LOCUS       NM_015158               5070 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens KN motif and ankyrin repeat domains 1 (KANK1),
            transcript variant 1, mRNA.
ACCESSION   NM_015158
VERSION     NM_015158.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5070)
  AUTHORS   Qin,C., Zhang,H., Guo,X., Cheng,A., Liu,H. and Wang,Z.
  TITLE     Identification and Characterization of the Roles of circCASP9 in
            Gastric Cancer Based on a circRNA-miRNA-mRNA Regulatory Network
  JOURNAL   Oxid Med Cell Longev 2022, 9416825 (2022)
   PUBMED   35320976
  REMARK    GeneRIF: Identification and Characterization of the Roles of
            circCASP9 in Gastric Cancer Based on a circRNA-miRNA-mRNA
            Regulatory Network.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5070)
  AUTHORS   Li,M., Wu,W., Deng,S., Shao,Z. and Jin,X.
  TITLE     TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and
            proliferation of osteosarcoma by promoting KANK1 degradation
  JOURNAL   Cell Death Dis 12 (8), 767 (2021)
   PUBMED   34349117
  REMARK    GeneRIF: TRAIP modulates the IGFBP3/AKT pathway to enhance the
            invasion and proliferation of osteosarcoma by promoting KANK1
            degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5070)
  AUTHORS   Tadijan,A., Samarzija,I., Humphries,J.D., Humphries,M.J. and
            Ambriovic-Ristov,A.
  TITLE     KANK family proteins in cancer
  JOURNAL   Int J Biochem Cell Biol 131, 105903 (2021)
   PUBMED   33309958
  REMARK    GeneRIF: KANK family proteins in cancer.
            Review article
REFERENCE   4  (bases 1 to 5070)
  AUTHORS   Catic,A., Kurtovic-Kozaric,A., Sophian,A., Mazur,L., Skenderi,F.,
            Hes,O., Rohan,S., Rakheja,D., Kogan,J. and Pins,M.R.
  TITLE     KANK1-NTRK3 fusions define a subset of BRAF mutation negative renal
            metanephric adenomas
  JOURNAL   BMC Med Genet 21 (1), 202 (2020)
   PUBMED   33046021
  REMARK    GeneRIF: KANK1-NTRK3 fusions define a subset of BRAF mutation
            negative renal metanephric adenomas.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5070)
  AUTHORS   Medves,S., Duhoux,F.P., Ferrant,A., Toffalini,F., Ameye,G.,
            Libouton,J.M., Poirel,H.A. and Demoulin,J.B.
  TITLE     KANK1, a candidate tumor suppressor gene, is fused to PDGFRB in an
            imatinib-responsive myeloid neoplasm with severe thrombocythemia
  JOURNAL   Leukemia 24 (5), 1052-1055 (2010)
   PUBMED   20164854
  REMARK    GeneRIF: KANK1, a candidate tumor suppressor gene, is fused to
            PDGFRB in an imatinib-responsive myeloid neoplasm with severe
            thrombocythemia.
REFERENCE   6  (bases 1 to 5070)
  AUTHORS   Zhu,Y., Kakinuma,N., Wang,Y. and Kiyama,R.
  TITLE     Kank proteins: a new family of ankyrin-repeat domain-containing
            proteins
  JOURNAL   Biochim Biophys Acta 1780 (2), 128-133 (2008)
   PUBMED   17996375
REFERENCE   7  (bases 1 to 5070)
  AUTHORS   Wang,Y., Kakinuma,N., Zhu,Y. and Kiyama,R.
  TITLE     Nucleo-cytoplasmic shuttling of human Kank protein accompanies
            intracellular translocation of beta-catenin
  JOURNAL   J Cell Sci 119 (Pt 19), 4002-4010 (2006)
   PUBMED   16968744
  REMARK    GeneRIF: Kank can bind to beta-catenin and regulate the subcellular
            distribution of beta-catenin.
REFERENCE   8  (bases 1 to 5070)
  AUTHORS   Wang,Y., Onishi,Y., Kakinuma,N., Roy,B.C., Aoyagi,T. and Kiyama,R.
