LOCUS       NM_001388419           16188 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens kalirin RhoGEF kinase (KALRN), transcript variant 28,
            mRNA.
ACCESSION   NM_001388419
VERSION     NM_001388419.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 16188)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 16188)
  AUTHORS   Afanasyeva,E.A., Gartlgruber,M., Ryl,T., Decaesteker,B.,
            Denecker,G., Monke,G., Toprak,U.H., Florez,A., Torkov,A.,
            Dreidax,D., Herrmann,C., Okonechnikov,K., Ek,S., Sharma,A.K.,
            Sagulenko,V., Speleman,F., Henrich,K.O. and Westermann,F.
  TITLE     Kalirin-RAC controls nucleokinetic migration in ADRN-type
            neuroblastoma
  JOURNAL   Life Sci Alliance 4 (5), e201900332 (2021)
   PUBMED   33658318
  REMARK    GeneRIF: Kalirin-RAC controls nucleokinetic migration in ADRN-type
            neuroblastoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 16188)
  AUTHORS   Li,M., Ma,Y., Zhong,Y., Liu,Q., Chen,C., Qiang,L. and Wang,X.
  TITLE     KALRN mutations promote antitumor immunity and immunotherapy
            response in cancer
  JOURNAL   J Immunother Cancer 8 (2) (2020)
   PUBMED   33037113
  REMARK    GeneRIF: KALRN mutations promote antitumor immunity and
            immunotherapy response in cancer.
REFERENCE   4  (bases 1 to 16188)
  AUTHORS   Paskus,J.D., Tian,C., Fingleton,E., Shen,C., Chen,X., Li,Y.,
            Myers,S.A., Badger,J.D. 2nd, Bemben,M.A., Herring,B.E. and
            Roche,K.W.
  TITLE     Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF
            Protein-Dependent Neuroligin-1 Mechanism of Action
  JOURNAL   Cell Rep 29 (10), 2944-2952 (2019)
   PUBMED   31801062
  REMARK    GeneRIF: Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF
            Protein-Dependent Neuroligin-1 Mechanism of Action.
REFERENCE   5  (bases 1 to 16188)
  AUTHORS   Dang,M., Song,Y., Li,Q., Zhang,C., Peng,Y., Wei,Z. and Huang,P.
  TITLE     Genetic Variation of the Kalirin Gene is Associated with ICAS in
            the Chinese Population
  JOURNAL   J Mol Neurosci 66 (2), 157-162 (2018)
   PUBMED   30232674
  REMARK    GeneRIF: SNPs of the KALRN gene are associated with intracranial
            atherosclerotic stenosis in the northern Chinese population.
REFERENCE   6  (bases 1 to 16188)
  AUTHORS   McPherson,C.E., Eipper,B.A. and Mains,R.E.
  TITLE     Genomic organization and differential expression of Kalirin
            isoforms
  JOURNAL   Gene 284 (1-2), 41-51 (2002)
   PUBMED   11891045
REFERENCE   7  (bases 1 to 16188)
  AUTHORS   Johnson,R.C., Penzes,P., Eipper,B.A. and Mains,R.E.
  TITLE     Isoforms of kalirin, a neuronal Dbl family member, generated
            through use of different 5'- and 3'-ends along with an internal
            translational initiation site
  JOURNAL   J Biol Chem 275 (25), 19324-19333 (2000)
   PUBMED   10777487
REFERENCE   8  (bases 1 to 16188)
  AUTHORS   Kawai,T., Sanjo,H. and Akira,S.
  TITLE     Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and
            Pleckstrin-Homology (PH) domains
  JOURNAL   Gene 227 (2), 249-255 (1999)
   PUBMED   10023074
REFERENCE   9  (bases 1 to 16188)
  AUTHORS   Colomer,V., Engelender,S., Sharp,A.H., Duan,K., Cooper,J.K.,
            Lanahan,A., Lyford,G., Worley,P. and Ross,C.A.
  TITLE     Huntingtin-associated protein 1 (HAP1) binds to a Trio-like
            polypeptide, with a rac1 guanine nucleotide exchange factor domain
  JOURNAL   Hum Mol Genet 6 (9), 1519-1525 (1997)
   PUBMED   9285789
REFERENCE   10 (bases 1 to 16188)
  AUTHORS   Alam,M.R., Johnson,R.C., Darlington,D.N., Hand,T.A., Mains,R.E. and
            Eipper,B.A.
  TITLE     Kalirin, a cytosolic protein with spectrin-like and GDP/GTP
            exchange factor-like domains that interacts with peptidylglycine
            alpha-amidating monooxygenase, an integral membrane
            peptide-processing enzyme
  JOURNAL   J Biol Chem 272 (19), 12667-12675 (1997)
   PUBMED   9139723
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC117381.5, AC117401.3,
            AC112129.4, AC069233.16, AC080008.23 and AC022336.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Huntington's disease (HD), a neurodegenerative disorder
            characterized by loss of striatal neurons, is caused by an
            expansion of a polyglutamine tract in the HD protein huntingtin.
