LOCUS       NM_001136191            5183 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens KN motif and ankyrin repeat domains 2 (KANK2),
            transcript variant 2, mRNA.
ACCESSION   NM_001136191 XM_005259850
VERSION     NM_001136191.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5183)
  AUTHORS   Loncaric,M., Stojanovic,N., Rac-Justament,A., Coopmans,K.,
            Majhen,D., Humphries,J.D., Humphries,M.J. and Ambriovic-Ristov,A.
  TITLE     Talin2 and KANK2 functionally interact to regulate microtubule
            dynamics, paclitaxel sensitivity and cell migration in the
            MDA-MB-435S melanoma cell line
  JOURNAL   Cell Mol Biol Lett 28 (1), 56 (2023)
   PUBMED   37460977
  REMARK    GeneRIF: Talin2 and KANK2 functionally interact to regulate
            microtubule dynamics, paclitaxel sensitivity and cell migration in
            the MDA-MB-435S melanoma cell line.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5183)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5183)
  AUTHORS   Xu,Y., Guo,C., Pan,W., Zhao,C., Ding,Y., Xie,X., Wei,Z., Sun,Y. and
            Yu,C.
  TITLE     Nephrotic-syndrome-associated mutation of KANK2 induces pathologic
            binding competition with physiological interactor KIF21A
  JOURNAL   J Biol Chem 297 (2), 100958 (2021)
   PUBMED   34274317
  REMARK    GeneRIF: Nephrotic-syndrome-associated mutation of KANK2 induces
            pathologic binding competition with physiological interactor
            KIF21A.
REFERENCE   4  (bases 1 to 5183)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5183)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5183)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 5183)
  AUTHORS   Kakinuma,N., Zhu,Y., Wang,Y., Roy,B.C. and Kiyama,R.
  TITLE     Kank proteins: structure, functions and diseases
  JOURNAL   Cell Mol Life Sci 66 (16), 2651-2659 (2009)
   PUBMED   19554261
  REMARK    Review article
REFERENCE   8  (bases 1 to 5183)
  AUTHORS   Zhu,Y., Kakinuma,N., Wang,Y. and Kiyama,R.
  TITLE     Kank proteins: a new family of ankyrin-repeat domain-containing
            proteins
  JOURNAL   Biochim Biophys Acta 1780 (2), 128-133 (2008)
   PUBMED   17996375
REFERENCE   9  (bases 1 to 5183)
  AUTHORS   Zhang,Y., Zhang,H., Liang,J., Yu,W. and Shang,Y.
  TITLE     SIP, a novel ankyrin repeat containing protein, sequesters steroid
            receptor coactivators in the cytoplasm
  JOURNAL   EMBO J 26 (11), 2645-2657 (2007)
   PUBMED   17476305
  REMARK    GeneRIF: SIP, a novel ankyrin repeat containing protein, sequesters
            steroid receptor coactivators in the cytoplasm.
REFERENCE   10 (bases 1 to 5183)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009000.6 and AC011485.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001136191.2.
