LOCUS       NM_001322996            3076 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens kalirin RhoGEF kinase (KALRN), transcript variant 13,
            mRNA.
ACCESSION   NM_001322996
VERSION     NM_001322996.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3076)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 3076)
  AUTHORS   Afanasyeva,E.A., Gartlgruber,M., Ryl,T., Decaesteker,B.,
            Denecker,G., Monke,G., Toprak,U.H., Florez,A., Torkov,A.,
            Dreidax,D., Herrmann,C., Okonechnikov,K., Ek,S., Sharma,A.K.,
            Sagulenko,V., Speleman,F., Henrich,K.O. and Westermann,F.
  TITLE     Kalirin-RAC controls nucleokinetic migration in ADRN-type
            neuroblastoma
  JOURNAL   Life Sci Alliance 4 (5), e201900332 (2021)
   PUBMED   33658318
  REMARK    GeneRIF: Kalirin-RAC controls nucleokinetic migration in ADRN-type
            neuroblastoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3076)
  AUTHORS   Li,M., Ma,Y., Zhong,Y., Liu,Q., Chen,C., Qiang,L. and Wang,X.
  TITLE     KALRN mutations promote antitumor immunity and immunotherapy
            response in cancer
  JOURNAL   J Immunother Cancer 8 (2) (2020)
   PUBMED   33037113
  REMARK    GeneRIF: KALRN mutations promote antitumor immunity and
            immunotherapy response in cancer.
REFERENCE   4  (bases 1 to 3076)
  AUTHORS   Paskus,J.D., Tian,C., Fingleton,E., Shen,C., Chen,X., Li,Y.,
            Myers,S.A., Badger,J.D. 2nd, Bemben,M.A., Herring,B.E. and
            Roche,K.W.
  TITLE     Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF
            Protein-Dependent Neuroligin-1 Mechanism of Action
  JOURNAL   Cell Rep 29 (10), 2944-2952 (2019)
   PUBMED   31801062
  REMARK    GeneRIF: Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF
            Protein-Dependent Neuroligin-1 Mechanism of Action.
REFERENCE   5  (bases 1 to 3076)
  AUTHORS   Dang,M., Song,Y., Li,Q., Zhang,C., Peng,Y., Wei,Z. and Huang,P.
  TITLE     Genetic Variation of the Kalirin Gene is Associated with ICAS in
            the Chinese Population
  JOURNAL   J Mol Neurosci 66 (2), 157-162 (2018)
   PUBMED   30232674
  REMARK    GeneRIF: SNPs of the KALRN gene are associated with intracranial
            atherosclerotic stenosis in the northern Chinese population.
REFERENCE   6  (bases 1 to 3076)
  AUTHORS   McPherson,C.E., Eipper,B.A. and Mains,R.E.
  TITLE     Genomic organization and differential expression of Kalirin
            isoforms
  JOURNAL   Gene 284 (1-2), 41-51 (2002)
   PUBMED   11891045
REFERENCE   7  (bases 1 to 3076)
  AUTHORS   Johnson,R.C., Penzes,P., Eipper,B.A. and Mains,R.E.
  TITLE     Isoforms of kalirin, a neuronal Dbl family member, generated
            through use of different 5'- and 3'-ends along with an internal
            translational initiation site
  JOURNAL   J Biol Chem 275 (25), 19324-19333 (2000)
   PUBMED   10777487
REFERENCE   8  (bases 1 to 3076)
  AUTHORS   Kawai,T., Sanjo,H. and Akira,S.
  TITLE     Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and
            Pleckstrin-Homology (PH) domains
  JOURNAL   Gene 227 (2), 249-255 (1999)
   PUBMED   10023074
REFERENCE   9  (bases 1 to 3076)
  AUTHORS   Colomer,V., Engelender,S., Sharp,A.H., Duan,K., Cooper,J.K.,
            Lanahan,A., Lyford,G., Worley,P. and Ross,C.A.
  TITLE     Huntingtin-associated protein 1 (HAP1) binds to a Trio-like
            polypeptide, with a rac1 guanine nucleotide exchange factor domain
  JOURNAL   Hum Mol Genet 6 (9), 1519-1525 (1997)
   PUBMED   9285789
REFERENCE   10 (bases 1 to 3076)
  AUTHORS   Alam,M.R., Johnson,R.C., Darlington,D.N., Hand,T.A., Mains,R.E. and
            Eipper,B.A.