            This gene encodes a protein that interacts with the
            huntingtin-associated protein 1, which is a huntingtin binding
            protein that may function in vesicle trafficking. [provided by
            RefSeq, Apr 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743,
                              SAMEA2151741 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682506.1/ ENSP00000508359.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               AC117381.5         202302-202746
            446-520             AC117401.3         4663-4737           c
            521-635             AC112129.4         127924-128038       c
            636-828             AC112129.4         98177-98369         c
            829-1341            AC112129.4         93612-94124         c
            1342-1464           AC112129.4         63954-64076         c
            1465-1656           AC112129.4         36696-36887         c
            1657-1788           AC112129.4         32875-33006         c
            1789-2019           AC112129.4         28372-28602         c
            2020-2142           AC112129.4         15602-15724         c
            2143-2334           AC069233.16        23983-24174
            2335-2543           AC069233.16        34273-34481
            2544-2718           AC069233.16        37835-38009
            2719-2914           AC069233.16        52608-52803
            2915-3081           AC069233.16        61950-62116
            3082-3201           AC069233.16        69794-69913
            3202-3420           AC069233.16        73445-73663
            3421-3570           AC069233.16        78026-78175
            3571-3685           AC069233.16        81083-81197
            3686-3801           AC069233.16        85299-85414
            3802-3924           AC069233.16        85901-86023
            3925-4107           AC069233.16        94315-94497
            4108-4226           AC069233.16        95748-95866
            4227-4293           AC069233.16        101028-101094
            4294-4403           AC069233.16        101662-101771
            4404-4473           AC069233.16        113801-113870
            4474-4563           AC069233.16        116383-116472
            4564-4656           AC069233.16        121946-122038
            4657-4768           AC069233.16        127342-127453
            4769-4959           AC069233.16        129832-130022
            4960-5061           AC069233.16        130461-130562
            5062-5204           AC069233.16        131878-132020
            5205-5307           AC069233.16        135449-135551
            5308-5554           AC080008.23        49781-50027
            5555-5838           AC080008.23        119358-119641
            5839-5940           AC080008.23        120790-120891
            5941-6036           AC080008.23        124146-124241
            6037-6167           AC080008.23        137746-137876
            6168-6234           AC080008.23        142539-142605
            6235-6338           AC080008.23        144386-144489
            6339-6408           AC080008.23        144672-144741
            6409-6495           AC080008.23        145369-145455
            6496-6588           AC080008.23        146303-146395
            6589-6639           AC080008.23        147861-147911
            6640-6717           AC080008.23        148789-148866
            6718-6903           AC080008.23        153387-153572
            6904-7075           AC080008.23        153950-154121
            7076-7314           AC080008.23        158598-158836
            7315-7565           AC080008.23        161302-161552
            7566-7689           AC080008.23        165128-165251
            7690-7749           AC080008.23        166396-166455
            7750-7777           AC080008.23        180742-180769
            7778-7949           AC080008.23        181270-181441
            7950-8071           AC080008.23        183072-183193
            8072-8203           AC080008.23        184531-184662
            8204-8368           AC080008.23        186807-186971
            8369-8447           AC080008.23        188976-189054
            8448-8648           AC022336.12        3995-4195
            8649-8787           AC022336.12        8307-8445
            8788-16188          AC022336.12        9985-17385
FEATURES             Location/Qualifiers
     source          1..16188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1-q21.2"
     gene            1..16188
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /note="kalirin RhoGEF kinase"
                     /db_xref="GeneID:8997"
                     /db_xref="HGNC:HGNC:4814"
                     /db_xref="MIM:604605"
     exon            1..445
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..9333
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /EC_number="2.7.11.1"