            
            Summary: This gene encodes a member of the KN motif and ankyrin
            repeat domains (KANK) family of proteins, which play a role in
            cytoskeletal formation by regulating actin polymerization. The
            encoded protein functions in the sequestration of steroid receptor
            coactivators and possibly other proteins. Mutations in this gene
            are associated with impaired kidney podocyte function and nephrotic
            syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.145010.1, BC082762.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000586659.6/ ENSP00000465650.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC009000.6         8027-8087
            62-260              AC009000.6         9752-9950
            261-376             AC009000.6         10982-11097
            377-1588            AC009000.6         11530-12741
            1589-1756           AC011485.6         1190-1357
            1757-1859           AC011485.6         1463-1565
            1860-2099           AC011485.6         3093-3332
            2100-2187           AC011485.6         3921-4008
            2188-2407           AC011485.6         5218-5437
            2408-2550           AC011485.6         6787-6929
            2551-2751           AC011485.6         9662-9862
            2752-2841           AC011485.6         9944-10033
            2842-5183           AC011485.6         13299-15640
FEATURES             Location/Qualifiers
     source          1..5183
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..5183
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /note="KN motif and ankyrin repeat domains 2"
                     /db_xref="GeneID:25959"
                     /db_xref="HGNC:HGNC:29300"
                     /db_xref="MIM:614610"
     exon            1..61
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            62..260
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            261..376
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..2895
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /note="isoform 2 is encoded by transcript variant 2; KN
                     motif and ankyrin repeat domain-containing protein 2;
                     kidney ankyrin repeat-containing protein 2;
                     SRC1-interacting protein; matrix-remodeling-associated
                     protein 3; ankyrin repeat domain-containing protein 25;
                     SRC-interacting protein; steroid receptor coactivator
                     interacting protein"
                     /codon_start=1
                     /product="KN motif and ankyrin repeat domain-containing
                     protein 2 isoform 2"
                     /protein_id="NP_001129663.1"
                     /db_xref="CCDS:CCDS12255.1"
                     /db_xref="GeneID:25959"
                     /db_xref="HGNC:HGNC:29300"
                     /db_xref="MIM:614610"
                     /translation="MAQVLHVPAPFPGTPGPASPPAFPAKDPDPPYSVETPYGYRLDL
                     DFLKYVDDIEKGHTLRRVAVQRRPRLSSLPRGPGSWWTSTESLCSNASGDSRHSAYSY
                     CGRGFYPQYGALETRGGFNPRVERTLLDARRRLEDQAATPTGLGSLTPSAAGSTASLV
                     GVGLPPPTPRSSGLSTPVPPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSV
                     LQEEKRQLTVQLKSQKFLGHPTAGRGRSELCLDLPDPPEDPVALETRSVGTWVRERDL
                     GMPDGEAALAAKVAVLETQLKKALQELQAAQARQADPQPQAWPPPDSPVRVDTVRVVE
                     GPREVEVVASTAAGAPAQRAQSLEPYGTGLRALAMPGRPESPPVFRSQEVVETMCPVP
                     AAATSNVHMVKKISITERSCDGAAGLPEVPAESSSSPPGSEVASLTQPEKSTGRVPTQ
                     EPTHREPTRQAASQESEEAGGTGGPPAGVRSIMKRKEEVADPTAHRRSLQFVGVNGGY
                     ESSSEDSSTAENISDNDSTENEAPEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSR
                     ESQHIPTAEGASGSNTEEEIRMELSPDLISACLALEKYLDNPNALTERELKVAYTTVL