  TITLE     Kalirin, a cytosolic protein with spectrin-like and GDP/GTP
            exchange factor-like domains that interacts with peptidylglycine
            alpha-amidating monooxygenase, an integral membrane
            peptide-processing enzyme
  JOURNAL   J Biol Chem 272 (19), 12667-12675 (1997)
   PUBMED   9139723
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC080008.23 and AL137629.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001322996.1.
            
            Summary: Huntington's disease (HD), a neurodegenerative disorder
            characterized by loss of striatal neurons, is caused by an
            expansion of a polyglutamine tract in the HD protein huntingtin.
            This gene encodes a protein that interacts with the
            huntingtin-associated protein 1, which is a huntingtin binding
            protein that may function in vesicle trafficking. [provided by
            RefSeq, Apr 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.95762.1,
                                           SRR14038192.3572049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               AC080008.23        71596-71844
            250-533             AC080008.23        119358-119641
            534-638             AC080008.23        120787-120891
            639-734             AC080008.23        124146-124241
            735-865             AC080008.23        137746-137876
            866-932             AC080008.23        142539-142605
            933-1036            AC080008.23        144386-144489
            1037-1106           AC080008.23        144672-144741
            1107-1193           AC080008.23        145369-145455
            1194-1286           AC080008.23        146303-146395
            1287-1337           AC080008.23        147861-147911
            1338-1415           AC080008.23        148789-148866
            1416-1601           AC080008.23        153387-153572
            1602-1773           AC080008.23        153950-154121
            1774-2012           AC080008.23        158598-158836
            2013-3022           AC080008.23        161302-162311
            3023-3076           AL137629.1         1902-1955
FEATURES             Location/Qualifiers
     source          1..3076
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1-q21.2"
     gene            1..3076
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /note="kalirin RhoGEF kinase"
                     /db_xref="GeneID:8997"
                     /db_xref="HGNC:HGNC:4814"
                     /db_xref="MIM:604605"
     exon            1..249
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2267
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /EC_number="2.7.11.1"
                     /note="isoform 12 is encoded by transcript variant 13;
                     huntingtin-associated protein interacting protein (duo);
                     serine/threonine-protein kinase with Dbl- and pleckstrin
                     homology domain"
                     /codon_start=1
                     /product="kalirin isoform 12"
                     /protein_id="NP_001309925.1"
                     /db_xref="GeneID:8997"
                     /db_xref="HGNC:HGNC:4814"
                     /db_xref="MIM:604605"
                     /translation="MKGGDRAYTRGPSLGWLFAKCCCCFPCRDAYSHSSSENGGKSES
                     VANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKS
                     FDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSS
                     SLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPP
                     KNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDK
                     IVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYI
                     VAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEK
                     AVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRV
                     FLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVV
                     LQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPARLPQASP
                     RPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKNDLGGCNG
                     TSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSI
                     LAPLTKATAAESSDGSIK"
     exon            250..533
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            534..638
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            639..734
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            735..865
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            866..932
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1036
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1106
