LOCUS       NM_198471               2787 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens KN motif and ankyrin repeat domains 3 (KANK3), mRNA.
ACCESSION   NM_198471 XM_170882
VERSION     NM_198471.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2787)
  AUTHORS   Dai,Z., Xie,B., Yang,B., Chen,X., Hu,C. and Chen,Q.
  TITLE     KANK3 mediates the p38 MAPK pathway to regulate the proliferation
            and invasion of lung adenocarcinoma cells
  JOURNAL   Tissue Cell 80, 101974 (2023)
   PUBMED   36463587
  REMARK    GeneRIF: KANK3 mediates the p38 MAPK pathway to regulate the
            proliferation and invasion of lung adenocarcinoma cells.
REFERENCE   2  (bases 1 to 2787)
  AUTHORS   Tadijan,A., Samarzija,I., Humphries,J.D., Humphries,M.J. and
            Ambriovic-Ristov,A.
  TITLE     KANK family proteins in cancer
  JOURNAL   Int J Biochem Cell Biol 131, 105903 (2021)
   PUBMED   33309958
  REMARK    GeneRIF: KANK family proteins in cancer.
            Review article
REFERENCE   3  (bases 1 to 2787)
  AUTHORS   Kim,I., Kang,J., Gee,H.Y. and Park,J.W.
  TITLE     A novel HIF1AN substrate KANK3 plays a tumor-suppressive role in
            hepatocellular carcinoma
  JOURNAL   Cell Biol Int 42 (3), 303-312 (2018)
   PUBMED   29047187
  REMARK    GeneRIF: Authors identified KANK3 as a new substrate for the oxygen
            sensor hypoxia-inducible factor 1-alpha inhibitor (HIF1AN), which
            hydroxylates HIF-1/2alpha and other ankyrin repeat
            domain-containing proteins at asparagine residues.
REFERENCE   4  (bases 1 to 2787)
  AUTHORS   Kakinuma,N., Zhu,Y., Wang,Y., Roy,B.C. and Kiyama,R.
  TITLE     Kank proteins: structure, functions and diseases
  JOURNAL   Cell Mol Life Sci 66 (16), 2651-2659 (2009)
   PUBMED   19554261
  REMARK    Review article
REFERENCE   5  (bases 1 to 2787)
  AUTHORS   Zhu,Y., Kakinuma,N., Wang,Y. and Kiyama,R.
  TITLE     Kank proteins: a new family of ankyrin-repeat domain-containing
            proteins
  JOURNAL   Biochim Biophys Acta 1780 (2), 128-133 (2008)
   PUBMED   17996375
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC066124.1.
            
            On Nov 23, 2018 this sequence version replaced NM_198471.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066124.1, AB284126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330915.7/ ENSP00000328923.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2787              BC066124.1         1-2787
FEATURES             Location/Qualifiers
     source          1..2787
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2787
                     /gene="KANK3"
                     /gene_synonym="ANKRD47"
                     /note="KN motif and ankyrin repeat domains 3"
                     /db_xref="GeneID:256949"
                     /db_xref="HGNC:HGNC:24796"
                     /db_xref="MIM:614611"
     exon            1..38
                     /gene="KANK3"
                     /gene_synonym="ANKRD47"
                     /inference="alignment:Splign:2.1.0"
     exon            39..100
                     /gene="KANK3"
                     /gene_synonym="ANKRD47"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2532
                     /gene="KANK3"
                     /gene_synonym="ANKRD47"
                     /note="ankyrin repeat domain 47; kidney ankyrin
