tgaacctgca
     1021 gaaggattgg caggtttcca cagctccagc ccacgagcat caactcggat tccagagctg
     1081 gtccaggagg gagctgagcc tccagagggt gtggtgaagg ttccaaatca cctccctctc
     1141 ccaggccctc ctttctcatt ccagaatgtg cttgtagttc tagaggacaa ggaagatgaa
     1201 cacaatgcca gagaagcaga ggtgttgttc acccctggct cccctacgcc aagcccgcca
     1261 cctctgccat cacccatccc tgagaatgag ctcctcctgg aagaaatcga gctcaacatc
     1321 agcgagattc cacccccgcc acctgtagag gtggacatga gaagcattgg catcagggta
     1381 actgaggaaa gcctgggcct tgccagggtg gatccaggca gcatctccag cctgaaacag
     1441 caggtctcgg ccctggaggg agagttgtct ggaagaaccg aggaactggc acaggtcaga
     1501 actgctctcc agcagcagga agaggaaatc aaagctaggg agcaaagaat tcgagagctg
     1561 gagttcactg tagcccaact ggaaggacag tttcaccaag agaacgccaa agacactcag
     1621 ggccagacgg acgtgatggt gaacactgac cctgtccatg gactcttgac cagggagtcg
     1681 tgtgataagg gcattgaagt caaccttcta ggcagcatgg agtctgaaag ctgggggcac
     1741 cgaggagagg agaatggcct cctatggggg ccagatggtc ataaacaagg gaatcagagc
     1801 ccagcagaac gtgtgcttct gccccagctg tcactgccac agggacccga gcaggtcctt
     1861 acctcctctg tacatagctt cctctccact gaactcagga ttgaagaagc aggcactgaa
     1921 caggaaggag gccctcaggg aggaaccagg ggagcaggag gctttctgtg gggcagcgac
     1981 agaaagactc ccccagcagg gagggaggag accagttcca atctcccagg gaaggagcac
     2041 ccgggaaggc caccaagctc gccaacggat gccactattg ggcagtatgt gaagaagatc
     2101 caggagctcc tgcaggagca gtggaactgc ctggagcatg ggtacccgga gctggccagc
     2161 gccatcaagc agccagcctc caagctcagc agcatccaga gccagctgct gagctccctc
     2221 aacctgctgc tgtcggccta ctcggcccag gctcacccac ccaaggagcc accggcctcc
     2281 tcctcctccc cgccagtgga gatctcccca tcgaccagcc ttaaatccat aatgaaaaag
     2341 aaagactatg gcttccgtgc aggaggtaat gggaccaaaa agaaccttca gtttgttggg
     2401 gttaacggtg ggtatgagac cacctcaagt gaggagacca gcggtgagga cagcacccca
     2461 gaggacttgt ctgacagcga ggcagagaag aagtgtgacg gcccagatca caagcatgtc
     2521 aaagatgccc atctcacctg cgaggctggg cagggcatcc ctgagggcac ctgccatgct
     2581 gcccaggaaa gtgggcctgg ggaagaagtc ccccactcca aggccgagag atataaaccc
     2641 tcagaagaat ttcttaatgc atgccgggca ctgagccagc atctgccaga aactgggacc
     2701 accacagacc agctcttgag gcaaagcttg aacaccatca gtcaagagtg gttccgcgtc
     2761 tccagccgga agtcgtctag ccccgccgtg gtggcctcct acctccacga ggtccagcct
     2821 cactccccac acttcctgaa actgcttgtc aacttggccg atcacaacgg gaacacggcc
     2881 cttcactaca gcgtgtccca ctccaacttc tccatcgtga agctgctgct ggagacaggc
     2941 gtctgcaatg tggaccatca gaacaaagct ggctacactg ccgtaatgat cactcccttg
     3001 gcttccgcag agaccaatga agacatggct gttgtctgga agctcttaag agaaggaaat
     3061 gtgaacattc aagctactca gggaggccag actgcgctga tgctgggagt cagccacgac
     3121 agggaggaca tggttcaagc gctgcttagc tgccaggcag atgtcaatct gcaggaccac
     3181 gatggatcct cggccctcat ggtggcctgt caccatggca acgtggacct ggtgcggctg