                     /note="isoform 25 is encoded by transcript variant 28;
                     huntingtin-associated protein interacting protein (duo);
                     serine/threonine-protein kinase with Dbl- and pleckstrin
                     homology domain"
                     /codon_start=1
                     /product="kalirin isoform 25"
                     /protein_id="NP_001375348.1"
                     /db_xref="CCDS:CCDS93359.1"
                     /db_xref="GeneID:8997"
                     /db_xref="HGNC:HGNC:4814"
                     /db_xref="MIM:604605"
                     /translation="MNPPEGAAEEGGAADSDVDAFFRTGSFRNDGLKASDVLPILKEK
                     VAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDM
                     RGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEG
                     LTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEF
                     PVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADF
                     QSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKEL
                     FLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIK
                     QISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQ
                     DLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQ
                     VLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHT
                     GVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHL
                     EVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELI
                     KQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSIS
                     HIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQM
                     NDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKD
                     IDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESM
                     LNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAG
                     HYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRR
                     DEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVS
                     MPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALD
                     WIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKG
                     HIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDR
                     EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEI
                     PPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYC
                     KNKPDSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEE
                     GKGELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRK
                     GRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGR
                     TPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSK
                     RDGVEDIDSQGDGSSQPDTISIASRTSQNTVDSDKLSGGCELTVVLQDFSAGHSSELT
                     IQVGQTVELLERPSERPGWCLVRTTERSPPLEGLVPSSALCISHSRSSVEMDCFFPLV
                     KDAYSHSSSENGGKSESVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGK
                     ADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADESKKGWGEDEPDEESHTPLPP
                     PMKIFDNDPTQDEMSSSLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLK
                     DPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMK
                     RIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKL
                     HIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDF
                     LRYSEKAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYV
                     IELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDND
                     PCKFALMNRETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERS
                     TAVMRSQPARLPQASPRPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQP
                     GDKFEASKNDLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQP
                     ASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEA
                     TGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDV
                     TCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNL
                     MPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTG
                     NCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPS
                     EPSEFVRLPEYDAAADGATISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAV
                     KFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLM
                     NHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDA
                     VQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKE
                     ETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNGS
                     YSKIPLDTSRLACFIERRKHQNDVRPIPNVKSYIVNRVNQGT"
     exon            446..520
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            521..635
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            636..828