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1193
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1286
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1337
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1415
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1601
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1773
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..2012
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..3076
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3044..3049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /note="hexamer: AATAAA"
     polyA_site      3076
                     /gene="KALRN"
                     /gene_synonym="ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP;
                     KALNC2; TRAD"
                     /note="major polyA site"
ORIGIN      
        1 agtggctccc agtaagtcag agctgcggcc gcggtgcggg gagagcacag cggggagggc
       61 gggagccggc tctcgggcgg cggcgctgaa gtttccttcc cgccgcgctc tcaccccggg
      121 ctggcgcccc gtgccatgcg ggagcgctgg ggcggcgggg caacatgaag ggcggcgaca
      181 gggcttacac ccgaggtccc tctttggggt ggctctttgc taagtgctgc tgttgcttcc
      241 cgtgtagaga tgcatactct cattcctcaa gcgagaatgg aggcaagtcc gagtccgtgg
      301 ccaacctgca ggcccagccc tccctgaact ccatccacag ttccccgggt cccaagcgct
      361 ccaccaacac tcttaagaag tggctgacga gtcctgtgcg tcggcttaac agcgggaagg
      421 cagatggaaa catcaaaaag cagaagaaag ttcgcgatgg tcggaagagc tttgacctgg
      481 gatctcccaa gcctggggat gaaacaaccc ctcagggaga cagcgctgat gagaagagca
      541 agaaaggttg gggtgaagat gagccggatg aagagtcaca cacacccctc ccaccaccta
      601 tgaagatttt tgacaacgac cctacacagg atgaaatgtc ctcctctttg ctagcagccc
      661 ggcaggcttc cactgaagta cctactgctg cagaccttgt caatgcaata gaaaagttgg
      721 tcaaaaacaa gctgagtcta gaaggaagct cataccgggg gagcttgaaa gaccctgcag
      781 gctgcctgaa tgaggggatg gccccaccca cacctcctaa aaacccagaa gaagaacaga
      841 aagccaaggc cctgagaggc aggatgtttg tcctgaatga gctggtacag acagagaaag
      901 actatgtcaa ggatctgggc attgtggtgg agggcttcat gaagagaata gaagaaaagg
      961 gtgtccctga ggatatgcga ggaaaggaca aaatcgtgtt tggaaatatt catcagattt
     1021 atgactggca taaggatttt ttcctggcgg aactggaaaa gtgtatccag gagcaagaca
     1081 gattggcaca gctctttatt aagcacgagc ggaagctgca catctacgtg tggtattgtc
     1141 agaataagcc gcgctcagag tacatcgttg ctgagtatga cgcctacttt gaggaggtaa
     1201 aacaggagat aaatcagagg ctgacactga gtgacttcct catcaagccc attcagagaa
     1261 taacaaaata ccagttgctc ctcaaggact tcctgagata cagtgagaag gctggtttgg
     1321 agtgttcaga tattgagaaa gcagtggagt taatgtgcct tgttcccaaa cgctgcaatg
     1381 acatgatgaa tctaggacgt ctgcagggct ttgagggcac tctgactgct caggggaagc
     1441 tgctgcagca ggacacattc tatgtgatcg agctggatgc aggcatgcag tcccggacca
     1501 aagagaggcg cgtgttcctc ttcgagcaga ttgtcatctt cagtgaactg ctcaggaagg
     1561 gatccctcac ccctggctac atgttcaaaa ggagcatcaa gatgaattac ttggtcctgg
     1621 aggagaatgt ggacaatgat ccctgcaagt ttgcactcat gaacagagag acttctgaga
     1681 gggttgttct gcaagccgcc aacgctgaca tccagcaggc ctgggtgcag gacatcaatc
     1741 aagtcttaga aacacagcga gactttttga atgcactgca atcgcccatt gagtatcaac
     1801 ggaaagaaag gagcacagct gtgatgaggt ctcaacctgc caggcttccc caagccagcc
     1861 ccaggcccta ctcctctgtt cctgcgggct cagagaagcc cccaaagggc tccagctata
     1921 acccacctct gcctcccctg aagatatcta cctccaatgg cagtccaggg tttgaatacc
     1981 accagcctgg ggacaagttc gaagccagca agaacgacct gggaggctgc aatgggacct
     2041 cgtccatggc cgtgatcaaa gattactatg cactgaagga gaatgaaatc tgtgtgagcc
     2101 aaggtgaggt ggtccaggtc ctcgccgtca accagcagaa catgtgtctg gtgtaccagc
     2161 ctgccagcga ccattccccc gccgccgagg gctgggtccc aggcagcatc ctggcgcccc
     2221 tcaccaaagc cacagcagca gaaagtagtg acgggagcat caagtaagtg cctcgttggc
     2281 ttccccggga gaggagtatg aggattaaaa atattcagaa acaaacaaaa gaacacaaaa
     2341 atgcaaacac atggtaggga attactactg cttattctca acagtaccac agaaccagtg
     2401 tttgagtgct gacaccatat gcaacatggg gcatccgggc tggagtgatc cagtttttta
     2461 gttggtggtg gcgatgattt ttctttcctt ttggtttata attttctgtt catttttccc
     2521 cctttctccc ccacattcat taagaaccct actgaaaccc taggtgacaa aaggtgtgcc
     2581 ttctgttgcc acatttgacc caccacagga ctcactggac tggacttcta tttatattgt
     2641 attaagtaac tgatatatat atatatatat atttttgatt gacaccaaaa aattaccttg
     2701 gcacaaatgc cagacctgtg aaggtcagag gcccgctgct tttcccagga gggagggaac
     2761 tttttggttg tctgtggcaa ttcctctgta cagattgtaa ctttttaaaa atttcccttc
     2821 accccgtcac ttgaatatat gttcatagta atttgtaaga tacttctttt ccttattttg
     2881 gttgcaagac ccttccgaac acattcctgt ataaagtatt ttgcactatt taaagaaacc
     2941 catatggatg aagtcaggat gtgcaatatg atggcgtcac agtgctcatc gttgtacctg
     3001 taatgtaact aatcagttta aatgtactat tttaaatatg taaaataaat tttcaccatg
     3061 agcatgtttt aatgaa
//