                     QEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPV
                     VQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGNINAKASQAGQ
                     TALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCD
                     ISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDDESPTSSSAEE"
     exon            377..1588
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1756
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1859
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2099
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2187
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2407
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2550
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2751
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2841
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..5183
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5161..5166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /note="hexamer: AATAAA"
     polyA_site      5183
                     /gene="KANK2"
                     /gene_synonym="ANKRD25; MXRA3; NPHS16; PPKWH; SIP"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgcgcg aagacgctcg ggcggcggga cccagggaag gcagcggccg gagcgcgcaa
       61 ggtgttgaaa gacagagaag cgaagacaga gacgtggaaa gacagggaga gagacacgga
      121 gagagacgca gaaggacaga gacgtggaga gagacgcaga gagacagaga cgtggagaga
      181 cacagagaga cgtggagaga cacagagaga cttggagaga gacaaagcaa gacaggacgg
      241 gagaacaagg acaagctcag gtaagcctca gccggtgctg caggcagtct gactcgcagt
      301 ccctcaagtg acttccaagg agcatctgta gaaaagaaga tggcccaggt cctgcacgtg
      361 cctgctccct tcccagggac ccctggccca gcctccccac ctgccttccc tgccaaggac
      421 cccgatccac cctactccgt ggagaccccc tatggctacc gcctggacct ggacttcctc
      481 aagtacgtgg atgacatcga gaagggccac acgctgcgac gcgtggcagt gcagcgccgc
      541 ccccgcctga gctcgctgcc ccgtggccct ggctcctggt ggacgtccac tgagtcgctg
      601 tgctccaatg ccagtgggga cagccgccac tcagcctatt cctactgcgg ccgtggcttc
      661 taccctcagt atggtgctct ggagacccgc ggtggcttca atccgcgggt ggagcgcacg
      721 ctgctggatg cccgtcgccg tctcgaggac caggcggcca cacccaccgg cctgggctcc
      781 ctgaccccca gtgcggccgg ctcgacagcc tccctggtgg gcgtggggtt gccacccccg
      841 acaccacgga gttcaggact gtccacaccg gtgcctccca gtgccgggca cctggcccac
      901 gtgcgggagc agatggcggg tgccctgcgg aagctgcggc agctggagga gcaggtgaag
      961 ctgatccctg tgctccaggt gaagctctcg gtgctccagg aggaaaagcg gcagctcaca
     1021 gtacaactta agagccagaa gttcctgggc caccccacag cgggccgggg tcgcagcgag
     1081 ctctgcctgg acctccccga tcccccagag gacccagtgg cactggagac ccggagtgtg
     1141 ggcacctggg ttcgagaacg ggacttgggc atgcctgatg gggaggctgc cctcgccgcc
     1201 aaggtcgctg tgctggagac ccagctcaag aaggcgctgc aggagctgca ggcagctcag
     1261 gcccggcagg ctgaccccca gccccaggcc tggccaccgc cggacagccc ggtccgcgtg
     1321 gatacagtcc gggtggtaga agggccacgg gaggtggagg tggtggccag cacagccgct
     1381 ggcgcccccg cacagcgggc ccagagcctg gagccttacg gcacagggct gagggccctg
     1441 gcaatgcctg gtaggcctga gagcccacct gtgttccgca gccaggaggt ggtggagaca
     1501 atgtgcccag tgcccgctgc agctaccagc aacgtccata tggtgaagaa gattagcatc
     1561 acagagcgaa gctgcgatgg agcagcaggc ctcccagaag ttcctgccga atcgtcttcg
     1621 tcacccccgg ggtccgaggt agcctccctt acacagcctg agaagagcac aggccgagtg
     1681 cccacccagg agcccaccca cagggagccc accaggcaag cagcctccca agagtccgag
     1741 gaggccgggg gcaccggcgg gcccccggca ggcgtgcgat ctatcatgaa acggaaagag
     1801 gaggttgcag accccacggc ccaccggagg agcctccagt tcgtgggggt caacggcggg
     1861 tatgagtcgt catccgagga ctccagcaca gcagagaaca tctcagacaa cgacagcaca
     1921 gagaacgagg ccccagagcc gagggagagg gttccgagtg tggccgaagc cccccagctc
     1981 aggcctgcag ggacggcagc ggccaagacc agccggcagg agtgtcagct gtctcgagaa
     2041 tctcagcaca tacccactgc tgagggggca tcaggatcaa acacggagga ggagatcagg