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1341
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1464
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1656
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1788
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..2019
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2142
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2334
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2543
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2718
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2914
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3081
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3201
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3420
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            3421..3570
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            3571..3685
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            3686..3801
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            3802..3924
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            3925..4107
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            4108..4226
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            4227..4293
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            4294..4403
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            4404..4473
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            4474..4563
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            4564..4656
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            4657..4768
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            4769..4959
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            4960..5061
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            5062..5204
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            5205..5307
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            5308..5554
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            5555..5838
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            5839..5940
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            5941..6036
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            6037..6167
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            6168..6234
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            6235..6338
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            6339..6408
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            6409..6495
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            6496..6588
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            6589..6639
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            6640..6717
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            6718..6903
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            6904..7075
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            7076..7314
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            7315..7565
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            7566..7689
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            7690..7749
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            7750..7777
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            7778..7949
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            7950..8071
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            8072..8203
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            8204..8368
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            8369..8447
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            8448..8648
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            8649..8787
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            8788..16188
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      16166..16171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /note="hexamer: AATATA"
     polyA_site      16188
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /note="major polyA site"
ORIGIN      
        1 aatagagaca ggcagacggg cgagcaggag agccagctgc cgctgctggg ggacagcggg
       61 cgcccaggca gcccgcaccc cggccccggg ccccggcccc agccagacag caggcggcca
      121 gcgccctggg gaaggggtac catgggggag ctggcggcag gcacccccag cccgccgcgc
      181 gcctccgcct gagggaggct cagcgtcctc tgccccagcc ccgccgccca acgcccgccc
      241 tcgaagctcc gcggccgcca gctctgcggc cgcagcagct gcgccccgcg ccctccgccc
      301 accgggcgcc gagcagccct cggccccagg cttcttcggc tcccggctgc ccgcggacgc
      361 cctcccacag tcatgaaccc ccctgaggga gcagcggagg aaggaggagc agcagactcg
      421 gacgtggacg cctttttccg gacagggtct tttcggaatg atggtttgaa agcttctgat
      481 gtccttccta tcctaaagga aaaggtggcc ttcgtgtctg ggggtcgtga taagcgaggc