                     repeat-containing protein 3; ankyrin repeat
                     domain-containing protein 47"
                     /codon_start=1
                     /product="KN motif and ankyrin repeat domain-containing
                     protein 3"
                     /protein_id="NP_940873.2"
                     /db_xref="CCDS:CCDS12199.1"
                     /db_xref="GeneID:256949"
                     /db_xref="HGNC:HGNC:24796"
                     /db_xref="MIM:614611"
                     /translation="MAKFALNQNLPDLGGPRLCPVPAAGGARSPSSPYSVETPYGFHL
                     DLDFLKYIEELERGPAARRAPGPPTSRRPRAPRPGLAGARSPGAWTSSESLASDDGGA
                     PGILSQGAPSGLLMQPLSPRAPVRNPRVEHTLRETSRRLELAQTHERAPSPGRGVPRS
                     PRGSGRSSPAPNLAPASPGPAQLQLVREQMAAALRRLRELEDQARTLPELQEQVRALR
                     AEKARLLAGRAQPEPDGEAETRPDKLAQLRRLTERLATSERGGRARASPRADSPDGLA
                     AGRSEGALQVLDGEVGSLDGTPQTREVAAEAVPETREAGAQAVPETREAGVEAAPETV
                     EADAWVTEALLGLPAAAERELELLRASLEHQRGVSELLRGRLRELEEAREAAEEAAAG
                     ARAQLREATTQTPWSCAEKAAQTESPAEAPSLTQESSPGSMDGDRAVAPAGILKSIMK
                     KRDGTPGAQPSSGPKSLQFVGVLNGEYESSSSEDASDSDGDSENGGAEPPGSSSGSGD
                     DSGGGSDSGTPGPPSGGDIRDPEPEAEAEPQQVAQGRCELSPRLREACVALQRQLSRP
                     RGVASDGGAVRLVAQEWFRVSSQRRSQAEPVARMLEGVRRLGPELLAHVVNLADGNGN
                     TALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRL
                     FCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYG
                     RLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQSESP
                     PGSQTATPGEGECGDNGENPQVQ"
     exon            101..1393
                     /gene="KANK3"
                     /gene_synonym="ANKRD47"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1493
                     /gene="KANK3"
                     /gene_synonym="ANKRD47"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1700
                     /gene="KANK3"
                     /gene_synonym="ANKRD47"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1785
                     /gene="KANK3"
                     /gene_synonym="ANKRD47"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..2002
                     /gene="KANK3"
                     /gene_synonym="ANKRD47"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2148
                     /gene="KANK3"
                     /gene_synonym="ANKRD47"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2349
                     /gene="KANK3"
                     /gene_synonym="ANKRD47"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2448
                     /gene="KANK3"
                     /gene_synonym="ANKRD47"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2787
                     /gene="KANK3"
                     /gene_synonym="ANKRD47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2770..2775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KANK3"
                     /gene_synonym="ANKRD47"
                     /note="hexamer: AATAAA"
     polyA_site      2787
                     /gene="KANK3"
                     /gene_synonym="ANKRD47"
                     /note="major polyA site"
ORIGIN      
        1 gggctcgggt gcgggcgcgg ctggggctgc ggcttcaggg tgcctctgac agctgctgca
       61 ggaaacatgg ccaagtttgc cctgaatcag aacctgcccg acctgggcgg cccccgcctg