     2101 atggagctaa gccctgacct catctcagcc tgcttggccc tggaaaagta cctggacaat
     2161 cccaacgccc tcacagagcg ggagctgaaa gtggcctaca ccacagtgct gcaggagtgg
     2221 ctgcgcctgg cctgccgcag cgacgcacac cccgagctgg tgcggcggca cctggtcacg
     2281 ttccgggcca tgtctgcgcg gctgctggac tacgtggtca acatcgccga cagcaacggc
     2341 aacacagccc tgcactactc cgtgtctcat gccaacttcc ccgtggtgca gcagctgctc
     2401 gacagcggtg tctgcaaggt ggacaaacag aaccgtgctg gctacagccc tattatgctc
     2461 accgccctgg ccaccctgaa gacccaggac gacatcgaga ctgtccttca gctcttccgg
     2521 cttggcaaca tcaatgccaa agccagccag gcaggacaga cggccctgat gctggccgtc
     2581 agccacgggc gggtggacgt tgtcaaagcc ctgctggcct gtgaggcaga tgtcaacgtg
     2641 caagatgatg acggctccac ggccctcatg tgcgcctgtg agcacggcca caaggagatc
     2701 gcggggctgc tgctggccgt gcccagctgt gacatctcac tcacagatcg cgatgggagc
     2761 acagctctga tggtggcctt ggacgcaggg cagagtgaga ttgcgtccat gctgtattcc
     2821 cgcatgaaca tcaagtgctc gtttgcccca atgtcagatg acgagagccc tacatcatcc
     2881 tcggcagaag agtagccgtg agggaggcgg ggaccagcca gaccgggagc aaaccgtccc
     2941 ttgtccccgt ctcctccctg ttcccgttcc tccctggccc accccactca cactccccaa
     3001 ggcccacggc tcaaaggcaa gcgagctctc cctctgcttc cctgggggag ccccgacggc
     3061 cacaggactc cagctccaag tgggttttct tggctcccct gttcaaagtg gccacagcgc
     3121 agaccgaagc aaaattcttg tatacattgg cgccagggct gatgctgggg tgtgggtttt
     3181 atgaagaaca ttgagaacaa tcagctggta attatggatg gaggaagagg gagaggaaaa
     3241 aaatattgta tttttgaatc attgttgcag gagggggtgg gaatcttagg atttgttgcc
     3301 agatttgaaa gtcactggaa cttgcatatt ttcattttaa tcctaagtgt tattacgcac
     3361 cagttggggt tcacccttca tcccccacat ttaattgtct gatatagaat agtgttgtgt
     3421 ccactgcccc gctagacggc tttcttaggg gaattttctt ctggttgttt cacaagacag
     3481 attctgtcct tgtcacccgg gacagaaaac tcagtctttt caccctcatt cagatgaagg
     3541 gactcaggac aggctctgtg acttacaggg acccaatcaa ttcacaatga gaaattaccg
     3601 gccaggcgtg gtgactcacg tctgtaatcc cagcactttg ggagggcaag gcaagagctt
     3661 gagcttgagc ctagacgtta aagaccagcc tgggcaacac agcaagaccc atctctacaa
     3721 gaaatttaaa aactagccag gcgtggtggt gcgcgcctgt agtcccagct acttgggagg
     3781 ctgagccctg gaggtcgagg ctacagtgag ctatgatcac accattgcac ttcagcctgg
     3841 gcgacacagc gagaccctgt ctcaagaaag aaaagaaaaa gagacaaatt acccagaaac
     3901 ccctcccttc cccacatgga ggccttggca aatgttaatt ttcctagaaa atccttcaga
     3961 cctgaagacg caggaaaaga atctggctct cagggtggct tctgcgtccc cgccgccagg
     4021 ccccagacta tggtcacagg gccgtcctgt tcctccccgg gactccagaa tttctctcct
     4081 caaaggaaag aaaacagggc atgcgcttgt tggcaaaacg cagggccggc tcccaaaaac
     4141 cccatgtgtg tacgattaaa agttggccgt ccccaggcct cccagcgcaa acttcaagag
     4201 acagggcttt gctgaaaacc aaacatgggc cagctgggct ttttaacaac ctagagactt
     4261 tccggagctg cctggaacag agcctgcggg aaacggggct tgccagagac actcacagtt
     4321 tccttcatgg cctgttttgg tcccctaaga atctccacat cattgtcttt cttgtgcctt
     4381 ttccttggtg agcaacagaa agggaagggt tccaagcctc taaaaatgtg ctttgtgatc
     4441 aggagtgcgc tccaaaccaa atacgcgcgc tgccctttcg aggccagtga gctcagcctc
     4501 caaggcttta aagccacatt tcagcaagag aaagcgctga gagctcgcag gttcattaaa
     4561 gaaggcaaag cactggtttc tctccttaga aaagtaggtt tcttggcttg atgtagactg
     4621 gcttgctttg atttttagtg aagggaatgt acgtaaaaca aaatagggct tggctggtca
     4681 aaggagacaa gcaggatgga tggatggatg gatggatgga tggatggatg gatggatgga
     4741 tgaatagata gatggtgttt gcatgtaaat tgcagagaaa acaaaaccaa agctgattgg
     4801 aaacaattaa ttgtgggtgt ctgaggggga aggtcgcagc tttgggcagc tttgagaagc
     4861 ggtacaagag ttctgtgcct gtgtgtccag ccctggagcc agccagtgca tttattttaa
     4921 gctcttagaa gcaactcctt ggcccaggaa tgcgtgaccc ctgagatggg tccacgcatc
     4981 tctctacact tccttctctc cgtgggatac tggactcgtg cctctgcgcc cattctcttc
     5041 tcacgcatat ccatgagctt taatttcact ttctgatcac ggtacgtcca taaagccagt
     5101 attacactta aatgaagtat tcttttttgt aatcgttttt tttagaaggt aaacaaattt
     5161 aataaagcta ccaataatgt tga
//