      541 ggacccatcc tgaccttccc tgctcgcagc aatcatgaca gaataagaca ggaagacctg
      601 cggaaactcg tgacgtattt ggccagcgtg ccaagtgagg acgtgtgcaa acgtggcttc
      661 actgtcatca tcgacatgcg gggctccaag tgggacctca tcaagcccct cctcaaaacg
      721 ctgcaggaag cctttccagc tgagatccat gtggccctca tcattaaacc cgacaacttc
      781 tggcagaaac agaagaccaa ctttggcagc tccaaattca tctttgagac gagcatggta
      841 tctgtggagg gcctcacaaa gctggtggac ccctcccagc tgacggagga gtttgatggc
      901 tccctggact acaaccatga ggagtggatc gaactgcggc tctccctgga ggagttcttc
      961 aacagcgccg tgcacctgct ctcgcgcctc gaggacctcc aggagatgct agcccggaag
     1021 gagtttcctg tggatgtgga gggctctcgg cggctcattg acgaacacac acagctcaag
     1081 aaaaaggtgc tgaaggcccc tgtggaggag ctggaccggg aggggcagcg gctgctgcag
     1141 tgcatccgct gcagcgacgg cttctcagga cgcaactgca tcccgggcag tgctgacttc
     1201 cagagcctgg tgcccaagat caccagtctc ctggacaagc tgcactccac ccggcagcac
     1261 ctgcaccaga tgtggcatgt gcgcaagctc aagctggacc agtgctttca gctgcggctc
     1321 ttcgagcagg atgctgagaa gatgtttgac tggataagcc acaacaagga gttattcctc
     1381 cagagccaca cggagatcgg agtcagctac cagtacgccc ttgacctcca gacgcagcac
     1441 aatcactttg ccatgaactc catgaatgcc tatgtcaaca tcaaccgcat catgtccgtg
     1501 gcttcccgcc tctctgaggc cggtcattat gcctcacaac aaatcaagca gatctccacc
     1561 cagctggacc aggagtggaa gagcttcgct gctgccctgg atgaacgcag caccatcctc
     1621 gccatgtctg ctgtgttcca ccagaaggct gagcagttcc tgtcgggagt ggatgcctgg
     1681 tgcaagatgt gcagtgaagg tggtctgcca tccgagatgc aagacctaga gctggcaatc
     1741 caccaccacc agaccttgta tgagcaggtg acccaagcct acacagaggt cagccaggat
     1801 ggcaaagcac tacttgatgt gctgcagcgg cccctgagcc ctgggaactc cgaatccctc
     1861 acggccacag ccaactactc caaggcagtg caccaggtgc tggacgtggt gcatgaggtg
     1921 ttacatcacc agcgacggct ggagagcatc tggcagcacc gcaaggtgcg gctccaccag
     1981 cggctgcagc tctgcgtctt ccagcaggat gtacagcagg tgttggactg gattgaaaac
     2041 catggtgagg cctttctcag caaacacact ggagttggga agtccctaca tcgagcccgg
     2101 gccctgcaga agaggcatga tgactttgaa gaggtggctc agaatacgta caccaatgcg
     2161 gacaagctcc tagaagcagc agagcagttg gctcagacgg gggaatgtga ccccgaggag
     2221 atctacaagg cagctcgaca cctggaggtg cgcatccaag acttcgtgcg cagggtggag
     2281 cagcggaagc ttctcctgga catgtctgtt tccttccaca cacacaccaa agagttgtgg
     2341 acatggatgg aagaccttca gaaggagatg ttggaggatg tctgtgcaga ttctgtggat
     2401 gcagtccagg aactgatcaa gcagttccag cagcagcaga ccgccactct agatgccaca
     2461 ctcaatgtca tcaaggaagg cgaagacctt atccagcagc tcaggtcagc gcctccctcc
     2521 ctcggggagc ccagcgaggc cagggactcg gctgtgtcca acaacaaaac accccacagc
     2581 agctccatca gccacatcga gtcggtcctg cagcagcttg atgatgccca ggtgcagatg
     2641 gaggagctgt tccacgagcg gaagatcaag ctggacatct tcctgcaact gcgcatcttt
     2701 gagcagtaca ccatcgaggt gacagcagag ctagacgcct ggaatgaaga cttgcttcgg
     2761 cagatgaatg acttcaacac agaggaccta accctggcag aacagcggct gcagcgccac
     2821 acagaacgga agctagccat gaacaacatg acctttgagg ttatccagca gggacaggat
     2881 ctgcaccagt acatcacgga ggtccaggca tcaggaattg agttgatctg tgaaaaagac
     2941 attgatctgg cagcccaggt gcaagagtta ttggaatttc tccatgagaa gcagcatgaa
     3001 ttggagctca atgcagagca gactcataag cggctagagc agtgcctcca attacgtcac
     3061 ctccaggctg aagtcaaaca ggttctggga tggatccgca atggagagtc aatgctcaac
     3121 gccagcctgg tcaatgccag ctctttgtcg gaagcagagc agctgcagcg ggagcacgag
     3181 cagttccaac tggccatcga gtccctcttt catgccactt ccttgcagaa gacgcaccag
     3241 agtgccctgc aggtacagca gaaagccgag gtgctgctcc aggccggcca ctacgatgcc
     3301 gatgccatcc gggaatgtgc tgagaaggtg gccctccact ggcagcagct catgctgaag
     3361 atggaagacc ggctaaaatt ggtcaatgcc tctgtggcct tttacaaaac ttctgaacag
     3421 gtgtgtagtg tcctggagag cttagagcaa gaataccgga gagatgagga ctggtgtggt
     3481 ggacgagata agctggggcc agcagcagag atcgaccatg tcattcccct catcagcaaa
     3541 catttggaac aaaaggaggc ctttcttaag gcctgcaccc tggctcggcg gaatgctgag
     3601 gtgtttctca agtacatcca caggaacaac gtcagcatgc ccagtgtcgc cagccacact
     3661 cggggacccg agcaacaagt gaaagccatc ctgagtgagc tcctgcagag ggagaatcgc
     3721 gtgctgcatt tctggacctt gaagaagcgg cggttagacc aatgccagca atatgtggtg
     3781 ttcgagcgca gcgctaagca ggcgcttgac tggatccaag aaacaggtga attttacctc
     3841 tcaacacata cctccactgg agagaccaca gaggagactc aggaactgct gaaagaatat
     3901 ggggaattca gggtgcctgc caagcaaaca aaggagaagg tgaagcttct gattcagctg
     3961 gccgatagct ttgtggaaaa aggccacatt catgccacgg agataaggaa atgggtgacc
     4021 acggtggaca agcactacag agatttctcc ctgaggatgg gaaagtaccg atactcactg
     4081 gagaaagccc taggagtcaa cacagaggat aataaggacc tggagctgga tattatccca
     4141 gcaagccttt cggatcggga ggtcaagctg cgggacgcca accacgaagt caatgaagag
     4201 aagcggaagt cagcccggaa gaaagaattt attatggctg aactactcca gacagagaag
     4261 gcttatgtaa gggatttgca tgagtgctta gagacctacc tgtgggaaat gaccagtggt
     4321 gtggaggaga tcccccctgg gatcctcaat aaagagcata tcatctttgg caacatccaa
     4381 gagatctacg atttccataa caacatcttc ctcaaagagc tggagaagta cgagcaactg