  TITLE     Alternative splicing of the human Kank gene produces two types of
            Kank protein
  JOURNAL   Biochem Biophys Res Commun 330 (4), 1247-1253 (2005)
   PUBMED   15823577
  REMARK    GeneRIF: Human Kank gene has several alternative first exons.
REFERENCE   9  (bases 1 to 5070)
  AUTHORS   Roy,B.C., Aoyagi,T., Sarkar,S., Nomura,K., Kanda,H., Iwaya,K.,
            Tachibana,M. and Kiyama,R.
  TITLE     Pathological characterization of Kank in renal cell carcinoma
  JOURNAL   Exp Mol Pathol 78 (1), 41-48 (2005)
   PUBMED   15596059
REFERENCE   10 (bases 1 to 5070)
  AUTHORS   Sarkar,S., Roy,B.C., Hatano,N., Aoyagi,T., Gohji,K. and Kiyama,R.
  TITLE     A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a
            growth suppressor of renal cell carcinoma
  JOURNAL   J Biol Chem 277 (39), 36585-36591 (2002)
   PUBMED   12133830
  REMARK    GeneRIF: Kank is localized to 9p24 and plays a role in cell growth
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161725.13 and AL136979.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 12, 2019 this sequence version replaced NM_015158.4.
            
            Summary: The protein encoded by this gene belongs to the Kank
            family of proteins, which contain multiple ankyrin repeat domains.
            This family member functions in cytoskeleton formation by
            regulating actin polymerization. This gene is a candidate tumor
            suppressor for renal cell carcinoma. Mutations in this gene cause
            cerebral palsy spastic quadriplegic type 2, a central nervous
            system development disorder. A t(5;9) translocation results in
            fusion of the platelet-derived growth factor receptor beta gene
            (PDGFRB) on chromosome 5 with this gene in a myeloproliferative
            neoplasm featuring severe thrombocythemia. Alternative splicing of
            this gene results in multiple transcript variants. A related
            pseudogene has been identified on chromosome 20. [provided by
            RefSeq, Dec 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.28357.1, AL833161.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382297.7/ ENSP00000371734.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AL161725.13        138558-138617
            61-180              AL136979.16        51743-51862
            181-2841            AL136979.16        85657-88317
            2842-3039           AL136979.16        104904-105101
            3040-3148           AL136979.16        106011-106119
            3149-3388           AL136979.16        107231-107470
            3389-3476           AL136979.16        109601-109688
            3477-3696           AL136979.16        113138-113357
            3697-3839           AL136979.16        115645-115787
            3840-4040           AL136979.16        117058-117258
            4041-4139           AL136979.16        119344-119442
            4140-5070           AL136979.16        120026-120956
FEATURES             Location/Qualifiers
     source          1..5070
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.3"
     gene            1..5070
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /note="KN motif and ankyrin repeat domains 1"
                     /db_xref="GeneID:23189"
                     /db_xref="HGNC:HGNC:19309"
                     /db_xref="MIM:607704"
     exon            1..60