     3241 ctcctggcac acccagcctg cgacagcagc ctgactgaca aggctggccg cacagctttg
     3301 tccatcgctc tgaagtcacc cacccatatg gaaattgctg ggcttctgag agcccacgcg
     3361 gagcagggca ggtccctggg gctgtagggg ctgcagaaga actggccgtg gggaacaaaa
     3421 gccttcttct ctggactcct ccctcgccct tgaagagggc agaggtcaca ggccagagag
     3481 ccacccttct agagaagaaa ctatgtcaaa tatgcacata cattcctgtt gtataattct
     3541 gctcattagg atgctttgta gtttttgcct taggccaagc ctgaaaacta cacgggcttc
     3601 agagcagggt tcaaggtgca aggtgagggg tacgtcggtg tcatccaaac atccaaaaca
     3661 tcttcagcct tgaattcctc atgactctac cctctgtaac attgtgtagc aagcaggcag
     3721 gcaggagcac attagcacat tagaaaagca atacttttta catggaattt tacagtgcac
     3781 tatctttctg ttttttaagc aagtgtatac aaatatgtcc cattgatatg catgtctata
     3841 gatgggaggg gatttaagcc aaccccctgg caagcattct gtaggggacc ctagaagaat
     3901 caccgtgcag actggtgaaa ctgaacaagc accatttggg agctttgttt cgatggggtt
     3961 gacagagaaa tcttaaaatc tgacagggta gaagaagcac tttggcatca atgccatatg
     4021 tacagtcttg actatttctg agtcatctag tggctccaat ttgctccagg gaaattggaa
     4081 ttaattaaga aatttattat ctagtaagtt gctatgtaat aaagaaaaaa aagaaattca
     4141 atccaatgac acacaccaca tgtatttggg cagagtcaga ttctctcagc tattttgagt
     4201 ctgtggaaga aacaaaaaaa agcttcctcc tgaggatggg ttattgtcat caagaagcca
     4261 cctgcatagc cgtatccatt acctcatggt aattcccggt gctttcccct catatcccct
     4321 agaagcaaat atctgttctg aggttttttg ggacttctgg ctgcaatagg agcaagggac
     4381 ccaggcaggg cagagcaata ccttccgaag cttccatatt ccctggggcc agcacatgca
     4441 aggtttatat ggtcagtagc tcacgtgaag tcatctgaat ctttcttaaa tctgctctct
     4501 taaaatctct tatgcaaaaa aaaaaaaaaa aagcccctta tataaaaaga agtaatgtca
     4561 aagtttgatg agctttacat tggaaactca aaagcttgca ctctcatttt ggctcagatg
     4621 ccaatttgct gggtgcccct gtggtgagtc atgaaacctc cttgggccgc aatttcatca
     4681 tctctaaaaa cagaaattgt catacaacct acctcctggg aggtgctgca caagaagcag
     4741 ctgatggaag tttcaaaatc caatttgtgg ccgagcgcgg tggttcacgc ctgtaatccc
     4801 agcactttgg gaggccgagg caggtggatc acctgaggtc gggagtttga gaccagcctg
     4861 acatacatgg agaaaccccg tctctaccaa aaatacaaaa attagctggg gcgtggtggc
     4921 aggcgcctgt aattccagct acttgggagg ctgaggcagg agactcactt gaacccggga
     4981 ggcggaggtt tcagtgagcc gagatcgtgc cattgcactc cagcctgggt aacgagcaaa
     5041 actctgtctc aaaaaaaaaa aaaaaaaaaa tccaatttgt aacccattaa ggccatctac
     5101 agcaatggta cagcaaactt cttttgccat tgtgattcat aagagaggct cagagtccca
     5161 gaacacaatg acatgtgttg atgcaactca gaggtggaga gaatggagca aataatgaga
     5221 aaaaaaatgc tttaaatgag tttattttga cctcaaaata cattgtaaga gcaacatcct
     5281 acgttaataa atgttctagc ccggtgcttc gcgaacattt atgtgcatac aaatcacctg
     5341 ggatcttgtt agaaggcagt aggtctgggg tggggcctga gattctgcat ttctaaccag
     5401 gtcctgggag atgctgatgc tatcgagcca caaccacact ttgagtagca agcctctggc
     5461 ctatccttat tgtttgttat attaaaatgc tgcctctca
//