     4441 cctgaggatg tgggacactg ctttgttacc tgggcagaca aatttcagat gtatgtcacc
     4501 tactgtaaaa acaagcctga ttccaaccag cttatcctgg agcatgcggg caccttcttt
     4561 gatgagatac aacagcggca tggtctggcc aactccatct cttcctacct aattaagcct
     4621 gtccaaagga tcaccaaata tcaactgctc ctgaaggaac ttttaacttg ctgtgaagaa
     4681 gggaaagggg agctcaagga tggcctggag gtgatgctca gtgtcccaaa gaaagccaat
     4741 gatgccatgc atgtcagcat gctggaaggg ttcgacgaga acctggatgt gcagggggag
     4801 ttgattctcc aggatgcctt tcaagtgtgg gacccgaagt cgctgatccg gaaggggcgg
     4861 gagcggcact tgttcctctt tgagatctcc ttggttttta gcaaggagat caaagattct
     4921 tcaggacaca cgaaatatgt ttacaagaac aagctactga cctcagagct gggtgtgacc
     4981 gagcacgtgg agggcgatcc ctgcaaattc gccttgtggt ctgggcgcac cccatcctca
     5041 gacaataaaa cagtgctgaa agcctccaac attgaaacca agcaggagtg gatcaagaac
     5101 attcgagaag tgattcaaga aaggatcatt cacctgaaag gagctttaaa ggagccactt
     5161 cagctcccca aaacaccagc caaacagagg aacaatagta agagggatgg agtggaggat
     5221 attgacagcc agggggatgg gagcagccaa ccagacacca tctccattgc ttctaggacc
     5281 tctcagaaca cagtggacag tgacaagctc tctggtggat gtgagctgac agtggtcctc
     5341 caggacttca gtgcgggcca cagcagtgag ctgaccatcc aggtggggca gacggtagag
     5401 ctgctggagc ggcccagcga gcggcctggt tggtgtctgg tccgtaccac cgaacggagc
     5461 ccgcccttgg agggtctggt ccccagcagc gccctgtgca tctcacactc ccgaagcagc
     5521 gtggagatgg actgcttctt ccccttggtg aaagatgcat actctcattc ctcaagcgag
     5581 aatggaggca agtccgagtc cgtggccaac ctgcaggccc agccctccct gaactccatc
     5641 cacagttccc cgggtcccaa gcgctccacc aacactctta agaagtggct gacgagtcct
     5701 gtgcgtcggc ttaacagcgg gaaggcagat ggaaacatca aaaagcagaa gaaagttcgc
     5761 gatggtcgga agagctttga cctgggatct cccaagcctg gggatgaaac aacccctcag
     5821 ggagacagcg ctgatgagag caagaaaggt tggggtgaag atgagccgga tgaagagtca
     5881 cacacacccc tcccaccacc tatgaagatt tttgacaacg accctacaca ggatgaaatg
     5941 tcctcctctt tgctagcagc ccggcaggct tccactgaag tacctactgc tgcagacctt
     6001 gtcaatgcaa tagaaaagtt ggtcaaaaac aagctgagtc tagaaggaag ctcataccgg
     6061 gggagcttga aagaccctgc aggctgcctg aatgagggga tggccccacc cacacctcct
     6121 aaaaacccag aagaagaaca gaaagccaag gccctgagag gcaggatgtt tgtcctgaat
     6181 gagctggtac agacagagaa agactatgtc aaggatctgg gcattgtggt ggagggcttc
     6241 atgaagagaa tagaagaaaa gggtgtccct gaggatatgc gaggaaagga caaaatcgtg
     6301 tttggaaata ttcatcagat ttatgactgg cataaggatt ttttcctggc ggaactggaa
     6361 aagtgtatcc aggagcaaga cagattggca cagctcttta ttaagcacga gcggaagctg
     6421 cacatctacg tgtggtattg tcagaataag ccgcgctcag agtacatcgt tgctgagtat
     6481 gacgcctact ttgaggaggt aaaacaggag ataaatcaga ggctgacact gagtgacttc
     6541 ctcatcaagc ccattcagag aataacaaaa taccagttgc tcctcaagga cttcctgaga
     6601 tacagtgaga aggctggttt ggagtgttca gatattgaga aagcagtgga gttaatgtgc
     6661 cttgttccca aacgctgcaa tgacatgatg aatctaggac gtctgcaggg ctttgagggc
     6721 actctgactg ctcaggggaa gctgctgcag caggacacat tctatgtgat cgagctggat
     6781 gcaggcatgc agtcccggac caaagagagg cgcgtgttcc tcttcgagca gattgtcatc
     6841 ttcagtgaac tgctcaggaa gggatccctc acccctggct acatgttcaa aaggagcatc
     6901 aagatgaatt acttggtcct ggaggagaat gtggacaatg atccctgcaa gtttgcactc
     6961 atgaacagag agacttctga gagggttgtt ctgcaagccg ccaacgctga catccagcag
     7021 gcctgggtgc aggacatcaa tcaagtctta gaaacacagc gagacttttt gaatgcactg
     7081 caatcgccca ttgagtatca acggaaagaa aggagcacag ctgtgatgag gtctcaacct
     7141 gccaggcttc cccaagccag ccccaggccc tactcctctg ttcctgcggg ctcagagaag
     7201 cccccaaagg gctccagcta taacccacct ctgcctcccc tgaagatatc tacctccaat
     7261 ggcagtccag ggtttgaata ccaccagcct ggggacaagt tcgaagccag caagaacgac
     7321 ctgggaggct gcaatgggac ctcgtccatg gccgtgatca aagattacta tgcactgaag
     7381 gagaatgaaa tctgtgtgag ccaaggtgag gtggtccagg tcctcgccgt caaccagcag
     7441 aacatgtgtc tggtgtacca gcctgccagc gaccattccc ccgccgccga gggctgggtc
     7501 ccaggcagca tcctggcgcc cctcaccaaa gccacagcag cagaaagtag tgacgggagc
     7561 atcaagaagt catgttcatg gcatactcta cgcatgagaa agcgggcgga agtggagaac
     7621 acgggtaaaa atgaagccac agggcctcgt aaacccaagg atattctggg caacaaagtc
     7681 tctgttaaag agacgaacag ttccgaggaa tcagagtgtg atgatcttga ccctaatact
     7741 agcatggaga tcttaaatcc aaatttcatc caagaagtgg ccccagaatt ccttgtgccc
     7801 ttggtggatg tgacctgctt gcttggggac acagtgatac tgcagtgcaa agtctgtggg
     7861 cggccaaagc ccaccatcac ttggaagggt ccagaccaga acatccttga cactgataac
     7921 agctcagcca catacacggt ctcctcttgt gattctggag aaatcaccct gaagatctgt
     7981 aatctgatgc cccaagacag tgggatttat acctgcatag caacaaatga ccacgggacc
     8041 acatcaacgt ctgcaacagt caaagtgcaa ggtgttccag cagcccctaa ccgccccatt
     8101 gcccaggaga gaagctgcac ctccgtgatt ctccgctggc tgcccccctc cagcacagga
     8161 aactgcacta tttctggtta cactgtggag tacagagagg aaggttctca gatctggcag
     8221 cagtcagtgg cttcgacctt ggacacttac ctcgtcatcg aagaccttag tcccgggtgt
     8281 ccttatcagt tcagagtcag tgccagtaac ccctggggaa tcagccttcc cagcgagccc