      121 tgcccggtcc ccgccgccgg gggcgcacgc agcccgagct cgccctactc ggtggagacg
      181 ccctacggct tccacctgga cctggacttc ctcaagtaca tagaggagct ggagcgtggc
      241 cccgctgccc gccgcgcccc gggacccccg acctcgcgcc gtccccgcgc gccccggccc
      301 ggcctcgcgg gcgcacgtag cccaggcgcc tggacatcca gcgagtccct ggccagtgac
      361 gacggtggag caccgggcat actctcccag ggcgcgccct cggggctcct gatgcagccg
      421 ctgtcgccgc gcgcgcccgt gcgcaacccg cgcgtcgagc acacgctccg ggagaccagc
      481 cggcggctgg agctggcgca gacacacgag cgcgcgccca gccccggccg cggggtcccg
      541 cgcagcccac gcgggtccgg ccgcagcagc cccgccccta accttgcccc tgcttcgccc
      601 ggccctgccc aactgcagct ggtgcgcgag cagatggccg cggcgctgcg gcgcctgcgc
      661 gagctcgagg accaggcgcg aacgctgccc gagctgcagg agcaggtgcg cgcgctgcgc
      721 gccgagaagg cgcggctgct ggccgggcgc gcgcagcccg agccggacgg ggaggctgag
      781 acgcgcccgg acaagctcgc ccagctgcgg cggctcaccg agcgcctggc cacctccgag
      841 cgcggcggcc gtgccagggc cagcccccgg gctgacagcc cagacggcct ggctgcaggg
      901 cgcagcgagg gcgcgctcca ggtcctcgac ggggaggtcg ggagtctcga tgggacgccc
      961 cagacccggg aggtggccgc cgaggccgtg cccgagaccc gagaagcggg tgcccaggcc
     1021 gtgccggaga cccgggaggc cggcgtggag gctgcccccg agaccgtgga ggcggacgcg
     1081 tgggtgaccg aggcgctgct ggggctgcct gcggccgccg agcgcgagct agagctgctg
     1141 cgcgccagtc tggagcacca gcgcggggtg agtgagcttc tgcggggccg gttgcgggag
     1201 ctggaggaag cccgcgaggc tgcggaggag gcagcggcgg gggcccgggc ccagctacgc
     1261 gaggccacca cccagacccc gtggagctgt gccgaaaagg ccgcgcagac cgagtccccg
     1321 gcagaggcgc cctccttgac tcaggagagc tcgcccggat ccatggacgg agacagggcc
     1381 gtggcgcccg cgggcatcct caaatccatc atgaagaaga gagacggcac acctggtgcc
     1441 caacccagct ccggacccaa gagcctgcag tttgttgggg tcctcaacgg agagtacgag
     1501 agctcctcca gcgaggacgc cagcgacagc gatggcgaca gcgagaacgg tggcgccgag
     1561 cccccgggta gctcctcggg ctccggggat gacagcggcg ggggatccga ctcgggcacc
     1621 cctggccctc ccagcggcgg ggacatccgg gaccctgagc ccgaggcgga ggcagagcct
     1681 cagcaggtgg cacaggggag gtgcgagctg agcccgcgtc tgagggaggc gtgcgtagcg
     1741 ctgcagcggc agctgagccg gccccgcgga gtagccagcg acggcggcgc agtgcgcctc
     1801 gtggcccagg agtggtttcg agtgtccagc cagcggcgct ctcaggcgga gcccgtggcc
     1861 aggatgctgg aaggggtgag gcgcctggga cccgaactgc tggcgcacgt ggtgaacctg
     1921 gcggatggca acgggaacac ggccctgcac tacagtgtgt cccacgggaa cctggccatc
     1981 gcaagcctgc tcctggatac gggggcctgc gaggtcaacc gccagaaccg agccggctac
     2041 tcggccctca tgctggctgc actcacctct gtgaggcagg aagaggagga catggctgtg
     2101 gtccagagac tcttctgcat gggtgatgtc aatgccaagg ccagtcagac ggggcagaca
     2161 gccctcatgc tggccatcag ccatggccga caggacatgg tggcaaccct actggcgtgt
     2221 ggggctgatg tgaatgcgca ggatgcggat ggggccacag cgctgatgtg tgccagtgag
     2281 tatgggcgcc tggacaccgt gcggctgctg ctcacccagc caggctgtga ccctgccatc
     2341 ctggacaatg agggcaccag tgccctggcc atcgccctgg aggctgagca ggatgaggtg
     2401 gccgctctgc tacatgccca cctgagctcg ggccagcccg acacccagag cgagtcaccc
     2461 cctggctccc agacagccac acctggtgaa ggagaatgcg gtgacaatgg agagaacccc
     2521 caggttcagt aagctgcctc gtctggctca ctacacctag ctgtggggag atctcctcgt
     2581 cagtcacctc agcctttggc gcacagaagg gtccagggtc ccctgctcag aggctaacac
     2641 tggccgaaga gaaaggcaat ttcagttggg gtgactgtgg caggaagggg ctcactctgg
     2701 ccccaccaag gtgaggtggg gaccaagtga tagagccctg atccacccac tctctgaaac
     2761 ttctttgcta ataaaacatt cctacta
//