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /inference="alignment:Splign:2.1.0"
     exon            61..180
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..4202
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /note="isoform L is encoded by transcript variant 1;
                     kidney ankyrin repeat-containing protein; ankyrin repeat
                     domain-containing protein 15"
                     /codon_start=1
                     /product="KN motif and ankyrin repeat domain-containing
                     protein 1 isoform L"
                     /protein_id="NP_055973.2"
                     /db_xref="CCDS:CCDS34976.1"
                     /db_xref="GeneID:23189"
                     /db_xref="HGNC:HGNC:19309"
                     /db_xref="MIM:607704"
                     /translation="MAHTTKVNGSASGKAGDILSGDQDKEQKDPYFVETPYGYQLDLD
                     FLKYVDDIQKGNTIKRLNIQKRRKPSVPCPEPRTTSGQQGIWTSTESLSSSNSDDNKQ
                     CPNFLIARSQVTSTPISKPPPPLETSLPFLTIPENRQLPPPSPQLPKHNLHVTKTLME
                     TRRRLEQERATMQMTPGEFRRPRLASFGGMGTTSSLPSFVGSGNHNPAKHQLQNGYQG
                     NGDYGSYAPAAPTTSSMGSSIRHSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKE
                     LEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCGVRKRSYSAGNASQLEQ
                     LSRARRSGGELYIDYEEEEMETVEQSTQRIKEFRQLTADMQALEQKIQDSSCEASSEL
                     RENGECRSVAVGAEENMNDIVVYHRGSRSCKDAAVGTLVEMRNCGVSVTEAMLGVMTE
                     ADKEIELQQQTIESLKEKIYRLEVQLRETTHDREMTKLKQELQAAGSRKKVDKATMAQ
                     PLVFSKVVEAVVQTRDQMVGSHMDLVDTCVGTSVETNSVGISCQPECKNKVVGPELPM
                     NWWIVKERVEMHDRCAGRSVEMCDKSVSVEVSVCETGSNTEESVNDLTLLKTNLNLKE
                     VRSIGCGDCSVDVTVCSPKECASRGVNTEAVSQVEAAVMAVPRTADQDTSTDLEQVHQ
                     FTNTETATLIESCTNTCLSTLDKQTSTQTVETRTVAVGEGRVKDINSSTKTRSIGVGT
                     LLSGHSGFDRPSAVKTKESGVGQININDNYLVGLKMRTIACGPPQLTVGLTASRRSVG
                     VGDDPVGESLENPQPQAPLGMMTGLDHYIERIQKLLAEQQTLLAENYSELAEAFGEPH
                     SQMGSLNSQLISTLSSINSVMKSASTEELRNPDFQKTSLGKITGNYLGYTCKCGGLQS
                     GSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACTNNES
                     TLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEY
                     PLEEEEEEEDEDTRGMAEGHHAVNIEGLKSARVEDEMQVQECEPEKVEIRERYELSEK
                     MLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAI
                     SPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAA
                     LAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNI
                     QDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL
                     YAHVNFAKAQSPGTPRLGRKTSPGPTHRGSFD"
     exon            181..2841
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..3039
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3148
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /inference="alignment:Splign:2.1.0"
     exon            3149..3388
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3476
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3696
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..3839
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /inference="alignment:Splign:2.1.0"
     exon            3840..4040
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /inference="alignment:Splign:2.1.0"
     exon            4041..4139