     8341 tcggagtttg tgcgacttcc agaatatgat gctgctgctg atggtgccac catttcttgg
     8401 aaggaaaatt ttgactcagc ttacactgag ctgaatgaaa ttggaagagg ccgtttctct
     8461 atagtaaaga aatgcattca caaagctacc cgcaaagatg tggctgtgaa atttgttagc
     8521 aaaaaaatga agaagaaaga acaggctgcc cacgaggctg ccctgcttca gcacctacag
     8581 cacccccagt acatcactct ccatgacacc tatgagtccc ccacatccta catcctgatc
     8641 ttggaactga tggatgatgg ccggctctta gactacctta tgaatcatga tgaactgatg
     8701 gaggaaaaag tagctttcta tatccgagac atcatggagg ctctgcagta ccttcacaac
     8761 tgcagggttg cacatttgga cataaagcct gaaaacctgc tcattgacct acggattcca
     8821 gtgcctcgag tgaagctcat tgacttggag gatgctgtcc agatctcggg tcacttccac
     8881 attcaccacc tgctggggaa ccctgagttt gctgccccag aagtcattca aggcatcccc
     8941 gtctccctgg ggacagacat ctggagcatc ggggttctga catatgtcat gctgagtggg
     9001 gtctccccct tcttggatga gagcaaagag gagacatgta tcaacgtatg cagggtggat
     9061 ttcagcttcc cccatgaata cttctgtggt gtgagcaatg ctgccagaga tttcatcaat
     9121 gtgatcttac aggaagattt tcggaggcgg cccacagcag ccacatgctt gcagcatcca
     9181 tggctgcagc cccataatgg cagctactct aagatccccc tggacacctc ccgcctagca
     9241 tgcttcatag aacgtcgcaa gcaccagaat gatgtgcggc ctattcccaa tgtcaagagc
     9301 tacattgtca accgggtgaa ccaagggacg tagccatctc ccagccccta tggtttcaca
     9361 tagacgtgca gtgtgaacca aagcaagact gaatgtgact gtaaataatt ctgttcatca
     9421 tttcactccg tgcagttctc tgaattgaga gatgtacctc ttaaacctcg tcagtggtta
     9481 ttcagggtct gagcagcagt aaaagtcacc ctaaatcaag gggcttttca gaaggtcatt
     9541 ctgaagaaat aaagaggcaa agggtcacag aagtgttcag aagaagggca aagataagaa
     9601 caatattagc tgttacgaaa ttttaactgt atcttccaaa atgagtggtt aactgggcaa
     9661 accttaagct cacaagagta taaaagatct ctggctttgc tgaaatttta agcaagaagt
     9721 tctatttaat ggagatgtca tgtatatcaa ctattctggt ttagataact tagatatagt
     9781 ttcttaatag gatagatacc cacatacagt ataatatatc ccattcaggt ttcagagttt
     9841 tctaatatag agatatatat attaaatcaa tcacaagtaa ttttgagtgc tccagttaag
     9901 acagtaattt atttaccgaa tcattacatt gttttgacta agcacaatta gatgacaagt
     9961 ttttttagag cattttatag atcttgtata gaaatctttt accagaacct gtgcattaag
    10021 agaaagcaat gttgcccttt tgaatgagaa aattttttct gtcaatcgca ggttatttga
    10081 ttaagatagg ttctttctgt atatgaaacg ctccccgcaa attcactggc agctcagaat
    10141 tattctggaa agaaagcctg ccaggaaata aattcaaata cagtatgagc tgcggggata
    10201 tttttgtgtc tacaccaggt ttgaaataag taaacaaata caagaggttc atataaaagg
    10261 gcaaatgaaa acctttccta cagttcctat gaacaacgta ccaacacttt ctgatttctt
    10321 ctacagctgt agaataccat ctttcagaaa gttggctggc tttatttcta actccttatt
    10381 gaagctaagg ggtgcttact aaaaggaggc agccatatag gccttttaaa ggcctggttc
    10441 taagtccttt ttaaagccat ggaacaaaac ctgatacatc accctaacag agcattaagt
    10501 tgtaactgag attgcaatac ctgtcaccat gcagccgctg atagttctct gaactaaaag
    10561 gactaattgt actttgaggc caatgctgct ttctggtgta tattctccat acaagattat
    10621 tattaactgc tctttttccc tctggtggaa aaaaaattaa acctgggcat ttcatgggtt
    10681 ttctttcttt atttttgttc atttgttttg gagggaggga gcttgttttt tgtgtttgta
    10741 catgatccac ccttagtttt ctagaatgtg tgttgaaaat tgcgattata caagtaagat
    10801 tttaaaaatg taactcaagt gtttgttcaa atcaggttta atggtgttgc ttctctccta
    10861 taatgggata gagaaaatta aaatcacgta gtacagaagt gcaagaagag aatttatgaa
    10921 ggatgaatag aactacaaac ctatctaaat gaaaaagaaa tggtggaaac taagcctgaa
    10981 ctttaacata taaaaaacac ttattcccac agagaaaatg taaaattaaa aatcatcatc
    11041 tttttttttc cattggtttc aaagacaact tcctcattcg ccctccacct catcccatcc
    11101 aagattatag attgataaat taatggaaag tataagcaat aagactagat agcacttagt
    11161 atttttggga ttaaccaaat atatggaaac cgactccgac tgtatttgtt tcttaatttt
    11221 caaatggccc tgggtcataa agcctcactc cctcagaggt ctctcgacta acccctatag
    11281 tcttcatttg gacctttatg tatttacaaa cactctatga tacaatacat aaaaatttaa
    11341 aacatacatt aaacatggtt actaaaattt ttcaaaatgt aaaacatatt tagtaaaaaa
    11401 attttagtaa acatgttttc attgtgttta aaaaatttaa aacatattta ctaaaaatcc
    11461 ttttagtaaa cagtttacta aaaccctttc aataaacatg tcttcattat ggtatacagc
    11521 ataaaagagg aaagcctgag ccgggcgcgg cggctcacgc ctgtgatccc agcactttgg
    11581 gaggccgagg cgggtggatc acaaggtcag cagttcgaga ccagcctgac taacatggtg
    11641 aaaccctgtc tccactaaaa atacaaaaaa atcatctggg cgtagtggcg ggcactcgta
    11701 atcccagcga cttgggaggc tgaggcagga gaatcgcttg aaaccggaag gcggaggttg
    11761 ccgtgagccg agattgcacc actgcactct agcctgggca ataagagcaa aattctgtct
    11821 cgaaaaaaaa ggaaagcctg gcccataggg tttgtcatgg gacaaactgt aggctctgag
    11881 gattcccaat atccataaag tccagcttgg caagttctgt tctgtccact gtggatgacc
    11941 tgaatcaaga tccccctgct gagccattct gagtttttat aacaagttga gtttctgctt
    12001 gagaaggcca gggcccagaa caatggtgtg cagaccacgg caggtggggg acaaggaggg
    12061 tatttttgaa attatgttat gggggcagtt gacagaatgt tagacagacc ccaagctttc
    12121 atatcagctt ttacaacaga gttgggagga tccagatgtg gggttgcatg gaattccccc
    12181 aagtacacat atttgggaag tgagaagaca ggaaaggagg gacctagaaa tgaaaagtag
    12241 gatgattttg ttaactggag ccaaggtaca atcattagac tagaatgaac ttaatagagg
    12301 ccccaagaga aagggggtat attttatata gtttgataac ggagggaaac taacagggag
    12361 gctccctgtc tgcaaagctc ctggtccctc ccaacagaga taagagagta gtcttggttc
    12421 aagagttctc cacagcaagt tggaaataac aaggaatccc agatgatgat gatcctgggg
    12481 aatgtacttt aggttgctct gagggcaacc gtgcttaggg aaaaaggatc aggggccact
    12541 cttgttcctg ttttggcgga gagatttatt acttggtagt aaagaagaga ggagagaaga
    12601 gaaaatggtc catttctatc attatgatgg tagttcacag tgggagtgaa ctttcagctg
    12661 aaatgggaaa aacaaacaat ggtcaaggtc acaagtttct tgcttggctt ttattcattg
    12721 catagggttt tgagcttttt gttttgtttt gttttgtaag ggtgggatac agaaagaatg
    12781 aaaagatcag ggacaaccca taataacttt taagaagtat taatataatg atttcctaca
    12841 tcttttacat ttgtttcaaa ttaaatagat atatatccac ttacagctga atgtggtaaa
    12901 atttttaaga aaaaaatggt aatgttggag atatccttca ggtctctctc agccataaac
    12961 aatgtaaggg ggagtagagg aagcagagga gaaagctagc ttcactgctt tgtggtccac
    13021 aaagccttta taaatagtag tgcctttcag aggggaggat gggagataaa gaagttcatt
    13081 gcatttagat gtactgatat tgcagcattt tttctttact ttaaaatatc ttgtaaatga
    13141 aaacatctga atataggggt gggaccagga atgtttgagt ttcaatctca gctattcctg
    13201 attcatcttt tcttacagaa agtctttgtt tttccttccc caaatgtccc cattggtaaa
    13261 atgggagttg ggggatgggg aaggagggag gacattaatc ttacaggaat gttgagaaat
    13321 aaccttggtg gggacatcta taaaatactt tgattttttt aagtgctaca cactgccagt
    13381 gctaagaatt ttattgatag taactttgaa cattccaggt tttcaatatt cacgtcttta
    13441 gataccaatt ataaactcat gagattaaat tctgtaaatt gttttcagtt ggaagtatca
    13501 ggtgctcttt gtctaaatgt tatttggtct tagcctataa tttcgatcat ttaagagctt
    13561 gtctaccgaa aagggttagg agagctgatg aagtcttatg tccataagtt gttttctcca
    13621 gtatttctta tggcagatgc gaagagtaaa atgcccttga aagcaactgc taccttcctt
    13681 ctcaagcttt atgctctgga aaaaaggaca gagaagaacc caacaaccac tttcttcact
    13741 tgggagggca gaagtgagaa gaaaatatct tctcatacca caatttattt ttcacagcct
    13801 cacaggaatc taagagacaa attaaatgca caggcaaatt aaatgcatag aaatgaattg
    13861 gactgctcat ttttggagga caaaccttga atcttttttt ttttttttag gtggttaggt
    13921 cttttaggag ttgcatattt gctatcccat aacctccatg attagagccc acgagttagg
    13981 cattactttt ttcttgcctc tgtggaagag catggcaatt tagatttgtg agaatatgag
    14041 ggagcaaata tgatataaac taaattttgc attaactaaa actttgtccc atgcatttaa
    14101 tacaggagga aattattttg tacgtaagag gtctttgtag tagggcaaag ttcaaactca
    14161 ccatgtcctt attcagtatg gtcaatgaat tgtgctggat gagtttcgag gaatgtagac
    14221 cttcttcctt tctctcctgg gtcgcacctc tgtggagtct gggttagaca aatgcaatat
    14281 gtgacctttc agtgaattta tttataaaac tgcaccttga tttttcctca ctatttaaag
    14341 cctagggatg atttgatgat gaatgattaa acccatggtg ggcttagaga cgacagagct
    14401 cacacacgct ccatcaagaa aaggaaagct actatgttaa tatttatttt ctaaaaatat
    14461 taaggctctc agttgtttca ttaattctaa agggttaaaa agggctgaaa tttgtttata
    14521 gcactaaatg tttttaatag gaaatttact cacataaaaa atttaagcag aagtagtaga
    14581 atacagatta tcataaaaca tattttctat gaaaggcatt tcttcctcat cttcaataaa
    14641 tatgaagaag ttagaggaga ggaaaaagca atcactctaa gacaactttt cgtctttgag
    14701 ggacattatg ataagcctga aattaatacg cacaggctat tgcatttttc tgtgagaaat
    14761 gtgccccttt gctgtgagat tctaaaatgt gttcagattt agtttttatt caaatgatca
    14821 agataacgca ttagttagat aactgctatt tcagatagtg aggttagctg agaaaaggaa
    14881 gcatggtaga agaaatgcaa ataacaattc ttggaatgcc aactcctgag gcttagttta
    14941 accaagctaa tttgttggcc cagggatggc catcatatga gtttccatca atacctgact
    15001 tccatcaaca actgaatcca tgttctggag tattacagag actgttacta tgacctcaaa
    15061 gactgtggct acgaatctga agttaacaag acatacatct tctcttacta acttaagcca
    15121 tatctgtcaa ctctatgttt gatttttctg accctggtgc ttttacttct gtttctgcca
    15181 aacttcagcc tactctatgg ggaaggtgag taaaactagt agttagaaca aatatgaaga
    15241 ctgaaaaaaa ctaaacatac tcttcataat gagatcctgt tcagagaaca gtagtgatca
    15301 aagtgcaaac tgttggaaaa tatggatata tgtacatctg tacatgtata tagtgtataa
    15361 tatgtatgta tatgttattg ctcatatgca gaaatctatc catttgcaga cagcccaggt
    15421 gggtcaatgt ttctaatgga aaaccattta gggccattca aaaccattag ggctaatttg
    15481 tggagacgaa ttctactcat tctggaatta atttgctgtc ttttgacatc cacaaagcca
    15541 aactaacaaa gtgtgaaaca taaaggggcc atcatttagt ttattctgtt tatctggact
    15601 tataactatc tttacatttg aactattaat agttgatttg caaactgtat tggcatctct
    15661 tggttttgag tgacccctgc ccccctcaag tcttttgaga atttggagtg ggcttcactg
    15721 gccattcaga caaagggcct tattcataag tggacaggtt tccccatagg gaccatcgca
    15781 catatacata taagtacata cttccatcag gcttgtaaca attgatttaa aatcactcca
    15841 cagtattgat aaatagctct atattttcaa ggtgcagaag aattccacag ccttaattat
    15901 ttcagtgtct tgctggtctg ccttaagtgt atcttctggg tttttggtta ttttattatt
    15961 tttaaatttt tctgctgttg ttcattttgt atgcacacaa tgtcgttttg taaaggtagg
    16021 ttgtaaatat tttatttgta agtcaaaatc actcatgtgt aatgttgtaa agtgatgacc
    16081 tgctgtcttg ttactgctac agtaaatgtt ataagttatg gatgaaactt caaaatgtac
    16141 atctcacatg ttatgcattc ctataaatat actatactaa agatacta
//