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /inference="alignment:Splign:2.1.0"
     exon            4140..5070
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5050..5055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /note="hexamer: AATAAA"
     polyA_site      5070
                     /gene="KANK1"
                     /gene_synonym="ANKRD15; CPSQ2; KANK"
                     /note="major polyA site"
ORIGIN      
        1 gagctccggg tccgcggcgg agcgagcgag cggccggcag gttgggagga gcggccgaag
       61 gttgaatgcc tttgagaact tgatgcataa aatttgcatg actcctcact cctttctgga
      121 tctctcattg gactcaagcc agcatggctc acaccacaaa ggttaacggc agtgcctcag
      181 gaaaagcagg tgatattctc agtggagacc aggacaagga acagaaagac ccttactttg
      241 tggagacccc ctatggttat caactagact tagatttcct caaatatgtg gatgacatac
      301 agaagggaaa taccatcaaa agactgaaca tccagaagag gcggaagccg tccgtgccat
      361 gcccagaacc caggaccaca tctggtcagc aaggtatatg gacttccact gaatccctct
      421 catcctccaa cagtgatgac aacaagcagt gccccaactt cctcatagcc agaagtcaag
      481 ttacatcaac tccaatctca aagccacctc cccctctgga gacctcactc ccttttctta
      541 ccatcccaga aaatcgacag ctgccacctc cctcaccaca actcccaaag cataaccttc
      601 atgtcaccaa gacactgatg gagacccgga gaagactgga acaggagaga gccaccatgc
      661 agatgacacc gggtgagttc agaaggccca ggctggccag ttttggaggc atgggcacca
      721 caagctccct cccttctttt gtgggttctg gaaaccacaa tcctgccaag caccagcttc
      781 agaatggata ccaaggtaat ggggattatg gtagctatgc cccagctgct cccaccactt
      841 cctccatggg gagctccatc cgccacagcc ccctgagctc agggatctcc accccagtga
      901 ccaacgtgag ccccatgcac ctgcagcaca tccgcgagca gatggccatt gctctgaaac
      961 gcctgaagga gctggaggag caggtgcgaa ccatccctgt gctccaggta aagatctctg
     1021 tcttgcaaga agagaaaagg cagttggtct cacagctgaa aaaccaaagg gctgcatccc
     1081 agatcaatgt ctgtggtgtg aggaagcggt cctatagtgc ggggaacgcc tcccagctgg
     1141 aacagctctc ccgggcccga agaagtggcg gggaattata cattgactat gaggaggaag
     1201 aaatggagac cgtagaacag agcacgcaga ggataaagga gttccggcaa cttacagcag
     1261 acatgcaagc cctggagcag aagatccagg acagcagctg tgaggcctcc tcagagctca
     1321 gggagaatgg agagtgccgg tctgtggctg tgggtgccga ggagaacatg aacgacatcg
     1381 tcgtgtacca cagaggctcc aggtcctgta aggatgcagc tgtagggaca cttgttgaga
     1441 tgagaaattg tggggtcagc gtgacagagg ccatgcttgg agtgatgact gaagctgaca
     1501 aagaaattga gctgcaacag cagaccatag aatccttgaa ggaaaagatc tatcgcctag
     1561 aagtacagct tagagaaacc acccatgacc gggagatgac taaactgaaa caagagctgc
     1621 aggctgctgg atcgaggaaa aaggttgaca aagccacgat ggcccagccg cttgttttca
     1681 gtaaggtggt ggaggcagtg gtgcagacca gagaccaaat ggtcggcagt cacatggacc
     1741 tggtggacac gtgtgttggg acctccgtgg aaacaaacag tgtaggcatc tcctgccagc
     1801 ctgaatgtaa gaataaagtc gtagggcctg agctgcctat gaattggtgg attgttaagg
     1861 agagggtgga aatgcatgac cgatgtgctg ggaggtctgt ggaaatgtgt gacaagagtg
     1921 tgagtgtgga agtcagcgtc tgcgaaacag gcagcaacac agaggagtct gtgaacgacc
     1981 tcacactcct caagacaaac ttgaatctca aagaagtgcg gtctatcggt tgtggagatt
     2041 gttctgttga cgtgaccgtc tgctctccaa aggagtgcgc ctcccggggc gtgaacactg
     2101 aggctgttag ccaggtggaa gctgccgtca tggcagtgcc tcgtactgca gaccaggaca
     2161 ctagcacaga tttggaacag gtgcaccagt tcaccaacac cgagacggcc accctcatag
     2221 agtcctgcac caacacttgt ctaagcactt tggacaagca gaccagcacc cagactgtgg
     2281 agacgcggac agtagctgta ggagaaggcc gtgtcaagga catcaactcc tccaccaaga
     2341 cgcggtccat tggtgttgga acgttgcttt ctggccattc tgggtttgac aggccatcag
     2401 ctgtgaagac caaagagtca ggtgtggggc agataaatat taacgacaac tatctggttg
     2461 gtctcaaaat gaggactata gcttgtgggc caccacagtt gactgtgggg ctgacagcca
     2521 gcagaaggag cgtgggggtt ggggatgacc ctgtagggga atctctggag aacccccagc
     2581 ctcaagctcc acttggaatg atgactggcc tggatcacta cattgagcgt atccagaagc
     2641 tgctggcaga acagcagaca ctgctggctg agaactacag tgaactggca gaagctttcg
     2701 gggaacctca ctcacagatg ggctccctca actctcagct catcagcacc ctgtcgtcta
     2761 tcaactctgt catgaaatct gcaagcactg aagagctgag gaaccctgac ttccagaaaa
     2821 ccagtctggg taaaatcaca ggcaattatt tgggatatac ctgtaagtgt gggggccttc
     2881 agtcaggaag tcccttaagc tcccagacat cccagcctga gcaagaagtg gggacctcag
     2941 aaggaaagcc aatcagcagc ctggatgcct tccccactca ggaaggtacg ctgtctccag
     3001 tgaacctgac agacgaccag atcgccgctg gcctctatgc atgtacaaac aatgaaagta
     3061 cactgaagtc catcatgaag aagaaagatg gtaacaaaga ttcaaatggc gcaaaaaaga
     3121 atcttcagtt tgttggcatt aatggagggt atgaaacaac ttcaagtgat gattccagct
     3181 cagatgaaag ctcttcttcc gagtcagatg acgagtgtga tgtcattgag tatcctcttg
     3241 aagaagagga ggaggaggag gatgaagaca ctcggggaat ggcagaaggg caccatgcag
     3301 ttaatattga aggtttgaag tctgccaggg tggaagatga aatgcaggtt caagaatgtg
     3361 aacctgagaa ggtggaaatc agagagaggt atgaattaag tgaaaagatg ttgtctgcat
     3421 gcaacttact gaaaaatact ataaatgacc ccaaagcttt gaccagcaaa gatatgaggt
     3481 tctgtctgaa caccctccag cacgagtggt tccgcgtgtc cagtcagaag tcagccattc
     3541 cagccatggt gggggactac atagctgctt ttgaggccat ttccccagat gtcctccgct
     3601 atgtcatcaa cttggcagac ggcaacggca acacagccct ccattacagc gtgtcccact
     3661 ccaacttcga gattgtgaag ctgctgttag atgccgatgt gtgtaatgtg gatcaccaga
     3721 acaaggcagg ctacaccccc atcatgttgg cggccctcgc cgctgtggaa gcagagaagg
     3781 acatgcggat tgtggaagaa ctcttcggct gtggggatgt gaatgccaaa gctagtcagg
     3841 cgggacagac ggccctcatg ctggcggtca gtcacggacg gatagacatg gtgaagggcc
     3901 ttctggcctg tggggctgat gtcaacatcc aggatgacga gggctccacg gccctcatgt
     3961 gtgccagcga gcacggacac gtggagattg tcaagctgct gctggcccag cccggctgca
     4021 acggtcacct agaggacaac gatggcagca ctgcgctctc aatcgccctg gaagcaggac
     4081 acaaggacat cgctgttctt ctgtatgccc atgtcaactt tgcaaaagcc cagtctccgg
     4141 gcacccctag gcttggaagg aagacgtctc ctggccccac ccaccgaggt tcatttgatt
     4201 gattgtatgc aaatagccct ttatttacat gccactatta agctgctaat tgttcctgtt
     4261 ggggtgacag atactgaatg tatacgtatt gtgcctgagc tcaccagcaa acagaagcat
     4321 caagcccagg ggtaaaggct gaagctttca cagtgcagag actgctagcc tgggcacaca
     4381 cacctccttt ctggccgtct tctgtgtagg gcacacttta acccagtctc tgttgctgtt
     4441 gagtctctgc tccgttttgt acagtcacag ggaattctga tctgaagggg caccttctgt
     4501 tcactcccac aaagtggtgt ctggttctca ctgagacgtt ttaagatttt tccacaaata
     4561 tttatatgta ctaaatgtgg aaccattaga aagttcttcc aaaatctcat tccagcatag
     4621 ttttggattt ttcttttgtc ttattttaaa ataaggaagt cgagatgact ttgatcattg
     4681 gtaacttggg cctgggccag acaaagtata aaacttacaa aagaatattc tcatttggtc
     4741 ttaactaggt agatgtaata tatgactttt tataaaaagg gtatctatat gaacttgaca
     4801 cagtattttc agcttttgta ttccatacta aagccatgaa gaactacacg taacatcatc
     4861 atttgtatta attgcacaac tccaatgcta aaggttggat tgtgttagag gaatcggctc
     4921 tgtatttgcc tctagagaaa cacagtgttc tctttgtatt tatggattcc tttttaccgt
     4981 gtcacattta ctttggtcct ctatgtattt aaatgtttga agtgccttag actcttgcca
     5041 tattttcaaa ataaaattcc attaagctct
//
